公开(公告)号：US20240101615A1

公开(公告)日：2024-03-28

申请号：US18158384

申请日：2023-01-23

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Zibo CHEN ,  Scott Boyken ,  Sherry Bermeo ,  Robert A. Langan ,  David Baker

IPC: C07K14/435 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y15/00 ,  C07K14/00 ,  C07K19/00 ,  G01N33/53 ,  G06N3/00 ,  G16B5/00 ,  G16B15/00 ,  H03K19/00

CPC classification number: C07K14/435 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y15/00 ,  C07K14/00 ,  C07K19/00 ,  G01N33/53 ,  G06N3/002 ,  G16B5/00 ,  G16B15/00 ,  H03K19/00 ,  C07K2319/00 ,  G16B5/10

Abstract: Disclosed herein are designed heterodimer proteins, monomeric polypeptides capable of forming heterodimer proteins, protein scaffolds including such polypeptides, and methods for using the heterodimer proteins and subunit polypeptides for designing logic gates.

公开(公告)号：US11820800B2

公开(公告)日：2023-11-21

申请号：US17285033

申请日：2019-11-04

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Zibo Chen ,  Scott Boyken ,  Sherry Bermeo ,  Robert A. Langan ,  David Baker

IPC: C07K14/00 ,  C07K14/435 ,  G01N33/53 ,  G16B15/00 ,  G16B5/00 ,  B82Y10/00 ,  G06N3/00 ,  H03K19/00 ,  B82Y5/00 ,  C07K19/00 ,  G16B5/10 ,  G16B5/30 ,  G01N33/542

CPC classification number: C07K14/435 ,  B82Y5/00 ,  B82Y10/00 ,  C07K14/00 ,  C07K19/00 ,  G01N33/53 ,  G06N3/002 ,  G16B5/00 ,  G16B15/00 ,  H03K19/00 ,  C07K2319/00 ,  G01N33/542 ,  G16B5/10 ,  G16B5/30 ,  Y10S977/914

Abstract: Disclosed herein are designed heterodimer proteins, monomeric polypeptides capable of forming heterodimer proteins, protein scaffolds including such polypeptides, and methods for using the heterodimer proteins and subunit polypeptides for designing logic gates.

公开(公告)号：US10988514B2

公开(公告)日：2021-04-27

申请号：US16088686

申请日：2017-03-31

Applicant: UNIVERSITY OF WASHINGTON

Inventor： David Baker ,  Scott Boyken ,  Zibo Chen ,  Chunfu Xu ,  Sherry Bermeo ,  Robert Langan

IPC: C07K14/00 ,  C07K14/435 ,  C07K1/113 ,  G16B15/20 ,  C07K2/00 ,  C07K16/18

Abstract: Methods and apparatus for identifying and screening hydrogen bond networks are provided. A computing device can determine a search space for hydrogen bond networks related to one or more molecules, where the search space can include a plurality of energy terms related to a plurality of residues related to the hydrogen bond networks. The computing device can search the search space to identify one or more hydrogen bond networks based on the plurality of energy terms. The computing device can screen the identified hydrogen bond networks to identity one or more screened hydrogen bond networks based on scores for the identified hydrogen bond networks. An output can be generated that is related to the one or more screened hydrogen bond networks. Also provided are polypeptides that can form homo-oligomers with modular hydrogen bond network-mediated specificity.