公开(公告)号：US20120013903A1

公开(公告)日：2012-01-19

申请号：US13258391

申请日：2009-07-30

Applicant: Huei Pei Kuo ,  Shih-Yuan Wang ,  David A. Fattal ,  Jingjing Li ,  Nobuhiko Kobayashi ,  Zhiyong Li

Inventor： Huei Pei Kuo ,  Shih-Yuan Wang ,  David A. Fattal ,  Jingjing Li ,  Nobuhiko Kobayashi ,  Zhiyong Li

IPC: G01J3/44 ,  B82Y20/00 ,  B82B1/00

CPC classification number: G01N21/658

Abstract: Embodiments of the present invention are directed to systems for performing surface-enhanced Raman spectroscopy. In one embodiment, a system (100, 400, 600, 800, 900, 950) for performing Raman spectroscopy comprises a substrate (102) substantially transparent to a range of wavelengths of electromagnetic radiation and a plurality of nanowires (104, 602) disposed on a surface of the substrate. The nanowires are substantially transparent to the range of wavelengths of electromagnetic radiation. The system includes a material disposed on each of the nanowires. The electromagnetic radiation is transmitted within the substrate, into the nanowires, and emitted from the ends of the nanowires to produce enhanced Raman scattered light from molecules located on or in proximity to the material.

Abstract translation: 本发明的实施例涉及用于进行表面增强拉曼光谱的系统。 在一个实施例中，用于执行拉曼光谱的系统（100,400,600,800,900,950）包括对电磁辐射的波长范围基本上透明的基底（102）和设置的多个纳米线（104,602） 在基板的表面上。 纳米线对于电磁辐射的波长范围基本上是透明的。 该系统包括设置在每个纳米线上的材料。 电磁辐射在衬底内传输到纳米线中，并从纳米线的端部发射，以产生来自位于材料上或附近的分子的增强的拉曼散射光。

公开(公告)号：US07474397B2

公开(公告)日：2009-01-06

申请号：US11413377

申请日：2006-04-28

Applicant: Shih-Yuan Wang ,  Zhiyong Li

Inventor： Shih-Yuan Wang ,  Zhiyong Li

IPC: G01J3/44

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01N21/658

Abstract: Raman-enhancing structures include a layer of dielectric material, a superlens configured to focus electromagnetic radiation having a wavelength greater than about 100 nanometers to a two-dimensional focal area having linear dimensions less than about 100 nanometers on a surface of the layer of dielectric material, and at least two nanoparticles comprising a Raman-enhancing material disposed proximate the focal area. Additional Raman-enhancing structures include a layer of dielectric material, a layer of conductive material, and at least two nanoparticles comprising a Raman-enhancing material disposed on a second, opposite surface of the layer of dielectric material. The layer of conductive material has a plurality of apertures therethrough that are arranged in a two-dimensional array. Methods for conducting Raman spectroscopy are performed using such structures and systems.

Abstract translation: 拉曼增强结构包括介电材料层，配置成将具有大于约100纳米的波长的电磁辐射聚焦到具有小于约100纳米的线性尺寸的二维聚焦区域的超薄膜在电介质材料层的表面上 以及至少两个纳米颗粒，其包含靠近焦点区域设置的拉曼增强材料。 附加的拉曼增强结构包括电介质材料层，导电材料层，以及至少两个包含拉曼增强材料的纳米颗粒，该拉曼增强材料设置在电介质材料层的第二相对表面上。 导电材料层具有以二维阵列布置的穿过其中的多个孔。 使用这种结构和系统进行拉曼光谱的方法。

公开(公告)号：US07405822B2

公开(公告)日：2008-07-29

申请号：US11584020

申请日：2006-10-20

Applicant: Zhiyong Li ,  Wei Wu ,  Shih-Yuan Wang

Inventor： Zhiyong Li ,  Wei Wu ,  Shih-Yuan Wang

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01N21/658

Abstract: Raman spectroscopy systems include an analyte, a radiation source configured to emit incident radiation having a wavelength, and a detector that is capable of detecting only radiation having wavelengths within a detectable range that includes at least one wavelength corresponding to hyper Raman scattered radiation scattered by the analyte. The wavelength of the incident radiation is outside the detectable range. In particular systems, all wavelengths of radiation that are scattered in the direction of the detector impinge on the detector. Raman spectroscopy methods include providing an analyte and irradiating the analyte with incident radiation having a wavelength, providing a detector capable of detecting only wavelengths of radiation within a detectable range that does not include the wavelength of the incident radiation, and detecting Raman scattered radiation scattered by the analyte. A continuous path free of radiation filters may be provided between the analyte and the detector.

Abstract translation: 拉曼光谱系统包括分析物，被配置为发射具有波长的入射辐射的辐射源，以及检测器，其能够仅检测波长在可检测范围内的辐射，所述波长包括对应于由所述波长散射的超拉曼散射辐射的至少一个波长 分析物。 入射辐射的波长在可检测范围之外。 在特定系统中，在检测器的方向上散射的所有辐射波长都照射在检测器上。 拉曼光谱方法包括提供分析物并用具有波长的入射辐射照射分析物，提供检测器，该检测器仅能够检测不包括入射辐射波长的可检测范围内的辐射波长，并且检测散射的拉曼散射辐射 分析物。 可以在分析物和检测器之间提供不含辐射过滤器的连续路径。

公开(公告)号：US07385691B2

公开(公告)日：2008-06-10

申请号：US11044676

申请日：2005-01-27

Applicant: M. Saif Islam ,  Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

Inventor： M. Saif Islam ,  Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658 ,  G01J3/44 ,  H01L31/02325 ,  H01L31/105

Abstract: Devices, systems, and methods for enhancing Raman spectroscopy and hyper-Raman are disclosed. A molecular analysis device for performing Raman spectroscopy comprises a substrate and a laser source disposed on the substrate. The laser source may be configured for emanating a laser radiation, which may irradiate an analyte disposed on a Raman enhancement structure. The Raman enhancement structure may be disposed on the substrate or apart from the substrate. The molecular analysis device also include a radiation receiver disposed on the substrate and configured for receiving a Raman scattered radiation, which may be generated by the irradiation of the analyte and Raman enhancement structure.

Abstract translation: 公开了用于增强拉曼光谱和超拉曼的装置，系统和方法。 用于执行拉曼光谱的分子分析装置包括设置在基板上的基板和激光源。 激光源可以被配置为发射激光辐射，其可照射设置在拉曼增强结构上的分析物。 拉曼增强结构可以设置在基板上或者离开基板。 分子分析装置还包括设置在基板上并被配置为用于接收可以通过分析物的照射和拉曼增强结构产生的拉曼散射辐射的辐射接收器。

公开(公告)号：US07307719B2

公开(公告)日：2007-12-11

申请号：US10941714

申请日：2004-09-14

Applicant: Shih-Yuan Wang ,  M. Saif Islam ,  Zhiyong Li

Inventor： Shih-Yuan Wang ,  M. Saif Islam ,  Zhiyong Li

IPC: G01J3/44 ,  G01J3/45

CPC classification number: G01N21/658 ,  G01J3/26

Abstract: Wavelength-tunable radiation amplifying structures for Raman spectroscopy are disclosed that include resonant cavities having Raman signal-enhancing structures disposed therein. Systems that include the amplifying structures and methods of performing spectroscopic analysis using the structures and systems are also disclosed.

Abstract translation: 公开了用于拉曼光谱的波长可调辐射放大结构，其包括其中布置有拉曼信号增强结构的谐振腔。 还公开了包括放大结构的系统和使用该结构和系统进行光谱分析的方法。

公开(公告)号：US20070122313A1

公开(公告)日：2007-05-31

申请号：US11291019

申请日：2005-11-30

Applicant: Zhiyong Li ,  M. Islam ,  Shih-Yuan Wang

Inventor： Zhiyong Li ,  M. Islam ,  Shih-Yuan Wang

IPC: B01L3/00

CPC classification number: B81C1/00071 ,  B01L3/5027 ,  B01L2300/0896

Abstract: A nanochannel apparatus and method of fabrication provide an array of nanochannels with distal open or exposed ends formed in situ through a permanent support. A nanofluidic system includes the nanochannel apparatus, a fluidic interface, and a component interfaced to the nanochannel apparatus. The method includes encasing an array of nanowires in a support, and forming the array of nanochannels in situ in locations of the nanowires, such that distal ends of the nanochannels are exposed.

Abstract translation: 纳米通道装置和制造方法提供具有通过永久支撑原位形成的远端开放或暴露端的纳米通道阵列。 纳米流体系统包括纳米通道装置，流体界面和与纳米通道装置相连接的部件。 该方法包括将纳米线阵列包围在支撑体中，并且在纳米线的位置上原位形成纳米通道阵列，使得纳米通道的远端被暴露。

公开(公告)号：US20060275778A1

公开(公告)日：2006-12-07

申请号：US11144586

申请日：2005-06-03

Applicant: Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Philip Kuekes

Inventor： Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Philip Kuekes

IPC: C12Q1/68 ,  C12M1/34

CPC classification number: G01N33/48721 ,  B82Y5/00 ,  B82Y10/00 ,  G01N27/414

Abstract: Devices and methods for detecting the constituent parts of biological polymers are disclosed. A molecular analysis device comprises a molecule sensor and a molecule guide. The molecule sensor comprises a single electron transistor including a first terminal, a second terminal, and a nanogap or at least one quantum dot positioned between the first terminal and the second terminal. A nitrogenous material disposed on the at least one quantum dot is configured for an interaction with an identifiable configuration of a molecule. The molecule sensor develops an electronic effect responsive to the interaction. The molecule guide is configured for guiding at least a portion of the molecule substantially near the molecule sensor to enable the interaction.

Abstract translation: 公开了用于检测生物聚合物的组成部分的装置和方法。 分子分析装置包括分子传感器和分子引导件。 分子传感器包括单电子晶体管，其包括位于第一端子和第二端子之间的第一端子，第二端子和纳米隙隙或至少一个量子点。 设置在至少一个量子点上的含氮材料被配置用于与分子的可识别构型的相互作用。 分子传感器产生响应于相互作用的电子效应。 分子引导件被配置用于基本上在分子传感器附近引导分子的至少一部分，以实现相互作用。

公开(公告)号：US20150103340A1

公开(公告)日：2015-04-16

申请号：US14405334

申请日：2012-07-29

Applicant: Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Shih-Yuan Wang ,  Huei Pei Kuo ,  Steven Barcelo ,  Zhang-Lin Zhou

Inventor： Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Shih-Yuan Wang ,  Huei Pei Kuo ,  Steven Barcelo ,  Zhang-Lin Zhou

IPC: G01N21/65

CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01J3/4412 ,  G01N2021/651 ,  G01N2201/06113 ,  Y10S977/902

Abstract: A scattering spectroscopy nanosensor includes a nanoscale-patterned sensing substrate to produce an optical scattering response signal indicative of a presence of an analyte when interrogated by an optical stimulus. The scattering spectroscopy nanosensor further includes a protective covering to cover and protect the nanoscale-patterned sensing substrate. The protective covering is to be selectably removed by exposure to an optical beam incident on the protective covering. The protective covering is to prevent the analyte from interacting with the nanoscale-patterned sensing substrate prior to being removed.

Abstract translation: 散射光谱纳米传感器包括纳米级图案化的感测衬底，以产生指示当通过光学刺激询问的分析物存在时的光学散射响应信号。 散射光谱纳米传感器还包括覆盖并保护纳米级图案化感测基板的保护覆盖层。 通过暴露在入射到保护罩上的光束可选地去除保护罩。 保护性覆盖物是在去除之前防止分析物与纳米级图案化的感测基板相互作用。

公开(公告)号：US08462333B2

公开(公告)日：2013-06-11

申请号：US12905891

申请日：2010-10-15

Applicant: Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Michael Josef Stuke ,  Lars Helge Thylen ,  Fung Suong Ou ,  Min Hu

Inventor： Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Michael Josef Stuke ,  Lars Helge Thylen ,  Fung Suong Ou ,  Min Hu

IPC: G01J3/44

CPC classification number: G01N21/658

Abstract: An apparatus for performing SERS includes a substrate and flexible nano-fingers, each of the nano-fingers having a first end attached to the substrate, a free second end, and a body portion extending between the first end and the second end, in which the nano-fingers are arranged in an array on the substrate. The apparatus also includes an active material layer disposed on each of the second ends of the plurality of nano-fingers, in which the nano-fingers are to be in a substantially collapsed state in which the active layers on at least two of the nano-fingers contact each other under dominant attractive forces between the plurality of nano-fingers and in which the active material layers are to repel each other when the active material layers are electrostatically charged.

Abstract translation: 用于执行SERS的装置包括基底和柔性纳米指，每个纳米指具有连接到基底的第一端，自由的第二端和在第一端和第二端之间延伸的主体部分，其中 纳米手指以阵列排列在基板上。 该装置还包括设置在多个纳米手指的每个第二端上的活性材料层，其中纳米指状物将处于基本上塌陷的状态，其中在至少两个纳米手指上的活性层， 手指在多个纳米手指之间的主导吸引力下彼此接触，并且当活性材料层被静电充电时，活性材料层将彼此排斥。

公开(公告)号：US08404491B2

公开(公告)日：2013-03-26

申请号：US12916299

申请日：2010-10-29

Applicant: Zhiyong Li ,  Michael Josef Stuke ,  Shih-Yuan Wang ,  Huei Pei Kuo

Inventor： Zhiyong Li ,  Michael Josef Stuke ,  Shih-Yuan Wang ,  Huei Pei Kuo

IPC: G01N21/76

CPC classification number: G01N33/5438 ,  B82Y15/00 ,  G01N21/648 ,  G01N21/658 ,  Y10T436/25

Abstract: A luminescent chemical sensor integrated with at least one molecular trap. The luminescent chemical sensor includes at least one molecular trap and at least one metallic-nanofinger device integrated with at least one molecular trap. The molecular trap includes a plurality of electrodes that trap at least one analyte molecule. The metallic-nanofinger device includes a substrate, and a plurality of nanofingers coupled with the substrate. A nanofinger of the plurality includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger of the plurality of nanofingers are to self-arrange into a close-packed configuration with the analyte molecule. A method for using, and a chemical-analysis apparatus including the luminescent chemical sensor are also provided.

Abstract translation: 与至少一个分子阱集成的发光化学传感器。 发光化学传感器包括至少一个分子阱和至少一个与至少一个分子陷阱集成的金属纳米酮装置。 分子阱包括捕获至少一种分析物分子的多个电极。 金属纳米装置包括衬底和与衬底耦合的多个纳米器件。 多个纳米针板包括柔性柱和联接到柔性柱的顶点的金属帽。 至少纳米角蛋白和多个纳米针的第二纳米梳理器将自分配成与分析物分子紧密堆积的构型。 还提供了使用方法和包括发光化学传感器的化学分析装置。