公开(公告)号：US07915383B2

公开(公告)日：2011-03-29

申请号：US12160704

申请日：2006-01-13

申请人： Bok-Luel Lee ,  Ji-Won Park ,  Byung-Rok Je ,  Nam-Chul Ha

发明人： Bok-Luel Lee ,  Ji-Won Park ,  Byung-Rok Je ,  Nam-Chul Ha

IPC分类号： C07K1/00

CPC分类号： C07K1/22 ,  C07K9/001 ,  C07K14/43504

摘要： The present invention provides a separate and purified peptidoglycan-recognition protein having an amino acid sequence as set forth in SEQ ID NO: 1 and also a peptidoglycan detection kit comprising the separate and purified peptidoglycan-recognition protein.

摘要翻译： 本发明提供了具有SEQ ID NO：1所示氨基酸序列的单独和纯化的肽聚糖识别蛋白，以及包含分离和纯化的肽聚糖识别蛋白的肽聚糖检测试剂盒。

公开(公告)号：US07521565B2

公开(公告)日：2009-04-21

申请号：US10574795

申请日：2004-10-15

申请人： Tai Au Lee ,  Sang Sun Park ,  Doo Byung Lee ,  Sang Jung Kim

发明人： Tai Au Lee ,  Sang Sun Park ,  Doo Byung Lee ,  Sang Jung Kim

IPC分类号： C07D403/06

CPC分类号： C07D403/06

摘要： 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one or its salt is prepared in high yield by reacting a compound of formula 2 with a compound of formula 3 and a compound of formula 4 in the presence of an acid, an alkylsilylhalide compound or an acylhalide compound, in an solvent, and thus, such an inventive process can be favorably applied to a large-scale mass production thereof.

摘要翻译： -1,2,3,9-四氢-9-甲基-3 - [（2-甲基-1H-咪唑-1-基）甲基] -4H-咔唑-4-酮或其盐通过使 在酸，烷基甲硅烷基卤化合物或酰卤化合物的存在下，在溶剂中，式2化合物与式3化合物和式4化合物反应，因此，本发明方法可有利地应用于大量 - 大规模生产。

公开(公告)号：US06924368B2

公开(公告)日：2005-08-02

申请号：US10726555

申请日：2003-12-04

申请人： Jong Wook Lee ,  In Young Ko ,  Heui Keun Kang ,  Jung Hyun Nam ,  Moo Young Song ,  Hyung Jin Moon ,  Tae Hun Song

发明人： Jong Wook Lee ,  In Young Ko ,  Heui Keun Kang ,  Jung Hyun Nam ,  Moo Young Song ,  Hyung Jin Moon ,  Tae Hun Song

IPC分类号： C12N15/09 ,  C07K16/08 ,  C12N1/21 ,  C12N15/13 ,  C12P21/08 ,  C07H21/04

CPC分类号： C07K16/082 ,  C07K2317/565

摘要： The present invention relates to a variable region of the monoclonal antibody against the S-surface antigen of hepatis B virus and a gene encoding the same, a recombinant vector containing the said gene, and a transformant obtained from the said recombinant vector.

摘要翻译： 本发明涉及针对乙型肝炎病毒的S表面抗原的单克隆抗体的可变区和编码该单克隆抗体的基因，含有该基因的重组载体和从所述重组载体获得的转化体。

公开(公告)号：US20240262819A1

公开(公告)日：2024-08-08

申请号：US18559466

申请日：2022-05-10

申请人： YUHAN CORPORATION ,  GREEN CROSS CORPORATION

发明人： Dong-Hoon KIM ,  Jae-Eun JOO ,  Seung-Yub SHIN ,  Sool-Ki KWON ,  Jong-Suk PARK

IPC分类号： C07D453/02 ,  A61K31/439

CPC分类号： C07D453/02 ,  A61K31/439

摘要： Provided are a compound having an inhibitory activity against glucosylceramide synthase (GCS), i.e., compounds having a 2,3-dihydro-1H-indene, 1,2,3,4-tetrahydronaphthalene, or chromane moiety, or pharmaceutically acceptable salt thereof, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof, wherein the compound or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and exhibits the effects of alleviating symptoms in the central nervous system as well as in the peripheral nervous system, through excellent blood-brain barrier permeability, and therefore, the compound or pharmaceutically acceptable salt thereof can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.

公开(公告)号：US20240238380A1

公开(公告)日：2024-07-18

申请号：US18562322

申请日：2022-05-20

申请人： YUHAN CORPORATION

发明人： Seyoung LIM ,  Ji Eun YANG ,  Sukyung KIM ,  Bo Ra SIM ,  Yunji LEE ,  Do Hoon KIM ,  Mi Kyeong JU ,  Hyun Ho CHOI ,  Han Na HONG ,  Junhwan KIM

IPC分类号： A61K38/26 ,  A61K38/18 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10

CPC分类号： A61K38/26 ,  A61K38/1841 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10

摘要： The present invention relates to a pharmaceutical composition for the prevention or treatment of diabetes, obesity, dyslipidemia, or metabolic syndrome by administering in combination with a GLP-1 (glucagon-like peptide-1) receptor agonist, comprising a GDF15 (growth differentiation factor-15) variant, a long-acting GDF15 fusion protein, or a long-acting GDF15 fusion protein dimer as an active ingredient.

公开(公告)号：US20230255967A1

公开(公告)日：2023-08-17

申请号：US18014262

申请日：2021-07-01

申请人： YUHAN CORPORATION

发明人： Dong-Min Park ,  Su-Hyeon Kim ,  Eun-Pa Cheon ,  Tae-Lin Ha ,  Jun-Mo Yang ,  Yoong-Sik Park

IPC分类号： A61K31/506 ,  A61K9/20

CPC分类号： A61K31/506 ,  A61K9/2013 ,  A61K9/2095 ,  A61K9/2054 ,  A61K9/2027

摘要： The present invention provides a pharmaceutical composition comprising (S)—N-(1-(2-((4-amino-3-nitrophenyl)amino)-6-propylpyrimidin-4-yl)pyrrolidin-3-yl)acetamide or a pharmaceutically acceptable salt thereof having an activity as a 5-HT4 receptor agonist and an acidifying agent; and a process for preparing the same.

公开(公告)号：US20230212249A1

公开(公告)日：2023-07-06

申请号：US18068506

申请日：2022-12-19

申请人： YUHAN CORPORATION

发明人： Byung Hyun CHOI ,  In Hwan LIM ,  Jun Young PARK ,  Jin Hyoung LEE ,  Ki Hong KIM ,  Hae Yong JO ,  Jun Hwan KIM ,  Moo Young SONG ,  Jong Gyun KIM

IPC分类号： C07K14/605 ,  C12P21/02 ,  C07K14/50 ,  C07K19/00 ,  C07K16/46 ,  C12N5/00 ,  C12N15/00

CPC分类号： C07K14/605 ,  C12P21/02 ,  C07K14/50 ,  C07K19/00 ,  C07K16/46 ,  C12N5/00 ,  C07K2319/30 ,  C12N15/00

摘要： A method for producing a dual function protein includes a biologically active protein and an FGF21 mutant protein. The method allows stable production of a target protein by effectively preventing decomposition of the target protein, and thus has a high potential for commercial usage.

公开(公告)号：US11623925B2

公开(公告)日：2023-04-11

申请号：US17873966

申请日：2022-07-26

申请人： YUHAN CORPORATION

发明人： Ja-Heouk Khoo ,  Doo-Byung Lee ,  Jun-Sup Lee ,  Hyun Ju ,  Woo-Seob Shin

IPC分类号： C07D403/04 ,  C07D239/47

摘要： The present invention provides a novel process for preparing a diaminopyrimidine derivative or acid addition salt thereof having an activity as a 5-HT4 receptor agonist. And also, the present invention provides novel crystalline forms of a hydrochloride of the diaminopyrimidine derivative and processes for preparing the same.

公开(公告)号：US11560416B2

公开(公告)日：2023-01-24

申请号：US16606279

申请日：2018-04-20

申请人： YUHAN CORPORATION

发明人： Byung Hyun Choi ,  In Hwan Lim ,  Jun Young Park ,  Jin Hyoung Lee ,  Ki Hong Kim ,  Hae Yong Jo ,  Jun Hwan Kim ,  Moo Young Song ,  Jong Gyun Kim

IPC分类号： C12N15/62 ,  C12N15/09 ,  C12N5/00 ,  C07K16/46 ,  C07K19/00 ,  C07K14/605 ,  C07K14/50 ,  C12P21/02 ,  C12N15/00

摘要： A method for producing a dual function protein includes a biologically active protein and an FGF21 mutant protein. The method allows stable production of a target protein by effectively preventing decomposition of the target protein, and thus has a high potential for commercial usage.

公开(公告)号：US20220024918A1

公开(公告)日：2022-01-27

申请号：US17368712

申请日：2021-07-06

申请人： YUHAN CORPORATION

发明人： Tae Dong HAN ,  Hee Jae TAK ,  Eun Kyung KIM ,  Dong Hoon KIM ,  Su Bin CHOI ,  Sol PARK ,  Hyun Ho CHOI ,  Tae Wang KIM ,  Mi Kyeong JU ,  Na Ry HA

IPC分类号： C07D471/04 ,  C07D519/00

摘要： The present technology provides triazolopyridin-3-ones or pharmaceutically acceptable salts thereof, preparation processes thereof, pharmaceutical compositions comprising the same, and uses thereof. The triazolopyridin-3-ones or their pharmaceutically acceptable salts exhibit inhibitory activity on VAP-1 and therefore can be usefully applied, e.g., for the treatment and prophylaxis of nonalcoholic hepatosteatosis (NASH).