公开(公告)号：US08263291B2

公开(公告)日：2012-09-11

申请号：US12085455

申请日：2006-11-27

申请人： Izabela Naydenova ,  Hosam Sherif ,  Suzanne Martin ,  Raghavendra Jallapuram ,  Vincent Toal

发明人： Izabela Naydenova ,  Hosam Sherif ,  Suzanne Martin ,  Raghavendra Jallapuram ,  Vincent Toal

IPC分类号： G03H1/04 ,  G03H1/22 ,  G01N19/10 ,  G01N7/04

CPC分类号： G01N21/81 ,  G02B1/04 ,  G03H1/18 ,  G03H1/28 ,  G03H2001/0016 ,  G03H2001/0044 ,  G03H2001/0415 ,  G03H2001/0432 ,  G03H2001/2263 ,  G03H2210/22 ,  G03H2240/53 ,  G03H2260/12 ,  G11B7/24044 ,  G11B7/245 ,  C08L33/26 ,  C08L33/08

摘要： A sensor device comprising a holographic element comprises a grating or hologram recorded in a holographic recording medium wherein at least one physical and/or chemical and/or optical characteristic of the holographic element or the image produced by it varies as a result of variation in relative humidity or moisture content in the air surrounding the element. Also provided is an acrylamide-based photopolymer and an acrylamide-based reflection hologram.

摘要翻译： 包括全息元件的传感器装置包括记录在全息记录介质中的光栅或全息图，其中全息元件或其产生的图像的至少一个物理和/或化学和/或光学特性由于相对的变化而变化 潮湿或湿气含量在元素周围的空气中。 还提供了基于丙烯酰胺的光聚合物和基于丙烯酰胺的反射全息图。

公开(公告)号：US20120026564A1

公开(公告)日：2012-02-02

申请号：US12847105

申请日：2010-07-30

申请人： Michael Teruki Takemori ,  Amitabh Bansal ,  Andrew A. Burns ,  Mark Cheverton ,  Sumeet Jain

发明人： Michael Teruki Takemori ,  Amitabh Bansal ,  Andrew A. Burns ,  Mark Cheverton ,  Sumeet Jain

IPC分类号： G03H1/26 ,  G03H1/02

CPC分类号： G03H1/04 ,  B42D25/328 ,  G03H1/0011 ,  G03H1/0248 ,  G03H1/181 ,  G03H1/2249 ,  G03H1/2645 ,  G03H1/28 ,  G03H2001/0016 ,  G03H2001/0044 ,  G03H2001/0415 ,  G03H2001/0432 ,  G03H2001/0434 ,  G03H2001/186 ,  G03H2001/2223 ,  G03H2001/2263 ,  G03H2001/2273 ,  G03H2001/2289 ,  G03H2270/31

摘要： A method of making a hologram includes recording a first hologram in a holographic recording medium at a first deformation ratio; changing the first deformation ratio to a second deformation ratio that is different from the first deformation ratio; and recording a second hologram in the holographic recording medium at the second deformation ratio to form a recorded holographic medium.

摘要翻译： 制造全息图的方法包括以第一变形率将全息图记录在全息记录介质中; 将所述第一变形率变更为与所述第一变形率不同的第二变形率; 并以第二变形率在全息记录介质中记录第二全息图以形成记录的全息介质。

公开(公告)号：US20110135697A1

公开(公告)日：2011-06-09

申请号：US12999087

申请日：2009-06-18

申请人： Fiorenzo Omenetto ,  David L. Kaplan

发明人： Fiorenzo Omenetto ,  David L. Kaplan

IPC分类号： A61K9/00 ,  B32B3/10 ,  A23L1/00 ,  A23P1/08

CPC分类号： G03H1/02 ,  A61J3/007 ,  A61J2200/30 ,  A61J2200/60 ,  A61J2205/20 ,  A61J2205/30 ,  A61K9/2893 ,  A61K9/4883 ,  G03H1/0011 ,  G03H1/0244 ,  G03H1/0272 ,  G03H2001/0044 ,  Y10T428/24802

摘要： The present invention relates to edible silk holographic elements and methods for making the same. Edible silk holographic elements are used to label pharmaceuticals and foods, or may be formulated to deliver pharmaceuticals.

摘要翻译： 本发明涉及食用丝全息元件及其制造方法。 食用丝全息元件用于标签药品和食品，或者可以配制成用于递送药物。

公开(公告)号：US20090021697A1

公开(公告)日：2009-01-22

申请号：US12032650

申请日：2008-02-16

申请人： Barry Burles ,  Roger Bradley Millington ,  Christopher Robin Lowe ,  Satyamoorthy Kabilan ,  Jeffrey Blyth

发明人： Barry Burles ,  Roger Bradley Millington ,  Christopher Robin Lowe ,  Satyamoorthy Kabilan ,  Jeffrey Blyth

IPC分类号： A61B3/125 ,  A61B5/00

CPC分类号： A61B3/125 ,  A61B5/14532 ,  A61B5/1455 ,  G01N21/75 ,  G01N21/77 ,  G01N21/78 ,  G01N2021/758 ,  G01N2021/7723 ,  G01N2021/7773 ,  G03H1/0248 ,  G03H1/0406 ,  G03H1/0408 ,  G03H1/18 ,  G03H1/2249 ,  G03H1/265 ,  G03H1/28 ,  G03H2001/0044 ,  G03H2001/0415 ,  G03H2001/0432 ,  G03H2001/186 ,  G03H2001/2263 ,  G03H2001/2284 ,  G03H2001/2615 ,  G03H2001/2655 ,  G03H2001/266 ,  G03H2210/20 ,  G03H2210/22 ,  G03H2210/30 ,  G03H2210/45 ,  G03H2210/52 ,  G03H2210/63 ,  G03H2250/40 ,  G03H2270/12 ,  G03H2270/55

摘要： An ophthalmic device which comprises a holographic element comprising a medium comprising a phenylboronic acid group and, disposed therein, a hologram, wherein an optical characteristic of the element changes as a result of a variation of a physical property of the medium, and wherein the variation arises as a result of interaction between the medium and an analyte present in an ocular fluid.

摘要翻译： 一种眼科装置，其包括全息元件，其包括含有苯基硼酸基团的介质，并且在其中设置全息图，其中该元件的光学特性由于介质的物理性质的变化而改变，并且其中变化 由于介质和眼液中存在的分析物之间的相互作用而产生。

公开(公告)号：US20060127898A1

公开(公告)日：2006-06-15

申请号：US10509781

申请日：2003-04-04

申请人： Christopher Lowe ,  Colin Davidson ,  Jeffrey Blyth ,  Satyamoorthy Kabilan ,  Alexander Marshall ,  Blanca Madrigal Gonzalez ,  Anthony James

发明人： Christopher Lowe ,  Colin Davidson ,  Jeffrey Blyth ,  Satyamoorthy Kabilan ,  Alexander Marshall ,  Blanca Madrigal Gonzalez ,  Anthony James

IPC分类号： G03H1/00 ,  C12Q1/68

CPC分类号： G01N21/7703 ,  G01N21/4788 ,  G02B5/32 ,  G03H2001/0044 ,  G03H2250/44 ,  G03H2270/53

摘要： A sensor for the detection of an analyte, comprising a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the hologram changes as a result of a variation of a physical property occurring throughout the volume of the medium, wherein the medium is obtainable by formation in situ in the presence of a pore-forming agent, wherein the agent is not present in the sensor or does not react with the analyte and the sensor.

摘要翻译： 一种用于检测分析物的传感器，包括全息元件，该全息元件包括介质和设置在介质整个体积中的全息图，其中全息图的光学特性由于在整个体积内发生的物理性质的变化而改变 介质，其中介质可以通过在成孔剂存在下原位形成而获得，其中该试剂不存在于传感器中或不与分析物和传感器反应。

公开(公告)号：US20040263923A1

公开(公告)日：2004-12-30

申请号：US10763995

申请日：2004-01-22

发明人： John Moon ,  Alan D. Kersey ,  Martin A. Putnam ,  Tuo Li

IPC分类号： G03H001/00

CPC分类号： G01N33/552 ,  G01N21/4788 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/7743 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/54386 ,  G03H1/0005 ,  G03H1/02 ,  G03H1/0236 ,  G03H1/26 ,  G03H2001/0033 ,  G03H2001/0044 ,  G03H2210/53 ,  G03H2210/63 ,  G03H2230/10 ,  G03H2250/12 ,  G06K19/04 ,  G06K19/06009

摘要： A hybrid random bead/chip based microarray includes a plurality of loose optical identification elements (or beads) comprising a substrate having at least one identifiable code disposed thereon. The are randomly placed on a substrate, e.g., tray, plate, slide, or nullchipnull in an identifiable position (or location) on the slide (not necessarily immobily fixed). For example, the beads are randomly distributed (but oriented) in one dimension along grooves in the slide. Then, each bead code is read and its location determined, i.e., the bead code and location are mapped to its location on the chip. The beads on the chip may then be read/examined (and re-read if desired) by a conventional chip reader. The beads may be functionalized with a desired probe and/or reacted with a desired analyte when in the loose state and/or when on the chip. After reading the chip, the beads may be removed from the chip for further or alternative processing.

公开(公告)号：US20040058455A1

公开(公告)日：2004-03-25

申请号：US10428785

申请日：2003-05-05

发明人： David G. Grier ,  Lewis Gruber

IPC分类号： C12M001/34 ,  G01N033/543

CPC分类号： G01N33/54313 ,  G01N21/4788 ,  G01N21/7703 ,  G01N21/7743 ,  G01N33/5436 ,  G03H2001/0044 ,  G03H2001/0077 ,  Y10T428/2991

摘要： The present invention relates to a sensor for detecting chemical, biological, biochemical or other environmental stimuli, and includes a plurality of colloidal particles having chemical receptors bound to each particle's surface, wherein when a target stimulus is directed to the bound chemical receptor, the gelled matrix contracts or expands, which changes the lattice constant, thereby changing the pattern of diffracted light in a measurable manner so that the target stimulus' presence can be detected by a spectrometer. The plurality of colloidal particles are composed of a material having a first dielectric constant, and the gel and surrounding medium have a second dielectric constant. The colloidal particles can be assembled using holographic optical tweezers and polymerized to create an integrated sensor array, which diffracts light in a detectable characteristic manner.

摘要翻译： 本发明涉及一种用于检测化学，生物，生物化学或其他环境刺激的传感器，并且包括具有结合到每个颗粒表面的化学受体的多个胶体颗粒，其中当靶刺激指向结合的化学受体时，胶凝 矩阵收缩或扩展，其改变晶格常数，从而以可测量的方式改变衍射光的图案，使得目标刺激的存在可以由光谱仪检测。 多个胶体颗粒由具有第一介电常数的材料构成，凝胶和周围介质具有第二介电常数。 可以使用全息光学镊子组装胶体颗粒并进行聚合以产生集成的传感器阵列，其以可检测的特征方式衍射光。

公开(公告)号：US06436651B1

公开(公告)日：2002-08-20

申请号：US09503554

申请日：2000-02-11

申请人： Dennis S. Everhart ,  Mark L. Jones ,  Rosann Marie Kaylor

发明人： Dennis S. Everhart ,  Mark L. Jones ,  Rosann Marie Kaylor

IPC分类号： G01N3353

CPC分类号： A61F13/42 ,  C23F1/02 ,  C23F1/40 ,  G01N21/4788 ,  G03H1/0244 ,  G03H1/182 ,  G03H2001/0044 ,  G03H2001/0491 ,  G03H2001/2655 ,  G03H2270/55 ,  Y10S435/808 ,  Y10S436/805

摘要： The present invention provides an inexpensive and sensitive device and method for detecting and quantifying analytes present in a medium. The device comprises a metalized film upon which is printed a specific, predetermined pattern of analyte-specific receptors. Upon attachment of a target analyte to select areas of the plastic film upon which the receptor is printed, diffraction of transmitted and/or reflected light occurs via the physical dimensions and defined, precise placement of the analyte. A diffraction image is produced which can be easily seen with the eye or, optionally, with a sensing device.

摘要翻译： 本发明提供了用于检测和定量存在于介质中的分析物的廉价且敏感的装置和方法。 该装置包括金属化膜，在其上印刷特定的预定图案的分析物特异性受体。 在将目标分析物附着到选择受体的塑料薄膜的选择区域时，透射和/或反射光的衍射通过分析物的物理尺寸和定义的精确放置而发生。 产生可以用眼睛或可选地用感测装置容易地看到的衍射图像。

公开(公告)号：US6060256A

公开(公告)日：2000-05-09

申请号：US991644

申请日：1997-12-16

申请人： Dennis S. Everhart ,  Mark L. Jones ,  Rosann Marie Kaylor

发明人： Dennis S. Everhart ,  Mark L. Jones ,  Rosann Marie Kaylor

IPC分类号： A61F13/42 ,  B41M3/00 ,  G01N21/47 ,  G01N33/567 ,  G01N21/00 ,  G01N33/48 ,  G01N33/566

CPC分类号： A61F13/42 ,  G01N21/4788 ,  G03H1/0244 ,  G03H1/182 ,  G03H2001/0044 ,  G03H2001/0491 ,  G03H2001/2655 ,  G03H2270/55 ,  Y10S435/808 ,  Y10S436/805

摘要： The present invention provides an inexpensive and sensitive device and method for detecting and quantifying analytes present in a medium. The device comprises a metalized film upon which is printed a specific, predetermined pattern of analyte-specific receptors. Upon attachment of a target analyte to select areas of the plastic film upon which the receptor is printed, diffraction of transmitted and/or reflected light occurs via the physical dimensions and defined, precise placement of the analyte. A diffraction image is produced which can be easily seen with the eye or, optionally, with a sensing device.

公开(公告)号：US20140110886A1

公开(公告)日：2014-04-24

申请号：US14143921

申请日：2013-12-30

申请人： Cambridge Enterprise Limited

发明人： CHRISTOPHER ROBIN LOWE ,  COLIN ALEXANDER BENNETT DAVIDSON ,  JEFFREY BLYTH

IPC分类号： G03H1/04

CPC分类号： G03H1/0465 ,  G03H1/00 ,  G03H1/0005 ,  G03H1/0244 ,  G03H1/0248 ,  G03H1/0486 ,  G03H2001/0044 ,  G03H2001/0415 ,  G03H2001/186 ,  G03H2001/2231 ,  G03H2222/33 ,  G03H2240/20 ,  G03H2260/16 ,  G03H2260/62 ,  G03H2270/52

摘要： A method for the production of a holographic sensor which comprises a support medium supporting a reflection hologram wherein the support medium interacts with its physical or chemical environment to create an optical response which is a change in one or more optical properties of the hologram, the method comprising the steps of: a) introducing a colloidal dispersion of a recording material into the support medium; and b) ablating the colloidal particles of the recording material using a pulsed laser to form the holographic element in the support medium. The method of production can be used to introduce a reflection holographic grating into a hydrophobic support medium, in particular, polydimethylsiloxane (PDMS), which possesses an extraordinary ability to swell in the presence of both liquid and/or gaseous low molecular weight hydrocarbons and organic solvents and thus has many applications as a holographic sensor.

摘要翻译： 一种用于生产全息传感器的方法，其包括支撑反射全息图的支撑介质，其中支撑介质与其物理或化学环境相互作用以产生作为全息图的一个或多个光学特性变化的光学响应，该方法 包括以下步骤：a）将记录材料的胶体分散体引入载体介质中; 和b）使用脉冲激光烧蚀记录材料的胶体颗粒，以在支撑介质中形成全息元件。 生产方法可用于将反射全息光栅引入到疏水性支持介质，特别是聚二甲基硅氧烷（PDMS）中，聚二甲基硅氧烷（PDMS）在液态和/或气态低分子量烃和有机物存在下具有非凡的溶胀能力 溶剂，因此作为全息传感器具有许多应用。