公开(公告)号：US06987835B2

公开(公告)日：2006-01-17

申请号：US10397498

申请日：2003-03-26

Applicant: Paul A. Lovoi

Inventor： Paul A. Lovoi

IPC: H01J35/06 ,  H01J35/32 ,  H01J9/04 ,  A61N5/10

CPC classification number: A61N5/1001 ,  A61N5/1002 ,  H01J9/04 ,  H01J9/24 ,  H01J35/06 ,  H01J35/32 ,  H01J2235/164

Abstract: A miniature x-ray tube capable of intra vascular use, has a micro cathode preferably formed by MEMS techniques. The very fine wire of the cathode filament is formed on a semiconductor base and draws a current sufficiently low that lead wires in a cathode heater circuit, passing through a probe line connected to the x-ray tube, can be very small wires, which helps maintain sufficient dielectric spacing in the high voltage circuit handled by the same probe line. In a preferred embodiment the probe line comprises a glass fiber, held at a small diameter to allow flexibility for navigating small-radius turns within the vessels. In a preferred embodiment the fiber is overcoated with a high-dielectric polymer to significantly increase the dielectric strength of the overall cable, without adding significantly to stiffness. The high voltage ground conductor is a coaxial sheath on the outside of the polymer. Exterior to the ground conductor is a further flexible layer having paths for coolant.

Abstract translation: 能够进行血管内使用的微型X射线管具有优选通过MEMS技术形成的微型阴极。 阴极灯丝的细线形成在半导体基底上，并且使电流足够低，阴极加热器电路中的导线穿过连接到X射线管的探针线可以是非常小的线，这有助于 在由相同探针线处理的高压电路中保持足够的介电间距。 在优选实施例中，探针线包括保持在小直径的玻璃纤维，以允许在血管内导航小半径匝的灵活性。 在优选的实施方案中，纤维用高电介质聚合物涂覆，以显着增加整个电缆的介电强度，而不显着增加硬度。 高压接地导体是聚合物外侧的同轴护套。 接地导体的外部是具有用于冷却剂的路径的另一柔性层。

公开(公告)号：US20040192997A1

公开(公告)日：2004-09-30

申请号：US10397498

申请日：2003-03-26

Inventor： Paul A. Lovoi

IPC: A61N005/00

CPC classification number: A61N5/1001 ,  A61N5/1002 ,  H01J9/04 ,  H01J9/24 ,  H01J35/06 ,  H01J35/32 ,  H01J2235/164

Abstract: A miniature x-ray tube capable of intra vascular use, as for irradiating the interior wall of a blood vessel to prevent restenosis, as well as uses in other natural or surgically-created body cavities, has a micro cathode preferably formed by MEMS techniques. The very fine wire of the cathode filament is formed on a semiconductor base and draws a current sufficiently low that lead wires in a cathode heater circuit, passing through a probe line connected to the x-ray tube, can be very small wires, which helps maintain sufficient dielectric spacing in the high voltage circuit handled by the same probe line. In a preferred embodiment the probe line comprises a glass fiber, providing needed dielectric strength and allowing for a direct seal to the x-ray tube. The glass fiber is held at a small diameter to allow flexibility for navigating small-radius turns within the vessels. In a preferred embodiment the fiber is overcoated with a high-dielectric polymer to significantly increase the dielectric strength of the overall cable, without adding significantly to stiffness. The high voltage ground conductor is a coaxial sheath on the outside of the polymer. Exterior to the ground conductor is a further flexible layer having paths for coolant.

Abstract translation: 能够进行血管内使用的微型X射线管，用于照射血管的内壁以防止再狭窄以及其它天然或外科手术产生的体腔中的用途具有优选通过MEMS技术形成的微型阴极。 阴极灯丝的细线形成在半导体基底上，并且使电流足够低，阴极加热器电路中的导线穿过连接到X射线管的探针线可以是非常小的线，这有助于 在由相同探针线处理的高压电路中保持足够的介电间距。 在优选实施例中，探针线包括玻璃纤维，提供所需的介电强度并允许直接密封到X射线管。 玻璃纤维保持在较小的直径，以允许在容器内导航小半径的弯曲的灵活性。 在优选的实施方案中，纤维用高电介质聚合物涂覆，以显着增加整个电缆的介电强度，而不显着增加硬度。 高压接地导体是聚合物外侧的同轴护套。 接地导体的外部是具有用于冷却剂的路径的另一柔性层。

公开(公告)号：US06623418B2

公开(公告)日：2003-09-23

申请号：US09851430

申请日：2001-05-09

Applicant: Leif Smith

Inventor： Leif Smith

IPC: A61N500

CPC classification number: A61N5/1001 ,  H01J35/32 ,  H01J2235/164

Abstract: A miniaturized radiation device, having a support member in the form of a flexible sheet, and a circuit pattern of electrical contact pads and interconnecting conductor lines or leads provided on said support member. The pads are interconnected via said patterned lines. There is also a plurality of radiation chips electrically connected to selected ones of said pads. Preferably the device is wrapped around a core member, that may be a wire, such that the assembly is suitable for the insertion into a living body for the controlled administration of radiation at a therapy location.

公开(公告)号：US06580940B2

公开(公告)日：2003-06-17

申请号：US09776559

申请日：2001-02-02

Applicant: George Gutman

Inventor： George Gutman

IPC: A61N510

CPC classification number: A61N5/1001 ,  A61N2005/1091 ,  H01J2235/164

Abstract: An x-ray system for treatment cancer by delivering x-ray radiation directly to a desired region of tissue comprising an x-ray source with directed narrow space distribution of x-rays (linear accelerator), conditioning optics which direct and monochromotize x-ray radiation, an implantable needle with means for shaping beam installed across the x-ray beam, and expanding pipe-guide connecting conditioning optics with implantable needle whereby the energy, intensity, and space distribution of the delivered to the tumor x-ray radiation may be adjusted in accordance with the predefined treatment requirements.

公开(公告)号：US20020191745A1

公开(公告)日：2002-12-19

申请号：US09884229

申请日：2001-06-19

Inventor： Mark Dinsmore

IPC: G01N023/04

CPC classification number: H01J35/08 ,  A61N5/1001 ,  H01J35/32 ,  H01J2235/164

Abstract: A therapeutic radiation source includes a spiral-shaped, laser-heated thermionic cathode. A fiber optic cable directs a beam of radiation, having a power level sufficient to heat at least a portion of the electron-emissive surface to an electron emitting temperature, from a laser source onto the cathode. The cathode generates an electron beam along a beam path by thermionic emission, and strikes a target positioned in its beam path. The target includes radiation emissive material that emits therapeutic radiation in response to incident accelerated electrons from the electron beam. The spiral-shaped conductive element has a plurality of spaced apart turns, and is disposed in a vacuum. An interstitial spacing is defined between adjacent turns, so that heat transfer across the spacing between each adjacent turn is essentially eliminated, thereby substantially reducing heat loss in the cathode caused by thermal conduction.

Abstract translation: 治疗性辐射源包括螺旋状激光加热的热离子阴极。 光纤电缆将具有足以将至少一部分电子发射表面的电子发射温度从激光源加热到阴极的辐射束引导。 阴极通过热离子发射沿光束路径产生电子束，并且撞击位于其光束路径中的目标。 目标包括响应于来自电子束的入射加速电子发射治疗辐射的辐射发射材料。 螺旋状导电元件具有多个间隔开的匝，并且设置在真空中。 在相邻匝之间限定间隙，从而基本上消除了每个相邻匝之间的间隔的热传递，从而大大减少了由热传导引起的阴极热损失。

公开(公告)号：US20020003856A1

公开(公告)日：2002-01-10

申请号：US09776559

申请日：2001-02-02

Inventor： George Gutman

IPC: A61N005/10

CPC classification number: A61N5/1001 ,  A61N2005/1091 ,  H01J2235/164

Abstract: An x-ray system for treatment cancer by delivering x-ray radiation directly to a desired region of tissue comprising an x-ray source with directed narrow space distribution of x-rays (linear accelerator), conditioning optics which direct and monochromotize x-ray radiation, an implantable needle with means for shaping beam installed across the x-ray beam, and expanding pipe-guide connecting conditioning optics with implantable needle whereby the energy, intensity, and space distribution of the delivered to the tumor x-ray radiation may be adjusted in accordance with the predefined treatment requirements.

Abstract translation: 一种用于通过将x射线辐射直接递送到包含x射线源的x射线源的X射线源（线性加速器）的X射线照射系统，该X射线源直接和单色X射线 放射线，具有安装在X射线束两端的成形梁的装置的可植入针，以及用可植入针扩张导管连接调节光学器件，由此传送到肿瘤X射线辐射的能量，强度和空间分布可以是 根据预定义的治疗要求进行调整。

公开(公告)号：US06320932B2

公开(公告)日：2001-11-20

申请号：US09748590

申请日：2000-12-22

Applicant: Mark Dinsmore

Inventor： Mark Dinsmore

IPC: A61N510

CPC classification number: A61N5/1001 ,  H01J35/065 ,  H01J35/32 ,  H01J2235/087 ,  H01J2235/164

Abstract: This invention is directed to a radiation source comprising a power supply, a flexible fiber optic cable assembly, a light source, and a target assembly. The power supply includes a first terminal and a second terminal, and elements for establishing an output voltage between the first terminal and the second terminal. The flexible fiber optical cable assembly has an originating end and a terminating end, and includes a fiber optical element extending from the originating end to the terminating end. The cable is adapted for transmitting light incident on the originating end to the terminating end. The light source includes elements for generating a beam of light at and directed to the originating end of the fiber optical cable assembly. The target assembly is affixed to the terminating end of the fiber optical cable assembly and is electrically coupled to the power supply by way of the first terminal and the second terminal. The target assembly includes elements for emitting radiation in a predetermined spectral range, in response to light transmitted to the terminating end.

Abstract translation: 本发明涉及一种包括电源，柔性光缆组件，光源和目标组件的辐射源。 电源包括第一端子和第二端子，以及用于在第一端子和第二端子之间建立输出电压的元件。 柔性光纤光缆组件具有起始端和终止端，并且包括从起始端延伸到终端的光纤元件。 电缆适用于将入射在起始端的光线发射到终端。 光源包括用于在光纤光缆组件的起始端处产生光束并被引导到光纤光缆组件的始端的元件。 目标组件固定到光纤光缆组件的终端，并通过第一终端和第二终端电耦合到电源。 目标组件包括响应于传输到终端的光而在预定光谱范围内发射辐射的元件。

公开(公告)号：US20100246766A1

公开(公告)日：2010-09-30

申请号：US12665491

申请日：2008-06-17

Applicant: Johann Kindlein ,  Evert Hendrik Agterhuis ,  Godefridus Hendricus Maria Gubbels ,  Frank Simonis

Inventor： Johann Kindlein ,  Evert Hendrik Agterhuis ,  Godefridus Hendricus Maria Gubbels ,  Frank Simonis

IPC: A61N5/10 ,  H01J35/06

CPC classification number: A61N5/1001 ,  H01J35/06 ,  H01J35/14 ,  H01J35/16 ,  H01J2235/062 ,  H01J2235/081 ,  H01J2235/087 ,  H01J2235/164 ,  H01J2235/165 ,  H01J2235/205

Abstract: A miniature X-ray source device for effecting radiation therapy at least comprising a vacuum tube containing a cathode and an anode spaced apart at some distance from each other; emitting means for emitting free electrons from the cathode; electric field generating means for applying during use a high-voltage electric field between the cathode and the anode for accelerating the emitted free electrons towards the anode, as well as an exit window for X-ray radiation being generating at the anode. The present invention provides an improved miniature X-ray source device, that can also properly be used in treating skin cancer and which is easy to handle. The anode is provided with a flat X-ray emitting surface. In particular, the cathode exhibits a concave shaped surface having a center part surrounded by an upright circumferential edge, wherein the center part of the concave shaped surface is provided with an electron emitting material.

Abstract translation: 一种用于进行放射治疗的微型X射线源装置，至少包括一个真空管，该真空管包含彼此间隔一定距离的阴极和阳极; 用于从阴极发射自由电子的发射装置; 电场产生装置，用于在使用期间施加阴极和阳极之间的高电压电场，用于加速向阳极发射的自由电子，以及在阳极处产生X射线辐射的出射窗口。 本发明提供一种改进的微型X射线源装置，其也可以适当地用于治疗皮肤癌，并且易于处理。 阳极设置有平坦的X射线发射表面。 特别地，阴极具有凹形状的表面，其中心部分被直立的周向边缘包围，其中凹形表面的中心部分设置有电子发射材料。

公开(公告)号：US06658088B2

公开(公告)日：2003-12-02

申请号：US09792072

申请日：2001-02-26

Applicant: Jonas Tiren

Inventor： Jonas Tiren

IPC: H01J3500

CPC classification number: A61N5/1001 ,  H01J35/32 ,  H01J2201/304 ,  H01J2235/164

Abstract: A miniature X-ray source includes a support structure provided with a through hole, an anode arranged at one end of the hole and a cathode at the other end of the hole, thereby defining a cavity, wherein the anode and cathode are adapted to be energized to generate X-ray radiation. The support structure has a cross-sectional shape that is determined such that a desired radiation distribution of the radiation generated by the X-ray source is achieved. Also a method of manufacturing miniature X-ray sources is disclosed.

Abstract translation: 微型X射线源包括设置有通孔的支撑结构，布置在孔的一端的阳极和在孔的另一端的阴极，从而限定空腔，其中阳极和阴极适于 通电以产生X射线辐射。 支撑结构具有被确定为使得由X射线源产生的辐射的期望的辐射分布被实现的横截面形状。 还公开了一种制造微型X射线源的方法。

公开(公告)号：US20030012339A1

公开(公告)日：2003-01-16

申请号：US09902659

申请日：2001-07-12

Applicant: Medtronic AVE, Inc

Inventor： Graham S. Kerslick ,  Victor I Chornenky ,  Ali Jaafar

IPC: H05H001/00 ,  G21G004/00 ,  H01J035/00

CPC classification number: A61N5/1001 ,  A61N5/1002 ,  H01J35/32 ,  H01J2235/062 ,  H01J2235/164

Abstract: A cathode for a miniature X-ray device includes an insulating shell, a cathode and an anode. The cathode includes a focusing cup formed into an end. The focusing cup can include a thin metal layer that conforms to an inner surface of the cathode. An emitting material having a low work function, such as diamond, is deposited directly onto the internal surface of the focusing cup. The anode has a flat receiving surface for collecting electrons emitted from the anode. An interior coating is applied as a circumferential belt on the interior surface of the insulating shell. The interior coating, formed of a negative secondary emission yield material, extends lengthwise in the region of the cathode to an anode gap, covering the region of the insulating shell most likely to be subject to stray electrons emitted from the cathode.

Abstract translation: 用于微型X射线装置的阴极包括绝缘壳，阴极和阳极。 阴极包括形成在一端的聚焦杯。 聚焦杯可以包括符合阴极内表面的薄金属层。 具有低功函数的发射材料（例如金刚石）直接沉积在聚焦杯的内表面上。 阳极具有用于收集从阳极发射的电子的平坦的接收表面。 内部涂层作为周向带施加在绝缘壳体的内表面上。 由负二次发射产生材料形成的内部涂层在阴极的区域中纵向延伸到阳极间隙，覆盖最可能经受从阴极发射的杂散电子的绝缘壳体的区域。