公开(公告)号：US09387343B2

公开(公告)日：2016-07-12

申请号：US13367807

申请日：2012-02-07

申请人： Johann Kindlein ,  Arie Luite Visscher ,  Johan Henning ,  Wouter Peter Engels

发明人： Johann Kindlein ,  Arie Luite Visscher ,  Johan Henning ,  Wouter Peter Engels

IPC分类号： A61N5/10

CPC分类号： A61N5/1007 ,  A61N5/1075 ,  A61N2005/1008 ,  A61N2005/1012 ,  A61N2005/1094

摘要： A medical apparatus for effecting radiation treatment on a pre-selected anatomical portion of an animal body is disclosed. The medical apparatus may include a plurality of treatment channels configured to be positioned adjacent a body tissue and a plurality of delivery channels coupled to a corresponding number of treatment channels. The medical apparatus may also include a plurality of source channels configured to receive one or more energy sources, a tracking channel configured to receive a tracking element, and a connecting element configured to connect each delivery channel with either one of the plurality of sources channels or the tracking channel.

摘要翻译： 公开了一种用于对动物体的预先选择的解剖部分进行放射治疗的医疗装置。 医疗设备可以包括被配置为邻近身体组织定位的多个治疗通道以及耦合到相应数量的治疗通道的多个输送通道。 医疗设备还可以包括被配置为接收一个或多个能量源的多个源通道，被配置为接收跟踪元件的跟踪通道，以及被配置为将每个输送通道与多个源通道中的任一个连接的连接元件 跟踪通道。

公开(公告)号：US07697147B2

公开(公告)日：2010-04-13

申请号：US12132874

申请日：2008-06-04

申请人： Johann Kindlein

发明人： Johann Kindlein

IPC分类号： G01B11/24

CPC分类号： A61B6/08 ,  A61B6/032 ,  A61B6/548 ,  A61B2090/366 ,  A61N5/1049 ,  A61N2005/105 ,  A61N2005/1059

摘要： An apparatus for the representation of an area on the three-dimensional surface of a patient's body, with a control device which provides three-dimensional coordinates of at least one area to be represented on the surface of the patient's body, wherein the area pre-sets a desired intersection area of a radiation area on the surface of the patient's body, characterized in that at least one projection device featuring a laser is provided, by which the desired intersection area can be projected to the three-dimensional surface of the patient's body on the basis of the provided coordinates, while at least one laser beam generated by the laser can be guided along the contour of the desired intersection area sufficiently rapidly, so that the impression of a closed contour around the desired intersection area results.

摘要翻译： 一种用于表示患者身体的三维表面上的区域的装置，具有提供要表示在患者身体的表面上的至少一个区域的三维坐标的控制装置，其中， 设置患者身体表面上的辐射区域的期望的交叉区域，其特征在于，提供具有激光器的至少一个投影装置，通过该投影装置可以将期望的交叉区域投影到患者身体的三维表面 基于所提供的坐标，同时由激光器产生的至少一个激光束可以沿着期望的交叉区域的轮廓充分快速地被引导，从而导致围绕期望的交叉区域的封闭轮廓的印象。

公开(公告)号：US20090251709A1

公开(公告)日：2009-10-08

申请号：US12132874

申请日：2008-06-04

申请人： Johann Kindlein

发明人： Johann Kindlein

IPC分类号： G01B11/25 ,  G01B11/24

CPC分类号： A61B6/08 ,  A61B6/032 ,  A61B6/548 ,  A61B2090/366 ,  A61N5/1049 ,  A61N2005/105 ,  A61N2005/1059

摘要： An apparatus for the representation of an area on the three-dimensional surface of a patient's body, with a control device which provides three-dimensional coordinates of at least one area to be represented on the surface of the patient's body, wherein the area pre-sets a desired intersection area of a radiation area on the surface of the patient's body, characterised in that at least one projection device featuring a laser is provided, by which the desired intersection area can be projected to the three-dimensional surface of the patient's body on the basis of the provided coordinates, while at least one laser beam generated by the laser can be guided along the contour of the desired intersection area sufficiently rapidly, so that the impression of a closed contour around the desired intersection area results.

摘要翻译： 一种用于表示患者身体的三维表面上的区域的装置，具有提供要表示在患者身体的表面上的至少一个区域的三维坐标的控制装置，其中， 设置患者身体表面上的辐射区域的期望的交叉区域，其特征在于，提供具有激光器的至少一个投影装置，通过该投影装置可以将期望的交叉区域投影到患者身体的三维表面 基于所提供的坐标，同时由激光器产生的至少一个激光束可以沿着期望的交叉区域的轮廓充分快速地被引导，从而导致围绕期望的交叉区域的封闭轮廓的印象。

公开(公告)号：US07404791B2

公开(公告)日：2008-07-29

申请号：US10669359

申请日：2003-09-25

申请人： Luis A. Linares ,  Johann Kindlein

发明人： Luis A. Linares ,  Johann Kindlein

IPC分类号： A61N5/00

CPC分类号： A61N5/1015 ,  A61N2005/1018

摘要： A device for radiation treatment of proliferative tissue surrounding a cavity in an animal body includes at least a first inflatable chamber having a wall for placement in the cavity, a supportive probe having an elongated body with a distal end connected with the first inflatable chamber and a proximal end remaining outside the cavity, a device for inflating and deflating the first chamber, and a radiation delivering device for placing at least one energy emitting source within the cavity for performing said radiation treatment. It is possible to temporarily position a solid energy emitting source in a reproducible manner at different locations within the inflated chamber, such that subsequent identical radiation treatment sessions can be performed, whereas the comfort of the patient is maxim and an out hospitalization treatment is possible.

摘要翻译： 用于放射治疗动物体腔周围的增生组织的装置包括至少一个具有用于放置在空腔中的壁的第一可充气室，支撑探针，其具有与第一可充气室连接的远端的细长体，以及 近端保留在空腔外部，用于使第一腔室充气和放气的装置，以及辐射递送装置，用于将至少一个能量发射源放置在空腔内用于执行所述辐射治疗。 可以将可再生能量的固体能量发射源临时定位在充气室内的不同位置，从而可以执行后续相同的辐射治疗会话，而患者的舒适度是最大的并且出院住院治疗是可能的。

公开(公告)号：US07399269B2

公开(公告)日：2008-07-15

申请号：US10307355

申请日：2002-12-02

申请人： Johann Kindlein ,  Leo Hovestadt

发明人： Johann Kindlein ,  Leo Hovestadt

IPC分类号： A61N5/00

CPC分类号： A61N5/103 ,  A61N5/1001 ,  A61N5/1007 ,  A61N5/1027 ,  A61N5/1048

摘要： The invention relates to a process for brachytherapy by using a dose measuring system, wherein, in at least one point of an area subjected to radiation treatment, the individual radiation dose contribution from at least one dwell position of at least one radiation source is measured in real time, the thus obtained measured dose value is compared with the corresponding value calculated by a treatment planning system, and the further course of the treatment is adapted on the basis of the degree of agreement between the measured value and the calculated value. Furthermore, the invention relates to a control program, a treatment control system, a treatment planning system and a dose measuring system.

摘要翻译： 本发明涉及一种通过使用剂量测量系统进行近距离放射治疗的方法，其中在经受辐射治疗的区域的至少一个点处，对来自至少一个辐射源的至少一个停留位置的个体辐射剂量贡献在 将由此获得的测量剂量值与由治疗计划系统计算的相应值进行比较，并且根据测量值与计算值之间的一致程度来改变治疗的进一步的过程。 此外，本发明涉及控制程序，治疗控制系统，治疗计划系统和剂量测量系统。

公开(公告)号：US07016471B2

公开(公告)日：2006-03-21

申请号：US10878160

申请日：2004-06-29

申请人： Johann Kindlein

发明人： Johann Kindlein

IPC分类号： H01J35/06

CPC分类号： A61N5/1001 ,  H01J35/20 ,  H01J35/32 ,  H01J2235/205

摘要： A miniature X-ray source device connected to a distal end of a guiding wire for insertion towards a desired location within an animal body for effecting radiation thereby. The X-ray source device at least includes a vacuum tube containing a cathode and an anode spaced apart at a distance from each other; an emitter for emitting free electrons from the cathode; an electric field generator for applying a high-voltage electric field between the cathode and the anode for accelerating the emitted free electrons towards the anode; and a getter material located in a high-voltage electric field free region in the vacuum tube. The vacuum tube is at least partly transparent to X-ray radiation emitted by the anode.

摘要翻译： 连接到导丝的远端的微型X射线源装置，用于插入到动物体内的所需位置，从而实现辐射。 X射线源装置至少包括一个真空管，该真空管包含彼此间隔一定距离的阴极和阳极; 用于从阴极发射自由电子的发射器; 电场发生器，用于在阴极和阳极之间施加高压电场，用于加速向阳极发射的自由电子; 以及位于真空管中的高压无电场区域中的吸气剂材料。 真空管对于由阳极发射的X射线辐射至少部分透明。

公开(公告)号：US20060015166A1

公开(公告)日：2006-01-19

申请号：US11165128

申请日：2005-06-24

申请人： Johann Kindlein ,  Hans Schot

发明人： Johann Kindlein ,  Hans Schot

IPC分类号： A61N1/06

CPC分类号： A61N5/1015

摘要： The invention relates to a device for radiation treatment of proliferative tissue surrounding a cavity in an animal body comprising radiation delivering means for placing at least one energy emitting source at a desired position within said cavity for performing said radiation treatment. The invention also relates to an implant element to be implanted into a cavity in an animal body for radiation treatment of proliferative tissue surrounding said cavity. The invention aims to provide a device and method for radiation treatment of proliferative tissue surrounding a cavity in an animal body, wherein the radiation treatment is performed in a far more accurate and reproducible manner and wherein the device causes far less discomfort to the patient. According to the invention said device comprises an permanent implant element suitable for placement in said body cavity, said element being made from a non-deformable material and having an outer surface being conformal to the inner surface of said body cavity.

摘要翻译： 本发明涉及一种用于放射治疗包围动物体腔内的增生组织的装置，该装置包括用于将至少一个能量发射源放置在所述空腔内的所需位置以进行所述放射治疗的辐射递送装置。 本发明还涉及一种待植入动物体腔内的植入元件，用于辐射治疗围绕所述腔的增生组织。 本发明的目的在于提供一种用于放射治疗动物体内空腔周围的增生组织的装置和方法，其中以更准确和更可重复的方式进行放射治疗，并且其中该装置对患者的不舒适程度较小。 根据本发明，所述装置包括适于放置在所述体腔中的永久植入元件，所述元件由不可变形的材料制成并具有与所述体腔的内表面共形的外表面。

公开(公告)号：US20050177020A1

公开(公告)日：2005-08-11

申请号：US10674356

申请日：2003-10-01

申请人： Johann Kindlein ,  Arie Visscher ,  Ulrike Lutz ,  Jeroen Schuurman ,  Mark Adam

发明人： Johann Kindlein ,  Arie Visscher ,  Ulrike Lutz ,  Jeroen Schuurman ,  Mark Adam

IPC分类号： G21K1/00 ,  A61M36/00 ,  A61M36/04 ,  A61M36/12 ,  A61N5/10 ,  A61N5/00

CPC分类号： A61N5/1007 ,  A61N2005/1011 ,  A61N2005/1023

摘要： The invention relates to a device for implanting at least one row of X radioactive seeds and Y non-radioactive spacers with Xε[1, 2, . . . ] and Yε[0, 1, . . . ] in a desired configuration to a desired location in an animal body for effecting radiation therapy of cancerous tissue in said body, said device comprising: at least one elongated hollow needle with an open distal end to be inserted towards said desired location in the body and with a proximal end to be connected to a seed loading apparatus; and at least one pushing element for implanting during retraction of the elongated hollow needle said row of radioactive seeds and non-radioactive spacers from said seed loading apparatus through said hollow needle towards said location. The prior art rows of seeds/spacers have the disadvantage, that after insertion into the body or near to the tissue to be irradiated no physical relation between the inserted seeds and spacers exists other than through the tissue of the body, thus affecting the radiation treatment to be performed. Therefore in order to avoid mutual displacement of the seeds/spacers after insertion of the row into the body due to movements of the patient the device according to the invention further comprises at least one tube-shaped element with at least one open end to be inserted through said hollow needle towards said desired location; and at least one tube-shaped sleeve member with an open distal and open proximal end for inserting said tube-shaped element through said hollow needle towards said desired location, wherein said tube-shaped element serves to accommodate said row of radioactive seeds and non-radioactive spacers.

摘要翻译： 本发明涉及用Xepsilon [1,2]注入至少一行X放射性种子和Y型非放射性间隔物的装置。 。 。 ]和Yepsilon [0,1]。 。 。 ]以期望的配置到动物体内的所需位置，用于对所述体内的癌组织进行放射治疗，所述装置包括：至少一个细长的中空针头，其具有敞开的远端，以朝向身体中的所述期望位置插入;以及 其近端连接到种子装载装置; 以及至少一个推动元件，用于在所述细长中空针将所述放射性种子排和非放射性间隔物从所述种子装载装置通过所述中空针向所述位置缩回时进行植入。 现有技术的种子/隔离物排的缺点在于，在插入体内或靠近要照射的组织之后，插入的种子和间隔物之间​​不存在物理关系，而不是通过身体的组织而存在，从而影响放射治疗 被执行。 因此，为了避免由于患者的移动而将排插入体内的种子/间隔物的相互移位，根据本发明的装置还包括至少一个具有至少一个开放端插入的管状元件 通过所述中空针朝向所述所需位置; 以及至少一个管形套筒构件，其具有开放的远侧和近端近端，用于将所述管状元件穿过所述中空针头朝向所述期望位置插入，其中所述管状元件用于容纳所述一排放射性种子， 放射性隔片。

公开(公告)号：US08301228B2

公开(公告)日：2012-10-30

申请号：US13013051

申请日：2011-01-25

申请人： Johann Kindlein ,  Dimos Baltas ,  Georgios Sakas ,  Frans Kuipers ,  Hans Martin Schot

发明人： Johann Kindlein ,  Dimos Baltas ,  Georgios Sakas ,  Frans Kuipers ,  Hans Martin Schot

IPC分类号： A61B6/00

CPC分类号： A61N5/1031 ,  A61N5/1001 ,  A61N5/1007 ,  A61N5/1039 ,  A61N2005/1012 ,  A61N2005/1032 ,  A61N2005/1074 ,  G06F19/00 ,  G06F19/3481

摘要： The invention relates to a real time radiation treatment planning system for use in effecting radiation therapy of a pre-selected anatomical portion of an animal body using hollow needles. According to embodiments of the invention, the system may include a processing means processing means-configured to perform a three-dimensional imaging algorithm and a three-dimensional image segmentation algorithm, with respect to one or more specific organs within the pre-selected anatomical portion and with respect to the needles, for converting the image data obtained with an imaging means into a three-dimensional image of the anatomical portion, using at least one single or multi-objective anatomy-based genetic optimization algorithm. For pre-planning or virtual simulation purposes, the processing means is arranged to determine in real time the optimal number and position of at least one of the needles, positions of energy emitting sources within the needles, and the dwell times of the energy emitting sources at the positions. For post-planning purposes, the processing means is arranged to determine, based on three-dimensional image information, in real time the real needle positions and the dwell times of the energy emitting sources for the positions.

摘要翻译： 本发明涉及一种实时放射治疗计划系统，用于使用空心针对动物体的预先选择的解剖部分进行放射治疗。 根据本发明的实施例，系统可以包括处理装置处理装置，其被配置为相对于预先选择的解剖部分内的一个或多个特定器官执行三维成像算法和三维图像分割算法 并且相对于针，用于使用至少一个单目标或多目标基于解剖的遗传优化算法将用成像装置获得的图像数据转换成解剖部分的三维图像。 对于预先规划或虚拟模拟目的，处理装置被布置成实时确定针中的至少一个针的最佳数量和位置，针内的能量发射源的位置以及能量发射源的停留时间 在职位。 为了规划后的目的，处理装置被布置成基于三维图像信息实时确定位置的能量发射源的实际针位置和停留时间。

公开(公告)号：US20120108951A1

公开(公告)日：2012-05-03

申请号：US13347225

申请日：2012-01-10

申请人： Wilco VAN DER LUGT ,  Jeroen SCHUURMAN ,  Johan HENNING ,  Stefan KWA ,  Johann KINDLEIN

发明人： Wilco VAN DER LUGT ,  Jeroen SCHUURMAN ,  Johan HENNING ,  Stefan KWA ,  Johann KINDLEIN

IPC分类号： A61B5/055 ,  A61B6/00

CPC分类号： A61B5/055 ,  A61B6/06 ,  A61B8/12 ,  A61B8/4461 ,  A61B8/483 ,  A61B90/36 ,  A61B2017/00274 ,  A61B2018/00547 ,  A61N5/1027 ,  A61N5/1049 ,  A61N2005/1011 ,  G06T11/008 ,  G06T2211/428

摘要： The invention relates to a method for determining the position of a surgical tool relative to a target volume inside an animal body according to a pre-plan comprising the steps of i) obtaining a plurality of two-dimensional images of said target volume using imaging means, each 2D-image being represented by an image data slice I(x,y,z); ii) reconstructing from said plurality of image data slices I(x,y,z) a three-dimensional image of said target volume using transformation means, said 3D-image being represented by a volumetric image data array V(x,y,z); iii) displaying said three-dimensional image of said target volume to an user using displaying means.

摘要翻译： 本发明涉及一种用于根据预先计划确定外科手术工具相对于动物体内的目标体积的位置的方法，包括以下步骤：i）使用成像装置获得所述目标体积的多个二维图像 每个2D图像由图像数据切片I（x，y，z）表示; ii）使用变换装置从所述多个图像数据切片I（x，y，z）重建所述目标体积的三维图像，所述3D图像由体积图像数据阵列V（x，y，z）表示 ）; iii）使用显示装置将所述目标体积的所述三维图像显示给用户。