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    Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use
    21.
    发明授权
    Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use 失效
    包含α-肾上腺素能受体拮抗剂和一氧化氮供体的组合物和试剂盒及使用方法

    公开(公告)号：US06294517B1

    公开(公告)日：2001-09-25

    申请号：US09145143

    申请日：1998-09-01

    申请人： David S. Garvey ,  Joseph D. Schroeder ,  Inigo Saenz de Tejada

    发明人： David S. Garvey ,  Joseph D. Schroeder ,  Inigo Saenz de Tejada

    IPC分类号： A01N4354

    CPC分类号： C07D459/00 ,  A61K45/06 ,  C07C381/00 ,  C07D211/62 ,  C07D233/24 ,  C07D239/95 ,  C07D401/04 ,  C07D405/12 ,  Y10S514/929 ,  Y10S514/968

    摘要： The present invention describes novel compositions and kits comprising alpha-adrenergic receptor antagonists and compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, or stimulate nitric oxide synthesis. In preferred embodiments, the alpha-adrenergic receptor antagonist is an alkaloid selected from the group consisting of rauwolscine, corynanthine, yohimbine, apoyohimbine, beta-yohimbine, yohimbol, pseudoyohimbine and epi-3&agr;-yohimbine, and the compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, or stimulates nitric oxide synthesis is selected from the group consisting of L-arginine, S-nitroso-N-acetylcysteine, S-nitroso-captopril, S-nitroso-homocysteine, S-nitroso-cysteine and S-nitroso-glutathione. In other embodiments, the present invention describes novel compositions comprising yohimbine and L-arginine. In still other embodiments, the invention describes novel compositions comprising yohimbine and L-arginine where the yohimbine is derived from yohimbe bark or Rauwolfia root. The novel compositions of the invention are useful for treating impotence in males and females.

    摘要翻译： 本发明描述了包含α-肾上腺素能受体拮抗剂和捐赠，转移或释放一氧化氮，提高内源性松弛因子的内源水平或刺激一氧化氮合成的化合物的新型组合物和试剂盒。 在优选的实施方案中，α-肾上腺素能受体拮抗剂是选自以下的生物碱：羊尿苷，色氨酸，育亨宾，去氨嘌呤，β-育亨宾，育亨宾，假蛋黄嘌呤和epi-3α-育亨宾，以及捐赠，转移或释放的化合物 一氧化氮提高内源性舒张因子的内源水平，或刺激一氧化氮合成选自L-精氨酸，S-亚硝基-N-乙酰半胱氨酸，S-亚硝基卡托普利，S-亚硝基高半胱氨酸，S 亚硝基半胱氨酸和S-亚硝基 - 谷胱甘肽。 在其它实施方案中，本发明描述了包含育亨宾和L-精氨酸的新型组合物。 在其它实施方案中，本发明描述了包含育亨宾和L-精氨酸的新型组合物，其中育亨宾衍生自yohimbe树皮或Rauwolfia根。 本发明的新型组合物可用于治疗男性和女性的阳。。

    Method for treating itching of the vagina
    22.
    发明授权
    Method for treating itching of the vagina 有权
    治疗阴道瘙痒的方法

    公开(公告)号：US06280716B1

    公开(公告)日：2001-08-28

    申请号：US09706223

    申请日：2000-11-03

    申请人： Perry A. Ratcliff

    发明人： Perry A. Ratcliff

    IPC分类号： A61K900

    CPC分类号： A61K9/0014 ,  A61K8/20 ,  A61K8/22 ,  A61K8/24 ,  A61K33/40 ,  A61K33/42 ,  A61K47/02 ,  A61Q11/00 ,  A61Q15/00 ,  Y10S424/15 ,  Y10S514/887 ,  Y10S514/931 ,  Y10S514/934 ,  Y10S514/937 ,  Y10S514/944 ,  Y10S514/966 ,  Y10S514/967 ,  Y10S514/968 ,  A61K2300/00

    摘要： A method and solution or gel topical preparation containing chlorine dioxide and a phosphate compound, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium monofluorophosphate, is disclosed for treating itching of the vagina. The preferred concentration ranges are between about 0.005% to about 2.0% chlorine dioxide, and between about 0.02% to about 3.0% phosphate compound. The phosphate compound retards escape of chlorine dioxide in the pH range of about 6.0 to 7.4, at which pH chlorine dioxide becomes activated and releases sufficient chlorine dioxide to reduce motility and become lethal to the involved micro-organisms.

    摘要翻译： 公开了含有二氧化氯和磷酸盐化合物如磷酸氢二钠，磷酸二氢钠，磷酸三钠和单氟磷酸钠的方法和溶液或凝胶局部制剂，用于治疗阴道的瘙痒。 优选的浓度范围为约0.005％至约2.0％的二氧化氯和约0.02％至约3.0％的磷酸盐化合物。 磷酸盐化合物在约6.0至7.4的pH范围内阻止二氧化氯的逸出，在该pH范围内，二氧化氯被激活并释放足够的二氧化氯以降低运动性并对所涉及的微生物致死。

    Process for producing suppositories by compression and suppositories obtained by the process
    25.
    发明授权
    Process for producing suppositories by compression and suppositories obtained by the process 失效
    通过该方法获得的压制和栓剂制备栓剂的方法

    公开(公告)号：US5629012A

    公开(公告)日：1997-05-13

    申请号：US450884

    申请日：1995-05-26

    申请人： S.o slashed.ren Halskov

    发明人： S.o slashed.ren Halskov

    IPC分类号： A61K9/02

    CPC分类号： A61K9/02 ,  Y10S424/15 ,  Y10S514/966 ,  Y10S514/967 ,  Y10S514/968

    摘要： Suppositories, produced by a process in which a suppository basic mass is produced containing (a) 50-75% of 5-aminosalicylic acid as an active ingredient, (b) 2-5% talc, magnesium stearate and/or polyvinyl pyrrolidone and (c) 20-48% by weight of a polyethylene glycol having an average molecular weight of at least 4000, and the produced mass is compressed to suppositories in a tabletting machine.

    摘要翻译： 制备栓剂，其中制备含有（a）50-75％的5-氨基水杨酸作为活性成分的栓剂基质，（b）2-5％滑石，硬脂酸镁和/或聚乙烯吡咯烷酮和（ c）20-48重量％的平均分子量为至少4000的聚乙二醇，并且将生产的物质压制成压片机中的栓剂。

    Genital lubricants containing zinc as an anti-viral agent
    26.
    发明授权
    Genital lubricants containing zinc as an anti-viral agent 失效
    含锌作为抗病毒剂的生殖润滑剂

    公开(公告)号：US5599551A

    公开(公告)日：1997-02-04

    申请号：US361967

    申请日：1994-12-22

    申请人： Patrick D. Kelly

    发明人： Patrick D. Kelly

    IPC分类号： A61K9/00 ,  A61K31/315 ,  A61K33/30 ,  A61K7/40 ,  A01N55/02 ,  A61K31/325

    CPC分类号： A61K33/30 ,  A61K31/315 ,  A61K9/0034 ,  Y10S514/886 ,  Y10S514/931 ,  Y10S514/934 ,  Y10S514/944 ,  Y10S514/966 ,  Y10S514/967 ,  Y10S514/968 ,  Y10S514/969

    摘要： This invention relates to an article of manufacture comprising an aqueous gel containing a selected zinc salt contained within a deformable plastic-walled tubular container, for convenient and consistent use as a topical genital lubricant during acts of sexual intercourse. The zinc salt must be organic, water-soluble, and have substantial dissociation rates to release divalent zinc ions. Suitable zinc salts include zinc acetate, zinc propionate, zinc butyrate, zinc formate, zinc gluconate, zinc glycerate, zinc glycolate, and zinc lactate. The gel must also contain a thickening agent (such as chemically treated cellulose) and a lubricating agent (such as glycerin), and it must be free of heparin, dextran sulfate, or any other anti-coagulant or other component which poses a substantial risk of adverse effects if the lubricant is used frequently and repeatedly over a period of months or years. The zinc-containing lubricants described herein can reduce the risk that a previously uninfected person will become infected by genital herpes viruses, and possibly by HIV, hepatitis, or papilloma viruses or other sexually transmitted pathogens, during or after intercourse with an infected partner.

    摘要翻译： 本发明涉及一种制品，其包含含有可变形塑料壁管状容器中所含的选择的锌盐的含水凝胶，用于在性交行为期间方便和一致地用作局部生殖润滑剂。 锌盐必须是有机的，水溶性的，并且具有显着的解离速率以释放二价锌离子。 合适的锌盐包括乙酸锌，丙酸锌，丁酸锌，甲酸锌，葡糖酸锌，甘油酸锌，乙醇酸锌和乳酸锌。 凝胶还必须含有增稠剂（如化学处理的纤维素）和润滑剂（如甘油），并且必须不含肝素，硫酸葡聚糖或任何具有重大危险的其他抗凝血剂或其他成分 如果在几个月或几年的时间内经常和多次使用润滑剂，则会产生不利影响。 本文所述的含锌润滑剂可以降低以前未感染的人在与受感染的伴侣之间或之后发生的生殖器疱疹病毒以及可能由艾滋病毒，肝炎或乳头瘤病毒或其他性传播病原体感染的风险。

    Medical prevention of lacerations to the vagina and perineum
    27.
    发明授权
    Medical prevention of lacerations to the vagina and perineum 失效
    医疗预防对阴道和会阴的撕裂

    公开(公告)号：US5562899A

    公开(公告)日：1996-10-08

    申请号：US395693

    申请日：1995-02-28

    申请人： Allen Gerber

    发明人： Allen Gerber

    IPC分类号： A61K38/16 ,  A61K31/00 ,  A61K33/00 ,  C12N1/00 ,  C12P1/04

    CPC分类号： A61K38/164 ,  Y10S435/822 ,  Y10S514/906 ,  Y10S514/967 ,  Y10S514/968

    摘要： A common complication of vaginal delivery is the tearing of the muscles of the vagina and perineum. This tearing results in an irregular laceration which the surgeon must then repair. Current obstetrical practice is to prevent this irregular laceration by performing an episiotomy to create a regular laceration which is later sutured. However, both natural tearing of the vaginal and perineal muscles during delivery and surgical episiotomies are subject to further, more grave, complications. The use of medical therapy instead of surgical therapy will reduce the incidence of lacerations of the muscles of the vagina and perineum. The use of medical therapy for the relaxation of the muscles of the vagina and perineum is described.

    摘要翻译： 阴道分娩的常见并发症是阴道和会阴肌肉的撕裂。 这种撕裂导致外科医生必须修复的不规则撕裂。 目前的产科实践是通过进行外阴切开术以产生稍后被缝合的常规撕裂来防止这种不规则的裂伤。 然而，在分娩期间和手术外阴切开术期间，阴道和会阴肌的自然撕裂都会进一步，更严重的并发症。 使用医学治疗而不是手术治疗将减少阴道和会阴肌肉的撕裂的发生率。 描述了使用药物疗法来放松阴道和会阴肌肉。

    Composition for treatment of abnormal conditions of the epithelium of bodily orifices
    28.
    发明授权
    Composition for treatment of abnormal conditions of the epithelium of bodily orifices 失效
    用于治疗身体孔上皮异常病症的组合物

    公开(公告)号：US5489435A

    公开(公告)日：1996-02-06

    申请号：US87606

    申请日：1993-07-06

    申请人： Perry A. Ratcliff

    发明人： Perry A. Ratcliff

    IPC分类号： A61K8/20 ,  A61K8/22 ,  A61K8/24 ,  A61K9/00 ,  A61K33/40 ,  A61K33/42 ,  A61K47/02 ,  A61Q11/00 ,  A61Q15/00 ,  A61Q19/00 ,  A61K33/00

    CPC分类号： A61K47/02 ,  A61K33/40 ,  A61K33/42 ,  A61K8/20 ,  A61K8/22 ,  A61K8/24 ,  A61K9/0014 ,  A61Q11/00 ,  A61Q15/00 ,  Y10S424/15 ,  Y10S514/944 ,  Y10S514/945 ,  Y10S514/966 ,  Y10S514/967 ,  Y10S514/968

    摘要： A stable solution, cream, salve, or spray composition containing activated stabilized chlorine dioxide and phosphates, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium monofluorophosphate, is disclosed for the prevention and treatment of abnormal conditions of the epithelium of bodily orifices. Examples of such abnormal conditions of the epithelium of the rectal, vaginal, urethral, oral, nasal, ocular, and auditory canal orifices include bacterial infections, such as Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis, and fungal infections, such as Candida, and leukoplakia. The preferred concentration ranges are between about 0.005%-2.0% chlorine dioxide, and between about 0.02%-3.0% phosphate. The phosphate compound retards escape of chlorine dioxide in the pH range of 6.0 to 7.4, at which pH stabilized chlorine dioxide becomes activated and releases sufficient chlorine dioxide to reduce motility and become lethal to the involved micro-organisms.

    摘要翻译： 公开了含有活化稳定的二氧化氯和磷酸盐如磷酸氢二钠，磷酸二氢钠，磷酸三钠和单氟磷酸钠的稳定溶液，霜剂，药膏或喷雾组合物，用于预防和治疗上皮的异常状况 身体孔。 直肠，阴道，尿道，口腔，鼻，眼和耳道孔的上皮的这种异常状况的实例包括细菌感染，例如放线杆菌放线菌纲和牙龈卟啉单胞菌，以及真菌感染如念珠菌和白斑病。 优选的浓度范围为约0.005％-2.0％二氧化氯和约0.02％-3.0％磷酸盐。 磷酸盐化合物在6.0至7.4的pH范围内阻止二氧化氯的逸出，在此pH值稳定的二氧化氯被激活并释放足够的二氧化氯以降低运动性并对所涉及的微生物致死。

    Method for preparing time-stable solutions of non-pyrogenic magnesium gluconocitrates
    29.
    发明授权
    Method for preparing time-stable solutions of non-pyrogenic magnesium gluconocitrates 失效
    制备非致热原镁葡萄糖酸盐的时间稳定溶液的方法

    公开(公告)号：US4962208A

    公开(公告)日：1990-10-09

    申请号：US293990

    申请日：1989-01-06

    申请人： Alfred R. Globus

    发明人： Alfred R. Globus

    IPC分类号： A61K31/19 ,  A61K33/10

    CPC分类号： A61K31/19 ,  A61K33/10 ,  Y10S514/968

    摘要： A method is improved for producing highly stable non-pyrogenic solutions of magnesium gluconocitrate. According to this process a specially prepared non-pyrogenic magnesium hydroxycarbonate or magnesium carbonate, gluconic acid anhydride and citric acid are first admixed to form a powder. The admixed powder is then added to an aqueous medium and heated to a temperature of at least about 80.degree. C. to rapidly drive out substantially all of the carbon dioxide. Alternatively, the aqueous medium may be heated to a temperature of at least 80.degree. C. prior to the addition of the powder. The magnesium hydroxycarbonate or magnesium carbonate is prepared by heating to 165.degree. C. for about 18 hours in thin layers in the presence of steam and an oxidizing atmosphere whereby any and all traces of organic material which could be pyrogen forming is eliminated by oxidation thereof.

    摘要翻译： 改进了用于生产高度稳定的非葡萄糖酸镁的非致热原溶液的方法。 根据该方法，首先将特殊制备的非致热性羟基碳酸镁或碳酸镁，葡萄糖酸酐和柠檬酸混合以形成粉末。 然后将混合的粉末加入到水性介质中并加热到至少约80℃的温度以快速排出基本上所有的二氧化碳。 或者，在添加粉末之前，将水性介质加热至至少80℃的温度。 羟基碳酸镁或碳酸镁是通过在蒸汽和氧化气氛的存在下以薄层加热至165℃制备约18小时，由此通过其氧化可消除可能形成热解原的有机材料的任何痕迹。