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91 条记录 (耗时 0.014 秒)

    Immobilization of Streptokinase
    23.
    发明授权
    Immobilization of Streptokinase 失效
    固定链激酶

    公开(公告)号：US4305926A

    公开(公告)日：1981-12-15

    申请号：US74983

    申请日：1979-09-13

    申请人： Johannes Everse ,  Kathleen E. Everse ,  Leo C. Mercer

    发明人： Johannes Everse ,  Kathleen E. Everse ,  Leo C. Mercer

    IPC分类号： A61L33/00 ,  C12N11/02 ,  A61L15/03 ,  A61F13/00 ,  A61K9/70

    CPC分类号： C12N11/02 ,  A61L33/0047

    摘要： The invention comprises the construction of an implantable device consisting of a clot lysing inhibitor immobilized onto a biocompatible polymer, and the method of regulation of blood clotting time, the prevention of blood clot formation, and the hydrolysis of existing blood clots with the use of said device. A method is also disclosed to prevent the growth of fibrous connective tissue on prosthetic devices.

    摘要翻译： 本发明包括由固定在生物相容性聚合物上的凝块溶解抑制剂组成的可植入装置的构造，以及调节血液凝固时间的方法，预防血块形成和使用所述血液凝块形成水解现有血块 设备。 还公开了一种防止纤维结缔组织在假体装置上生长的方法。

    Slow-releasing medical preparation to be administered by adhering to a wet mucous surface
    24.
    发明授权
    Slow-releasing medical preparation to be administered by adhering to a wet mucous surface 失效
    慢性释放的药物制剂通过粘附在湿的粘液表面进行施用

    公开(公告)号：US4292299A

    公开(公告)日：1981-09-29

    申请号：US202384

    申请日：1980-07-07

    申请人： Yoshiki Suzuki ,  Hiroshi Ikura ,  Gentaro Yamashita

    发明人： Yoshiki Suzuki ,  Hiroshi Ikura ,  Gentaro Yamashita

    IPC分类号： A61K9/02 ,  A61K9/00 ,  A61K9/22 ,  A61K9/24 ,  A61K9/70 ,  A61L15/03

    CPC分类号： A61K9/209 ,  A61K9/006 ,  A61K9/70

    摘要： PCT No. PCT/JP79/00284 Sec. 371 Date Nov. 6, 1979 Sec. 102(e) Date July 7, 1980 PCT Filed July 7, 1980 PCT Pub. No. WO80/00916 PCT Pub. Date May 15, 1980A medical preparation composed of an adhesive layer comprising polymers which have adhesiveness to a wet mucous surface and swellability upon moistening and a nonadhesive layer which has no adhesiveness to a wet mucous surface and is water soluble or water disintegrable, with at least one of the layers made to contain a medicament. The medical preparation is administered by adhering to a wet mucous surface of the mucous membrane and skin of men or animals, whereby exhibiting a property to release the medicament slowly extending over a long period of time to cure or prevent general or local diseases.

    摘要翻译： PCT No.PCT / JP79 / 00284 Sec。 371日期1979年11月6日 102（e）日期1980年7月7日PCT提交1980年7月7日PCT公布。 出版物WO80 / 0091600 日期1980年5月15日由包含对湿粘性表面具有粘附性和润湿时的溶胀性的聚合物的粘合层组成的药物制剂和与湿粘性表面无粘合性并且具有水溶性或水分解性的非粘附层， 制成含有药物的层中的至少一层。 医疗制剂通过粘附在粘膜和湿性粘膜表面上而施用，其粘膜表面与男性或动物的皮肤呈现特性，从而显示出缓慢延长药物的性能，以缓解长期的时间，以治愈或预防一般或局部疾病。

    Dressing film
    28.
    发明授权
    Dressing film 失效
    连衣裙

    公开(公告)号：US3579628A

    公开(公告)日：1971-05-18

    申请号：US3579628D

    申请日：1967-07-03

    申请人： JOHNSON & JOHNSON

    发明人： GANDER ROBERT J ,  ROVEE DAVID T

    IPC分类号： A61L15/24 ,  A61L26/00 ,  C08F20/62 ,  A61L15/00 ,  A61L15/01 ,  A61L15/03

    CPC分类号： A61L26/0076 ,  A61L15/24 ,  A61L26/0014 ,  C08F20/62 ,  C08L33/02

    摘要： DRESSINGS HAVING A HYDROPHILIC ACRYLIC FILM COMPONENT ADAPTED TO CONTACT A WOUND SURFACE ARE PREPARED IN WHICH THE WOUND CONTACTING FILM IS INSOLUBLE IN BODY FLUIDS BUT HAS A SUBSTANTIAL AFFINITY FOR WATER. MOISTURE ABSORBED BY THE FILM ACTS TO PLASTICIZE THE FILM AND PROVIDED A MOIST, FLEXIBLE, CONFORMING SURFACE TO THE UNDERLYING WOUND TISSUE. THE DRESSING MAY CONSIST OF A SINGLE PIECE OF THE HYDROPHILIC ACRYLIC FILM OR THE FILM MAY FORM A PART OF A COMPOSITE DRESSING WHEREIN THE WOUND CONTACTING SURFACE OF THE DRESSING IS FORMED OF A HYDROPHILIC ACRYLIC FILM. THE HYDROPHILIC ACRLIC FILMS ARE PARTICULARLY SUITABLE FOR USE AS OCCLUSIVE DRESSINGS AND FOR CONTROLLING THE PROLIFERATION OF BACTERIA WHERE THE SAME HAVE, DISPERSED THERETHROUGH, COMPOSITIONS WHICH REACT WITH WATER TO GENERATE A BACTERIOSTATIC SUBSTANCE. WHERE THE FILM BASE IS A HYDROPHILIC ACRYLIC THE EFFECTIVENESS OF THE PRESENCE OF THE BACTERIOSTAT-GENERATING MATERIALS, WHEN PRESENT IS APPRECIABLY INCREASED WHILE ANY CHANCE OF TISSUE IRRITATION IS SUBSTANTIALLY REDUCED.

    Hybrid system for solubilizing pharmaceutically active substances in polymer matrices
    29.
    发明授权
    Hybrid system for solubilizing pharmaceutically active substances in polymer matrices 有权
    用于将药物活性物质溶解在聚合物基质中的混合体系

    公开(公告)号：US07256234B2

    公开(公告)日：2007-08-14

    申请号：US10948763

    申请日：2004-09-22

    申请人： Jens Nierle ,  Christian Gäde

    发明人： Jens Nierle ,  Christian Gäde

    IPC分类号： A61F13/00 ,  A61F13/02 ,  A61L15/15 ,  A61L15/03 ,  C08J ,  A61K9/00 ,  A61K9/70

    CPC分类号： A61K9/0014 ,  A61K9/7053 ,  A61K47/20 ,  Y10S514/944 ,  Y10S514/946

    摘要： The present invention is directed to a hybridized polymer matrix, a method of making such, and products incorporating such a matrix. The hybridized polymer matrix comprises a solvent-free polymer matrix base, a hybridized matrix comprising one or more poly(1-vinyl-2-pyrrolidones) and dimethyl sulfoxide, and at least one active substance. The hybridized polymer matrix is useful in the preparation of transdermal therapeutic systems, particularly making possible the introduction of pharmaceutically active substances which are otherwise difficult to dissolve, such as ibuprofen, into a non-polar matrix.

    摘要翻译： 本发明涉及杂交聚合物基质，其制备方法以及掺入这种基质的产品。 杂化聚合物基质包含无溶剂的聚合物基质基质，包含一种或多种聚（1-乙烯基-2-吡咯烷酮）和二甲基亚砜的杂化基质和至少一种活性物质。 杂交的聚合物基质可用于制备透皮治疗系统，特别是可能将其它难以溶解的药物活性物质（例如布洛芬）引入非极性基质中。