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    Leukotriene B4 derivatives, process for their production and their use as pharmaceutical agents
    21.
    发明授权
    Leukotriene B4 derivatives, process for their production and their use as pharmaceutical agents 失效
    白三烯B4衍生物，其制备方法及其作为药剂的用途

    公开(公告)号：US5859054A

    公开(公告)日：1999-01-12

    申请号：US682724

    申请日：1996-11-08

    申请人： Werner Skuballa ,  Bernd Buchmann ,  Josef Heindl ,  Wolfgang Frohlich ,  Roland Ekerdt ,  Claudia Giesen

    发明人： Werner Skuballa ,  Bernd Buchmann ,  Josef Heindl ,  Wolfgang Frohlich ,  Roland Ekerdt ,  Claudia Giesen

    IPC分类号： C07D521/00 ,  A61K31/19 ,  A61K31/195 ,  A61K47/40 ,  A61P1/00 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  A61P43/00 ,  C07C43/115 ,  C07C59/13 ,  C07C59/58 ,  C07C59/62 ,  C07C59/72 ,  C07C67/31 ,  C07C67/343 ,  C07C69/708 ,  C07C69/734 ,  C07C235/04 ,  C07C235/08 ,  C07C311/00 ,  C07C323/14 ,  A61K31/215

    CPC分类号： C07C59/72 ,  C07C235/08 ,  C07C59/62 ,  C07C69/708 ,  C07C2101/14

    摘要： Pharmacologically active leukotriene-B.sub.4 derivatives of general formula I, ##STR1## are described, in whichR.sub.1 represents CH.sub.2 OH, CH.sub.3, CF.sub.3, COOR.sub.4, CONR.sub.5 R.sub.6, orR.sub.2 represents H or an organic acid radical with 1-15 C atoms,R.sub.3 symbolizes H; C.sub.1 -C.sub.14 alkyl, C.sub.3 -C.sub.10 cycloalkyl optionally substituted singly or multiply; C.sub.6 -C.sub.10 aryl radicals, independently of one another, optionally substituted singly or multiply by halogen, phenyl, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, fluoromethyl, chloromethyl, trifluoromethyl, carbonyl, carboxyl or hydroxy; or a 5- to 6-membered aromatic heterocyclic ring with at least 1 heteroatom,R.sub.4 means hydrogen, C.sub.1 -C.sub.10 alkyl, C.sub.3 -C.sub.10 cycloalkyl; C.sub.6 -C.sub.10 aryl radicals optionally substituted by 1-3 halogen, phenyl, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, fluoromethyl, chloromethyl, trifluoromethyl, carboxyl or hydroxy; CH.sub.2 --CO--(C.sub.6 -C.sub.10) aryl or a 5- to 6-membered ring with at least 1 heteroatom,A symbolizes a trans, trans--CH.dbd.CH--CH.dbd.CH, a --CH.sub.2 CH.sub.2 --CH.dbd.CH-- or a tetramethylene group,B symbolizes a C.sub.1 -C.sub.10 straight-chain or branched-chain alkylene group, which optionally can be substituted by fluorine or the group ##STR2## D means a direct bond, oxygen, sulfur, --C.tbd.C--, --CH.dbd.CR.sub.7, or together with B can also mean a direct bond,R.sub.5 and R.sub.6 are the same or different, and represent H or C.sub.1 -C.sub.4 alkyl or R.sub.6 represents H and R.sub.5 represents C.sub.1 -C.sub.15 alkanoyl or R.sub.8 SO.sub.2, and are optionally substituted with OH,R.sub.7 means H, C.sub.1 -C.sub.5 alkyl, chlorine, bromine,R.sub.8 has the same meaning as R.sub.3,n is 2-5, and, if R.sub.4 means hydrogen, their salts with physiologically compatible bases and their cyclodextrin clathrates.

    摘要翻译： PCT No.PCT / EP94 / 00216 Sec。 371日期：1996年11月8日 102（e）日期1996年11月8日PCT 1994年1月27日PCT公布。 出版物WO95 / 20564 日期：1995年8月3日描述了通式I的化学活性白三烯-BB衍生物，其中R1表示CH 2 OH，CH 3，CF 3，COOR 4，CONR 5 R 6或R 2表示H或有机酸基团，其中1 -15 C原子，R3表示H; 任选取代的C 1 -C 14烷基，C 3 -C 10环烷基或多或多个; 苯基，C 1 -C 4烷基，C 1 -C 4烷氧基，氟甲基，氯甲基，三氟甲基，羰基，羧基或羟基任意取代; C 6 -C 10芳基独立地彼此独立地被卤素，苯基， 或具有至少1个杂原子的5至6元芳族杂环，R 4表示氢，C 1 -C 10烷基，C 3 -C 10环烷基; 任选被1-3个卤素，苯基，C 1 -C 4烷基，C 1 -C 4烷氧基，氟甲基，氯甲基，三氟甲基，羧基或羟基取代的C 6 -C 10芳基; CH2-CO-（C6-C10）芳基或具有至少1个杂原子的5-至6-元环，A表示反式，反式-CH = CH-CH = CH，-CH 2 CH 2 -CH = CH-或 四亚甲基，B表示C1-C10直链或支链亚烷基，其任选可以被氟取代，或者基团D表示直接键，氧，硫，-C 3位C，-CH = CR7或与B一起也可以表示直接键合，R5和R6相同或不同，表示H或C1-C4烷基或R6表示H，R5表示C1-C15烷酰基或R8SO2，并且任选被 OH，R7表示H，C1-C5烷基，氯，溴，R8具有与R3相同的含义，n为2-5，如果R 4表示氢，则其与生理上相容的碱和它们的环糊精包合物的盐。

    Glycidyl azide polymer
    24.
    发明授权
    Glycidyl azide polymer 失效
    缩水甘油基叠氮化物聚合物

    公开(公告)号：US5359012A

    公开(公告)日：1994-10-25

    申请号：US95852

    申请日：1993-07-23

    申请人： Guy Ampleman

    发明人： Guy Ampleman

    IPC分类号： C07C247/04 ,  C08G59/28 ,  C08G59/62 ,  C08G65/331 ,  C07C43/11 ,  C07C43/115

    CPC分类号： C07C247/04 ,  C08G59/28 ,  C08G59/62 ,  C08G65/3311

    摘要： Glycidyl azide polymers, which are used as binders in composite explosive and propellant compositions, include hydroxyl groups which react with the isocyanate curing agent normally used in such compositions. Since the functionality of available linear glycidyl azide polymers is less than two, triols and/or triisocyanates are needed to crosslink the chains to form a matrix. A glycidyl azide polymer with increased functionality (higher than two) and reactivity obviates the need for triols and triisocyanates in the compositions. Moreover, a glycidyl azide polymer with primary hydroxyl groups would give faster curing reactions at lower temperatures without gassing problems, eliminating the need for a catalyst. Examples of glycidyl azide polymer having increased functionality have one of the formulae: ##STR1## wherein R is ##STR2## wherein m and n are different from zero, and m+n is 4 to 60.

    摘要翻译： 用作复合炸药和推进剂组合物中的粘合剂的缩水甘油基叠氮化物聚合物包括与通常用于该组合物中的异氰酸酯固化剂反应的羟基。 由于可用的直链缩水甘油基叠氮化物聚合物的官能度小于2，所以需要三醇和/或三异氰酸酯来交联链以形成基质。 具有增加的功能（高于2）和反应性的缩水甘油基叠氮化物聚合物消除了组合物中三醇和三异氰酸酯的需要。 此外，具有伯羟基的缩水甘油基叠氮化物聚合物将在更低的温度下产生更快的固化反应而没有气体问题，从而无需催化剂。 具有增加的功能性的缩水甘油基叠氮化物聚合物的实例具有以下公式之一：其中R和R是＆lt; IMAGE＆gt;其中m和n不同于0，并且m + n为4〜60。

    Ethers for aromatizing purposes
    25.
    发明授权
    Ethers for aromatizing purposes 失效
    用于芳构化目的的醚

    公开(公告)号：US5313002A

    公开(公告)日：1994-05-17

    申请号：US970870

    申请日：1992-11-03

    申请人： Johannes T. De Heij ,  Franciscus P. Van Lier ,  Harrie Renes

    发明人： Johannes T. De Heij ,  Franciscus P. Van Lier ,  Harrie Renes

    IPC分类号： A24B15/34 ,  C07C43/115 ,  C07C43/162 ,  C07C403/10 ,  C11B9/00 ,  A61K7/46 ,  C07C43/15

    CPC分类号： C11B9/0034 ,  C07C403/10 ,  C07C2101/14 ,  C07C2101/16

    摘要： The invention relates to novel ethers and their use as aroma precursors. The ethers are derived from ionol and related compounds. These aroma precursors do not have a substantial aroma as such under ambient conditions, but will break up into a complex mixture having useful organoleptic properties under heating. The ethers are especially suitable for use in products which are heated, burned or smouldered in some stage of their use. The compounds according to the invention are especially suitable for application to tobacco. Mixtures obtained by degrading (e.g. by heating) the ethers according to the invention may be used in a flavouring or perfuming mixture as well due to their organoleptic properties.

    摘要翻译： 本发明涉及新型醚及其作为香气前体的用途。 醚衍生自离子和相关化合物。 这些芳香前体在环境条件下不具有实质的香味，但会在加热下分解成具有有用感官特性的复杂混合物。 这些醚特别适用于在其使用的某些阶段被加热，燃烧或冒烟的产品中。 本发明的化合物特别适用于烟草。 根据本发明的降解（例如通过加热）醚获得的混合物也可以由于它们的感官特性而用于调味剂或加香混合物中。

    3,3-Dimethyl 2(3-butenyl) norbornanol-2 perfume compositions
    27.
    发明授权
    3,3-Dimethyl 2(3-butenyl) norbornanol-2 perfume compositions 失效
    3,3-二甲基2（3-丁烯基）降冰片烷醇-2香料组合物

    公开(公告)号：US4107094A

    公开(公告)日：1978-08-15

    申请号：US834400

    申请日：1977-09-19

    申请人： Kenneth K. Light ,  Manfred Hugo Vock ,  Edward J. Shuster ,  Frederick Louis Schmitt

    发明人： Kenneth K. Light ,  Manfred Hugo Vock ,  Edward J. Shuster ,  Frederick Louis Schmitt

    IPC分类号： C07C69/02 ,  A23G4/00 ,  A23G4/06 ,  A23L27/20 ,  A61K8/33 ,  A61K8/34 ,  A61K8/35 ,  A61K8/37 ,  A61Q13/00 ,  C07C27/00 ,  C07C31/137 ,  C07C33/05 ,  C07C35/29 ,  C07C41/00 ,  C07C43/115 ,  C07C43/162 ,  C07C43/305 ,  C07C45/00 ,  C07C49/317 ,  C07C49/527 ,  C07C67/00 ,  C07C239/00 ,  C07C251/44 ,  C07D303/04 ,  C11B9/00

    CPC分类号： A23G4/06 ,  C07C35/29 ,  C11B9/0046 ,  C11D3/0084

    摘要： Processes and compositions are described for the use in foodstuff, chewing gum, toothpaste and medicinal product flavor and aroma and perfume aroma augmenting, enhancing, modifying and imparting compositions and as foodstuff, chewing gum, toothpaste, medicinal product, perfume and perfumed article aroma imparting materials of 3,3-dimethyl-2(3-butenyl) norbornanol-2 (hereinafter referred to as the "norbornanol derivative" having the structure: ##STR1## (which structure is intended to cover both the "endo" and the "exo" isomers thereof) produced by a process which comprises reacting an allylic Grignard reagent having the structure: ##STR2## wherein X is chloro, bromo or iodo with camphene oxide having the structure: ##STR3## by either "exo" camphene oxide or "endo" camphene oxide or a mixture of "exo" and "endo" camphene oxide. Addition of the said norbornanol derivative to perfumes and colognes is indicated to produce sweet, woody, thujone-like aromas with strong fir-balsam, armoise, cedarleaf, piney, earthy and camphoraceous nuances.

    摘要翻译： 描述了用于食品，口香糖，牙膏和药用产品风味和芳香和香料香气的方法和组合物，其增强，增强，改性和赋予组合物以及作为食品，口香糖，牙膏，药用产品，香料和香料制品香气赋予 3,3-二甲基-2（3-丁烯基）降冰片烷醇-2的材料（以下称为“降冰片醇衍生物”，具有以下结构：（该结构旨在涵盖“endo”和“exo 通过包括使具有以下结构的烯丙基格利雅试剂（其中X为氯，溴或碘）与具有以下结构的camp氧化物反应的方法制得的：其异构体：通过“外部”camp oxide或“内 “camp hene oxide oxide oxide ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar ar 叶，松，泥土和樟脑的细微差别。

    Low Voc and Low Odor Aromatic Oil
    29.
    发明申请
    Low Voc and Low Odor Aromatic Oil 审中-公开

    公开(公告)号：US20180305268A1

    公开(公告)日：2018-10-25

    申请号：US15768404

    申请日：2016-10-17

    申请人： Dow Global Technologies LLC

    发明人： Sze-Sze Ng

    IPC分类号： C05G3/08 ,  C05C3/00 ,  C05C9/00 ,  C05F3/00 ,  C07C43/11 ,  C07C43/115

    摘要： A low VOC, low vapor pressure, low flash point and nonfoaming fertilizer stabilizer composition comprises: (A) two or more glycol ethers of Formula 1 Each of R1 and R3 are independently hydrogen or phenyl with the proviso that R1 and R3 are not simultaneously hydrogen, n is an integer of 3-10, and R2 is 90 to 100% hydrogen or 0 to 10% of one or more of methyl, ethyl or phenyl; and; and at least one fertilizer stabilizer, e.g., an N-alkyl thiophosphoric triamide.