公开(公告)号：US20030202955A1

公开(公告)日：2003-10-30

申请号：US10389560

申请日：2003-03-14

Applicant: Debio Recherche Pharmaceutique S.A.

Inventor： J. Milton Harris

IPC: A61K031/785 ,  A61K031/765 ,  C08G063/48 ,  C08G063/91

CPC classification number: G01N33/528 ,  A61K47/56 ,  A61K47/60 ,  A61K47/6903 ,  B01L3/508 ,  B01L99/00 ,  Y10S424/13 ,  Y10S530/816

Abstract: A degradable PEG hydrogel is described that, upon hydrolysis, releases conjugates of substantially non-peptidic polymers and biologically active molecules. For example, PEG and protein conjugates can be released in vivo from the hydrogels for therapeutic application.

公开(公告)号：US20030175238A1

公开(公告)日：2003-09-18

申请号：US10312095

申请日：2002-12-20

Inventor： Narendra Bam ,  Andrew G King ,  Ping-Yang Yeh ,  Charles Davis

IPC: A61K038/19 ,  C07K014/52 ,  C08G063/48 ,  C08G063/91

CPC classification number: C07K14/522 ,  A61K38/00 ,  A61K47/58 ,  A61K47/60

Abstract: Low molecular weight polypelptides with chemokine activity were conjugated to water-soluble polymers and retain biological activity. These conjugated chemokines demonstrate enhanced and unexpected biological properties when compared to unconjugated chemokines.

Abstract translation: 具有趋化因子活性的低分子量聚游泳肽与水溶性聚合物缀合并保留生物活性。 当与未结合的趋化因子相比时，这些共轭趋化因子表现出增强的和意想不到的生物学特性。

公开(公告)号：US20030170202A1

公开(公告)日：2003-09-11

申请号：US10323699

申请日：2002-12-18

Applicant: Rutgers, The State University of New Jersey

Inventor： Kathryn E. Uhrich

IPC: A61K031/765 ,  C08G063/48 ,  C08G063/91

CPC classification number: C08G83/005 ,  A61K9/0014 ,  A61K9/1075 ,  A61K9/127 ,  A61K9/5146 ,  A61K9/7084 ,  A61K47/6907 ,  C08L71/02 ,  G03C1/04 ,  G03C5/3056 ,  Y10S514/937 ,  Y10S514/969

Abstract: Polymeric micelles for encapsulation of hydrophobic molecules are provided. Methods and formulations for delivering hydrophobic molecules to a host via these micelles are also provided. Methods of stabilizing liposomes or lipid based formulations by addition of polymeric micelles are also provided.

公开(公告)号：US20030147844A1

公开(公告)日：2003-08-07

申请号：US10290695

申请日：2002-11-08

Inventor： Yun H. Choe ,  Richard B. Greenwald

IPC: A61K031/785 ,  C08G063/48 ,  C08G063/91

CPC classification number: C08G63/688 ,  A61K47/60 ,  C08G63/46 ,  C08G63/685

Abstract: Thiol-linked polymeric prodrugs and methods of making and using the same are disclosed. The use of a sulfhydryl bond as the basic link for linking the polymer to the drug allows a prodrug to be formed which takes advantage of plasma enzymes in vivo. A preferred conjugate is 1 Methods of preparing and treatment are also disclosed.

Abstract translation: 公开了硫醇连接的聚合物前药及其制备和使用方法。 使用巯基作为将聚合物与药物连接的基本连接使得能够形成利用体内血浆酶的前体药物。 优选的缀合物也公开了制备和处理方法。

公开(公告)号：US20030125451A1

公开(公告)日：2003-07-03

申请号：US10284989

申请日：2002-10-31

Applicant: Wacker Polymer Systems GmbH & Co. KG

Inventor： Hans-Peter Weitzel ,  Robert Braunsperger

IPC: C08G063/48 ,  C08G063/91

CPC classification number: C08F210/02 ,  C08F218/08

Abstract: A process for preparing aqueous dispersions or water-redispersible polymer powders of polyvinyl-alcohol-stabilized polymers based on vinyl ester(s), and ethylene, by continuous emulsion polymerization with no seed latex, and optionally drying the dispersion, by a) polymerizing in at least two pressurized reactors in series at a temperature of 40 to 100null C. and a pressure of 5 to 100 bar to a residual monomer content of less than 3% by weight, and continuing polymerizing in an unpressurized reactor at 20 to 60null C. and less than 1.0 bar; b) initiating polymerization by a redox system containing oxidizing and reducing components, at least part of the reducing component introduced within the first pressurized reactor, c) metering polyvinyl alcohol into the first pressure reactor such that its proportion is null6% by weight, based on the monomers continuously introduced to the reactor, d) introducing 10 to 60% by weight of total vinyl ester into the second pressure reactor, e) maintaining a weight ratio of redox system oxidation component to monomer of from 0.03 to 0.07 in the first reactor, and f) a residence time of 2.5 hours or less in that reactor.

Abstract translation: 一种制备基于乙烯基酯和乙烯的聚乙烯醇稳定聚合物的水性分散体或水分散性聚合物粉末的方法，通过不含种子胶乳的连续乳液聚合，并任选地干燥分散体，方法是通过以下步骤进行聚合：a） 至少两个加压反应器在40至100℃的温度下串联，压力为5至100巴，残留单体含量小于3重量％，并在20至60℃的非加压反应器中继续聚合 C.小于1.0巴; b）通过含有氧化和还原组分的氧化还原体系引发聚合，至少部分引入第一加压反应器中的还原组分，c）将聚乙烯醇计量到第一压力反应器中，使其比例为<= 6重量％ 基于连续引入反应器的单体，d）将10至60重量％的总乙烯基酯引入第二压力反应器中，e）在第一个反应器中将氧化还原体系氧化组分与单体的重量比保持在0.03至0.07之间 反应器，和f）在该反应器中停留时间为2.5小时或更短。

公开(公告)号：US20030124742A1

公开(公告)日：2003-07-03

申请号：US10226704

申请日：2002-08-22

Inventor： Ramesh K. Prakash

IPC: G01N033/543 ,  C08G063/48 ,  C08G063/91

CPC classification number: A61K47/65

Abstract: The present invention provides conjugates that preferentially bind to or otherwise associate with specific target cells and methods for using such compositions. Specifically, the present invention provides conjugates comprising a pendant polyalkylene glycol, and a ligand comprising a peptide that preferentially binds to or otherwise associates with a target-receptor. The present invention also provides methods for detecting a disease using such conjugates. In addition, the present invention provides methods for delivering chemical agents and drugs to a mammal using the conjugates of the invention.

Abstract translation: 本发明提供优先与特定靶细胞结合或以其它方式结合的缀合物以及使用这些组合物的方法。 具体而言，本发明提供了包含侧链聚亚烷基二醇和包含优先与靶受体结合或以其它方式结合的肽的配体的缀合物。 本发明还提供了使用这种缀合物检测疾病的方法。 此外，本发明提供使用本发明的缀合物向哺乳动物递送化学试剂和药物的方法。

公开(公告)号：US20030109635A1

公开(公告)日：2003-06-12

申请号：US10332027

申请日：2003-01-02

Inventor： Minoru Adachi ,  Shoji Uesugi

IPC: C08L001/00 ,  C08G063/48 ,  C08G063/91

CPC classification number: B41J2/1637 ,  B29C45/0013 ,  B29C45/2628 ,  B41J2/16 ,  B41J2/1634 ,  B41J2002/14387 ,  C08L63/00 ,  C08L101/00 ,  C08L61/20 ,  C08L2666/14

Abstract: The present invention provides a resin composition suitable for molding a microscopic structure that has small cure shrinkage, good mold transfer properties and excellent properties for post-processing such as polishing processing and laser processing. Such a resin is a thermosetting resin composition comprising 95 to 35 wt % of a thermosetting resin and 5 to 65 wt % of organic filler having a particle size of 10 nullm or less. From such a resin, an ink ejecting apparatus having a microscopic structure, for example, a nozzle of a diameter of 30 nullm, is integrally molded.

Abstract translation: 本发明提供一种适于成型具有小固化收缩率，良好的模具转印性能以及用于诸如抛光加工和激光加工的后处理的优异性能的微结构的树脂组合物。 这种树脂是包含95〜35重量％的热固性树脂和5〜65重量％的粒径为10μm以下的有机填料的热固性树脂组合物。 通过这种树脂，具有微观结构的喷墨装置，例如直径为30μm的喷嘴，是一体模制的。

公开(公告)号：US20030092904A1

公开(公告)日：2003-05-15

申请号：US10001044

申请日：2001-10-31

Inventor： Joel Myerson ,  Michel G. M. Perobost ,  Douglas J. Dellinger ,  Geraldine F. Dellinger

IPC: C07H021/04 ,  B05D003/00 ,  C08G063/91 ,  C08G063/48

CPC classification number: B82Y30/00 ,  B01J2219/00378 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00675 ,  B01J2219/00677 ,  C07B2200/11 ,  C07H21/00 ,  C40B50/14 ,  C40B60/14 ,  Y02P20/542

Abstract: A method of fabricating polynucleotide arrays includes dissolving a nucleotide monomer, oligonucleotide, or polynucleotide in a solvent containing ionic liquid and depositing the resulting solution on an array substrate. The method has particular application to fabrication of an addressable array of polynucleotides on a substrate that carries substrate bound moieties each with a hydroxyl group. The process may be repeated at specific locations on the array to elongate the polynucleotide deposited on the array.

Abstract translation: 制备多核苷酸阵列的方法包括将核苷酸单体，寡核苷酸或多核苷酸溶解在含有离子液体的溶剂中，并将所得溶液沉积在阵列基底上。 该方法特别适用于在载体上具有羟基的底物结合部分的底物上制造多核苷酸可寻址阵列。 该过程可以在阵列上的特定位置重复以延长沉积在阵列上的多核苷酸。

公开(公告)号：US20030092062A1

公开(公告)日：2003-05-15

申请号：US10033308

申请日：2001-10-24

Inventor： M. Parameswara Reddy ,  Firdous Farooqui

IPC: G01N033/53 ,  C08G063/48 ,  C08G063/91 ,  B05D003/00

CPC classification number: G01N33/54353

Abstract: This invention provides a system for immobilizing biological molecules onto a solid support having an available amino group that uses two steps. In a first step, a nucleophilic substitution reaction occurs so that the available amino group displaces a first leaving group of an activating compound to form an activated support. In a second step, the activated support reacts with biological molecules resulting in a composition of the formula: 1 wherein S is a solid support, preferably X is selected from the group consisting of 2 wherein R is selected from the group consisting of alkyl, aryl, and OR1 having no greater than about 18 carbon atoms, wherein R1 is selected from the group consisting of alkyl and aryl having no greater than about 18 carbon atoms, wherein X1 is selected from the group consisting of NH, oxygen, and sulfur, and wherein B is a biological molecule.

Abstract translation: 本发明提供了一种用于将生物分子固定在具有使用两个步骤的可用氨基的固体支持物上的系统。 在第一步中，发生亲核取代反应，使得可用的氨基取代活化化合物的第一离去基团以形成活化的载体。 在第二步中，活化的载体与生物分子反应，产生下式的组合物：其中S是固体支持物，优选X选自其中R选自烷基，芳基和 OR1不大于约18个碳原子，其中R1选自不大于约18个碳原子的烷基和芳基，其中X1选自NH，氧和硫，其中B 是一种生物分子。

公开(公告)号：US20030077635A1

公开(公告)日：2003-04-24

申请号：US10238732

申请日：2002-09-11

Applicant: DAKO A/S

Inventor： Jesper Lohse

IPC: C12Q001/68 ,  G01N033/53 ,  G01N033/537 ,  G01N033/543 ,  C08G063/48 ,  C08G063/91

CPC classification number: C08G83/003 ,  C12Q1/682 ,  G01N33/582 ,  G01N33/585 ,  C12Q2525/313 ,  C12Q2565/102

Abstract: Novel dendrimers as well as novel dendrimer complexes are disclosed. Such dendrimers and/or dendrimer complexes may be used for the detection of various components of a sample and as detection systems and signal enhancement/amplification systems. The dendrimers and dendrimer complexes may also be used for labelling various entities/compounds. Furthermore, labelling kits and detection kits comprising one or more labelled dendrimers or one or more dendrimer complexes are also one of the possible uses.

Abstract translation: 公开了新颖的树枝状大分子以及新颖的树枝状大分子复合物。 这种树枝状大分子和/或树枝状大分子复合物可以用于检测样品的各种组分以及检测系统和信号增强/扩增系统。 树枝状大分子和树枝状大分子复合物也可用于标记各种实体/化合物。 此外，包含一个或多个标记的树枝状聚合物或一种或多种树枝状大分子复合物的标记试剂盒和检测试剂盒也是可能的用途之一。