公开(公告)号：US4405805A

公开(公告)日：1983-09-20

申请号：US286996

申请日：1981-07-27

申请人： Thomas J. Giacobbe ,  Grace Tsien

发明人： Thomas J. Giacobbe ,  Grace Tsien

IPC分类号： C07C255/54 ,  C07C67/00 ,  C07C201/00 ,  C07C201/16 ,  C07C205/11 ,  C07C205/59 ,  C07C253/00 ,  C07C313/00 ,  C07C315/06 ,  C07C317/22 ,  C07C317/46 ,  C07C79/46

CPC分类号： C07C205/59 ,  C07C201/16

摘要： Crude phenoxybenzoic acid herbicide, e.g., acifluorfen, having one or more undesirable isomers/by-product impurities associated therewith is separated therefrom employing an inert solvent which is selective for the isomers/other by-products.

摘要翻译： 使用对异构体/其它副产物有选择性的惰性溶剂，将与其相关的一种或多种不期望的异构体/副产物杂质的粗苯氧基苯甲酸除草剂，例如氟锁草醚分离。

公开(公告)号：US2949483A

公开(公告)日：1960-08-16

申请号：US44696254

申请日：1954-07-30

申请人： CHEMSTRAND CORP

发明人： HAM GEORGE E

IPC分类号： C07C51/43 ,  C07C273/18 ,  C07C275/42 ,  C07C315/06 ,  C07C317/44 ,  C07C335/22

CPC分类号： C07C335/22 ,  C07C51/43 ,  C07C273/189 ,  C07C315/06 ,  C07C63/26 ,  C07C317/44 ,  C07C275/42

公开(公告)号：US20240239735A1

公开(公告)日：2024-07-18

申请号：US18559891

申请日：2022-05-13

申请人： WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD.

发明人： Liang WANG ,  Jun LOU ,  Yi YUAN ,  Xiaodan GUO ,  Yongkai CHEN ,  Yihan ZHANG ,  Huayun HONG ,  Wei PENG ,  Chaodong WANG

IPC分类号： C07C55/07 ,  A61K31/10 ,  A61K31/194 ,  A61K31/4155 ,  A61K45/06 ,  C07C51/43 ,  C07C57/145 ,  C07C59/255 ,  C07C315/06 ,  C07C317/14 ,  C07D403/04

CPC分类号： C07C55/07 ,  A61K31/10 ,  A61K31/194 ,  A61K31/4155 ,  A61K45/06 ,  C07C51/43 ,  C07C57/145 ,  C07C59/255 ,  C07C315/06 ,  C07C317/14 ,  C07D403/04 ,  C07B2200/13

摘要： An acid addition salt of a ROCK inhibitor, and a crystal form, a composition and the pharmaceutical use thereof are provided. The acid addition salt is an acid addition salt of compound A and any one of the following acids: hydrochloric acid, p-toluenesulfonic acid, benzenesulfonic acid, maleic acid, tartaric acid, oxalic acid, fumaric acid, sulfuric acid, methanesulfonic acid, phosphoric acid, succinic acid or citric acid (A). The acid addition salt of compound A and the crystal form thereof have the characteristics of high solubility, good stability, high purity, few impurities and high bioequivalence, and are beneficial for the storage, quality control and druggability of drugs.

公开(公告)号：US20240182408A1

公开(公告)日：2024-06-06

申请号：US18283772

申请日：2022-03-24

申请人： HOUSE FOODS GROUP INC.

发明人： Masae UEYAMA ,  Morihiro AOYAGI

IPC分类号： C07C315/06 ,  C12N9/88 ,  C12N9/90 ,  C12P11/00

CPC分类号： C07C315/06 ,  C12N9/88 ,  C12N9/90 ,  C12P11/00 ,  C12Y404/01004 ,  C12Y503/99

摘要： The present specification discloses a dry PRENCSO composition improved in storage stability, and a lachrymatory factor generating kit comprising the composition. The dry PRENCSO composition according to the present disclosure comprises PRENCSO and saccharide. The present disclosure also relates to a method for producing a dry PRENCSO composition, the method comprising drying a solution containing PRENCSO and saccharide. The present disclosure also relates to a lachrymatory factor generating kit comprising the dry PRENCSO composition, and a dry enzyme composition comprising alliinase and a lachrymatory factor synthase (LFS) and being dried. The present disclosure also relates to a method for generating a lachrymatory factor by contacting water with the dry PRENCSO composition and the dry enzyme composition.

公开(公告)号：US20230127147A1

公开(公告)日：2023-04-27

申请号：US18068151

申请日：2022-12-19

申请人： Fudan University

发明人： Fener CHEN ,  Minjie LIU ,  Meifen JIANG ,  Yingqi XIA ,  Huashan HUANG

IPC分类号： C07C315/02 ,  C07C315/06

摘要： A continuous-flow preparation method of diol sulfone using a two-stage micro-reaction system. The system includes a first micro-mixer, a first micro-channel reactor, a second micro-mixer, and a second micro-channel reactor communicated in sequence. The method includes: feeding hydrogen peroxide, a catalyst and a diol thioether solution simultaneously to the first micro-mixer followed by mixing; feeding the reaction mixture to the first micro-channel reactor for continuous oxidation; and feeding the reaction mixture and water simultaneously to the second micro-mixer and the second micro-channel reactor for continuous quenching and crystallization to obtain diol sulfone.

公开(公告)号：US20230054928A1

公开(公告)日：2023-02-23

申请号：US17780699

申请日：2020-11-27

申请人： SOOCHOW UNIVERSITY

发明人： Xiaobing WAN ,  Hanghang WANG ,  Yonggao ZHENG ,  Pengcheng LIAN ,  Jingjing LI

IPC分类号： C07C315/02 ,  C07C315/06

摘要： Disclosed is a method for preparing β-carbonyl sulfones. The method comprises: by taking an α-carbonyl diazo compound and sodium arylsulfinate as reaction substrates, cheap silver nitrate as an optimal catalyst, 1,10-phenanthroline as a ligand, and potassium persulfate as an oxidant, carrying out coupling reaction in a mixed solvent of acetonitrile and water to obtain a β-carbonyl sulfones compound. Compared with the prior art, the method has the following advantages: a wide range of reaction substrates, short reaction time, a relatively high reaction yield, a mild reaction condition, etc. In the present invention, non-toxic and harmless reagents are used as reaction raw materials, so that it has no harm to the environment and satisfies the requirements of contemporary green chemistry development. Post-reaction treatment is relatively simple, and is convenient for separation and purification. In addition, the reaction can achieve gram-scale synthesis, and lays a foundation for actual applications.

公开(公告)号：US20220098147A1

公开(公告)日：2022-03-31

申请号：US17429210

申请日：2020-02-06

申请人： BASF SE

发明人： Jun GAO ,  Indre THIEL ,  Christian SCHUETZ ,  Lukas METZGEN ,  Oliver BEY ,  Stefan BLEI

IPC分类号： C07C315/02 ,  C07C315/06

摘要： The invention relates to a process for producing 4,4′-dichlorodiphenyl sulfoxide comprising: (I) reacting thionyl chloride, chlorobenzene and aluminum chloride in a molar ratio of thionyl chloride:chlorobenzene:aluminum chloride of 1:(6 to 9):(1 to 1.5) at a temperature in the range from 0 to below 20° C., forming an intermediate reaction product and hydrogen chloride; (II) mixing aqueous hydrochloric acid and the intermediate reaction product at a temperature in the range from 70 to 110° C. to obtain an organic phase comprising 4,4′-dichlorodiphenyl sulfoxide and an aqueous phase; (III) cooling the organic phase comprising the 4,4′-dichlorodiphenyl sulfoxide to a temperature below the saturation point of 4,4′-dichlorodiphenyl sulfoxide to obtain a suspension comprising crystallized 4,4′-dichlorodiphenyl sulfoxide; (IV) solid-liquid-separation of the suspension to obtain a residual moisture containing solid 4,4′-dichlorodiphenyl sulfoxide comprising crystallized 4,4′-dichlorodiphenyl sulfoxide and mother liquor.

公开(公告)号：US11028047B2

公开(公告)日：2021-06-08

申请号：US16630630

申请日：2018-07-31

申请人： KURARAY CO., LTD.

发明人： Kunio Mayahara ,  Koji Tamura ,  Akinobu Takeda

IPC分类号： B01D3/34 ,  C07C315/06 ,  C07C29/80

摘要： A method for recovering dimethyl sulfoxide, including a step of contacting a recovered resist remover containing at least one compound selected from the group consisting of glycol ether, glycol and triol, and dimethyl sulfoxide with water and performing distillation.

公开(公告)号：US20210121422A1

公开(公告)日：2021-04-29

申请号：US16969521

申请日：2019-02-13

申请人： LIGAND PHARMACEUTICALS INCORPORATED ,  METAVANT SCIENCES GMBH

发明人： Lin Zhi ,  Ian Henderson ,  Joseph Kaloko ,  Martin Osterhout

IPC分类号： A61K31/185 ,  C07C309/24 ,  A61K31/155 ,  A61K31/427 ,  A61K31/4439 ,  A61K38/28 ,  A61K38/31 ,  A61K31/7032 ,  A61K31/702 ,  A61K31/64 ,  A61K31/366 ,  A61K31/455 ,  A61K45/06 ,  C07C315/04 ,  C07C201/12 ,  C07C209/36 ,  C07C67/343 ,  C07C67/00 ,  C07C231/02 ,  C07C231/12 ,  C07C315/06

摘要： Provided herein are solid state forms of compounds, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or co-crystals and prodrugs thereof which have glucagon receptor antagonist or inverse agonist activity. Further, provided herein are pharmaceutical compositions and methods of treating, preventing, ameliorating, delaying the time to onset or reducing the risk for the development or progression of at least one condition, disease, or disorder for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistance, hyperglycemia, ketoacidosis, or ketosis.

公开(公告)号：US10899705B2

公开(公告)日：2021-01-26

申请号：US16614599

申请日：2018-05-23

申请人： BASF SE

发明人： Jan Spielmann ,  Michael Zeilinger ,  Juergen Wortmann ,  Frieder Borgmeier

IPC分类号： C07C317/04 ,  C07C315/06 ,  C07C303/06 ,  C07C303/44 ,  C07C309/04

摘要： The present invention relates to a process for the manufacturing of methane sulfonic acid (MSA) by reaction of a radical initiator composition with methane and sulfur trioxide comprising the steps (a) preparation of the intiator composition by reacting aqueous hydrogen peroxide with the components methane sulfonic acid and methane sulfonic acid anhydride and (b) reaction of the initiator composition from step (a) with sulfur trioxide and methane to form methane sulfonic acid. The invention further relates to the use of methane sulfonic acid anhydride (MSA anhydride) in said process and to methane sulfonic acid manufactured by said process.