公开(公告)号：US20210389305A1

公开(公告)日：2021-12-16

申请号：US16900577

申请日：2020-06-12

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Shai NIMRI ,  Yochanan URI ,  Boaz RAN

IPC: G01N33/53 ,  B01L3/00 ,  G01N35/10 ,  G01N35/04 ,  G01N35/00 ,  G01N33/543

Abstract: An instrument for detecting signal from a biological sample includes a pipettor module configured to hold a plurality of pipettes in respective pipette positions, to hold liquid in one or more pipette tips, and to pipette liquid in and out of the one or more pipette tips. Each of the one or more pipette tips has a pipette tip point. The instrument further includes one or more magnets positioned such that each of the one or more pipette tips is adjacent one of the one or more magnets.

公开(公告)号：US20210387200A1

公开(公告)日：2021-12-16

申请号：US17343461

申请日：2021-06-09

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Garret BAUTISTA

IPC: B01L7/00

Abstract: A sample plate for a thermal cycler suitable for performing a polymerase chain reaction (PCR) procedure includes a base plate and a number of reaction vessels extending upward from the base plate. The sample plate further includes a vertical wall surrounding an outer perimeter defined by the reaction vessels. The vertical wall can be a continuation vertical wall, an intermittent vertical wall, or a perforated vertical wall. The intermittent vertical wall can include a plurality of wall portions, each of which plurality of wall portions is separated from other wall portions via a plurality of gaps.

公开(公告)号：US20210363574A1

公开(公告)日：2021-11-25

申请号：US17345834

申请日：2021-06-11

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Amy L. HIDDESSEN ,  Benjamin J. HINDSON

IPC: C12Q1/6848 ,  C12Q1/6844 ,  C12Q1/6816 ,  C12Q1/686

Abstract: System, including methods, apparatus, compositions, and kits, for making and using a stabilized emulsion. A method of generating a stabilized emulsion is provided. In the method, an aqueous phase may be provided. The aqueous phase may include an effective concentration of one or more skin-forming proteins. An emulsion may be formed. The emulsion may include droplets of a dispersed phase disposed in a continuous phase, with the aqueous phase being the continuous phase or the dispersed phase. The emulsion may be heated to create an interfacial skin between each droplet and the continuous phase, to transform the droplets into capsules.

公开(公告)号：US11175284B2

公开(公告)日：2021-11-16

申请号：US16193110

申请日：2018-11-16

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Clayton T. McKee

IPC: G01N33/53 ,  B01L3/00 ,  G01N33/558 ,  G01N33/543

Abstract: Lateral flow devices, methods and kits for performing lateral flow assays are provided.

公开(公告)号：US20210349105A1

公开(公告)日：2021-11-11

申请号：US17314376

申请日：2021-05-07

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： ROGER P. WALKER ,  HEIDI SCHOLZ

IPC: G01N33/68 ,  G01N33/569 ,  G01N33/533

Abstract: The present disclosure relates to the development of novel immunoassays for the detection of SARS-CoV-2 antigens and/or SARS-CoV-2 specific antibodies and, optionally, one or more cytokine in patient samples.

公开(公告)号：US11130125B2

公开(公告)日：2021-09-28

申请号：US16532825

申请日：2019-08-06

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Govind Kaigala ,  Robert Dean Lovchik ,  Anna Fomitcheva Khartchenko ,  Iago Pereiro Pereiro ,  Lorenzo Franco Teodoro Petrini

IPC: B01L3/00

Abstract: A method for manufacturing a fluidic device is provided. The method comprises providing a capillary, providing a structure having a fluidic channel and an opening, reducing an outer diameter of a portion of the capillary to be smaller than the opening of the structure. Furthermore, the method comprises inserting, at least partly, the portion of the capillary through the opening of the structure into the fluidic channel and applying heat to the structure to expand the inserted portion of the capillary to fit the capillary to the structure.

公开(公告)号：US20210283609A1

公开(公告)日：2021-09-16

申请号：US17333337

申请日：2021-05-28

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Kalyan Handique ,  Priyadarshini Gogoi ,  Saedeh Javdani Sepehri ,  Kyle Gleason

IPC: B01L3/00 ,  G01N15/10 ,  G01N15/14 ,  C12M1/00 ,  C12Q1/6834 ,  C12Q1/6841 ,  G01N33/574

Abstract: A system and method for isolating and analyzing single cells, comprising: a substrate having a broad surface; a set of wells defined at the broad surface of the substrate, and a set of channels, defined by the wall, that fluidly couple each well to at least one adjacent well in the set of wells; and fluid delivery module defining an inlet and comprising a plate, removably coupled to the substrate, the plate defining a recessed region fluidly connected to the inlet and facing the broad surface of the substrate, the fluid delivery module comprising a cell capture mode.

公开(公告)号：US11104938B2

公开(公告)日：2021-08-31

申请号：US16013845

申请日：2018-06-20

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Dianna Maar

IPC: C12Q1/68 ,  C12Q1/6848 ,  C12Q1/6832 ,  C12Q1/6858

Abstract: Methods and compositions for detecting genetic instability using digital amplification assays. The methods may be performed in a set of isolated volumes and generally may involve competitive hybridization of a competitor and a probe/primer with a normal allele and one or more mutant alleles of a microsatellite locus. The competitor may be configured to compete similarly with, or to outcompete, the primer/probe for hybridization with the normal allele. The primer/probe may be configured to outcompete the competitor for hybridization with various mutant alleles of the locus that alter the length of the repetitive sequence by different amounts. Isolated volumes in which the primer/probe outcompetes the competitor may be enumerated, and represent one or more of the mutant alleles. The methods may enable diagnosing microsatellite instability and treating a subject based on the diagnosis.

公开(公告)号：US20210254033A1

公开(公告)日：2021-08-19

申请号：US17225189

申请日：2021-04-08

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： XIAO-SONG GONG

IPC: C12N9/12

Abstract: Covalently-linked DNA polymerases are provided.

公开(公告)号：US11067433B2

公开(公告)日：2021-07-20

申请号：US16404637

申请日：2019-05-06

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Denis Pristinski

IPC: G01J1/42 ,  G02B27/10 ,  G01J1/04

Abstract: System, including methods and apparatus, for optical detection. The system may comprise a light source to generate a beam of light, an optical element including a light guide and an exit window, and at least one detector.