公开(公告)号：US20110073614A1

公开(公告)日：2011-03-31

申请号：US12962087

申请日：2010-12-07

Applicant: Daniel Py ,  Julian V. Chan ,  Giovanni Rodriguez

Inventor： Daniel Py ,  Julian V. Chan ,  Giovanni Rodriguez

IPC: B67D7/00

CPC classification number: B65D51/226 ,  B65D47/2075

Abstract: A device for storing and dispensing a substance includes a container having a body defining therein a storage chamber for receiving and storing the substance. The container includes a head located at one end of the body and a first passageway that is in fluid communication with the storage chamber of the body and defines a flow path therebetween. The container also includes a pierceable wall located on an opposite side of the passageway relative to the storage chamber, and a first connecting portion for connecting another component thereto. The device also includes a one-way valve assembly that includes a valve body including a body base defining a second passageway and at least one piercing portion engageable with the pierceable wall of the container. The valve assembly includes a second connecting portion connectable to the first connecting portion of the container for fixedly securing the valve assembly to the container.

Abstract translation: 用于存储和分配物质的装置包括具有在其中限定有用于接收和存储物质的储存室的主体的容器。 容器包括位于主体一端的头部和与主体的储存室流体连通并限定其间的流路的第一通道。 容器还包括位于通道相对于储存室的相对侧上的可穿透壁，以及用于将另一部件连接到其上的第一连接部分。 该装置还包括单向阀组件，该单向阀组件包括阀体，该阀体包括限定第二通道的主体基座和与容器的可刺穿壁可接合的至少一个穿孔部分。 阀组件包括可连接到容器的第一连接部分的第二连接部分，用于将阀组件固定地固定到容器。

公开(公告)号：US07905257B2

公开(公告)日：2011-03-15

申请号：US12496985

申请日：2009-07-02

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B1/20 ,  B65B55/14

CPC classification number: B65B3/04 ,  A61L2/08 ,  A61L2/087 ,  A61L2/24 ,  A61L2202/14 ,  B65B3/003 ,  B65B7/16 ,  B65B7/161 ,  B65B55/025 ,  B65B55/08 ,  B65B55/16

Abstract: A sterile filling machine and related method are provided for sterile filling a container with a substance. The container includes a heat resealable stopper and a chamber for receiving the substance therein. The sealed, empty containers are subjected to radiation capable of penetrating through the stopper and chamber for sterilizing the container. The previously sterilized containers are then transported through another sterilizing chamber, such as an e-beam chamber, to sterilize the penetrable surface. A needle is moved into engagement with the stopper to pierce the sterilized penetrable surface of the stopper and inject the substance through the needle and into the chamber of the container. Laser energy is then transmitted onto the penetrated surface of the stopper to fuse the stopper material and hermetically re-seal the stopper.

Abstract translation: 提供了一种无菌灌装机及相关方法，用于无菌填充具有物质的容器。 容器包括可热再封塞的塞子和用于在其中容纳物质的腔室。 密封的空容器经受能够穿过塞子和室的辐射，以对容器进行灭菌。 先前灭菌的容器然后通过另一个灭菌室，如电子束室输送，以对可穿透表面进行消毒。 针头与塞子移动接合以刺穿塞子的消毒的可渗透表面，并将物质通过针头注入容器的腔室。 然后将激光能量传递到塞子的穿透表面上，以使塞子材料熔化并密封地重新密封塞子。

公开(公告)号：US07861750B2

公开(公告)日：2011-01-04

申请号：US12025362

申请日：2008-02-04

Applicant: Daniel Py ,  Julian V. Chan

Inventor： Daniel Py ,  Julian V. Chan

IPC: B65B1/04

CPC classification number: B65D83/62 ,  A61J1/00 ,  A61J1/1443 ,  B65B3/30 ,  B65B31/044 ,  B65D83/425

Abstract: A dispenser for holding multiple doses of fluids or other substances, and for dispensing the substances, has a vial, a flexible bladder received within the vial, and a variable volume storage chamber formed between the bladder and vial. A filling valve is coupled in fluid communication with the storage chamber and defines (1) a normally closed, fluid-tight position hermetically sealing the storage chamber from the ambient atmosphere, and (2) an open position allowing the passage of fluid through the valve both to evacuate the storage chamber and to introduce fluid through the valve to fill the storage chamber. A pump is coupled in fluid communication with the storage chamber for pumping fluids out of the storage chamber. A dispensing valve is coupled in fluid communication with the pump and defines (1) a normally closed, fluid-tight position preventing the passage of fluid out of the dispenser, and (2) an open position for dispensing pumped fluid therethrough. The sealed, empty dispenser is sterilized, such as by applying gamma radiation thereto. Then, the sterilized, sealed, empty dispenser is filled with fluid by engaging the filling valve with an evacuating/dispensing member to evacuate the storage chamber, and by introducing fluid from the filling member through the open filling valve and into the storage chamber. The filling member is withdrawn from the valve, and a spring moves the valve to a closed position to hermetically seal the fluid within the dispenser.

Abstract translation: 用于保持多个剂量的流体或其它物质并用于分配物质的分配器具有小瓶，容纳在小瓶内的柔性囊，以及形成在膀胱和小瓶之间的可变体积存储室。 填充阀与储存室流体连通地联接并且限定（1）将储存室与环境大气密封的常闭密封的流体密封位置，和（2）允许流体通过阀门的打开位置 两者都抽真空储存室并引入流体通过阀门填充储存室。 泵与储存室流体连通地联接，用于将流体泵出储存室。 分配阀与泵流体连通地联接并限定（1）常闭的，流体密封的位置，防止流体从分配器通过，以及（2）用于分配泵送的流体通过的打开位置。 密封的空分配器被灭菌，例如通过对其施加γ射线。 然后，通过使填充阀与排气/分配构件接合以消除储存室，并且通过将来自填充构件的流体通过打开的填充阀引入并进入储存室，灭菌的密封的空分配器充满流体。 填充构件从阀中取出，并且弹簧将阀移动到关闭位置以将分配器内的流体气密地密封。

公开(公告)号：USD625830S1

公开(公告)日：2010-10-19

申请号：US29357366

申请日：2010-03-11

Applicant: Daniel Py ,  Julian Chan ,  Jeffrey Willey

Designer： Daniel Py ,  Julian Chan ,  Jeffrey Willey

IPC: B67D7/74 ,  B67D7/78

CPC classification number: B65D47/36 ,  A61J1/202 ,  A61J9/00 ,  A61J9/008 ,  A61J11/04 ,  B65B3/04 ,  B65D47/063 ,  B65D47/265 ,  B65D47/32 ,  B65D51/002

公开(公告)号：US07810529B2

公开(公告)日：2010-10-12

申请号：US12371386

申请日：2009-02-13

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B1/04 ,  B65D39/00 ,  A61M5/32

CPC classification number: A61J1/2096 ,  A61J1/1406 ,  A61J1/1468 ,  A61J1/18 ,  A61L2/08 ,  B29C65/16 ,  B29C65/1616 ,  B29C65/1619 ,  B29C65/1654 ,  B29C65/1677 ,  B29C65/18 ,  B29C66/001 ,  B29C66/1222 ,  B29C66/1224 ,  B29C66/12461 ,  B29C66/1312 ,  B29C66/342 ,  B29C66/534 ,  B29C66/5344 ,  B29C66/542 ,  B29C66/612 ,  B29C66/71 ,  B29C66/73755 ,  B29C66/7392 ,  B29C66/73921 ,  B29C66/7394 ,  B29C66/8322 ,  B29C67/004 ,  B29L2031/7158 ,  B29L2031/753 ,  B65B3/003 ,  B65B7/161 ,  B65D51/002 ,  B29C65/00 ,  B29K2025/08 ,  B29K2023/00

Abstract: A device defining a chamber for receiving a substance and a thermoplastic portion in fluid communication with the chamber is provided along with a method of filling and sealing the substance within the chamber. The thermoplastic portion defines a penetrable region that is penetrable by a filling member and is heat resealable to hermetically seal an aperture therein by applying laser radiation at a predetermined wavelength and power. The thermoplastic portion comprises a thermoplastic body defining a predetermined wall thickness and includes a styrene block copolymer, an olefin and a predetermined amount of pigment allowing the body to absorb laser radiation at the predetermined wavelength, substantially prevent the passage of radiation through the predetermined wall thickness, and hermetically seal the aperture in the penetrable region in a predetermined time period. The body includes a predetermined amount of lubricant that reduces friction forces at an interface of the filling member and body during penetration thereof.

Abstract translation: 提供了一种用于接收物质的腔室和与腔室流体连通的热塑性部分的装置以及在腔室内填充和密封物质的方法。 热塑性部分限定可渗透区域，其可由填充构件穿透，并且可热再密封以通过施加预定波长和功率的激光辐射来密封其中的孔。 热塑性部分包括限定预定壁厚的热塑性本体，并且包括苯乙烯嵌段共聚物，烯烃和预定量的颜料，其允许身体吸收预定波长的激光辐射，基本上防止辐射通过预定壁厚 并且在预定时间段内气密地密封可穿透区域中的孔。 主体包括预定量的润滑剂，其减少了在穿透填充构件和主体的界面处的摩擦力。

公开(公告)号：US20100178097A1

公开(公告)日：2010-07-15

申请号：US12710516

申请日：2010-02-23

Applicant: Daniel Py ,  Julian Chan ,  David Fellows ,  Eric E. Hartman ,  Bing He

Inventor： Daniel Py ,  Julian Chan ,  David Fellows ,  Eric E. Hartman ,  Bing He

IPC: A46B11/02

CPC classification number: B65D83/0094 ,  A45D34/04 ,  A45D2200/055 ,  A45D2200/056 ,  A61M35/003 ,  B05B11/00416 ,  B05B11/3015 ,  B05B11/3032 ,  B05B11/3033 ,  B05B11/3094 ,  B65B1/04 ,  B65D83/0033 ,  G01F11/025 ,  G01F11/08

Abstract: A dispenser for dispensing a substance, such as a pharmaceutical, ophthalmic, dermatological, cosmeceutical, cosmetic or other product, has a body with a variable-volume storage chamber for storing the product. A dispensing portion of the dispenser is connected with the body and has a compression chamber in fluid communication with the storage chamber for receiving substance therefrom, and an outlet aperture coupled in fluid communication with the compression chamber. A one-way valve of the dispenser includes an axially-extending valve seat and an axially-extending flexible valve cover seated on the valve seat and defining a normally-closed, axially-extending seam therebetween forming a fluid-tight seal between the valve cover and valve seat. The flexible valve cover is movable relative to the valve seat and the seam is connectable in fluid communication with the outlet aperture to allow the passage of substance through the seam and out of the dispenser. The dispenser further comprises a manually-engageable actuator connected to the dispensing portion movable between first and second positions to dispense substance within the compression chamber through the outlet aperture, and an integral, dome-shaped spring for biasing the actuator in a direction from one of the first and second positions toward the other.

Abstract translation: 用于分配诸如药物，眼科，皮肤病学，药妆，化妆品或其他产品的物质的分配器具有用于存储产品的具有可变容积的储存室的主体。 分配器的分配部分与主体连接并且具有与储存室流体连通的用于从其接收物质的压缩室以及与压缩室流体连通的出口孔。 分配器的单向阀包括轴向延伸的阀座和位于阀座上的轴向延伸的柔性阀盖，并且在其间限定一个常闭的轴向延伸的接缝，形成在阀盖之间的流体密封 和阀座。 柔性阀盖可相对于阀座移动，并且接缝可与出口孔流体连通以允许物质通过接缝并从分配器中通过。 分配器还包括连接到分配部分的可手动接合致动器，其可在第一和第二位置之间移动，以通过出口孔分配压缩室内的物质;以及整体的圆顶形弹簧，用于沿致动器的方向 第一和第二个位置向另一个。

公开(公告)号：US20100154360A1

公开(公告)日：2010-06-24

申请号：US12715821

申请日：2010-03-02

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B3/02

CPC classification number: B29C67/004 ,  B29C45/006 ,  B29C45/1701 ,  B29C45/42 ,  B29C65/16 ,  B29C65/1616 ,  B29C66/001 ,  B29C66/0018 ,  B29C66/71 ,  B29C66/91212 ,  B29C66/91216 ,  B29C66/91221 ,  B29C66/91411 ,  B29C66/91431 ,  B29C66/961 ,  B29C2791/005 ,  B29L2031/565 ,  B65B3/003 ,  B65B3/022 ,  B65B55/06 ,  B29C65/00 ,  B29K2023/38

Abstract: A stopper and container body are molded in the same molding machine. An assembly device, such as a pick and place robot, transfers the stopper from one mold cavity into the opening in the container body located within another mold cavity, or vice versa, to assemble the stopper and container body. Then, the assembled container body and stopper are removed from the molding machine and transported to a needle filling and laser resealing station for filling and laser resealing. A laminar flow source directs a substantially laminar flow of air or sterile gas over the mold surfaces, stoppers and container bodies, and assembly device, to prevent contamination during assembly.

Abstract translation: 塞子和容器主体在相同的成型机中成型。 诸如拾放机器人的组装装置将止动器从一个模腔转移到位于另一个模腔内的容器主体中的开口中，反之亦然，以组装止动器和容器主体。 然后，将组装的容器主体和止动件从成型机中取出并输送到针填充和激光重新密封站，用于填充和激光重新密封。 层流源将空气或无菌气体的基本层流引导到模具表面，塞子和容器主体以及组装装置上，以防止在组装期间的污染。

公开(公告)号：US20100108719A1

公开(公告)日：2010-05-06

申请号：US12685359

申请日：2010-01-11

Applicant: Daniel Py

Inventor： Daniel Py

IPC: G01F11/00 ,  B67D7/58

CPC classification number: G01F11/021 ,  B05B11/3001 ,  B05B11/3015 ,  B05B11/3032 ,  B05B11/3047 ,  B05B11/3074 ,  B65D47/2031 ,  B65D83/00 ,  B65D83/0033 ,  B65D83/0072 ,  G01F11/02

Abstract: A dispenser has a housing, and a variable-volume storage chamber formed within the housing and defining a substantially fluid-tight seal between the chamber and exterior of the housing for storing a substance to be dispensed. A piston is mounted within the housing, and a one-way valve is mounted within the housing and coupled in fluid communication with the variable-volume storage chamber. A compression chamber is coupled in fluid communication between the piston and one-way valve, and at least one of the piston and valve is manually depressible relative to the other between (i) a first position in which the piston is located at least partially outside of the compression chamber for permitting substance to flow from the variable-volume storage chamber into the compression chamber, and (ii) a second position in which the piston is located at least partially within the compression chamber for pressurizing substance within the compression chamber above a valve opening pressure and, in turn, dispensing substance through the one-way valve and out of the dispenser.

Abstract translation: 分配器具有壳体和形成在壳体内的可变容积的储存室，并且在壳体的室和外部之间限定基本上流体密封的密封，用于存储待分配的物质。 活塞安装在壳体内，并且单向阀安装在壳体内并且与可变容积存储室流体连通地联接。 压缩室在活塞和单向阀之间流体连通地联接，并且活塞和阀门中的至少一个在第一位置之间相对于另一个手动地相对地被压下，其中活塞位于至少部分外部 的压缩室，用于允许物质从可变容积的储存室流入压缩室，以及（ii）第二位置，其中活塞至少部分地位于压缩室内，用于将压缩室内的物质加压在压缩室的上方 打开阀门的压力，并通过单向阀分配物质并从分配器中分出物质。

公开(公告)号：US20100094245A1

公开(公告)日：2010-04-15

申请号：US12577104

申请日：2009-10-09

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61J1/00 ,  B65D25/16 ,  B67D7/06 ,  B29C49/04

CPC classification number: B65D1/0215 ,  A61J1/05 ,  A61J1/1406 ,  A61J1/1412 ,  B05B11/00412 ,  B05B11/3028 ,  B29C47/003 ,  B29C47/004 ,  B29C49/04 ,  B29C49/22 ,  B29C65/665 ,  B29C66/7371 ,  B29C2791/001 ,  B29C2793/0027 ,  B29K2101/12 ,  B29L2031/565 ,  B65B3/04 ,  B65B7/16 ,  B65B51/22 ,  B65D1/0223 ,  B65D1/0276 ,  B65D1/0284 ,  B65D47/36 ,  B65D55/0818 ,  B65D77/06 ,  B65D2501/0036 ,  B65D2501/0063 ,  B65D2501/0072 ,  B67C2003/227

Abstract: A device comprising a body including a first polymer and a closure including a second polymer that is substantially not bondable to the first polymer and has a relatively higher shrinkage rate than the first polymer, wherein at least a portion of the closure overlaps at least a portion of the body, forming a hermetic seal therebetween and defining a sealed, empty, sterile container.

Abstract translation: 一种包括主体的装置，包括第一聚合物和封闭物，所述封闭物包括基本上不能与第一聚合物结合并且具有比第一聚合物相对较高的收缩率的第二聚合物，其中封闭物的至少一部分与至少一部分 的身体，在其间形成气密密封并限定密封的空的无菌容器。

公开(公告)号：US20100089946A1

公开(公告)日：2010-04-15

申请号：US12577126

申请日：2009-10-09

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65D35/56 ,  B65D37/00 ,  B29C47/00

CPC classification number: B65D47/24 ,  B05B11/3028 ,  B29C47/0021 ,  B29C47/0023 ,  B29C47/0026 ,  B29C47/065 ,  B29C47/068 ,  B29C49/04 ,  B29L2009/00 ,  B29L2031/7158 ,  B65D23/02 ,  B65D47/205 ,  B65D47/32

Abstract: A device comprises a first portion including a first polymer, and a second portion that is relatively flexible in comparison to the first portion and includes a second polymer that is substantially not bondable to the first polymer. A chamber of the device is hermetically sealable with respect to ambient atmosphere and is defined by (i) an interior of the second portion, and/or (ii) a space formed between the first and second portions. A third portion of the device includes a third polymer that is bondable to the first and second polymers and fixedly secures the first and second portions to each other.

Abstract translation: 一种装置包括包含第一聚合物的第一部分和与第一部分相比具有相对柔性的第二部分，并且包括基本上不能与第一聚合物结合的第二聚合物。 该装置的腔室相对于环境气氛可气密地密封，并且由（i）第二部分的内部和/或（ii）形成在第一和第二部分之间的空间限定。 该装置的第三部分包括可与第一和第二聚合物结合的第三聚合物，并将第一和第二部分彼此固定地固定。