-
公开(公告)号：US11091546B2
公开(公告)日：2021-08-17
申请号：US15566680
申请日：2016-04-15
发明人： Travis Young , David T. Rodgers , Ian Hardy , Chanhyuk Kim , Peter G. Schultz , Eric Hampton , Eduardo Laborda , Leonard Presta
摘要： Disclosed herein are chimeric antigen receptor effector cells (CAR-ECs) and CAR-EC switches. The switchable CAR-ECs are generally T cells. The one or more chimeric antigen receptors may recognize a peptidic antigen on the CAR-EC switch. The CAR-ECs and switches may be used for the treatment of a condition in a subject in need thereof.
-
公开(公告)号：US11078273B2
公开(公告)日：2021-08-03
申请号：US16071361
申请日：2017-01-20
发明人： Christoph Rader , Haiyong Peng , Xiuling Li
摘要： The disclosure provides antibodies, antibody fragments or antigen-binding fragments, as well as related antibody drug conjugates (ADCs) and chimeric antigen receptors (CARs), that specifically recognize human ROR2, Also provided in the disclosure are methods of using such antibodies in various diagnostic and therapeutic applications.
-
公开(公告)号：US20210221790A1
公开(公告)日：2021-07-22
申请号：US17055081
申请日：2019-05-14
IPC分类号： C07D401/14 , C07D401/12 , C07D471/08 , C07D471/04 , C07D401/04
摘要： Provided herein are compounds and compositions useful as modulators of ABHD12. Furthermore, the subject compounds and compositions are useful as immunotherapies in treating, for instance, cancer or infectious diseases.
-
公开(公告)号：US20210188793A1
公开(公告)日：2021-06-24
申请号：US17195351
申请日：2021-03-08
发明人： Justin S. CISAR , Cheryl A. GRICE , Todd K. JONES , Micah J. NIPHAKIS , Jae Won CHANG , Kenneth M. LUM , Benjamin F. CRAVATT
IPC分类号： C07D295/205 , C07C271/12 , C07D317/46 , C07D317/58 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D471/04 , C07D471/10 , C07D261/08 , C07D487/04 , C07D263/32 , C07D205/04 , C07D491/107 , C07D207/14 , C07D271/06 , C07D307/79 , C07D405/14 , C07D215/42 , C07D213/40 , A61P25/22 , C07D295/26 , C07D213/55 , C07D401/04 , C07D407/06 , C07D413/06 , C07C271/10 , C07D207/09 , C07D213/38 , C07D215/46 , C07D401/10 , C07D403/10 , C07D413/10
摘要： This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.
-
公开(公告)号：US20210164128A1
公开(公告)日：2021-06-03
申请号：US17172029
申请日：2021-02-09
摘要： Methods, compositions and kits are provided herein for insertional modification of nucleic acids by, for example transposase-mediated covalent insertion of insertion sequence into a sample nucleic acid molecule. Using sequence of the insertion to direct amplification of adjacent nucleic acid sequence, and using bar codes to map amplified sequence to partitions, one can map sample nucleic acid sequence to single molecules of the nucleic acid sample that are derived directly from the sample nucleic acid molecule.
-
公开(公告)号：US11021427B2
公开(公告)日：2021-06-01
申请号：US15733763
申请日：2019-04-17
发明人： Jin-Quan Yu , Pengxiang Shen
IPC分类号： C07C51/353 , C07C67/343 , C07C201/12 , C07C253/30 , C07F9/40 , C07D333/24 , C07D209/49 , C07D209/48 , B01J31/22 , B01J27/232 , C07D307/54
摘要： The invention includes procedures for stereoselective β-acylation of carboxylic acids having a β-carbon atom. For example, stereoselective acylation procedures include the following reactions: (I)
-
公开(公告)号：US20210121845A1
公开(公告)日：2021-04-29
申请号：US16989791
申请日：2020-08-10
IPC分类号： B01J19/00 , C12Q1/6874
摘要： The present disclosure provides methods, compositions, and kits for methods that can improve techniques nucleic acid analysis, and can allow for more reliable and accurate targeted, multiplexed, high throughput sequencing. The methods, compositions, and kits can be used for sequencing target loci of nucleic acid. The methods, compositions, and kits disclosed herein can be used for assisted de novo targeted sequencing. The methods, compositions, and kits disclosed herein can also be used for library labeling for de novo sequencing and phasing.
-
公开(公告)号：US20210109101A1
公开(公告)日：2021-04-15
申请号：US16884737
申请日：2020-05-27
IPC分类号： G01N33/574
摘要： The present invention provides methods for predicting response to a hormone-directed therapy or chemotherapy in a prostate cancer (PCa) patient comprising (a) performing a direct analysis comprising immunofluorescent staining and morphological characteristization of nucleated cells in a blood sample obtained from the patient to identify and enumerate circulating tumor cells (CTC); (b) individually characterizing genotypic, morphometric and protein expression parameters to generate a profile for each of the CTCs, and (c) predicting response to hormone-directed therapy in the prostate cancer PCa patient based on said profile. In some embodiments, the methods comprise repeating steps (a) through (c) at one or more timepoints after initial diagnosis of prostate cancer to sequentially monitor said genotypic, morphometric and protein expression parameters.
-
公开(公告)号：US20210109086A1
公开(公告)日：2021-04-15
申请号：US16885028
申请日：2020-05-27
申请人： The Scripps Research Institute , The Board of Trustees of The Leland Stanford Junior University
摘要： The present invention provides methods for diagnosing lung cancer in a subject comprising (a) generating circulating tumor cell (CTC) data from a blood sample obtained from the subject based on a direct analysis comprising immunofluorescent staining and morphological characteristics of nucleated cells in the sample, wherein CTCs are identified in context of surrounding nucleated cells based on a combination of the immunofluorescent staining and morphological characteristics; (b) obtaining clinical data for the subject; (c) combining the CTC data with the clinical data to diagnose lung cancer in the subject.
-
公开(公告)号：US20210094969A1
公开(公告)日：2021-04-01
申请号：US16949983
申请日：2020-11-23
发明人： Thomas D, Bannister , William R. Roush , John L. Cleveland , Jun Yong Choi , Reji N. Nair , Andy S. Tsai , Jitendra K. Mishra
IPC分类号： C07D495/04 , A61K31/519 , C07D487/04 , A61K31/155 , A61K31/5025
摘要： The invention provides compounds of formulae A, B, and C as described herein that inhibit monocarboxylate transporters, such as MCT1 and MCT4. Compounds of the invention can be used for treatment of a condition in a patient, wherein the condition is characterized by the heightened activity or by the high prevalence of MCT1 and/or MCT4, such as cancer or type II diabetes.
-
-
-
-
-
-
-
-
-
搜索结果
1653 条记录 (耗时 0.04 秒)