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    METHOD FOR THE SEPARATION OF PROTEINS CONTAINING AN ALBUMIN-BINDING
    35.
    发明申请
    METHOD FOR THE SEPARATION OF PROTEINS CONTAINING AN ALBUMIN-BINDING 有权
    用于分离含有氨基酸结合蛋白的方法

    公开(公告)号：US20150274771A1

    公开(公告)日：2015-10-01

    申请号：US14436150

    申请日：2013-10-25

    Applicant: AFFIBODY AB

    Inventor： Per Jonasson ,  Pär Eklund

    IPC: C07K1/22 ,  C07K14/00

    CPC classification number: C07K1/22 ,  C07K14/00 ,  C07K14/31 ,  C07K14/315 ,  C07K2319/70

    Abstract: The disclosure provides a method of separation of at least one ABD-containing molecule present in a liquid from other constituents in the liquid, comprising a step of affinity separation, in which step is used, as affinity ligand, an ABD binding polypeptide comprising an ABD binding motif BM, which motif consists of an amino acid sequence selected from EX2X3X4AX6X7EIX10X11LPNLX16X17X18QX20X21AFIX25X26LX28D (SEQ ID NO:166) and amino acid sequences with at least 89% identity thereto.

    Abstract translation: 本公开提供了一种将存在于液体中的至少一种含有ABD的分子与液体中的其它成分分离的方法，其包括亲和力分离步骤，其中使用步骤作为亲和配体，包含ABD的ABD结合多肽 结合基序BM，该基序由选自EX2X3X4AX6X7EIX10X11LPNLX16X17X18QX20X21AFIX25X26LX28D（SEQ ID NO：166）的氨基酸序列和与其具有至少89％同一性的氨基酸序列组成。

    HER3 BINDING POLYPEPTIDES
    36.
    发明申请
    HER3 BINDING POLYPEPTIDES 有权
    HER3结合多糖

    公开(公告)号：US20150252079A1

    公开(公告)日：2015-09-10

    申请号：US14431336

    申请日：2013-10-03

    Applicant: AFFIBODY AB

    Inventor： Magdalena Malm ,  John Löfblom ,  Stefan Ståhl

    IPC: C07K14/00 ,  A61K51/08 ,  G01N33/574

    CPC classification number: C07K14/00 ,  A61K51/088 ,  C07K14/71 ,  G01N33/57492 ,  G01N2333/71

    Abstract: The present disclosure relates to polypeptides which bind to human epidermal growth factor receptor 3 (HER3) and to use of such polypeptides in imaging and therapy. The disclosure provides an HER3 binding polypeptide comprising a HER3 binding motif, which motif consists of the amino acid sequence EKYX4AYX7EIW X11LPNLTX17X18QX20 AAFIGX26 LX28D (SEQ ID NO:110)

    Abstract translation: 本公开涉及结合人表皮生长因子受体3（HER3）的多肽以及在成像和治疗中使用这些多肽。 本公开提供了包含HER3结合基序的HER3结合多肽，该基序由氨基酸序列EKYX4AYX7EIW X11LPNLTX17X18QX20 AAFIGX26 LX28D（SEQ ID NO：110）

    POLYPEPTIDES HAVING AFFINITY FOR HER2
    37.
    发明申请
    POLYPEPTIDES HAVING AFFINITY FOR HER2 有权
    具有HER2的亲和力的多肽

    公开(公告)号：US20130280164A1

    公开(公告)日：2013-10-24

    申请号：US13928522

    申请日：2013-06-27

    Applicant: AFFIBODY AB

    Inventor： Lars Abrahmsén ,  Nina Herne ,  Joachim Feldwisch ,  Christofer Lendel ,  Vladimir Tolmachev

    IPC: A61K51/08

    CPC classification number: A61K51/08 ,  A61K38/00 ,  A61K51/088 ,  C07K16/32

    Abstract: HER2 binding polypeptides comprising the amino acid sequence EX1 RNAYWEIA LLPNLTNQQK RAFIRKLYDD PSQSSELLX2E AKKLNDSQ wherein X1 in position 2 is M, I or L, and X2 in position 39 is S or C (SEQ ID NO:1) are disclosed. Moreover, such peptides comprising a chelating environment are disclosed. Also radiolabeled polypeptides formed by the peptides comprising a chelating environment and radionuclides are disclosed. Furthermore, methods of in vivo imaging of the body of a mammalian subject having or suspected of having a cancer characterized by overexpression of HER2 comprising administration of such a radiolabeled polypeptide followed by obtainment of an image of the body using a medical imaging instrument and also methods of treating such cancer are disclosed. Furthermore, the use of such a radiolabeled polypeptide in diagnosis and treatment of cancer characterized by overexpression of HER2. Nucleic acids encoding the polypeptides, expression vectors comprising the nucleic acids and host cells comprising the expression vectors are also disclosed.

    Abstract translation: HER2结合多肽包含氨基酸序列EX1 RNAYWEIA LLPNLTNQQK RAFIRKLYDD PSQSSELLX2E AKKLNDSQ，其中位置2中的X1是M，I或L，而位置39的X2是S或C（SEQ ID NO：1）。 此外，公开了包含螯合环境的这些肽。 还公开了由包含螯合环境和放射性核素的肽形成的放射性标记的多肽。 此外，具有或怀疑具有HER2过表达的哺乳动物受试者的身体的体内成像方法包括施用这种放射性标记的多肽，然后使用医学成像仪获得身体的图像，以及方法 公开了治疗这种癌症的方法。 此外，这种放射性标记的多肽在诊断和治疗HER2过表达的癌症中的应用。 还公开了编码多肽的核酸，包含核酸的表达载体和包含表达载体的宿主细胞。

    ALZHEIMER ABETA PEPTIDE BINDING POLYPEPTIDE
    40.
    发明申请
    ALZHEIMER ABETA PEPTIDE BINDING POLYPEPTIDE 审中-公开

    公开(公告)号：US20200172588A1

    公开(公告)日：2020-06-04

    申请号：US16715798

    申请日：2019-12-16

    Applicant: AFFIBODY AB

    Inventor： Stefan Ståhl ,  John Löfblom ,  Hanna Lindberg ,  Torleif Härd

    IPC: C07K14/47

    Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for amyloid β (Aβ) peptides (in the following referred to as Aβ), comprising the amino acid sequence EX2X3YX5X6NLX9A X11QLCAX16IX18X19X20 ED (SEQ ID NO:632). The present disclosure also relates to the use of such Aβ peptide binding polypeptides as therapeutic, prognostic and/or diagnostic agents.

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