Abstract:
This invention relates to a broad-spectrum antimicrobial marine biologic composition for bloodstream infections, derived from smeLAL and optional hemolymph of sustainable aquaculture horseshoe crabs. The formulation serves as an injectable treatment with broad-spectrum antimicrobial activity and an array of therapeutic mechanisms. In one embodiment, subject to clinical studies and characterization of cross-species immunogenicity, the composition may act as a breakthrough antimicrobial—or as a last-resort therapy for critically ill sepsis patients. In an alternative embodiment, the biologically derived antimicrobial agent represents a viable primary therapy with advantages over synthetic antibiotics, including a rapid therapeutic window. Given unmatched efficacy, an adjuvant smeLAL immunoglobulin therapy may be warranted to allow routine use if needed to address cross-species immunogenicity. The invention can thus be administered through various methods, including infusion, subcutaneous injection, topical application, oral, or other delivery techniques, offering potential utility against antimicrobial-resistant pathogens and mutated infectious strains.
Abstract:
Multi-angle radiographic imaging enables 3D visualization of internal surgical targets like solid-tumors, heart vessels, blocked glands or any bodily cavities like fallopian or Eustachian tubes for diagnostics and surgery planning. Those images are dimensionally precise and easily replicated as life-forms with 3D printing for exact modeling. The “negative” aspects of the images are the diseased tissues requiring excision, as in a solid-tumor example. Needle biopsies are routine and can be radiographically guided. Similarly, guided needle delivery of a magnetic surgical fluid containing fullerenes into a target site, such as a solid tumor is less invasive than laparoscopic techniques. Introducing an external magnetic field force can then be used to propel, rotate and maneuver fullerenes into cellular matter or into tissue. Without such external force from the external magnetic field, the suspension of nanoparticles remains harmless due to their atomic scale, inertia and intrinsic repulsion from contact with nearby matter. Notably, fullerenes are hydrophobic and can move freely in biologic space (or interstitially) including amongst water molecules without contact. However, if energized and propelled by a controlled external magnetic source, the nanoparticle could readily penetrate cells, tissues, bone, or biological material. In addition to magnetic launching of the nanoparticles, rotation of the fullerene particles would create millions of nanoscale abrasive structures that can grind down larger structures like tissues, organs, or bones. By example, oscillating or reciprocal computer-controlled magnetic forces in radiographically defined space would activate fullerenes, inducing momentum and rotation that can exenterate a tumor, while chemically cauterizing small feeding vessels for hemostatic control and absent any damage to nearby normal, non-target matter. Essentially, biological material targeted with magnetically manipulated fullerenes could be ablated with a microscopic “sharpness” unattainable with conventional instrumentation. Magnetic forces are mathematically articulated and understood in highly precise terms, wherein objects subject to magnetic energy are controllable regarding mass, force and velocity. After completion of the surgical procedure, the magnetic fullerene fluid can be aggregated and removed along with flushing of attendant debris with a syringe or similar instrument.
Abstract:
The present invention relates to a cladding assembly for cladding a structure, including a frame member, a frame formed by frame members and a preformed panel including a panel member. The preformed panel is formed by a frame member fastened at least partially around an outer edge of the panel member or the panel member being operatively associated with the frame. The frame member of the present invention includes at least two ends and at least five walls including a structure facing wall, an opposed panel member abutting wall, an intermediate wall positioned between and extending substantially parallel to the structure facing wall and the panel member abutting wall, a connecting wall and either an outer frame wall or an inner frame wall. In some embodiments, the panel member is a fire retardant panel member.
Abstract:
Embodiments of a User Equipment (UE), Next Generation Node-B (gNB) and methods of communication are generally described herein. The UE receive training signals from a plurality of transmit-receive points (TRPs) associated with the gNB. Each training signal may comprise a reference signal resource identifier (ID) to indicate a corresponding TRP and a corresponding transmit direction of a plurality of transmit directions. The UE may, for each transmit direction of the plurality of transmit directions, determine an average signal quality measurement based on individual signal quality measurements in multiple receive directions. The UE may select, for reporting to the gNB, a subset of the average signal quality measurements to ensure that the average signal quality measurements excluded from the subset are less than or equal to a minimum value of the average signal quality measurements in the subset.
Abstract:
Acoustically insulated machines have an internal source of noise and an insulation member. The insulation member may include a plurality of porous, sound absorbing layers and a plurality of dense or facing layers attached to faces of the sound absorbing layers. The dense or facing layers each have a density that is greater than the densities of the sound absorbing layers. The insulation member may be oriented such that one of the dense or facing layers faces toward the internal source of noise. The insulation member may be configured such that most of the low frequency sound energy generated by the internal source of noise is not reflected back into the machine. That is, the dense or facing layer may be configured to allow a majority of low frequency sound energy from the internal source of noise to pass into the insulation member.
Abstract:
A method of operating a wireless communications network comprising a first plurality of base stations serving a second plurality of subscriber stations and at least one Radio Network Controller. The method comprises detecting (102) a malfunction affecting provision of services by a base station, determining (104) cell affected by said malfunction. If said base station continues (106) to transmit signal in said affected cell then power of signal transmitted by said base station in the affected cell is reduced (108) and adjusting (110) power of signal transmitted by base stations in cells adjacent to said affected cell to provide network coverage for the affected area.
Abstract:
A method includes detecting that a particular media device is communicatively coupled to one or more media devices in a set of media devices; in response to detecting that the particular media device is communicatively coupled to the one or more media devices in the set of media devices: automatically sending one or more remote operating codes, for remotely controlling the particular media device, to a remote control device.
Abstract:
Communication transmission methods and systems are provided. Firstly, a base station is configured to set an indicator for determining whether a first wireless communication technology and a second communication technology are allowed simultaneously for transmissions by the base station. Then, a user equipment, is configured to receive a voice call by a user equipment from the base station and determine whether to answer the voice call using the first wireless communication technology or the second communication technology, when the first wireless communication technology and the second communication technology are not allowed simultaneously shown by the indicator.
Abstract:
Automatic provisioning of an access point base station or femtocell. The method may include the femtocell transmitting first information (e.g., location information, signal measurement information, capability information, etc.) to a service provider (e.g., over an IP network). The femtocell may receive second information from the service provider, where the second information includes one or more operational parameters. The operational parameters may include hand-off parameters, admission policy parameters, PN or scrambling codes, power parameters, and/or other parameters. The femtocell may operate according to the received parameters to provide access for a plurality of access terminals in a local area.
Abstract:
A method and apparatus are provided for determining the layout of a form automatically to accommodate text in the form. Under the method and apparatus, a set of parameters define the sizing and alignment of elements of the form. Sizing and positioning instructions that are separate from the sizing and alignment parameters set the sizing and positioning of elements of the form based on the sizing and alignment parameters. The instructions determine the minimum size for the form, based in part on text in the form. The difference between the minimum size for the form and a desired size for the form is then distributed across the form to size and position the elements in the form.