公开(公告)号：US20220145393A1

公开(公告)日：2022-05-12

申请号：US17517431

申请日：2021-11-02

Applicant: Oklahoma Medical Research Foundation ,  The Board of Regents of the University of Oklahoma

Inventor： Matlock Jeffries

IPC: C12Q1/6883

Abstract: The present invention includes a method for determining whether a subject diagnosed with osteoarthritis is at increased risk for progression to severe osteoarthritis within 12-24 months, the method comprising the steps of: (a) preparing a blood sample; (b) measuring in the blood sample prepared in step (a) a level of DNA methylation; (c) comparing the DNA methylation level(s) measured in step (b) to a control blood sample level(s) of DNA methylation, and (d) identifying the subject as being at increased risk for progression to severe osteoarthritis within 12-24 months when the DNA methylation is increased by at least 2 fold as compared to the control blood level(s) of DNA methylation.

公开(公告)号：US20220089665A1

公开(公告)日：2022-03-24

申请号：US17532307

申请日：2021-11-22

Applicant: The Board of Regents of the University of Oklahoma

Inventor： Heloise Anne Pereira ,  Anne KASUS-JACOBI ,  Gina L. GRIFFITH

IPC: C07K14/47 ,  A61K38/17 ,  A61K45/06

Abstract: Peptide compounds and compositions containing the peptide compounds and methods for treating various infections, wounds, and skin conditions such as atopic dermatitis. Examples of wounds that may be treated include surface wounds such as lacerations, abrasions, avulsions, incisions, and amputations, pressure sores, bed sores, wounds due to peripheral vascular disease, post-surgical wounds, diabetic ulcers and wounds, burns, ocular wounds and abrasions, ocular ulcers, and treatment of inflammatory conditions such as dry eye. The peptide compounds and compositions may be used as treatments to enhance acceptance of grafts such as skin grafts and organ grafts.

公开(公告)号：US11180452B2

公开(公告)日：2021-11-23

申请号：US16904364

申请日：2020-06-17

Applicant: CFD RESEARCH CORPORATION ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA

Inventor： Anuj Singhal ,  Robert H. Cichewicz ,  Lin Du ,  JianLan You ,  Hanumantha Rao Paritala ,  Abigail Grace Edwards

IPC: C07D209/30 ,  A61K47/60 ,  A01N43/38 ,  C07D417/12 ,  A01N55/00 ,  C07D401/12 ,  A01N43/40 ,  C07D471/04 ,  C07F7/18 ,  A01N43/90 ,  A61K47/54 ,  A01N25/08

Abstract: A method of selectively inhibiting pathogenic microbes includes: providing a compound that is functional as a selective antimicrobial having a structure of Formula 1, or derivative thereof, salt thereof, or stereoisomer thereof, or having any chirality at any chiral center, or tautomer, polymorph, solvate, or combination thereof; and contacting a pathogenic microbe with the compound such that the pathogenic microbe is selectively inhibited; wherein: ring A is a cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or polycycle combination thereof; X is S, SO, or SO2; Y is a linker or bond; Z is CH, CR2, or N; Z1 is C or N to form an imidazopyridine; each Z2, Z3, or Z4 is independently CH, CR2, or N; each Z5 or Z6 is C or CH; each R1, R2, R3 and/or R4 is independently a substituent; m is 0, 1, 2, 3, or 4; and n is zero or a positive integer.

公开(公告)号：US20210359151A1

公开(公告)日：2021-11-18

申请号：US17285360

申请日：2019-10-14

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA

Inventor： David FERRY ,  Vincent WHITESIDE ,  Ian R. SELLERS

IPC: H01L31/0735

Abstract: A photovoltaic device configured to substantially avoid radiative recombination of photo-generated carriers, reduce loss of energy of the photo-generated carriers through the phonon emission, extract photo-generated carriers substantially exclusively from the multi-frequency satellite valley(s) of the bandstructure of the used semiconductor material as opposed to the single predetermined extremum of the bandstructure. Methodologies of fabrication and operation of such a device.

公开(公告)号：US20210318324A1

公开(公告)日：2021-10-14

申请号：US17255375

申请日：2019-07-05

Applicant: The Board of Regents of the University of Oklahoma

Inventor： Maria Jesus Ruiz Echevarria

IPC: G01N33/574 ,  C12Q1/6886

Abstract: An assay system and method for generating quantitative data for a subject by determining an expression level of a biomarker panel in a sample obtained from the subject, the biomarker panel having at least one biomarker selected from a first biomarker group including the genes CDC45, CENPI, CLSPN, ERCC6L, EXO1, NCAPG, and optionally at least one additional biomarker selected from a second biomarker group including the genes BUB1B, CDK1, E2F7, GSG2, NUSAP1, RAD51, and RRM2 in any combination, wherein the expression level is obtained by measuring expression of the biomarker panel in the sample, and wherein the subject has a cancer, or is suspected of having a cancer. The cancer may be, for example, prostate cancer, brain cancer, lung cancer, breast cancer, bladder cancer, or ovarian cancer.

公开(公告)号：US20210278380A1

公开(公告)日：2021-09-09

申请号：US17194539

申请日：2021-03-08

Applicant: The Board of Regents of the University of Oklahoma

Inventor： Si Wu ,  Lushuang Huang ,  Zhe Wang

IPC: G01N30/72 ,  H01J49/16

Abstract: A spray-capillary device is configured to process ultra low-volume samples. The spray-capillary device includes a spray capillary that includes an inlet end and a discharge end. The spray capillary includes a porous section at the discharge end. A downstream connector provides an interface between the porous section of the spray capillary, a conductive fluid, and a high voltage electrical source. The application of voltage to the downstream connector causes electrospray ionization, which can be used to draw ultra law volume samples into the inlet end. A gas injection assembly can be used to increase the pressure on the inlet end of the spray capillary to encourage movement of the sample through the spray capillary. The spray-capillary device is well suited for providing ultra low samples to a mass spectrometer detection device.

公开(公告)号：US20210260101A1

公开(公告)日：2021-08-26

申请号：US17231854

申请日：2021-04-15

Applicant: The Board of Regents of the University of Oklahoma

Inventor： Charles V. Rice ,  Daniel T. Glatzhofer

IPC: A61K31/785 ,  A61K31/407 ,  A61K31/427 ,  A01N43/44 ,  A01N43/86 ,  A01N33/04 ,  A61P31/04

Abstract: Compositions of β-lactam antibiotics and branched poly(ethylenimine) (BPEI), and β-lactam antibiotics and potentiating compounds of polyethylene glycol (PEG)-BPEI conjugates, and methods of their use to treat infections and to remove bacterial biofilms from surfaces of devices and wounds. The BPEI and PEG-BPEI conjugates potentiate the activity of the β-lactam antibiotics so the compositions have synergistic effects against various Gram-positive bacteria. For example, the compositions can be used to treat Gram-positive bacteria, such as Methicillin-resistant Staphylococcus aureus (MRSA) and Methicillin-resistant Staphylococcus epidermidis (MRSE), that have developed resistance against most β-lactam antibiotics. The BPEI and PEG-BPEI conjugates result in the resensitization of such resistant bacterial strains to traditional antibiotic therapies such as β-lactam antibiotics.

公开(公告)号：US11092549B2

公开(公告)日：2021-08-17

申请号：US16419492

申请日：2019-05-22

Applicant: Saint Louis University ,  The Board of Regents of the University of Oklahoma

Inventor： John K. Walker ,  Keith Haynes ,  Narges Abdali ,  Valentin V. Rybenkov ,  Helen I. Zgurskaya

IPC: G01N21/64 ,  C12Q1/04 ,  C07D401/04

Abstract: Described are compounds and methods useful in measuring membrane permeability and efflux transporter activity in bacteria, including multidrug resistance Gram negative bacteria.

公开(公告)号：US20210236597A1

公开(公告)日：2021-08-05

申请号：US17165070

申请日：2021-02-02

Applicant: The Board of Regents of the University of Oklahoma

Inventor： David C. KEM

IPC: A61K38/17 ,  C07K14/72 ,  G01N33/566

Abstract: Compounds, compositions, and delivery devices, for treating and diagnosing conditions and diseases associated with activation of the gonadotropin releasing hormone receptor (GnRHR), particularly those involving GnRHR activating autoantibodies (GnRHR AAbs). In one non-limiting embodiment, the disease is Polycystic Ovary Syndrome (PCOS). The therapeutic compounds in at least certain non-limiting embodiments include peptides which comprise D-amino acids (D-amino acid peptides) which are able to bind with high affinity to GnRHR AAbs.

公开(公告)号：US20210214079A1

公开(公告)日：2021-07-15

申请号：US17146352

申请日：2021-01-11

Applicant: The Board of Regents of the University of Oklahoma

Inventor： Phillip B. Chilson ,  Antonio R. Segales Espinosa ,  William J. Doyle ,  Tyler M. Bell ,  Brian R. Greene ,  Joshua J. Martin ,  Elizabeth A. Pillar-Little ,  Gustavo Britto Hupsel de Azevedo

IPC: B64C39/02

Abstract: An unmanned aerial system (UAS) adapted to measure one or more atmospheric conditions has a frame and a plurality of motorized rotors suspended on arms extending outward from the frame. The UAS further includes a flight control module that includes a computer programmable flight control board and a sensor package that has an air sampling scoop, a first sensor positioned inside the air sampling scoop, and a ducted fan inside the air sampling scoop. The ducted fan is configured to draw air through the air sampling scoop in contact with the first sensor. The ducted fan can be configured to operate only when the UAS is above a predetermined altitude. The UAS may also be configured to operate in a “wind vane” mode in which wind speed and direction is determined based on the pitch and heading of the UAS.