公开(公告)号：US20230097470A1

公开(公告)日：2023-03-30

申请号：US17408864

申请日：2021-08-23

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： SHIH-YI WEI ,  MIN-KUAN HSU ,  JIAN-BANG JHENG

IPC: C07C59/46 ,  C07D313/00 ,  C07C51/377

Abstract: The invention relates to processes for preparing Carboprost or Carboprost Tromethamine, and intermediates prepared from the process, and 5,6-trans isomer free Carboprost or Carboprost Tromethamine prepared therefrom. The invention also relates to a novel crystalline form of Carboprost Tromethamine.

公开(公告)号：US20230002339A1

公开(公告)日：2023-01-05

申请号：US17336865

申请日：2021-06-02

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： CHUN-YU LIN ,  TZYH-MANN WEI ,  SHIH-YI WEI

IPC: C07D307/93 ,  C07F7/18 ,  C07C67/317 ,  C07C69/734 ,  C07C49/573 ,  C07C45/65 ,  C07C67/24 ,  C07C69/157 ,  C07D307/42 ,  C12P7/38

Abstract: The invention relates to processes for preparing benzoprostacyclin analogues and intermediates prepared from the process, and the benzoprostacyclin analogues prepared therefrom. The invention also relates to cyclopentenone intermediates in racemic or optically active form.

公开(公告)号：US20220024849A1

公开(公告)日：2022-01-27

申请号：US16938238

申请日：2020-07-24

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： SHIH-YI WEI ,  MING-KUN HSU ,  TZYH-MANN WEI

IPC: C07C201/02

Abstract: Processes for preparing latanoprostene bunod and an intermediate prepared from the process. Also latanoprostene bunod compositions having high-purity latanoprostene bunod.

公开(公告)号：US20210188757A1

公开(公告)日：2021-06-24

申请号：US16720711

申请日：2019-12-19

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： SHIH-YI WEI ,  JIAN-BANG JHENG ,  MING-KUN HSU ,  MIN-KUAN HSU ,  TZYH-MANN WEI

IPC: C07C59/72 ,  C07C51/43

Abstract: There is provided a crystalline Form I of anhydrous Treprostinil and processes for the preparation thereof. The crystalline Form I of anhydrous Treprostnil is a stable crystalline form, which can provide steady physicochemical properties for pharmaceutical formulations, and is advantageous widely and safety used in storage, shipment, and handling for commercially considerations.

公开(公告)号：US10781160B1

公开(公告)日：2020-09-22

申请号：US16592835

申请日：2019-10-04

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Jian-Bang Jheng

IPC: C07C69/736 ,  C07C67/52

Abstract: There is provided stable crystalline Form I and Form II of Hexadecyl Treprostinil (C16TR) and processes for the preparation thereof. The stable crystalline Form I and Form II of Hexadecyl Treprostinil present advantages in storage, formulation, shipment and handling for commercially considerations.

公开(公告)号：US20170073323A1

公开(公告)日：2017-03-16

申请号：US15360247

申请日：2016-11-23

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Yu-Chih Yeh ,  Min-Kuan Hsu ,  Li-Ta Kao

IPC: C07D313/00

CPC classification number: C07D313/00 ,  C07C51/347 ,  C07C59/72 ,  C07C67/10 ,  C07C69/608 ,  C07C69/618 ,  C07C231/02 ,  C07C405/00 ,  C07C405/0016 ,  C07C405/0041 ,  C07C2601/08 ,  C07D309/12 ,  C07D407/12 ,  C07D407/14 ,  C07F7/1804

Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.

Abstract translation: R2，R3和R4如说明书中所定义。 还提供了用于制备不含异构体的前列腺素及其衍生物的新型中间体。

公开(公告)号：US20160016883A1

公开(公告)日：2016-01-21

申请号：US14802072

申请日：2015-07-17

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Yu-Chih Yeh ,  Min-Kuan Hsu ,  Li-Ta Kao

IPC: C07C69/618 ,  C07C59/72 ,  C07D313/00 ,  C07D407/12 ,  C07C69/608

CPC classification number: C07D313/00 ,  C07C51/347 ,  C07C59/72 ,  C07C67/10 ,  C07C69/608 ,  C07C69/618 ,  C07C231/02 ,  C07C405/00 ,  C07C405/0016 ,  C07C405/0041 ,  C07C2601/08 ,  C07D309/12 ,  C07D407/12 ,  C07D407/14 ,  C07F7/1804 ,  C07F7/1864

Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.

公开(公告)号：US20150336923A1

公开(公告)日：2015-11-26

申请号：US14801999

申请日：2015-07-17

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Yu-Chih Yeh ,  Min-Kuan Hsu ,  Li-Ta Kao

IPC: C07D313/00

CPC classification number: C07D313/00 ,  C07C51/347 ,  C07C59/72 ,  C07C67/10 ,  C07C69/608 ,  C07C69/618 ,  C07C231/02 ,  C07C405/00 ,  C07C405/0016 ,  C07C405/0041 ,  C07C2601/08 ,  C07D309/12 ,  C07D407/12 ,  C07D407/14 ,  C07F7/1804 ,  C07F7/1864

Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.

公开(公告)号：US09115109B2

公开(公告)日：2015-08-25

申请号：US13967473

申请日：2013-08-15

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Yu-Chih Yeh ,  Min-Kuan Hsu ,  Li-Ta Kao

IPC: C07D313/00 ,  C07C405/00 ,  C07C59/72 ,  C07C67/10 ,  C07C231/02 ,  C07D407/14

CPC classification number: C07D313/00 ,  C07C51/347 ,  C07C59/72 ,  C07C67/10 ,  C07C69/608 ,  C07C69/618 ,  C07C231/02 ,  C07C405/00 ,  C07C405/0016 ,  C07C405/0041 ,  C07C2601/08 ,  C07D309/12 ,  C07D407/12 ,  C07D407/14 ,  C07F7/1804 ,  C07F7/1864

Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.

Abstract translation: 提供了基本上不含5,6-反式异构体的式I-2化合物的制备方法：其中R2，R3和R4如说明书中所定义。 还提供了用于制备不含异构体的前列腺素及其衍生物的新型中间体。