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公开(公告)号：US08343763B2
公开(公告)日：2013-01-01
申请号：US13402519
申请日：2012-02-22
申请人： Nicole Hilgraf , Peter Diederik Jan Grootenhuis , Mehdi Numa , Dean Stamos , Corey Anderson , Tara Whitney
发明人： Nicole Hilgraf , Peter Diederik Jan Grootenhuis , Mehdi Numa , Dean Stamos , Corey Anderson , Tara Whitney
IPC分类号： A61K31/427 , A61P29/00 , A61P19/02 , A61P25/06 , A61P25/00 , A61P25/08 , A61P25/28 , A61P25/24 , A61P25/22 , A61P9/06 , A61P25/18 , A61P21/00 , A61P1/00 , A61P13/10 , A61P9/12
CPC分类号： C07D417/14
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US08193352B2
公开(公告)日：2012-06-05
申请号：US12552430
申请日：2009-09-02
申请人： Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud LeTiran , Joseph Drumm
发明人： Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud LeTiran , Joseph Drumm
IPC分类号： C07D401/14 , C07D403/14 , A61K31/506 , A61K31/4439
CPC分类号： C07D401/14 , C07D403/14
摘要： The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
摘要翻译： 本发明涉及抑制细菌回旋酶和/或Topo IV的化合物和包含所述化合物的药学上可接受的组合物。 这些化合物及其组合物可用于治疗细菌感染。 因此，本发明还涉及用于治疗哺乳动物细菌感染的方法。
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公开(公告)号：US20110059936A1
公开(公告)日：2011-03-10
申请号：US12942395
申请日：2010-11-09
申请人： David J. Lauffer , Robert J. Davies , Dean Stamos , Alexander Aronov , David D. Deininger , Ronald Grey, JR. , Jinwang Xu , Pan Li , Brian Ledford , Luc Farmer , Randy Scott Bethiel , Dylan Jacobs , Kira McGinty
发明人： David J. Lauffer , Robert J. Davies , Dean Stamos , Alexander Aronov , David D. Deininger , Ronald Grey, JR. , Jinwang Xu , Pan Li , Brian Ledford , Luc Farmer , Randy Scott Bethiel , Dylan Jacobs , Kira McGinty
IPC分类号： A61K31/497 , A61K31/5377 , A61K31/496 , A61K31/444 , A61K31/4439 , A61K31/501 , A61K31/537 , A61P35/00 , A61P35/04
CPC分类号： C07D417/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D407/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D451/02 , C07D451/06 , C07D453/02 , C07D471/04 , C07D471/08 , C07D495/04 , C07D498/08 , C07D513/04 , C12N9/99
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供了制备本发明化合物的方法，包含本发明化合物的药学上可接受的组合物，以及使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20100144739A1
公开(公告)日：2010-06-10
申请号：US12441187
申请日：2007-09-18
申请人： Alexander Aronov , Jon Come , John Court , David Deininger , David Lauffer , Pan Li , Kira McGinty , Suganthini Nanthakumar , Dean Stamos , Kirk Tanner
发明人： Alexander Aronov , Jon Come , John Court , David Deininger , David Lauffer , Pan Li , Kira McGinty , Suganthini Nanthakumar , Dean Stamos , Kirk Tanner
IPC分类号： A61K31/5025 , C07D487/04 , C12N9/99 , C07D409/14 , A61K31/497 , A61P35/00
CPC分类号： C07D497/04 , C07D513/04
摘要： The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
摘要翻译： 本发明提供了可用作c-Met酪氨酸激酶抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种增殖性疾病的方法。
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公开(公告)号：US07727992B2
公开(公告)日：2010-06-01
申请号：US10459420
申请日：2003-06-11
申请人： Paul S. Charifson , David D. Deininger , Joseph Drumm , Anne-Laure Grillot , Yusheng Liao , Patricia Oliver-Shaffer , Dean Stamos
发明人： Paul S. Charifson , David D. Deininger , Joseph Drumm , Anne-Laure Grillot , Yusheng Liao , Patricia Oliver-Shaffer , Dean Stamos
IPC分类号： C07D239/42 , A61K31/505 , A61K31/44 , C07D239/00 , C07D401/00
CPC分类号： C07D401/04 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K45/06 , C07C275/06 , C07D401/14 , C07D403/04 , Y02A50/473 , Y02A50/478 , A61K2300/00
摘要： The present invention relates to compounds which inhibit bacterial gyrase and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to a method for preparing these compounds.
摘要翻译： 本发明涉及抑制细菌促旋酶的化合物和包含所述化合物的药学上可接受的组合物。 这些化合物及其组合物可用于治疗细菌感染。 因此，本发明还涉及用于治疗哺乳动物细菌感染的方法。 本发明还涉及一种制备这些化合物的方法。
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公开(公告)号：US20090176771A1
公开(公告)日：2009-07-09
申请号：US12246778
申请日：2008-10-07
申请人： Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
发明人： Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
IPC分类号： A61K31/55 , C07D243/12 , A61P31/04
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
摘要翻译： 本发明涉及抑制细菌促旋酶和/或Topo IV的化合物和包含所述化合物的药学上可接受的组合物。 这些化合物及其组合物可用于治疗细菌感染。 因此，本发明还涉及用于治疗哺乳动物细菌感染的方法。
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公开(公告)号：US07495014B2
公开(公告)日：2009-02-24
申请号：US10767638
申请日：2004-01-29
申请人： Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven M. Ronkin , Dean Stamos , Emanuele Perola , Tiensheng Wang , Arnaud LeTiran , Joseph Drumm
发明人： Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven M. Ronkin , Dean Stamos , Emanuele Perola , Tiensheng Wang , Arnaud LeTiran , Joseph Drumm
IPC分类号： A61K31/44 , C07D401/04 , C07D401/14
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
摘要翻译： 本发明涉及抑制细菌促旋酶和/或Topo IV的化合物和包含所述化合物的药学上可接受的组合物。 这些化合物及其组合物可用于治疗细菌感染。 因此，本发明还涉及用于治疗哺乳动物细菌感染的方法。
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公开(公告)号：US20090030051A1
公开(公告)日：2009-01-29
申请号：US12221921
申请日：2008-08-07
申请人： Dean Stamos , Martin Trudeau , Randy S. Bethiel , Steven M. Ronkin , Michael C. Badia , Jeffrey O. Saunders
发明人： Dean Stamos , Martin Trudeau , Randy S. Bethiel , Steven M. Ronkin , Michael C. Badia , Jeffrey O. Saunders
IPC分类号： A61K31/421 , A61P37/02 , A61P9/00 , A61P35/00
CPC分类号： C07C275/40 , C07B2200/07 , C07C275/42 , C07D263/32 , C07F9/653
摘要： The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
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公开(公告)号：US20070254868A1
公开(公告)日：2007-11-01
申请号：US11726170
申请日：2007-03-21
申请人： David Lauffer , Robert Davies , Dean Stamos , Alexander Aronov , David Deininger , Ronald Grey , Jinwang Xu , Pan Li , Brian Ledford , Luc Farmer , Randy Bethiel , Dylan Jacobs , Kira McGinty
发明人： David Lauffer , Robert Davies , Dean Stamos , Alexander Aronov , David Deininger , Ronald Grey , Jinwang Xu , Pan Li , Brian Ledford , Luc Farmer , Randy Bethiel , Dylan Jacobs , Kira McGinty
IPC分类号： A61K31/4439 , A61K31/437 , A61K31/454 , A61K31/55 , C07D213/82 , C07D401/04 , C07D471/04 , C12N9/99 , C07D403/14 , C07D223/00 , A61P35/00 , A61K31/497 , A61K31/44
CPC分类号： C07D417/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D407/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D451/02 , C07D451/06 , C07D453/02 , C07D471/04 , C07D471/08 , C07D495/04 , C07D498/08 , C07D513/04 , C12N9/99
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供了制备本发明化合物的方法，包含本发明化合物的药学上可接受的组合物，以及使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07087642B2
公开(公告)日：2006-08-08
申请号：US10287405
申请日：2002-11-04
申请人： Dean Stamos , Martin Trudeau , Scott Bethiel , Steven Ronkin , Michael Badia , Jeffrey Saunders
发明人： Dean Stamos , Martin Trudeau , Scott Bethiel , Steven Ronkin , Michael Badia , Jeffrey Saunders
IPC分类号： A61K47/00 , A61K31/27 , C07C229/00 , C07C255/00
CPC分类号： C07C275/40 , C07B2200/07 , C07C275/42 , C07D263/32 , C07F9/653
摘要： The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
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