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公开(公告)号：US08039002B2
公开(公告)日：2011-10-18
申请号：US11836369
申请日：2007-08-09
Applicant: Chin-Fen Yang , George Kemble
Inventor： Chin-Fen Yang , George Kemble
IPC: A61K39/145 , C12N7/01
CPC classification number: A61K39/145 , A61K39/00 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/543 , C07K14/005 , C12N7/00 , C12N2760/16122 , C12N2760/16134 , C12N2760/16164
Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.
Abstract translation: 提供了包含（禽流感）流感血凝素和神经氨酸酶变体的多肽，多核苷酸，方法，组合物和疫苗。
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公开(公告)号：US20110070263A1
公开(公告)日：2011-03-24
申请号：US12858386
申请日：2010-08-17
Applicant: Chin-Fen Yang , George Kemble , Chongguang Liu
Inventor： Chin-Fen Yang , George Kemble , Chongguang Liu
IPC: A61K39/145 , C12N7/01 , C12N7/02
CPC classification number: C07K14/11 , A61K39/12 , A61K39/145 , A61K2039/525 , A61K2039/5254 , C07K14/005 , C12N7/045 , C12N9/2402 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234 , C12Y302/01018
Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
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公开(公告)号：US20110052618A1
公开(公告)日：2011-03-03
申请号：US12769304
申请日：2010-04-28
Applicant: Chin-Fen YANG , George KEMBLE , Kanta SUBBARAO , Brian MURPHY
Inventor： Chin-Fen YANG , George KEMBLE , Kanta SUBBARAO , Brian MURPHY
IPC: A61K39/145 , A61P31/16 , A61P37/04 , C12N7/01 , C12N7/02
CPC classification number: C12N7/00 , A61K39/12 , A61K2039/5254 , A61K2039/543 , A61K2039/58 , C07K14/005 , C12N2501/70 , C12N2760/16121 , C12N2760/16122 , C12N2760/16134 , C12N2760/16161 , C12N2760/16162 , C12N2760/16171 , C12Q1/701
Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.
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公开(公告)号：US20090175908A1
公开(公告)日：2009-07-09
申请号：US12399077
申请日：2009-03-06
Applicant: Chin-Fen Yang , George Kemble , Chongguang Liu
Inventor： Chin-Fen Yang , George Kemble , Chongguang Liu
IPC: A61K39/145 , C07K14/00 , C07H21/04 , C12N7/01 , C12N15/63 , C12N5/10 , C12N7/02 , A61K38/16 , A61K31/7088 , A61P31/16
CPC classification number: C07K14/005 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5254 , A61K2039/53 , C07H21/04 , C12N7/00 , C12N9/2402 , C12N15/86 , C12N2740/16122 , C12N2740/16222 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16161 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16261
Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
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公开(公告)号：US20090175907A1
公开(公告)日：2009-07-09
申请号：US12254131
申请日：2008-10-20
Applicant: Erich Hoffman , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
Inventor： Erich Hoffman , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
IPC: A61K39/145 , C12N7/01 , C12N15/74 , A61P31/16
CPC classification number: C12N15/86 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16262 , C12N2840/20
Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。 还提供了生产在例如25℃下有效复制的冷适应（ca）流感病毒的方法（和包含其的免疫原性组合物）。
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Patent Agency Ranking
公开(公告)号：US07465456B2
公开(公告)日：2008-12-16
申请号：US11133345
申请日：2005-05-20
Applicant: Erich Hoffmann , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
Inventor： Erich Hoffmann , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
IPC: A61K39/145 , C12Q1/70 , C12P19/34
CPC classification number: C12N15/86 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16262 , C12N2840/20
Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。 还提供了生产在例如25℃下有效复制的冷适应（ca）流感病毒的方法（和包含其的免疫原性组合物）。
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公开(公告)号：US20050158342A1
公开(公告)日：2005-07-21
申请号：US11018624
申请日：2004-12-22
Applicant: George Kemble , Gregory Duke
Inventor： George Kemble , Gregory Duke
CPC classification number: C12N7/00 , A61K39/12 , A61K39/145 , A61K2039/5254 , A61K2039/543 , C12N15/85 , C12N2760/16134 , C12N2760/16151 , C12N2760/16152 , C12N2760/16162 , C12N2760/16234 , C12N2760/16251 , C12N2760/16252 , C12N2760/16261 , C12N2840/20
Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. In addition, the present invention includes an improved method of rescue, wherein animal cells (e.g., SF Vero cells) are electroporated with plasmids and vectors of the invention.
Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。 此外，本发明包括一种改进的抢救方法，其中用本发明的质粒和载体对动物细胞（例如，SF Vero细胞）进行电穿孔。
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公开(公告)号：US08591914B2
公开(公告)日：2013-11-26
申请号：US13003559
申请日：2009-07-09
Applicant: Chin-Fen Yang , George Kemble
Inventor： Chin-Fen Yang , George Kemble
CPC classification number: C07K14/005 , A61K39/00 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N2760/16121 , C12N2760/16134 , C12N2760/16162 , C12N2760/16221 , C12N2760/16234 , C12N2760/16262
Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
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公开(公告)号：US08409843B2
公开(公告)日：2013-04-02
申请号：US13309498
申请日：2011-12-01
Applicant: George Kemble , Gregory Duke
Inventor： George Kemble , Gregory Duke
IPC: C12N7/00 , C12N5/07 , A61K39/145
CPC classification number: C12N7/00 , A61K39/12 , A61K39/145 , A61K2039/5254 , A61K2039/543 , C12N15/85 , C12N2760/16134 , C12N2760/16151 , C12N2760/16152 , C12N2760/16162 , C12N2760/16234 , C12N2760/16251 , C12N2760/16252 , C12N2760/16261 , C12N2840/20
Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. In addition, the present invention includes an improved method of rescue, wherein animal cells (e.g., SF Vero cells) are electroporated with plasmids and vectors of the invention.
Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。 此外，本发明包括一种改进的抢救方法，其中用本发明的质粒和载体对动物细胞（例如，SF Vero细胞）进行电穿孔。
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公开(公告)号：US08114415B2
公开(公告)日：2012-02-14
申请号：US12254131
申请日：2008-10-20
Applicant: Erich Hoffmann , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
Inventor： Erich Hoffmann , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
IPC: A61K39/145 , A61K39/00 , A61K39/12 , C12P21/04
CPC classification number: C12N15/86 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16262 , C12N2840/20
Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。 还提供了生产在例如25℃下有效复制的冷适应（ca）流感病毒的方法（和包含其的免疫原性组合物）。
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