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公开(公告)号：US08114415B2
公开(公告)日：2012-02-14
申请号：US12254131
申请日：2008-10-20
申请人： Erich Hoffmann , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
发明人： Erich Hoffmann , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
IPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , C12P21/04
CPC分类号： C12N15/86 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16262 , C12N2840/20
摘要： Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
摘要翻译： 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。 还提供了生产在例如25℃下有效复制的冷适应（ca）流感病毒的方法（和包含其的免疫原性组合物）。
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公开(公告)号：US07465456B2
公开(公告)日：2008-12-16
申请号：US11133345
申请日：2005-05-20
申请人： Erich Hoffmann , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
发明人： Erich Hoffmann , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
IPC分类号： A61K39/145 , C12Q1/70 , C12P19/34
CPC分类号： C12N15/86 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16262 , C12N2840/20
摘要： Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
摘要翻译： 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。 还提供了生产在例如25℃下有效复制的冷适应（ca）流感病毒的方法（和包含其的免疫原性组合物）。
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公开(公告)号：US20050266026A1
公开(公告)日：2005-12-01
申请号：US11133345
申请日：2005-05-20
申请人： Erich Hoffmann , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
发明人： Erich Hoffmann , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
CPC分类号： C12N15/86 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16262 , C12N2840/20
摘要： Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
摘要翻译： 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。 还提供了生产在例如25℃下有效复制的冷适应（ca）流感病毒的方法（和包含其的免疫原性组合物）。
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公开(公告)号：US20090175907A1
公开(公告)日：2009-07-09
申请号：US12254131
申请日：2008-10-20
申请人： Erich Hoffman , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
发明人： Erich Hoffman , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
IPC分类号： A61K39/145 , C12N7/01 , C12N15/74 , A61P31/16
CPC分类号： C12N15/86 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16262 , C12N2840/20
摘要： Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
摘要翻译： 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。 还提供了生产在例如25℃下有效复制的冷适应（ca）流感病毒的方法（和包含其的免疫原性组合物）。
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公开(公告)号：US08574591B2
公开(公告)日：2013-11-05
申请号：US13296933
申请日：2011-11-15
申请人： Erich Hoffmann , Hong Jin , George Kemble , Zhongying Chen
发明人： Erich Hoffmann , Hong Jin , George Kemble , Zhongying Chen
IPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , C12P21/04
CPC分类号： C12N15/86 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16262 , C12N2840/20
摘要： Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
摘要翻译： 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。 还提供了生产在例如25℃下有效复制的冷适应（ca）流感病毒的方法（和包含其的免疫原性组合物）。
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公开(公告)号：US20120288521A1
公开(公告)日：2012-11-15
申请号：US13296933
申请日：2011-11-15
申请人： Erich Hoffmann , Hong Jin , George Kemble , Zhongying Chen
发明人： Erich Hoffmann , Hong Jin , George Kemble , Zhongying Chen
IPC分类号： A61K39/145 , A61P31/16 , A61P37/04 , C12N7/01 , C12N15/74
CPC分类号： C12N15/86 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16262 , C12N2840/20
摘要： Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
摘要翻译： 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。 还提供了生产在例如25℃下有效复制的冷适应（ca）流感病毒的方法（和包含其的免疫原性组合物）。
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公开(公告)号：US20070161085A1
公开(公告)日：2007-07-12
申请号：US11668587
申请日：2007-01-30
申请人： George Trager , George Kemble , Richard Schwartz , Harshvardhan Mehta , Vu Truong-Le , Zhongying Chen , Alfred Pan , Eric Tsao , Chiaoyin Wang , Luisa Yee , Palani Balu
发明人： George Trager , George Kemble , Richard Schwartz , Harshvardhan Mehta , Vu Truong-Le , Zhongying Chen , Alfred Pan , Eric Tsao , Chiaoyin Wang , Luisa Yee , Palani Balu
CPC分类号： A61K39/145 , A61K35/76 , A61K39/12 , A61K47/02 , A61K47/183 , A61K47/26 , A61K47/42 , A61K2039/525 , A61K2039/5254 , B01D61/145 , B01D61/147 , C12N7/00 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234 , C12N2760/16251
摘要： Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided.
摘要翻译： 提供了适合作为流感疫苗优化流感病毒生产的方法和组合物。
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公开(公告)号：US20090246225A1
公开(公告)日：2009-10-01
申请号：US12330299
申请日：2008-12-08
申请人： George Robert Trager , George Kemble , Richard M. Schwartz , Harshvardhan Mehta , Vu Truong-Le , Zhongying Chen , Alfred A. Pan , Eric Tsao , Chiaoyin Kathy Wang , Luisa Yee , Palani Balu
发明人： George Robert Trager , George Kemble , Richard M. Schwartz , Harshvardhan Mehta , Vu Truong-Le , Zhongying Chen , Alfred A. Pan , Eric Tsao , Chiaoyin Kathy Wang , Luisa Yee , Palani Balu
IPC分类号： A61K39/145 , A61P31/16
CPC分类号： A61K39/145 , A61K35/76 , A61K39/12 , A61K47/02 , A61K47/183 , A61K47/26 , A61K47/42 , A61K2039/525 , A61K2039/5254 , B01D61/145 , B01D61/147 , C12N7/00 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234 , C12N2760/16251
摘要： Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided.
摘要翻译： 提供了适合作为流感疫苗优化流感病毒生产的方法和组合物。
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公开(公告)号：US08673613B2
公开(公告)日：2014-03-18
申请号：US12599761
申请日：2008-06-18
申请人： Hong Jin , Zhongying Chen
发明人： Hong Jin , Zhongying Chen
CPC分类号： G01N33/56983 , A61K39/12 , A61K39/145 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N2760/16122 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16261
摘要： The present invention encompasses methods of producing influenza B viruses in cell culture. The influenza B viruses may have desirable characteristics, such as enhanced replication in eggs and may be used, for example, in vaccines and in methods of treatment to protect against influenza B virus infection.
摘要翻译： 本发明包括在细胞培养物中产生乙型流感病毒的方法。 乙型流感病毒可能具有期望的特征，例如在卵中增强的复制，并且可以用于例如疫苗和治疗方法以防止乙型流感病毒感染。
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10.发明申请公开(公告)号：US20100322969A1
公开(公告)日：2010-12-23
申请号：US12599761
申请日：2008-06-18
申请人： Hong Jin , Zhongying Chen
发明人： Hong Jin , Zhongying Chen
IPC分类号： A61K39/145 , C12N7/01 , A61P31/16
CPC分类号： G01N33/56983 , A61K39/12 , A61K39/145 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N2760/16122 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16261
摘要： The present invention encompasses methods of producing influenza B viruses in cell culture. The influenza B viruses may have desirable characteristics, such as enhanced replication in eggs and may be used, for example, in vaccines and in methods of treatment to protect against influenza B virus infection.
摘要翻译： 本发明包括在细胞培养物中产生乙型流感病毒的方法。 乙型流感病毒可能具有期望的特征，例如在卵中增强的复制，并且可以用于例如疫苗和治疗方法以防止乙型流感病毒感染。
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