公开(公告)号：US20230183703A1

公开(公告)日：2023-06-15

申请号：US17925474

申请日：2021-05-14

Applicant: Hemayet ULLAH ,  Saadyah Eliezer AVERICK ,  HOWARD UNIVERSITY

Inventor： Hemayet ULLAH

IPC: C12N15/113 ,  G01N33/569

CPC classification number: C12N15/1131 ,  G01N33/56983 ,  G01N2333/165 ,  C12N2310/11

Abstract: The present disclosure provides compositions and methods for treating and detecting coronavirus infection, and in particular embodiments, provides compositions and methods for treating and detecting SARS-CoV-2 infection. The present disclosure also relates to the production of compositions for treating and detecting coronavirus infection, and in particular embodiments, to the production of compositions for treating and detecting SARS-CoV-2 infection.

公开(公告)号：US11236053B2

公开(公告)日：2022-02-01

申请号：US16634567

申请日：2018-07-26

Applicant: Emory University ,  Mercer University ,  Howard University ,  Union University

Inventor： Osman Güner ,  Bernard Lassegue ,  Kathy Griendling ,  Qian Xu ,  David Brown ,  J. Phillip Bowen ,  Amol Kulkarni ,  E. Blake Watkins

IPC: C07D239/26 ,  C07D213/50 ,  C07D307/54 ,  C07D215/14 ,  C07D213/65

Abstract: This disclosure relates to compounds and methods of treating or preventing a Nox related disease or condition comprising administering to a subject in need thereof a Nox inhibitor or pharmaceutical compositions comprising a Nox inhibitor disclosed herein, derivatives, or compounds disclosed herein optionally substituted with one or more substitutes including optional salt and prodrug forms. In certain embodiments, this disclosure relates to sulfonylurea compounds and uses reported herein.

公开(公告)号：US20210161553A1

公开(公告)日：2021-06-03

申请号：US17046449

申请日：2019-04-12

Applicant: HOWARD UNIVERSITY

Inventor： Roger C. LIN ,  Olmide A. OLULADE ,  Shannon A. SULLIVAN ,  Hamza HAIDER ,  Alexander W. SONG

IPC: A61B17/34

Abstract: In some embodiments, apparatuses and methods are provided herein useful to guide and support a medical device, such as a needle, relative to the skin of a patient. In some embodiments, the apparatus is attached to the skin of a patient through suction or adhesive materials, and allows for accurate placement of the medical instrument.

公开(公告)号：US20200163884A1

公开(公告)日：2020-05-28

申请号：US16698297

申请日：2019-11-27

Applicant: HOWARD UNIVERSITY

Inventor： Emmanuel Oyekanmi Akala

IPC: A61K9/14 ,  A61P35/00 ,  A61K31/395 ,  A61K31/337 ,  A61K47/10 ,  A61K47/18 ,  A61K47/34

Abstract: Provided is a method for preparing a drug loaded nanoparticle comprising: dissolving a macromonomer, a stabilizer and a crosslinker in a solvent to create a mixture; adding an initiator system to the mixture; dissolving a drug or combination of drugs in an organic phase containing the mixture; and recovering the drug loaded nanoparticle, a composition comprising the drug loaded nanoparticle prepared by the above method, and a method for treating cancer comprising administering the above composition to a subject in need thereof.

公开(公告)号：US10592668B2

公开(公告)日：2020-03-17

申请号：US15531139

申请日：2015-11-23

Applicant: HOWARD UNIVERSITY

Inventor： Charles J. Kim

IPC: G06F21/55 ,  G06F21/56 ,  G05B9/02 ,  G06F11/16 ,  G06F11/14

Abstract: A redundant and diverse secondary control system mirrors a primary control system but has some fundamental structural difference as compared to the primary control system to prevent a spread of a security breach from the primary control system to the secondary control system. The secondary control system may operate on different hardware built on different software written with different programming language as compared to the primary control system while performing the same function as that of the primary system. By hardware coding the algorithm to produce actuation signals, software based viruses and worms cannot interfere with the secondary control system's operation. A monitor device receives actuation signals from both the primary and secondary controls signals to determine whether an error occurred and to provide correct actuation signals to the controlled system.

公开(公告)号：US20180360043A1

公开(公告)日：2018-12-20

申请号：US16122712

申请日：2018-09-05

Applicant: Howard University ,  Georgetown University

Inventor： Sivanesan Dakshanamurthy ,  Hemayet Ullah

IPC: A01N43/653 ,  A01N43/38

Abstract: Compounds and methods are described herein that are effective to modulate plant response (e.g., plant susceptibility) to environmentally-induced stress. The compounds and methods described herein advantageously may be used to modulate environmental stress resistance in a wide variety of plants. Environmental stresses include, for example, high light intensity (UV exposure), temperature (e.g., high heat), high soil salinity, and low soil moisture (e.g., drought). As used herein, environmental stresses include any conditions that result in increased generation of reactive oxygen species (ROS) and accumulation of ROS in the plant cells. The compounds described herein that are effective to modulate resistance to the stress prevent, directly or indirectly, or increase phosphorylation of Tyr248 of the RACK1A protein.

公开(公告)号：US09864046B2

公开(公告)日：2018-01-09

申请号：US14305934

申请日：2014-06-16

Applicant: Howard University

Inventor： John M. M. Anderson ,  Mandoye Ndoye ,  Oludotun Ode ,  Henry C. Ogworonjo

IPC: G01S7/292 ,  G01S13/88 ,  G01S13/02 ,  G01S13/89 ,  G06K9/62 ,  G06K9/00

CPC classification number: G01S7/292 ,  G01S7/2923 ,  G01S13/0209 ,  G01S13/885 ,  G01S13/887 ,  G01S13/89 ,  G06K9/00791 ,  G06K9/6277

Abstract: The mathematical majorize-minimize principle is applied in various ways to process the image data to provide a more reliable image from the backscatter data using a reduced amount of memory and processing resources. A processing device processes the data set by creating an estimated image value for each voxel in the image by iteratively deriving the estimated image value through application of a majorize-minimize principle to solve a maximum a posteriori (MAP) estimation problem associated with a mathematical model of image data from the data. A prior probability density function for the unknown reflection coefficients is used to apply an assumption that a majority of the reflection coefficients are small. The described prior probability density functions promote sparse solutions automatically estimated from the observed data.

公开(公告)号：US09392073B2

公开(公告)日：2016-07-12

申请号：US14294883

申请日：2014-06-03

Applicant: Howard University

Inventor： Legand L. Burge, III

IPC: G06F12/08 ,  G06Q30/00 ,  H04L29/08 ,  H04W4/00 ,  H04W4/02 ,  G06Q30/02

CPC classification number: H04L67/2852 ,  G06F12/0862 ,  G06Q30/0224 ,  H04L29/0854 ,  H04L67/1095 ,  H04L67/2857 ,  H04L67/306 ,  H04M2242/40 ,  H04W4/02 ,  H04W4/50

Abstract: A context of a mobile device is determined. A context preference of a user associated with the mobile device is determined. The context of the mobile device and the user context preference is transmitted to another node and responsively returned data is received. Available free space in the mobile device is determined. All data whose timestamp is within a predetermined threshold is cached. The data is cached in at least a portion of the free space.

Abstract translation: 确定移动设备的上下文。 确定与移动设备相关联的用户的上下文偏好。 移动设备的上下文和用户上下文偏好被发送到另一个节点，并且响应地返回的数据被接收。 确定移动设备中的可用空间。 其时间戳在预定阈值内的所有数据被缓存。 数据被缓存在可用空间的至少一部分中。

公开(公告)号：US20160193237A1

公开(公告)日：2016-07-07

申请号：US14916803

申请日：2014-09-05

Applicant: HOWARD UNIVERSITY

Inventor： Pradeep K. Karla

IPC: A61K31/675 ,  A61K9/00 ,  A61K45/06 ,  A61K9/06

CPC classification number: A61K31/675 ,  A61K9/0034 ,  A61K9/06 ,  A61K31/47 ,  A61K31/4745 ,  A61K31/4985 ,  A61K45/06 ,  A61K2300/00

Abstract: Methods and compositions are provided for reducing transmission and/or infection of HIV in a subject by increasing the bioavailability of a drug in the subject. The methods and compositions provided herein include an efflux transporter inhibitor and a drug effective for reducing the transmission and/or infection of HIV in a subject. The efflux transporter inhibitor is effective to reduce the efflux of the drug through at least one of P-glycoprotein (Pgp), breast cancer resistant protein (BCRP), and multidrug resistant associated protein 1-9 (MRP1-9).

Abstract translation: 提供了通过增加受试者中药物的生物利用度来减少受试者中HIV的传播和/或感染的方法和组合物。 本文提供的方法和组合物包括外排转运蛋白抑制剂和有效减少受试者中HIV传播和/或感染的药物。 流出转运蛋白抑制剂通过P-糖蛋白（Pgp），乳腺癌耐药蛋白（BCRP）和多药耐药相关蛋白1-9（MRP1-9）中的至少一种有效减少药物的流出。

公开(公告)号：US20150335697A1

公开(公告)日：2015-11-26

申请号：US14817906

申请日：2015-08-04

Applicant: Howard University

Inventor： Evaristus A. Nwulia

IPC: A61K36/752 ,  A61K36/54 ,  A61M16/20 ,  A61M16/00 ,  A61M16/12 ,  A61M16/08 ,  A61K36/53 ,  A61M16/06

CPC classification number: A61K36/752 ,  A61K9/0043 ,  A61K9/007 ,  A61K36/00 ,  A61K36/53 ,  A61K36/54 ,  A61M16/0003 ,  A61M16/0057 ,  A61M16/0666 ,  A61M16/0875 ,  A61M16/107 ,  A61M16/12 ,  A61M16/122 ,  A61M16/208 ,  A61M21/00 ,  A61M2016/003 ,  A61M2021/0016 ,  A61M2205/8206 ,  A61M2205/8237

Abstract: A method, apparatus and kit have been discovered which regenerate with the use of odorants the connections of the neurons of the brain and central nervous system in the treatment of such person afflicted neuro-disorders caused by disease or trauma.

Abstract translation: 已经发现一种方法，装置和试剂盒，其通过使用气味剂再生，脑和神经系统的神经元的连接在这种人的治疗中受到疾病或创伤引起的神经障碍的影响。