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公开(公告)号：US20110056863A1
公开(公告)日：2011-03-10
申请号：US12990818
申请日：2009-05-26
IPC分类号： B65D85/00 , A61K9/70 , A61K31/445 , A61P25/28
CPC分类号： A61K9/7061 , A61K31/4465 , B65D81/24
摘要： [Object] An adhesive preparation containing donepezil is provided in which adhesive layer discoloration over time is inhibited.[Solution] The adhesive preparation containing donepezil has an adhesive layer containing donepezil and an acrylic adhesive on at least one side of a support, and a water content of the adhesive layer is 1000 ppm or more. The water content of the adhesive layer is preferably 8000 ppm or less and more preferably 7000 ppm or less.
摘要翻译： 提供了含有多奈哌齐的粘合剂，其中粘合剂层随着时间的变色被抑制。 [解决方案]含有多奈哌齐的粘合剂在载体的至少一侧上具有含有多奈哌齐和丙烯酸类粘合剂的粘合剂层，粘合剂层的含水量为1000ppm以上。 粘合剂层的含水量优选为8000ppm以下，更优选为7000ppm以下。
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公开(公告)号：US20100203108A1
公开(公告)日：2010-08-12
申请号：US12656700
申请日：2010-02-12
CPC分类号： A61K9/703 , A61F2013/00651 , A61K9/7061
摘要： The present invention provides to a patch and a patch preparation having low stretchability, which can be continuously adhered to the skin for a long time without undesirable detachment and marked falling off from the skin due to various factors during adhesion, and specifically provides a low stretchable patch and a patch preparation containing a support and an adhesive layer formed on one surface of the support, wherein a ratio P of the total length W (mm) of curved sections of a planar outer shape of the patch to the total length S (mm) of straight-line sections of the planar outer shape of the patch (W/S) is not more than 1.22, and, when the curved sections are approximated by a circular arc, the radius R (mm) of the circular arc is not less than 0.5 mm.
摘要翻译： 本发明提供一种具有低拉伸性的贴剂和贴片制剂，其可以在粘合期间由于各种因素而长时间连续地粘附到皮肤上而没有不希望的分离并且从皮肤上显着脱落，并且具体地提供了低伸缩性 贴片和贴片制剂，其包含支撑体和形成在支撑体的一个表面上的粘合剂层，其中贴片平面外形的弯曲部分的总长度W（mm）与总长度S（mm）之比P （W / S）的平面外形的直线部分的面积不大于1.22，并且当弯曲部分被圆弧近似时，圆弧的半径R（mm）不是 小于0.5毫米。
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33.发明申请Pressure-sensitive adhesive composition applicable to nail and adhesive agent for nail 审中-公开用于钉子的指甲和粘合剂的压敏粘合剂组合物公开(公告)号：US20090047333A1
公开(公告)日：2009-02-19
申请号：US12285606
申请日：2008-10-09
申请人： Akinori Hanatani , Hitoshi Akemi
发明人： Akinori Hanatani , Hitoshi Akemi
IPC分类号： A61K9/70
CPC分类号： A61K8/0208 , A61K8/02 , A61K8/891 , A61Q3/00 , C08L83/00 , C08L2666/02 , C09J183/04
摘要： The present invention aims at providing a pressure-sensitive adhesive composition applicable to nail, which shows superior adhesive performance (adhesive force, cohesion etc.), and superior drug releasability and drug stability, and an adhesive agent for nail, which uses this composition. The composition of the present invention contains a condensation polymer of a silicone resin and a silicone rubber. The composition of the present invention preferably contains not less than two kinds of condensation polymers having different resin/rubber ratios. The adhesive agent of the present invention has a support and an adhesive layer formed on one surface of the support, which contains the above-mentioned composition.
摘要翻译： 本发明的目的在于提供一种适用于指甲的压敏粘合剂组合物，其具有优异的粘合性能（粘合力，内聚力等）和优异的药物释放性和药物稳定性，以及使用该组合物的指甲粘合剂。 本发明的组合物含有有机硅树脂和硅橡胶的缩聚物。 本发明的组合物优选含有不少于两种具有不同树脂/橡胶比的缩聚物。 本发明的粘合剂具有形成在载体的一个表面上的载体和粘合剂层，其含有上述组合物。
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公开(公告)号：US5876745A
公开(公告)日：1999-03-02
申请号：US742487
申请日：1997-01-23
CPC分类号： A61K9/7053 , A61F13/0233 , A61F13/0243 , A61F13/0253 , A61K9/7061 , A61L15/58 , A61F2013/00153 , A61F2013/00234 , A61F2013/00608 , A61F2013/00663 , A61F2013/0071 , A61F2013/00906
摘要： A medical adhesive sheet comprising a support having a laminate structure comprising a non-porous sheet and a porous sheet, and a pressure-sensitive layer comprising an acrylic polymer prepared by polymerizing an alkyl (meth)acrylate as a main component monomer, and an organic liquid component which is compatible with the acrylic polymer, formed on the porous sheet side of the support, the layer being subjected to a crosslinking treatment, wherein the pressure-sensitive adhesive layer is embedded in the porous sheet, reaching the laminate interface between the non-porous sheet and the porous sheet. The medical adhesive sheet has improved anchoring property of its pressure-sensitive adhesive layer to the support while exhibiting a good balance between adhesion to the skin and low irritation to the skin.
摘要翻译： 一种医用胶粘片，其特征在于，具有包含无孔片材和多孔片材的叠层结构的支持体和包含通过聚合（甲基）丙烯酸烷基酯作为主要成分单体而制备的丙烯酸类聚合物的压敏层， 形成在载体的多孔片侧的与丙烯酸类聚合物相容的液体成分，该层进行交联处理，其中粘合剂层嵌入多孔片中，到达非粘合层之间的层压体界面， - 多孔片材。 医用粘合片具有改善其压敏粘合剂层对支持体的锚定性能，同时在与皮肤的粘附性和对皮肤的低刺激性之间具有良好的平衡。
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公开(公告)号：US5374429A
公开(公告)日：1994-12-20
申请号：US46962
申请日：1993-04-16
CPC分类号： A61K9/7061 , A61F13/023 , A61L15/58 , B32B27/12 , A61F2013/00578 , A61F2013/00604 , A61F2013/00744 , A61F2013/00906 , A61F2013/0091
摘要： A medical adhesive sheet comprising a support comprising a laminate of a polyester film having a thickness of from 0.5 to 6 .mu.m and a polyester nonwoven fabric having a basis weight of from 5 to 20 g/m.sup.2, and a pressure-sensitive adhesive layer laminated on the surface of the nonwoven fabric.
摘要翻译： 一种医用胶粘片，其特征在于，具有由厚度为0.5〜6μm的聚酯薄膜和单位面积重量为5〜20g / m 2的聚酯无纺布构成的层压体的层叠体和叠层的粘合剂层 在无纺织物的表面上。
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公开(公告)号：US5204109A
公开(公告)日：1993-04-20
申请号：US855493
申请日：1992-03-23
IPC分类号： A61K9/70 , A61K31/34 , A61K31/565
CPC分类号： A61K9/7061 , A61K31/34 , A61K31/565
摘要： A percutaneous gel preparation is disclosed, which comprises a substrate having one surface thereof a crosslinked gel layer formed by crosslinking a composition comprising the following ingredients (a) to (c), the weight ratio of the ingredient (b) to the ingredient (c) being from 1.0/0.25 to 1.0/2.0:(a) isosorbide dinitrate;(b) an acrylate polymer; and(c) a liquid ingredient compatible with the ingredient (b).
摘要翻译： 公开了一种经皮凝胶制剂，其包含其一个表面具有通过交联包含以下成分（a）至（c）的组合物，成分（b）与成分（c）的重量比）形成的交联凝胶层的基材 ）为1.0 / 0.25〜1.0 / 2.0：（a）硝酸异山梨酯; （b）丙烯酸酯聚合物; 和（c）与成分（b）相容的液体成分。
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公开(公告)号：US08591939B2
公开(公告)日：2013-11-26
申请号：US11196935
申请日：2005-08-04
申请人： Yuji Saeki , Masato Nishimura , Kensuke Matsuoka , Takateru Muraoka , Yoshifumi Hosaka , Mitsuhiko Hori , Kazuhisa Ninomiya , Hitoshi Akemi , Hidetoshi Kuroda
发明人： Yuji Saeki , Masato Nishimura , Kensuke Matsuoka , Takateru Muraoka , Yoshifumi Hosaka , Mitsuhiko Hori , Kazuhisa Ninomiya , Hitoshi Akemi , Hidetoshi Kuroda
IPC分类号： A61K31/445 , A61F13/02
CPC分类号： A61K9/7053 , A61K31/4468
摘要： The present invention provides a Fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which permits control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid. Specifically, the present invention provides a percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises Fentanyl, two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid compatible with the aforementioned two kinds of polyisobutylene and the aforementioned tackifier.
摘要翻译： 本发明提供了一种经济起始材料得到的含有芬太尼的经皮吸收性粘合剂制剂，其结构比以往更简单，具有足够的皮肤渗透性，并且通过改变两者的混合比可以控制皮肤渗透性 种类具有不同分子量的聚异丁烯，增粘剂和有机液体。 具体地说，本发明提供了一种经皮吸收性粘合剂制剂，其包含在其一个表面上层叠的载体和粘合剂层，其中所述粘合剂层包括芬太尼，两种具有不同分子量的聚异丁烯，增粘剂和与上述相容的有机液体 两种聚异丁烯和上述增粘剂。
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38.发明申请PRESSURE-SENSITIVE ADHESIVE COMPOSITION APPLICABLE TO NAIL AND ADHESIVE AGENT FOR NAIL 审中-公开适用于指甲和粘合剂的压敏粘合剂组合物公开(公告)号：US20100178321A1
公开(公告)日：2010-07-15
申请号：US12729675
申请日：2010-03-23
申请人： Akinori HANATANI , Hitoshi Akemi
发明人： Akinori HANATANI , Hitoshi Akemi
CPC分类号： A61K8/0208 , A61K8/02 , A61K8/891 , A61Q3/00 , C08L83/00 , C08L2666/02 , C09J183/04
摘要： The present invention aims at providing a pressure-sensitive adhesive composition applicable to nail, which shows superior adhesive performance (adhesive force, cohesion etc.), and superior drug releasability and drug stability, and an adhesive agent for nail, which uses this composition. The composition of the present invention contains a condensation polymer of a silicone resin and a silicone rubber. The composition of the present invention preferably contains not less than two kinds of condensation polymers having different resin/rubber ratios. The adhesive agent of the present invention has a support and an adhesive layer formed on one surface of the support, which contains the above-mentioned composition.
摘要翻译： 本发明的目的在于提供一种适用于指甲的压敏粘合剂组合物，其具有优异的粘合性能（粘合力，内聚力等）和优异的药物释放性和药物稳定性，以及使用该组合物的指甲粘合剂。 本发明的组合物含有有机硅树脂和硅橡胶的缩聚物。 本发明的组合物优选含有不少于两种具有不同树脂/橡胶比的缩聚物。 本发明的粘合剂具有形成在载体的一个表面上的载体和粘合剂层，其包含上述组合物。
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公开(公告)号：US20100010043A1
公开(公告)日：2010-01-14
申请号：US12475249
申请日：2009-05-29
IPC分类号： A61K31/445 , C07D211/08
CPC分类号： A61K31/4465 , A61K9/7053 , A61K9/7061
摘要： The present invention provides a percutaneously absorbable preparation comprising 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one and/or a hydrochloride thereof wherein the percuneously absorbable preoaration is able to administer to a patient such that Cmax per unit surface area of the percutaneously absorbable preparation is 0.025 to 0.5 ng/ml·cm2 in a plasma concentration profile.
摘要翻译： 本发明提供了包含2 - [（1-苄基哌啶-4-基）甲基] -5,6-二甲氧基茚满-1-酮和/或其盐酸盐的经皮吸收制剂，其中可以吸收的预制剂能够施用于 使得经皮吸收制剂的每单位表面积的C max在血浆浓度分布中为0.025至0.5ng / ml.cm 2。
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公开(公告)号：US20060034900A1
公开(公告)日：2006-02-16
申请号：US11196935
申请日：2005-08-04
申请人： Yuji Saeki , Masato Nishimura , Kensuke Matsuoka , Takateru Muraoka , Yoshifumi Hosaka , Mitsuhiko Hori , Kazuhisa Ninomiya , Hitoshi Akemi , Hidetoshi Kuroda
发明人： Yuji Saeki , Masato Nishimura , Kensuke Matsuoka , Takateru Muraoka , Yoshifumi Hosaka , Mitsuhiko Hori , Kazuhisa Ninomiya , Hitoshi Akemi , Hidetoshi Kuroda
IPC分类号： A61K31/445 , A61F13/02
CPC分类号： A61K9/7053 , A61K31/4468
摘要： The present invention provides a Fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which permits control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid. Specifically, the present invention provides a percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises Fentanyl, two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid compatible with the aforementioned two kinds of polyisobutylene and the aforementioned tackifier.
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