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公开(公告)号：US20100010043A1
公开(公告)日：2010-01-14
申请号：US12475249
申请日：2009-05-29
IPC分类号： A61K31/445 , C07D211/08
CPC分类号： A61K31/4465 , A61K9/7053 , A61K9/7061
摘要： The present invention provides a percutaneously absorbable preparation comprising 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one and/or a hydrochloride thereof wherein the percuneously absorbable preoaration is able to administer to a patient such that Cmax per unit surface area of the percutaneously absorbable preparation is 0.025 to 0.5 ng/ml·cm2 in a plasma concentration profile.
摘要翻译： 本发明提供了包含2 - [（1-苄基哌啶-4-基）甲基] -5,6-二甲氧基茚满-1-酮和/或其盐酸盐的经皮吸收制剂，其中可以吸收的预制剂能够施用于 使得经皮吸收制剂的每单位表面积的C max在血浆浓度分布中为0.025至0.5ng / ml.cm 2。
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2.发明申请METHOD FOR SUPPRESSING COLORING OF ADHESIVE PREPARTION CONTAINING DONEPEZIL AND METHOD FOR REDUCING AMOUNTS OF DONEPEZIL-RELATED SUBSTANCES FORMED 审中-公开用于抑制含有二苯醚的粘合制剂的着色方法和减少形成的与二苯醚相关的物质的量的方法公开(公告)号：US20100062045A1
公开(公告)日：2010-03-11
申请号：US12516998
申请日：2007-11-30
申请人： Sumiyo Nishi , Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Hitoshi Akemi , Satoko Washiro
发明人： Sumiyo Nishi , Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Hitoshi Akemi , Satoko Washiro
IPC分类号： A61K31/445 , A61K9/70 , A61P25/28
CPC分类号： A61K31/445 , A61K9/7061 , A61K31/375 , A61K33/04
摘要： [Object] By suppressing coloring of an adhesive preparation containing donepezil, a naturally colored appearance is realized.[Solution] In a method for suppressing coloring of an adhesive preparation having a support and a pressure-sensitive adhesive layer, which comprises a pressure-sensitive adhesive and donepezil in the pressure-sensitive adhesive layer, ascorbic acid, a metal salt or an ester thereof and metal metabisulfite salt are contained in the pressure-sensitive adhesive layer. This method preferably has: a step of preparing a mixture comprising the pressure-sensitive adhesive, the donepezil, the ascorbic acid, a metal salt or an ester thereof, and the metal metabisulfite salt; and a step of film-forming the pressure-sensitive adhesive layer by applying the mixture to the surface of the support.
摘要翻译： 通过抑制含有多奈哌齐的粘合剂的着色，实现了自然着色的外观。 [解决方案]在压敏粘合剂层中包含压敏粘合剂和多奈哌齐的粘合剂的制备方法中，具有支持体和粘合剂层的粘合剂的制备方法，抗坏血酸，金属盐或酯 并且在压敏粘合剂层中含有偏亚硫酸氢盐。 该方法优选具有：制备包含压敏粘合剂，多奈哌齐，抗坏血酸，金属盐或其酯和偏亚硫酸氢盐的混合物的步骤; 以及通过将所述混合物施加到所述载体的表面来成膜所述压敏粘合剂层的步骤。
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3.发明申请METHOD FOR SUPPRESSING DISCOLORATION OVER TIME OF ADHESIVE PREPARATION CONTAINING DONEPEZIL 审中-公开用于抑制含有二苯醚的胶粘剂制备时间的消除方法公开(公告)号：US20100048628A1
公开(公告)日：2010-02-25
申请号：US12517004
申请日：2007-11-30
申请人： Sumiyo Nishi , Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Hitoshi Akemi , Satoko Washiro
发明人： Sumiyo Nishi , Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Hitoshi Akemi , Satoko Washiro
IPC分类号： A61K31/445 , A61P25/28
CPC分类号： A61K31/445 , A61K9/7061 , A61K31/375 , A61K33/04
摘要： [Object] Discoloration, over time, of a donepezil-containing adhesive preparation is suppressed.[Solution] At least one species of stabilizer selected from the group consisting of ascorbic acid, a metal salt or an ester thereof, isoascorbic acid or a metal salt thereof, ethylenediamine tetraacetic acid or a metal salt thereof, 2-mercaptobenzimidazole, 3(2)-t-butyl-4-hydroxyanisole, 2,6-di-t-butyl-4-methylphenol, tetrakis[3-(3′,5′-di-t-butyl-4′-hydroxyphenyl)propionic acid]pentaerythritol, (±)-α-tocopherol, (±)-α-tocopherol acetate, rutin, hypophosphorous acid, a metal metabisulfite salt and a metal salt of hydroxymethanesulfinic acid, is blended in a pressure-sensitive adhesive layer containing a pressure-sensitive adhesive and donepezil.
摘要翻译： [目的]抑制多奈哌齐胶粘剂的变色，随着时间的推移。 [溶液]选自抗坏血酸，金属盐或其酯，异抗坏血酸或其金属盐，乙二胺四乙酸或其金属盐，2-巯基苯并咪唑，3（2 ）叔丁基-4-羟基苯甲醚，2,6-二叔丁基-4-甲基苯酚，四[3-（3'，5'-二叔丁基-4'-羟基苯基）丙酸]季戊四醇 ，（±）-α-生育酚，（±）-α-生育酚乙酸酯，芦丁，次磷酸，偏亚硫酸氢盐金属盐和羟基甲烷亚磺酸的金属盐混合在含有压敏粘合剂 和多奈哌齐。
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公开(公告)号：US20080131490A1
公开(公告)日：2008-06-05
申请号：US11987480
申请日：2007-11-30
申请人： Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Sumiyo Nishi , Satoko Washiro , Hitoshi Akemi
发明人： Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Sumiyo Nishi , Satoko Washiro , Hitoshi Akemi
IPC分类号： A61K9/70 , A61K31/445 , A61P25/28
CPC分类号： A61K31/445 , A61K9/7061 , A61K31/375 , A61K33/04
摘要： A donepezil-containing patch preparation is provided whereby production of donepezil-related substances in the pressure-sensitive adhesive layer is suppressed. A stabilizer comprising at least one or more species selected from the group consisting of ascorbic acid, metal salts or esters thereof, isoascorbic acid or metal salts thereof, ethylenediamine tetraacetic acid or metal salts thereof, cysteine, acetylcysteine, 2-mercaptobenzimidazole, 3(2)-t-butyl-4-hydroxyanisole, 2,6-di-t-butyl-4-methylphenol, tetrakis[3-(3′,5′-di-t-butyl-4′-hydroxyphenyl)propionic acid]pentaerythritol, 3-mercapto-1,2-propanediol, tocopherol acetate, rutin, quercetin, hydroquinone, metal salts of hydroxymethanesulfinic acid, metal metabisulfite salts, metal sulfite salts and metal thiosulfate salts is blended in a donepezil-containing pressure-sensitive adhesive layer provided on at least one side of a support.
摘要翻译： 提供了含多奈哌齐的贴剂，抑制了压敏粘合剂层中多奈哌齐相关物质的产生。 包含至少一种或多种选自抗坏血酸，金属盐或其酯，异抗坏血酸或其金属盐，乙二胺四乙酸或其金属盐，半胱氨酸，乙酰半胱氨酸，2-巯基苯并咪唑，3（2 ）叔丁基-4-羟基苯甲醚，2,6-二叔丁基-4-甲基苯酚，四[3-（3'，5'-二叔丁基-4'-羟基苯基）丙酸]季戊四醇 ，3-巯基-1,2-丙二醇，生育酚乙酸酯，芦丁，槲皮素，氢醌，羟基甲烷亚磺酸的金属盐，偏亚硫酸氢盐，金属亚硫酸盐和金属硫代硫酸盐，配制在含有多奈哌齐的压敏粘合剂层中 在支架的至少一侧。
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公开(公告)号：US09040077B2
公开(公告)日：2015-05-26
申请号：US12656700
申请日：2010-02-12
CPC分类号： A61K9/703 , A61F2013/00651 , A61K9/7061
摘要： The present invention provides to a patch and a patch preparation having low stretchability, which can be continuously adhered to the skin for a long time without undesirable detachment and marked falling off from the skin due to various factors during adhesion, and specifically provides a low stretchable patch and a patch preparation containing a support and an adhesive layer formed on one surface of the support, wherein a ratio P of the total length W (mm) of curved sections of a planar outer shape of the patch to the total length S (mm) of straight-line sections of the planar outer shape of the patch (W/S) is not more than 1.22, and, when the curved sections are approximated by a circular arc, the radius R (mm) of the circular arc is not less than 0.5 mm.
摘要翻译： 本发明提供一种具有低拉伸性的贴剂和贴片制剂，其可以在粘合期间由于各种因素而长时间连续地粘附到皮肤上而没有不希望的分离并且从皮肤上显着脱落，并且具体地提供了低伸缩性 贴片和贴片制剂，其包含支撑体和形成在支撑体的一个表面上的粘合剂层，其中贴片平面外形的弯曲部分的总长度W（mm）与总长度S（mm）之比P （W / S）的平面外形的直线部分的面积不大于1.22，并且当弯曲部分被圆弧近似时，圆弧的半径R（mm）不是 小于0.5毫米。
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公开(公告)号：US20100203108A1
公开(公告)日：2010-08-12
申请号：US12656700
申请日：2010-02-12
CPC分类号： A61K9/703 , A61F2013/00651 , A61K9/7061
摘要： The present invention provides to a patch and a patch preparation having low stretchability, which can be continuously adhered to the skin for a long time without undesirable detachment and marked falling off from the skin due to various factors during adhesion, and specifically provides a low stretchable patch and a patch preparation containing a support and an adhesive layer formed on one surface of the support, wherein a ratio P of the total length W (mm) of curved sections of a planar outer shape of the patch to the total length S (mm) of straight-line sections of the planar outer shape of the patch (W/S) is not more than 1.22, and, when the curved sections are approximated by a circular arc, the radius R (mm) of the circular arc is not less than 0.5 mm.
摘要翻译： 本发明提供一种具有低拉伸性的贴剂和贴片制剂，其可以在粘合期间由于各种因素而长时间连续地粘附到皮肤上而没有不希望的分离并且从皮肤上显着脱落，并且具体地提供了低伸缩性 贴片和贴片制剂，其包含支撑体和形成在支撑体的一个表面上的粘合剂层，其中贴片平面外形的弯曲部分的总长度W（mm）与总长度S（mm）之比P （W / S）的平面外形的直线部分的面积不大于1.22，并且当弯曲部分被圆弧近似时，圆弧的半径R（mm）不是 小于0.5毫米。
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公开(公告)号：US20080206315A1
公开(公告)日：2008-08-28
申请号：US12071867
申请日：2008-02-27
IPC分类号： A61K9/70
CPC分类号： A61L24/0015 , A61L15/58 , A61L24/04 , A61L2300/402
摘要： The present invention aims at providing an adhesive preparation wherein a drug is sufficiently dissolved in an adhesive layer and is not easily separated from the adhesive layer even during preservation of the adhesive preparation.The present invention provides an adhesive preparation having an adhesive layer on at least one surface of a support, wherein the adhesive layer comprises a first synthetic rubber having a viscosity average molecular weight of 1,600,000-6,500,000, a drug, an organic liquid component and a tackifier. The present invention further provides the aforementioned adhesive preparation, wherein the organic liquid component is contained in the adhesive layer in a proportion of 20 wt % or above relative to the total weight of the adhesive layer.
摘要翻译： 本发明的目的在于提供一种粘合剂制剂，其中药物在粘合剂层中充分溶解，并且即使在粘合剂制备过程中也不容易与粘合层分离。 本发明提供一种在支撑体的至少一个表面上具有粘合剂层的粘合剂制剂，其中粘合剂层包括粘均分子量为1,600,000-6,500,000的第一合成橡胶，药物，有机液体组分和增粘剂 。 本发明还提供了上述粘合剂制剂，其中粘合剂层中的有机液体组分相对于粘合剂层的总重量为20重量％以上。
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公开(公告)号：US08309119B2
公开(公告)日：2012-11-13
申请号：US12071867
申请日：2008-02-27
IPC分类号： A61K9/70 , A61K31/4468 , A61F13/02
CPC分类号： A61L24/0015 , A61L15/58 , A61L24/04 , A61L2300/402
摘要： The present invention aims at providing an adhesive preparation wherein a drug is sufficiently dissolved in an adhesive layer and is not easily separated from the adhesive layer even during preservation of the adhesive preparation.The present invention provides an adhesive preparation having an adhesive layer on at least one surface of a support, wherein the adhesive layer comprises a first synthetic rubber having a viscosity average molecular weight of 1,600,000-6,500,000, a drug, an organic liquid component and a tackifier. The present invention further provides the aforementioned adhesive preparation, wherein the organic liquid component is contained in the adhesive layer in a proportion of 20 wt % or above relative to the total weight of the adhesive layer.
摘要翻译： 本发明的目的在于提供一种粘合剂制剂，其中药物在粘合剂层中充分溶解，并且即使在粘合剂制备过程中也不容易与粘合层分离。 本发明提供一种在支撑体的至少一个表面上具有粘合剂层的粘合剂制剂，其中粘合剂层包括粘均分子量为1,600,000-6,500,000的第一合成橡胶，药物，有机液体组分和增粘剂 。 本发明还提供了上述粘合剂制剂，其中粘合剂层中的有机液体组分相对于粘合剂层的总重量为20重量％以上。
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