公开(公告)号：US20100010043A1

公开(公告)日：2010-01-14

申请号：US12475249

申请日：2009-05-29

申请人： Akinori Hanatani ,  Junichi Sekiya ,  Sachiko Terashi ,  Sumiyo Nishi ,  Hitoshi Akemi

发明人： Akinori Hanatani ,  Junichi Sekiya ,  Sachiko Terashi ,  Sumiyo Nishi ,  Hitoshi Akemi

IPC分类号： A61K31/445 ,  C07D211/08

CPC分类号： A61K31/4465 ,  A61K9/7053 ,  A61K9/7061

摘要： The present invention provides a percutaneously absorbable preparation comprising 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one and/or a hydrochloride thereof wherein the percuneously absorbable preoaration is able to administer to a patient such that Cmax per unit surface area of the percutaneously absorbable preparation is 0.025 to 0.5 ng/ml·cm2 in a plasma concentration profile.

摘要翻译： 本发明提供了包含2 - [（1-苄基哌啶-4-基）甲基] -5,6-二甲氧基茚满-1-酮和/或其盐酸盐的经皮吸收制剂，其中可以吸收的预制剂能够施用于 使得经皮吸收制剂的每单位表面积的C max在血浆浓度分布中为0.025至0.5ng / ml.cm 2。

公开(公告)号：US20100062045A1

公开(公告)日：2010-03-11

申请号：US12516998

申请日：2007-11-30

申请人： Sumiyo Nishi ,  Akinori Hanatani ,  Junichi Sekiya ,  Sachiko Terashi ,  Hitoshi Akemi ,  Satoko Washiro

发明人： Sumiyo Nishi ,  Akinori Hanatani ,  Junichi Sekiya ,  Sachiko Terashi ,  Hitoshi Akemi ,  Satoko Washiro

IPC分类号： A61K31/445 ,  A61K9/70 ,  A61P25/28

CPC分类号： A61K31/445 ,  A61K9/7061 ,  A61K31/375 ,  A61K33/04

摘要： [Object] By suppressing coloring of an adhesive preparation containing donepezil, a naturally colored appearance is realized.[Solution] In a method for suppressing coloring of an adhesive preparation having a support and a pressure-sensitive adhesive layer, which comprises a pressure-sensitive adhesive and donepezil in the pressure-sensitive adhesive layer, ascorbic acid, a metal salt or an ester thereof and metal metabisulfite salt are contained in the pressure-sensitive adhesive layer. This method preferably has: a step of preparing a mixture comprising the pressure-sensitive adhesive, the donepezil, the ascorbic acid, a metal salt or an ester thereof, and the metal metabisulfite salt; and a step of film-forming the pressure-sensitive adhesive layer by applying the mixture to the surface of the support.

摘要翻译： 通过抑制含有多奈哌齐的粘合剂的着色，实现了自然着色的外观。 [解决方案]在压敏粘合剂层中包含压敏粘合剂和多奈哌齐的粘合剂的制备方法中，具有支持体和粘合剂层的粘合剂的制备方法，抗坏血酸，金属盐或酯 并且在压敏粘合剂层中含有偏亚硫酸氢盐。 该方法优选具有：制备包含压敏粘合剂，多奈哌齐，抗坏血酸，金属盐或其酯和偏亚硫酸氢盐的混合物的步骤; 以及通过将所述混合物施加到所述载体的表面来成膜所述压敏粘合剂层的步骤。

公开(公告)号：US20100048628A1

公开(公告)日：2010-02-25

申请号：US12517004

申请日：2007-11-30

申请人： Sumiyo Nishi ,  Akinori Hanatani ,  Junichi Sekiya ,  Sachiko Terashi ,  Hitoshi Akemi ,  Satoko Washiro

发明人： Sumiyo Nishi ,  Akinori Hanatani ,  Junichi Sekiya ,  Sachiko Terashi ,  Hitoshi Akemi ,  Satoko Washiro

IPC分类号： A61K31/445 ,  A61P25/28

CPC分类号： A61K31/445 ,  A61K9/7061 ,  A61K31/375 ,  A61K33/04

摘要： [Object] Discoloration, over time, of a donepezil-containing adhesive preparation is suppressed.[Solution] At least one species of stabilizer selected from the group consisting of ascorbic acid, a metal salt or an ester thereof, isoascorbic acid or a metal salt thereof, ethylenediamine tetraacetic acid or a metal salt thereof, 2-mercaptobenzimidazole, 3(2)-t-butyl-4-hydroxyanisole, 2,6-di-t-butyl-4-methylphenol, tetrakis[3-(3′,5′-di-t-butyl-4′-hydroxyphenyl)propionic acid]pentaerythritol, (±)-α-tocopherol, (±)-α-tocopherol acetate, rutin, hypophosphorous acid, a metal metabisulfite salt and a metal salt of hydroxymethanesulfinic acid, is blended in a pressure-sensitive adhesive layer containing a pressure-sensitive adhesive and donepezil.

摘要翻译： [目的]抑制多奈哌齐胶粘剂的变色，随着时间的推移。 [溶液]选自抗坏血酸，金属盐或其酯，异抗坏血酸或其金属盐，乙二胺四乙酸或其金属盐，2-巯基苯并咪唑，3（2 ）叔丁基-4-羟基苯甲醚，2,6-二叔丁基-4-甲基苯酚，四[3-（3'，5'-二叔丁基-4'-羟基苯基）丙酸]季戊四醇 ，（±）-α-生育酚，（±）-α-生育酚乙酸酯，芦丁，次磷酸，偏亚硫酸氢盐金属盐和羟基甲烷亚磺酸的金属盐混合在含有压敏粘合剂 和多奈哌齐。

公开(公告)号：US20080131490A1

公开(公告)日：2008-06-05

申请号：US11987480

申请日：2007-11-30

申请人： Akinori Hanatani ,  Junichi Sekiya ,  Sachiko Terashi ,  Sumiyo Nishi ,  Satoko Washiro ,  Hitoshi Akemi

发明人： Akinori Hanatani ,  Junichi Sekiya ,  Sachiko Terashi ,  Sumiyo Nishi ,  Satoko Washiro ,  Hitoshi Akemi

IPC分类号： A61K9/70 ,  A61K31/445 ,  A61P25/28

CPC分类号： A61K31/445 ,  A61K9/7061 ,  A61K31/375 ,  A61K33/04

摘要： A donepezil-containing patch preparation is provided whereby production of donepezil-related substances in the pressure-sensitive adhesive layer is suppressed. A stabilizer comprising at least one or more species selected from the group consisting of ascorbic acid, metal salts or esters thereof, isoascorbic acid or metal salts thereof, ethylenediamine tetraacetic acid or metal salts thereof, cysteine, acetylcysteine, 2-mercaptobenzimidazole, 3(2)-t-butyl-4-hydroxyanisole, 2,6-di-t-butyl-4-methylphenol, tetrakis[3-(3′,5′-di-t-butyl-4′-hydroxyphenyl)propionic acid]pentaerythritol, 3-mercapto-1,2-propanediol, tocopherol acetate, rutin, quercetin, hydroquinone, metal salts of hydroxymethanesulfinic acid, metal metabisulfite salts, metal sulfite salts and metal thiosulfate salts is blended in a donepezil-containing pressure-sensitive adhesive layer provided on at least one side of a support.

摘要翻译： 提供了含多奈哌齐的贴剂，抑制了压敏粘合剂层中多奈哌齐相关物质的产生。 包含至少一种或多种选自抗坏血酸，金属盐或其酯，异抗坏血酸或其金属盐，乙二胺四乙酸或其金属盐，半胱氨酸，乙酰半胱氨酸，2-巯基苯并咪唑，3（2 ）叔丁基-4-羟基苯甲醚，2,6-二叔丁基-4-甲基苯酚，四[3-（3'，5'-二叔丁基-4'-羟基苯基）丙酸]季戊四醇 ，3-巯基-1,2-丙二醇，生育酚乙酸酯，芦丁，槲皮素，氢醌，羟基甲烷亚磺酸的金属盐，偏亚硫酸氢盐，金属亚硫酸盐和金属硫代硫酸盐，配制在含有多奈哌齐的压敏粘合剂层中 在支架的至少一侧。