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    Neural stimulation system providing auto adjustment of stimulus output as a function of sensed impedance
    31.
    发明授权
    Neural stimulation system providing auto adjustment of stimulus output as a function of sensed impedance 有权
    神经刺激系统提供作为感测阻抗的函数的刺激输出的自动调整

    公开(公告)号：US07317948B1

    公开(公告)日：2008-01-08

    申请号：US10364436

    申请日：2003-02-11

    Applicant: John D H King ,  James R Thacker

    Inventor： John D H King ,  James R Thacker

    IPC: A61N1/00

    CPC classification number: A61N1/36139 ,  A61N1/08 ,  A61N1/36071 ,  A61N1/3615

    Abstract: A neural stimulation system automatically corrects or adjusts the stimulus magnitude (stimulation energy) in order to maintain a comfortable and effective stimulation therapy. Because the changes in impedance associated with the electrode-tissue interface can indicate obstruction of current flow and positional lead displacement, lead impedance can indicate the quantity of electrical stimulation energy that should be delivered to the target neural tissue to provide corrective adjustment. Hence, a change in impedance or morphology of an impedance curve may be used in a feedback loop to indicate that the stimulation energy needs to be adjusted and the system can effectively auto correct the magnitude of stimulation energy to maintain a desired therapeutic effect.

    Abstract translation: 神经刺激系统自动校正或调整刺激量（刺激能量），以保持舒适有效的刺激疗法。 由于与电极 - 组织界面相关的阻抗变化可以指示电流和位置引线位移的阻塞，所以引线阻抗可以指示应该传送到目标神经组织的电刺激能量的量以提供校正调整。 因此，可以在反馈回路中使用阻抗曲线的阻抗或形态的变化，以指示需要调整刺激能量，并且系统能够有效地自动校正刺激能量的大小以维持所需的治疗效果。

    Apparatus and method for determining the relative position and orientation of neurostimulation leads
    32.
    发明授权
    Apparatus and method for determining the relative position and orientation of neurostimulation leads 有权

    公开(公告)号：US06993384B2

    公开(公告)日：2006-01-31

    申请号：US10310202

    申请日：2002-12-03

    Applicant: Kerry Bradley ,  James R. Thacker

    Inventor： Kerry Bradley ,  James R. Thacker

    IPC: A61N1/00

    CPC classification number: A61N1/08 ,  A61B5/053 ,  A61N1/0551

    Abstract: Interelectrode impedance or electric field potential measurements are used to determine the relative orientation of one lead to other leads in the spinal column or other body/tissue location. Interelectrode impedance is determined by measuring impedance vectors. The value of the impedance vector is due primarily to the electrode-electrolyte interface, and the bulk impedance between the electrodes. The bulk impedance between the electrodes is, in turn, made up of (1) the impedance of the tissue adjacent to the electrodes, and (2) the impedance of the tissue between the electrodes. In one embodiment, the present invention makes both monopolar and bipolar impedance measurements, and then corrects the bipolar impedance measurements using the monopolar measurements to eliminate the effect of the impedance of the tissue adjacent the electrodes. The orientation and position of the leads may be inferred from the relative minima of the corrected bipolar impedance values. These corrected impedance values may also be mapped and stored to facilitate a comparison with subsequent corrected impedance measurement values. Such comparison allows a determination to be made as to whether the lead position and/or orientation has changed appreciably over time. In another embodiment, one or more electrodes are stimulated and the resulting electric field potential on the non-stimulated electrodes is measured. Such field potential measurements provide an indication of the relative orientation of the electrodes. Once known, the relative orientation may be used to track lead migration, to setup stimulation configurations and parameters for nominal stimulation and/or navigation. Also, such measurements allow automatic adjustment of stimulation energy to a previously-defined optimal potential field in the case of lead migration or postural changes.

    Implantable cardiac stimulation device and method utilizing electrogram spectral analysis for therapy administration
    33.
    发明授权
    Implantable cardiac stimulation device and method utilizing electrogram spectral analysis for therapy administration 失效
    可植入式心脏刺激装置及利用电针谱分析进行治疗的方法

    公开(公告)号：US06622042B1

    公开(公告)日：2003-09-16

    申请号：US09852884

    申请日：2001-05-09

    Applicant: James R. Thacker

    Inventor： James R. Thacker

    IPC: A61N1365

    CPC classification number: A61N1/3622 ,  A61N1/3684 ,  A61N1/3962

    Abstract: An implantable cardiac stimulation device and method utilizes electrogram spectral analysis to administer electrical stimulation therapy to a heart to treat accelerated arrhythmias of the heart. The device includes an arrhythmia detector that initially detects an accelerated arrhythmia of the heart. An acquisition system then acquires an electrogram of the heart having both atrial and ventricular depolarization components. A processor then spectral analyzes the electrogram to provide spectral data related to the accelerated arrhythmia. The spectral data may be used for arrhythmia discrimination, arrhythmia tolerance discernment, and/or by a pulse generator to control stimulation therapy delivery timing.

    Abstract translation: 可植入心脏刺激装置和方法利用电描记图谱分析来对心脏进行电刺激治疗以治疗心脏加速的心律失常。 该装置包括心律失常检测器，该检测器最初检测到心脏加速的心律失常。 然后，获取系统获取具有心房和心室去极化组件的心脏的电描记图。 然后，处理器对光电图进行光谱分析，以提供与加速心律失常相关的光谱数据。 频谱数据可以用于心律失常鉴别，心律失常容忍辨别，和/或通过脉冲发生器来控制刺激治疗递送时机。

    Method for making a body implantable sensor
    34.
    发明授权
    Method for making a body implantable sensor 失效
    制造人体植入式传感器的方法

    公开(公告)号：US5490323A

    公开(公告)日：1996-02-13

    申请号：US380764

    申请日：1995-01-30

    Applicant: James R. Thacker ,  Alvin H. Weinberg ,  Shahram Moaddeb

    Inventor： James R. Thacker ,  Alvin H. Weinberg ,  Shahram Moaddeb

    IPC: A61B5/145 ,  A61B5/1459 ,  A61N1/05 ,  A61N1/365 ,  A61N1/37 ,  H01R43/00

    CPC classification number: A61N1/056 ,  A61N1/36557 ,  A61N1/3702 ,  Y10T29/49117

    Abstract: The present invention includes a body implantable lead having a multipolar proximal connector, at least a first conductor coupled to at least one stimulating electrode, a sensor for sensing at least one physiologic parameter of the body, and a second and a third conductor coupled to the sensor. The sensor is hermetically sealed in a D-shaped housing. Sensor components are mounted onto a microelectronic substrate which is advantageously placed on an inner flat portion of the D-shaped housing. End caps having sealing rings, either glass frit or metal, are used to seal the ends of the shell. A hermetic seal is easily achieved by heating the sealing material until they re-flow between the end caps and the shell. Advantageously, the sensor terminals are sized to fit snugly within a narrow bore of the end cap which is then circumferentially welded closed. The D-shaped sensor is placed on a carrier having at least two lumens. At least the first and second conductors pass through the lumens for connection with the stimulating electrode and the distal end of the sensor. Advantageously, the D-shaped housing reduces the area that needs to be hermetically sealed by more than half, and thus reduces the overall diameter of the lead. Advantageously, the conductors coupled to the sensor function independently from the stimulation conductors so that interference with basic operation of the pacemaker is prevented.

    Abstract translation: 本发明包括具有多极近端连接器的主体可植入引线，至少一个耦合到至少一个刺激电极的第一导体，用于感测身体的至少一个生理参数的传感器，以及耦合到该主体的第二和第三导体 传感器。 传感器密封在D形外壳中。 传感器组件安装在有利地放置在D形壳体的内部平坦部分上的微电子衬底上。 用密封环（玻璃料或金属）的端盖用于密封外壳的端部。 通过加热密封材料直到它们在端盖和壳体之间再流动，容易实现气密密封。 有利地，传感器端子的尺寸设计成紧密地配合在端盖的窄孔内，然后圆形焊接封闭。 D形传感器放置在具有至少两个流明的载体上。 至少第一和第二导体穿过腔以便与刺激电极和传感器的远端连接。 有利地，D形壳体将需要被密封的面积减少一半以上，从而减小了导线的总直径。 有利地，耦合到传感器的导体独立于刺激导体起作用，从而防止对起搏器的基本操作的干扰。

    System and method for converting tissue stimulation programs in a format usable by an electrical current steering navigator
    36.
    发明授权
    System and method for converting tissue stimulation programs in a format usable by an electrical current steering navigator 有权
    用电流转向导航器可使用的格式转换组织刺激程序的系统和方法

    公开(公告)号：US09278222B2

    公开(公告)日：2016-03-08

    申请号：US12501282

    申请日：2009-07-10

    Applicant: James R. Thacker ,  Michael Moffitt ,  Kerry Bradley ,  David K. L. Peterson

    Inventor： James R. Thacker ,  Michael Moffitt ,  Kerry Bradley ,  David K. L. Peterson

    IPC: A61N1/36 ,  A61N1/372 ,  G06F19/00

    CPC classification number: A61N1/37264 ,  A61N1/36071 ,  A61N1/36146 ,  A61N1/3615 ,  A61N1/36167 ,  A61N1/36185 ,  A61N1/37247 ,  G06F19/00 ,  G16H40/63

    Abstract: A method, computer medium, and system for programming a controller is provided. The controller controls electrical stimulation energy output to electrodes, and stores a set of programmed stimulation parameters associated with the electrodes. The programmed stimulation parameter set is compared with sets of reference stimulation parameters, each of the reference sets of stimulation parameters being associated with the electrodes. If an identical match is determined between the programmed stimulation parameter set and any one of the reference stimulation parameter sets exists based on the comparison, the identically matched stimulation parameter set is selected as an initial stimulation parameter set. If an identical match does not exist, a best between the programmed stimulation parameter set and the reference stimulation parameter sets is determined and selected as the initial stimulation parameter set. The controller is then programmed with a new set of programmable stimulation parameters based on the initial stimulation parameter set.

    Abstract translation: 提供了一种用于编程控制器的方法，计算机介质和系统。 控制器控制对电极的电刺激能量输出，并且存储与电极相关联的一组编程的刺激参数。 将编程的刺激参数集与参考刺激参数的集合进行比较，每个参考组的刺激参数与电极相关联。 如果在编程的刺激参数集之间确定相同的匹配，并且基于比较存在参考刺激参数集中的任一个，则选择相同匹配的刺激参数集作为初始刺激参数集。 如果不存在相同的匹配，则确定编程的刺激参数集和参考刺激参数集之间的最佳值，并将其选为初始刺激参数集。 然后基于初始刺激参数集，控制器用一组新的可编程刺激参数进行编程。

    NEURAL STIMULATION LEAD FIXATION
    39.
    发明申请
    NEURAL STIMULATION LEAD FIXATION 失效
    神经刺激引线固定

    公开(公告)号：US20130013044A1

    公开(公告)日：2013-01-10

    申请号：US13620138

    申请日：2012-09-14

    Applicant: James R. Thacker ,  Michael S. Colvin ,  David K.L. Peterson ,  James P. McGivern

    Inventor： James R. Thacker ,  Michael S. Colvin ,  David K.L. Peterson ,  James P. McGivern

    IPC: A61N1/05

    CPC classification number: A61N1/0558 ,  A61M25/1002 ,  A61M25/1011

    Abstract: An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A first injectable material is injected into the dura space to mechanically position the electrode array with respect to the spinal cord. Conjunctively for use with adhesives, or alternatively for use instead of the adhesives, a balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. An elastic aspect of the balloon serves as an internal contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.

    Abstract translation: 具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。 一个实施方案涉及脊髓刺激（SCS）引线。 将第一可注射材料注入硬脑膜空间以相对于脊髓机械地定位电极阵列。 结合使用粘合剂，或代替粘合剂代替使用，球囊可以位于电极引线阵列上。 气球充满空气，液体或柔顺材料。 当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。 气囊的弹性方面用作内部包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。

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