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31.发明申请公开(公告)号：US20170368100A1
公开(公告)日：2017-12-28
申请号：US15539313
申请日：2015-12-23
发明人： Thomas HUENIG
CPC分类号： A61K35/17 , A61K2035/122 , C07K16/28 , C12N5/0637 , G01N33/505 , G01N33/53
摘要： The invention relates to a method for determination of the frequency of regulatory T-cells in samples obtained from human blood and to methods for the preparation of compositions comprising predetermined amount of regulatory T-cells. The invention is based on the conception that a large fraction of regulatory T-cells present in human peripheral blood do not express detectable amounts of Foxp3, the master transcription factor used for identification of regulatory T-cells, as a result of cytokine deprivation outside of the tissue context.
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32.发明授权Antibodies or fragments thereof directed against a Staphylococcus aureus epitope of IsaA or IsaB 有权针对IsaA或IsaB的金黄色葡萄球菌表位的抗体或其片段公开(公告)号：US09260511B2
公开(公告)日：2016-02-16
申请号：US14077927
申请日：2013-11-12
发明人： Knut Ohlsen , Udo Lorenz
IPC分类号： A61K39/40 , C07K16/12 , A61K45/06 , G01N33/569
CPC分类号： G01N33/573 , A61K39/40 , A61K45/06 , C07K16/1271 , C07K16/40 , C07K2317/77 , G01N33/56938 , G01N2333/924 , G01N2469/10
摘要： The invention concerns antibodies or fragments thereof that are directed against a Staphylococcus aureus epitope.
摘要翻译： 本发明涉及针对金黄色葡萄球菌表位的抗体或其片段。
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公开(公告)号：US08948225B2
公开(公告)日：2015-02-03
申请号：US13664634
申请日：2012-10-31
发明人： Adam Bauer , Sven Hoefling , Lukas Worschech , Martin Kamp
CPC分类号： H01S5/3422 , B82Y20/00 , H01S5/3401 , H01S5/3416
摘要： An interband cascade laser amplifier medium (M) having a number of cascades (C) strung together along a transport direction (T) of charge carriers and each having an electron injector region (I), an amplifier region (V) and an electron collector region (K), wherein the amplifier region (V) has a hole quantum film (1) having a first semiconductor material and an electron quantum film (2) having a second semiconductor material, and wherein the electron collector region (K) has at least one collector quantum film (4) having a third semiconductor material and separated by a first barrier layer (3), and the electron injector region (I) has at least one injector quantum film (5) having a fourth semiconductor material and separated by a second barrier layer (3).
摘要翻译： 具有多个级联（C）的带间级联激光放大器介质（M）沿着电荷载流子的输送方向（T）串联在一起并且各自具有电子注入器区域（I），放大器区域（V）和电子收集器 区域（K），其中所述放大器区域（V）具有具有第一半导体材料的空穴量子膜（1）和具有第二半导体材料的电子量子膜（2），并且其中所述电子收集极区域（K） 至少一个具有第三半导体材料并由第一阻挡层（3）分离的收集器量子膜（4），并且电子注入器区域（I）具有至少一个具有第四半导体材料的注入量子膜（5） 第二阻挡层（3）。
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公开(公告)号：US20150023879A1
公开(公告)日：2015-01-22
申请号：US14383682
申请日：2013-03-08
IPC分类号： A61K49/00
CPC分类号： A61K49/0004 , A23G4/14 , A61C2201/002 , A61K9/0058 , A61K49/00 , A61K49/0069 , C12Q1/04 , C12Q1/37 , C12Q2304/00 , G01N33/528 , G01N33/68 , G01N33/6893 , Y02A50/54 , Y02A50/58
摘要： The document proposes a diagnostic chewing gum for identifying the presence of pathogens detectable via the mouth, in particular residing in nasal, oropharyngeal, laryngeal, oesophageal, ocular and/or pulmonal tissue of a user, comprising a base material or particles (3) embedded and/or attached to said base material; an element (1, 5-7), like e.g. a releasable flavor molecule, attached to said base material and/or said particles, for the generation of a change in the chewing gum directly detectable by the user; wherein said pathogen is selected from the group consisting of virus, bacterium, protozoa, prion, fungus or a combination thereof; and wherein the element (1, 5-7) generates the change upon direct or indirect contact with a marker (4) which is released by said pathogens, or, in case of a virus or prion, by the cellular structure hosting it.
摘要翻译： 该文件提出了一种诊断性口香糖，用于鉴定通过口，特别是居住在使用者的鼻，口咽，喉，食管，眼和/或肺组织中的可检测的病原体的存在，其包括基材或颗粒（3）嵌入 和/或附着在所述基材上; 元素（1，5-7），例如 附着在所述基材和/或所述颗粒上的可释放风味分子，用于产生用户可直接检测的口香糖的变化; 其中所述病原体选自病毒，细菌，原生动物，朊病毒，真菌或其组合; 并且其中所述元件（1,57）在与被所述病原体释放的标记物（4）直接或间接接触时产生所述变化，或者在病毒或朊病毒的情况下，由托管其的细胞结构产生变化。
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公开(公告)号：US20240122862A1
公开(公告)日：2024-04-18
申请号：US17766722
申请日：2020-10-13
CPC分类号： A61K9/485 , A61K9/4808 , A61K9/4816 , A61K33/04
摘要： The present invention discloses a therapeutic gas release system for oral administration comprising a therapeutic gas releasing compound A, and a therapeutic gas release triggering compound B, wherein compound A and B are separated from each other by an inner septum during storage of the system, wherein compound A and B are surrounded by an outer membrane, which is a gas-permeable and water- and solid-impermeable membrane, preferably a silicone membrane, and wherein therapeutic gas release from the system is activated before oral administration by breaking the inner septum. The therapeutic gas released from the system of the present invention is suitable for the treatment of (inflammatory) diseases of the gastrointestinal tract.
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公开(公告)号：US11744923B2
公开(公告)日：2023-09-05
申请号：US16748054
申请日：2020-01-21
发明人： Kai Stuckensen , Uwe Gbureck , Juergen Groll
CPC分类号： A61L27/56 , A61F2/30756 , A61L27/12 , A61L27/20 , A61L27/24 , A61L27/362 , A61L27/3633 , A61L27/3654 , A61F2002/30766 , A61F2002/30784 , A61F2310/00964 , A61F2310/00982 , A61L2430/02 , A61L2430/06 , A61L2430/24
摘要： The present invention relates to a monolithic multi-layered material having at least a first layer, from which anisotropic pores originate, and a second layer, in which the anisotropic pores continue. The present invention further relates to a monolithic medical material having at least a first layer, from which anisotropic pores originate, and a second layer, in which the anisotropic pores continue. The present invention further relates to a process for the production of a multi-layered material having anisotropic pores. It further relates to a multi-layered material which can be produced by the process according to the invention.
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公开(公告)号：US11016041B2
公开(公告)日：2021-05-25
申请号：US16252130
申请日：2019-01-18
申请人： Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V. , Julius-Maximilians-Universitaet Wuerzburg
发明人： Richard Schielein , Wolfgang Holub
IPC分类号： G01N23/046 , G01N23/18 , G01N23/083
摘要： A calculating unit for calculating a recording trajectory of a CT system has a receive interface, an optimizer and a control unit. The receive interface serves for receiving measurement and simulation data relative to the object to be recorded. The optimizer is configured to determine the recording trajectory based on known degrees of freedom of the CT system, based on the measurement and simulation data and based on a test task from a group having a plurality of test tasks. The control unit is configured to output data in correspondence with the recording trajectory for controlling the CT system.
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公开(公告)号：US20210047356A1
公开(公告)日：2021-02-18
申请号：US16645380
申请日：2018-08-29
发明人： Christian POSSIEL , Juergen SEIBEL
摘要： The present invention relates to a new class of sucrose esters and a method for their preparation.
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公开(公告)号：US20190185416A1
公开(公告)日：2019-06-20
申请号：US16324758
申请日：2017-08-11
发明人： Ralf WYRWA , Claudia RODE , Thomas SEEMANN , Lorenz MEINEL , Jennifer RITZER , Matthias SCHNABELRAUCH
IPC分类号： C07C237/04 , C07C231/12 , A61K47/18
CPC分类号： C07C237/04 , A61K47/186 , A61K47/54 , A61K47/65 , C07C231/12 , C07C233/07 , C07C269/04 , C07C237/20 , C07C237/36 , C07C271/28
摘要： It is an object of the present invention to introduce carboxylic acid-functionalities suitable for coupling into the denatonium structure by means of simple synthesis, namely the synthesis of bitter principle derivatives based on the denatonium structure according to formula 1: For example, according to the invention, lidocaine derivatives may be reacted with carboxylated benzyl halogenides. The carboxylated denatonium derivatives of the present invention are especially applied in medicine, biology, medical engineering as well as cosmetics, the pharmaceutical, chemical, and foodstuff industry.
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公开(公告)号：US20180271086A1
公开(公告)日：2018-09-27
申请号：US15542100
申请日：2016-01-07
IPC分类号： A01N1/02
摘要： The present invention relates to a gas delivery device comprising a gas releasing molecule and a gas permeable membrane. The invention also relates to the use of the gas delivery device for delivery of gas to an extracorporeal transplant, extracorporeal cells, a brain-dead transplant donor or foodstuff and in therapy. The invention further relates to the use of a gas permeable and liquid and solid impermeable membrane to separate a gas releasing molecule and its non-gaseous degradation products from an extracorporeal transplant, extracorporeal cells, a brain-dead transplant donor or foodstuff.
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