公开(公告)号：US08691850B2

公开(公告)日：2014-04-08

申请号：US11661820

申请日：2005-08-30

Applicant: Jens-Kerim Ergüden ,  Gunter Karig ,  Ulrich Rosentreter ,  Barbara Albrecht ,  Kerstin Henninger ,  Joachim Hütter ,  Nicole Diedrichs ,  Peter Nell ,  Sabine Arndt ,  Walter Hübsch ,  Andreas Knorr ,  Karl-Heinz Schlemmer ,  Dirk Brohm

Inventor： Jens-Kerim Ergüden ,  Gunter Karig ,  Ulrich Rosentreter ,  Barbara Albrecht ,  Kerstin Henninger ,  Joachim Hütter ,  Nicole Diedrichs ,  Peter Nell ,  Sabine Arndt ,  Walter Hübsch ,  Andreas Knorr ,  Karl-Heinz Schlemmer ,  Dirk Brohm

IPC: A61K31/4436 ,  C07D417/12

CPC classification number: C07D417/12

Abstract: The present application relates to novel phenylaminothiazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.

Abstract translation: 本申请涉及新的苯基氨基噻唑衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ 或预防高血压和其他心血管疾病。

公开(公告)号：US08198282B2

公开(公告)日：2012-06-12

申请号：US12647210

申请日：2009-12-24

Applicant: Tobias Wunberg ,  Judith Baumeister ,  Mario Jeske ,  Frank Suessmeier ,  Holger Zimmermann ,  Kerstin Henninger ,  Dieter Lang

Inventor： Tobias Wunberg ,  Judith Baumeister ,  Mario Jeske ,  Frank Suessmeier ,  Holger Zimmermann ,  Kerstin Henninger ,  Dieter Lang

IPC: A61K31/497 ,  A61P31/12

CPC classification number: C07D471/04

Abstract: This invention relates to substituted azaquinazolines, to a process for their preparation, to pharmaceutical compositions containing them, and to their use for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, in particular against cytomegaloviruses.

Abstract translation: 本发明涉及取代的氮杂喹唑啉，其制备方法，含有它们的药物组合物及其用于治疗和/或预防疾病的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的疾病。

公开(公告)号：US07867992B2

公开(公告)日：2011-01-11

申请号：US11655589

申请日：2007-01-19

Applicant: Holger Zimmermann ,  Rudolf Schohe-Loop ,  Kerstin Henninger ,  Dieter Lang ,  Kai Thede ,  Chantal Fuerstner ,  David Brueckner ,  Daniela Paulsen ,  Thomas Roelle ,  Johannes Koebberling ,  Marcus Bauser

Inventor： Holger Zimmermann ,  Rudolf Schohe-Loop ,  Kerstin Henninger ,  Dieter Lang ,  Kai Thede ,  Chantal Fuerstner ,  David Brueckner ,  Daniela Paulsen ,  Thomas Roelle ,  Johannes Koebberling ,  Marcus Bauser

IPC: A01N43/62 ,  A61K31/55 ,  C07D413/00

CPC classification number: C07D215/56 ,  C07D401/04

Abstract: The invention relates to substituted quinolones and to processes for their preparation as well as to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.

Abstract translation: 本发明涉及取代的喹诺酮及其制备方法，以及它们用于生产用于治疗和/或预防疾病的药物的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的药物。

公开(公告)号：US07767704B2

公开(公告)日：2010-08-03

申请号：US10594343

申请日：2005-03-11

Applicant: Holger Zimmermann ,  David Brueckner ,  Dirk Heimbach ,  Martin Hendrix ,  Kerstin Henninger ,  Guy Hewlett ,  Ulrich Rosentreter ,  Joerg Keldenich ,  Dieter Lang ,  Martin Radtke

Inventor： Holger Zimmermann ,  David Brueckner ,  Dirk Heimbach ,  Martin Hendrix ,  Kerstin Henninger ,  Guy Hewlett ,  Ulrich Rosentreter ,  Joerg Keldenich ,  Dieter Lang ,  Martin Radtke

IPC: A61K31/4164 ,  C07D233/54

CPC classification number: C07D233/90 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

Abstract: The invention relates to the substituted imidazoles of formula (I) and to methods for producing the same, to their use in the treatment and/or prophylaxis of diseases and to their use for producing drugs for use in the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.

Abstract translation: 本发明涉及式（I）的取代的咪唑及其制备方法，用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途 特别是用作抗病毒剂，特别是抗巨细胞病毒。

公开(公告)号：US07662822B2

公开(公告)日：2010-02-16

申请号：US11579919

申请日：2005-04-23

Applicant: Tobias Wunberg ,  Judith Baumeister ,  Mario Jeske ,  Frank Süβmeier ,  Holger Zimmermann ,  Kerstin Henninger ,  Dieter Lang

Inventor： Tobias Wunberg ,  Judith Baumeister ,  Mario Jeske ,  Frank Süβmeier ,  Holger Zimmermann ,  Kerstin Henninger ,  Dieter Lang

IPC: C07D471/04 ,  A61K31/497 ,  C07D213/75 ,  C07D213/73 ,  C07F9/06 ,  C07F9/28 ,  C07C265/12 ,  A61P31/12

CPC classification number: C07D471/04

Abstract: This invention relates to substituted azaquinazolines, to a process for their preparation, to pharmaceutical compositions containing them, and to their use for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, in particular against cytomegaloviruses.

Abstract translation: 本发明涉及取代的氮杂喹唑啉，其制备方法，含有它们的药物组合物及其用于治疗和/或预防疾病的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的疾病。

公开(公告)号：US20070185121A1

公开(公告)日：2007-08-09

申请号：US10556198

申请日：2004-04-28

Applicant: Tobias Wunberg ,  Judith Baumeister ,  Mario Jeske ,  Peter Nell ,  Susanne Nikolic ,  Frank Sussmeier ,  Holger Zimmermann ,  Rolf Grosser ,  Kerstin Henninger ,  Guy Hewlett ,  Jorg Keldenich ,  Dieter Lang

Inventor： Tobias Wunberg ,  Judith Baumeister ,  Mario Jeske ,  Peter Nell ,  Susanne Nikolic ,  Frank Sussmeier ,  Holger Zimmermann ,  Rolf Grosser ,  Kerstin Henninger ,  Guy Hewlett ,  Jorg Keldenich ,  Dieter Lang

IPC: A61K31/4985 ,  C07D403/14

CPC classification number: C07D487/04

Abstract: The invention relates to heterocyclyl-substituted dihydroquinazolines of formula (I), to processes for their preparation, to medicaments containing them, and to methods for the treatment and/or prophylaxis of diseases, in particular, for use as anti-viral agents, in particular, against cytomegaloviruses.

Abstract translation: 本发明涉及式（I）的杂环基取代的二氢喹唑啉，其制备方法，含有它们的药物，以及用于治疗和/或预防疾病，特别是用作抗病毒剂的方法 特别是针对巨细胞病毒。

公开(公告)号：US07109218B2

公开(公告)日：2006-09-19

申请号：US10497120

申请日：2002-11-28

Applicant: Ulrich Rosentreter ,  Thomas Krämer ,  Mitsuyuki Shimada ,  Walter Hübsch ,  Nicole Diedrichs ,  Thomas Krahn ,  Kerstin Henninger ,  Johannes-Peter Stasch ,  Ralf Wischnat

Inventor： Ulrich Rosentreter ,  Thomas Krämer ,  Mitsuyuki Shimada ,  Walter Hübsch ,  Nicole Diedrichs ,  Thomas Krahn ,  Kerstin Henninger ,  Johannes-Peter Stasch ,  Ralf Wischnat

IPC: C07D417/12 ,  A61K31/4418

CPC classification number: C07D417/12 ,  C07D213/85 ,  C07D417/14

Abstract: Compounds of the formula (I) a process for their preparation and their use as medicaments are described.

公开(公告)号：US07105553B2

公开(公告)日：2006-09-12

申请号：US10168197

申请日：2000-12-12

Applicant: Rüdiger Fischer ,  Gerald Kleymann ,  Ulrich Betz ,  Judith Baumeister ,  Wolfgang Bender ,  Peter Eckenberg ,  Gabriele Handke ,  Martin Hendrix ,  Kerstin Henninger ,  Axel Jensen ,  Jörg Keldenich ,  Udo Schneider ,  Olaf Weber

Inventor： Rüdiger Fischer ,  Gerald Kleymann ,  Ulrich Betz ,  Judith Baumeister ,  Wolfgang Bender ,  Peter Eckenberg ,  Gabriele Handke ,  Martin Hendrix ,  Kerstin Henninger ,  Axel Jensen ,  Jörg Keldenich ,  Udo Schneider ,  Olaf Weber

IPC: A61K31/426 ,  C07D277/54

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D277/54 ,  C07D417/12 ,  C07F7/1804 ,  C07F9/6539

Abstract: The present invention relates to novel compounds, to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.

Abstract translation: 本发明涉及新化合物，其制备方法及其用作药物，特别是抗病毒药物。

公开(公告)号：US20050227972A1

公开(公告)日：2005-10-13

申请号：US10497120

申请日：2002-11-28

Applicant: Ulrich Rosentreter ,  Thomas Kramer ,  Mitsuyuki Shimada ,  Walter Hubsch ,  Nicole Diedrichs ,  Thomas Krahn ,  Kerstin Henninger ,  Johannes-Peter Stasch ,  Ralf Wischnat

Inventor： Ulrich Rosentreter ,  Thomas Kramer ,  Mitsuyuki Shimada ,  Walter Hubsch ,  Nicole Diedrichs ,  Thomas Krahn ,  Kerstin Henninger ,  Johannes-Peter Stasch ,  Ralf Wischnat

IPC: A61K31/454 ,  A61K31/4545 ,  A61K31/5377 ,  A61K45/00 ,  A61P3/10 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P13/00 ,  A61P13/10 ,  A61P15/00 ,  A61P15/10 ,  A61P17/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/28 ,  A61P29/00 ,  A61P29/02 ,  A61P35/00 ,  A61P43/00 ,  C07D213/85 ,  C07D417/12 ,  C07D417/14 ,  A61K31/541 ,  A61K31/444 ,  A61K31/496 ,  C07D413/14

CPC classification number: C07D417/12 ,  C07D213/85 ,  C07D417/14

Abstract: Compounds of the formula (I) a process for their preparation and their use as medicaments are described.

Abstract translation: 描述了式（I）化合物的制备方法及其作为药物的用途。

公开(公告)号：US20050222247A1

公开(公告)日：2005-10-06

申请号：US10996230

申请日：2004-11-23

Applicant: Stephen Boyer ,  Kentaro Hashimoto ,  Thomas Rolle ,  Peter Sandner ,  Beatrix Stelte-Ludwig ,  Hanna Tinel ,  Kerstin Henninger ,  Arnel Concepcion ,  Osamu Sakurai ,  Kanako Hirai ,  Tadashi Inoue ,  Yuki Mochizuki ,  Noriko Nunami ,  Masaomi Tajimi ,  Noriyuki Yamamoto ,  Yasuhiro Tsukimi

Inventor： Stephen Boyer ,  Kentaro Hashimoto ,  Thomas Rolle ,  Peter Sandner ,  Beatrix Stelte-Ludwig ,  Hanna Tinel ,  Kerstin Henninger ,  Arnel Concepcion ,  Osamu Sakurai ,  Kanako Hirai ,  Tadashi Inoue ,  Yuki Mochizuki ,  Noriko Nunami ,  Masaomi Tajimi ,  Noriyuki Yamamoto ,  Yasuhiro Tsukimi

IPC: A61K31/353 ,  A61K31/403 ,  A61K31/4192 ,  C07D311/58 ,  C07D405/12 ,  C07D311/74

CPC classification number: C07D311/58 ,  C07D405/12

Abstract: This invention relates to chroman derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The chroman derivatives of the present invention have an excellent activity as BETA 3 antagonists and are useful for the prophylaxis and treatment of diseases associated with BETA 3 activity, in particular for the treatment of urological disorder or disease, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor oeractivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; and inflammatory disorders, such as asthma and COPD.

Abstract translation: 本发明涉及可用作药物制剂的活性成分的苯并二氢吡喃衍生物及其盐。 本发明的苯并二氢吡喃衍生物作为BETA 3拮抗剂具有优异的活性，可用于预防和治疗与BETA 3活性相关的疾病，特别是用于治疗泌尿系统疾病或疾病，如逼尿肌过度活动（膀胱过度活动症） ，尿失禁，神经源性逼尿肌反应性（逼尿肌hyperflexia），特发性逼尿肌过度活动（逼尿肌不稳定），良性前列腺增生和下尿路症状; 和炎症性疾病，如哮喘和COPD。