-
公开(公告)号：US20120177681A1
公开(公告)日：2012-07-12
申请号：US13223793
申请日：2011-09-01
Applicant: Manmohan Singh , David A.G. Skibinski , Tom Yao-Hsiang Wu , Yongkai Li , Alex Cortez , Xiaoyue Zhang , Yefen Zou , Timothy Z. Hoffman , Jianfeng Pan , Kathy Yue
Inventor： Manmohan Singh , David A.G. Skibinski , Tom Yao-Hsiang Wu , Yongkai Li , Alex Cortez , Xiaoyue Zhang , Yefen Zou , Timothy Z. Hoffman , Jianfeng Pan , Kathy Yue
IPC: A61K39/39 , C07F9/6512 , A61K31/675 , A61P31/12 , C07F9/553 , C07F9/645 , A61P37/04 , A61P31/04 , C07F9/6561 , C07F9/38
CPC classification number: C07F9/6561 , A61K31/661 , A61K31/6615 , A61K31/662 , A61K39/02 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/13 , A61K39/145 , A61K39/292 , A61K39/39 , A61K2039/55505 , A61K2039/55511 , C07D471/04 , C07D487/04 , C07F9/645 , C07F9/6512 , C07F9/65583 , C07F9/65616 , Y02A50/466
Abstract: Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.
Abstract translation: 可以将免疫增强剂吸附到不溶性金属盐如铝盐上，以改变其药代动力学，药效学，肌内留置时间和/或免疫刺激作用。 修饰免疫增强剂以引入可介导吸附的部分，例如膦酸酯基团。 即使以吸附形式递送，这些改性化合物也可以保留或改善其体内免疫活性。
-
公开(公告)号：US07731967B2
公开(公告)日：2010-06-08
申请号：US10837117
申请日：2004-04-29
Applicant: Derek O'Hagan , Manmohan Singh
Inventor： Derek O'Hagan , Manmohan Singh
IPC: A61K39/00
CPC classification number: A61K39/39 , A61K2039/55511 , A61K2039/55555
Abstract: The invention provides, inter alia, immunogenic compositions comprising a first antigen, at least two adjuvants, wherein a first adjuvant comprises a polymer derived from poly(lactides) and/or poly(lactide-co-glycolides), and wherein a second adjuvant comprises an imidazoquinoline, wherein said first antigen is encapsulated within, adsorbed or conjugated to, co-lyophilized or mixed with said first adjuvant, and a pharmaceutically acceptable excipient, wherein said composition elicits a cellular immune response when administered to a vertebrate subject. The invention also provides methods of producing immunogenic compositions, methods for producing a cytotoxic-T lymphocyte (CTL) response in a vertebrate subject, and methods of immunization.
Abstract translation: 本发明尤其提供包含第一抗原，至少两种佐剂的免疫原性组合物，其中第一佐剂包含衍生自聚（丙交酯）和/或聚（丙交酯 - 共 - 乙交酯）的聚合物，并且其中第二佐剂包含 咪唑并喹啉，其中所述第一抗原包被在所述第一佐剂中并被共冻干或混合，吸附或缀合，以及药学上可接受的赋形剂，其中所述组合物在施用于脊椎动物受试者时引起细胞免疫应答。 本发明还提供产生免疫原性组合物的方法，在脊椎动物受试者中产生细胞毒性T淋巴细胞（CTL）应答的方法和免疫方法。
-
公开(公告)号：US07604802B2
公开(公告)日：2009-10-20
申请号：US10340034
申请日：2003-01-08
Applicant: Derek O'Hagan , Manmohan Singh
Inventor： Derek O'Hagan , Manmohan Singh
IPC: A61K39/00
CPC classification number: A61K39/245 , A61K39/00 , A61K39/12 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , A61K2039/57 , A61K2039/6081 , A61K2039/6093 , C12N2710/16634 , Y10S977/802 , Y10S977/918
Abstract: A method for producing a cellular immune response in a vertebrate subject comprising administering to the vertebrate subject a vaccine composition comprising a protein particle antigen and a pharmaceutically acceptable excipient is disclosed.
Abstract translation: 公开了一种在脊椎动物对象中产生细胞免疫应答的方法，包括对脊椎动物给药包含蛋白质颗粒抗原和药学上可接受的赋形剂的疫苗组合物。
-
34.发明申请Immunogenic Compositions Containing Anthrax Antigen, Biodegradable Polymer Microparticles, And Polynucleotide-Containing Immunological Adjuvant 有权含有炭疽菌抗原，可生物降解聚合物微粒和含多核苷酸的免疫佐剂的免疫原性组合物公开(公告)号：US20080317784A1
公开(公告)日：2008-12-25
申请号：US11667642
申请日：2005-11-15
Applicant: Derek T. O'Hagan , Manmohan Singh , Dennis M. Klinman
Inventor： Derek T. O'Hagan , Manmohan Singh , Dennis M. Klinman
CPC classification number: A61K9/0019 , A61K9/1647 , A61K9/167 , A61K39/00 , A61K39/07 , A61K2039/55555 , A61K2039/55561
Abstract: Immunogenic compositions and kits, as well as methods of stimulating immune responses and methods of immunization using the same. The compositions and kits comprise: (a) an antigen derived from Bacillus anthracis; (b) polymer microparticles comprising a biodegradable polymer; and (c) a polynucleotide-containing immunological adjuvant.
Abstract translation: 免疫原性组合物和试剂盒，以及刺激免疫应答的方法和使用其免疫的方法。 组合物和试剂盒包括：（a）源自炭疽芽孢杆菌的抗原; （b）包含可生物降解聚合物的聚合物微粒; 和（c）含有多核苷酸的免疫佐剂。
-
公开(公告)号：US06861410B1
公开(公告)日：2005-03-01
申请号：US10103673
申请日：2002-03-21
Applicant: Gary S. Ott , Derek O'Hagan , Manmohan Singh
Inventor： Gary S. Ott , Derek O'Hagan , Manmohan Singh
CPC classification number: A61K9/0019 , A61K9/107 , A61K47/26 , C07H15/24
Abstract: The present invention is directed to novel adjuvant compositions, which target the cellular and/or humoral arms of immunity. According to an embodiment of the invention, an oil-in-water adjuvant composition is provided that comprises: (a) water; (b) a metabolizable oil comprising at least one branched or unbranched long-chain hydrocarbon moiety; (c) a steroid; and (d) a saponin.
-
Patent Agency Ranking
公开(公告)号：US06573238B2
公开(公告)日：2003-06-03
申请号：US09187780
申请日：1998-11-06
Applicant: Bret Shirley , Maninder Hora , Derek O'Hagan , Manmohan Singh
Inventor： Bret Shirley , Maninder Hora , Derek O'Hagan , Manmohan Singh
IPC: A61K3800
CPC classification number: A61K9/0019 , A61K9/0024 , A61K9/1647 , A61K9/1694 , A61K38/30 , A61K47/183
Abstract: Methods for preparing biodegradable microparticles are provided. Also provided are microparticles prepared by the method which include IGF-1 entrapped therein. The microparticles allow for controlled release of IGF-1 and other polypeptides over prolonged periods of time.
Abstract translation: 提供了制备可生物降解的微粒的方法。 还提供了通过包含IGF-1的方法制备的微粒。 微粒允许在长时间内控制释放IGF-1和其他多肽。
-
公开(公告)号：US5873576A
公开(公告)日：1999-02-23
申请号：US927960
申请日：1997-09-11
Applicant: Lannie Dietle , Manmohan Singh Kalsi
Inventor： Lannie Dietle , Manmohan Singh Kalsi
CPC classification number: F16J15/164 , F16J15/3244
Abstract: A hydrodynamically lubricated squeeze packing type rotary shaft seal suitable for lubricant retention and environmental exclusion which incorporates one or more resilient protuberances which and cooperate with the gland walls to hold the seal straight in its installation groove in unpressurized and low pressure lubricant retention applications thereby preventing skew-induced wear caused by impingement of abrasive contaminants present in the environment, and which also serve as radial bearings to prevent tipping of the seal within its installation gland.
Abstract translation: 一种流体动力学润滑的挤压包装型旋转轴密封，适用于润滑剂保留和环境排除，其包含一个或多个弹性突起，其与压盖壁配合，以在非加压和低压润滑剂保持应用中将密封件直接保持在其安装槽中，从而防止扭曲 由环境中存在的研磨性污染物的冲击引起的磨损，并且还用作径向轴承以防止密封件在其安装压盖内倾倒。
-
公开(公告)号：US20230119950A1
公开(公告)日：2023-04-20
申请号：US17968993
申请日：2022-10-19
IPC: G06F16/438 , G06F7/08
Abstract: The present disclosure generally relates to a system and method for providing audio and image data. The system and method may receive blurbs from users that include audio and image data. The exemplary disclosed system and method may prioritize or push a given blurb based on consumption by other users. The exemplary disclosed system and method may further prioritize or push a given blurb based on an aggregate metric based on consumption and engagement by other users.
-
公开(公告)号：US10357568B2
公开(公告)日：2019-07-23
申请号：US14005525
申请日：2012-03-23
Applicant: Luis Brito , Manmohan Singh , Derek O'Hagan
Inventor： Luis Brito , Manmohan Singh , Derek O'Hagan
Abstract: To formulate amphiphilic pharmacological agents (in particular, amphiphilic immunopotentiators) in oil-in-water emulsions the invention provides an oil-in-water emulsion comprising an aqueous phase, an oil phase, a surfactant, and a phospholipid.
-
公开(公告)号：US10076240B2
公开(公告)日：2018-09-18
申请号：US15624689
申请日：2017-06-15
Applicant: Manish Dinkarrao Kulkarni , Manmohan Singh Sidhu
Inventor： Manish Dinkarrao Kulkarni , Manmohan Singh Sidhu
CPC classification number: A61B3/0083 , A61B3/0033 , A61B3/0041 , A61B3/102 , A61B34/25 , A61B2560/0431
Abstract: There is a need for robust and portable system, and apparatus for ophthalmology. We propose use of foldable ophthalmic system. Our system will have a chin-rest (or face-rest or forehead rest) that can be folded so that the ocular device could be transported in a brief-case type casing. Our system can be used for many modalities including optical coherence tomography.
-
-
-
-
-
-
-
-
-
Search Results
101
records
(took 0.025 seconds)
