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56 条记录 (耗时 0.016 秒)

    Process for preparing 2',3'-didehydro-2'3'-dideoxynucleosides and 2',3'-dideoxynucleosides
    33.
    发明申请
    Process for preparing 2',3'-didehydro-2'3'-dideoxynucleosides and 2',3'-dideoxynucleosides 审中-公开
    制备2'，3'-二脱水-2,3'-二脱氧核苷和2'，3'-二脱氧核苷的方法

    公开(公告)号：US20060199959A1

    公开(公告)日：2006-09-07

    申请号：US10567696

    申请日：2004-07-29

    申请人： Giorgio Bertolini ,  Patrizia Castoldi ,  Mauricio Deleo ,  Marco Frigerio ,  Maurizio Velati

    发明人： Giorgio Bertolini ,  Patrizia Castoldi ,  Mauricio Deleo ,  Marco Frigerio ,  Maurizio Velati

    IPC分类号： C07F9/6512

    CPC分类号： C07H19/06 ,  C07H19/16 ,  Y02P20/55

    摘要： A process for preparing 2′,3′-didehydro-2′,3′-dideoxynucleosides and 2′,3′-dideoxynucleosides is described, which comprises the reductive elimination reaction of a compound of formula in which X, Y, P′ is H or a protecting group and B is a natural or modified, optionally substituted purine or pyrimidine base or a five- or six-membered monocyclic or eleven- or twelve-membered bicyclic, optionally substituted heterocyclic system containing at least one nitrogen atom, by reaction with zinc metal and a suitable activating agent, characterized in that the divalent zinc is removed by precipitation, from an organic phase, of the corresponding zinc sulfide, by adding a solution of a mineral sulfide to the organic phase.

    摘要翻译： 描述了制备2'，3'-二脱氢-2'，3'-双脱氧核苷和2'，3'-二脱氧核苷的方法，其包括式X化合物的还原消除反应，其中X，Y，P' H或保护基，B是通过反应的天然或修饰的任选取代的嘌呤或嘧啶碱基或五元或六元单环或十一元或十二元双环，任选取代的含有至少一个氮原子的杂环体系 其中锌金属和合适的活化剂，其特征在于，通过向有机相中加入无机硫化物溶液，通过从有机相中沉淀出相应的硫化锌来除去二价锌。

    Process for preparing 2,5-disubstituted 3-alkylthiophenes
    34.
    发明申请
    Process for preparing 2,5-disubstituted 3-alkylthiophenes 审中-公开
    制备2,5-二取代的3-烷基噻吩的方法

    公开(公告)号：US20060069272A1

    公开(公告)日：2006-03-30

    申请号：US10530858

    申请日：2003-10-13

    申请人： Giorgio Bertolini ,  Marco Frigerio

    发明人： Giorgio Bertolini ,  Marco Frigerio

    IPC分类号： C07D333/16

    CPC分类号： C07D333/22 ,  C07D333/08 ,  C07D333/16

    摘要： The present invention relates to a process for preparing 2,5-disubstituted 3-alkyl-thiophenes and more particularly to a process for preparing them that comprises an acylation reaction in position 5 of 2-substituted 3-alkylthiophenes. This process does not need reagents which are difficult to handle and does not need anhydrous conditions or inert atmosphere. The resulting product is obtained in high purity.

    摘要翻译： 本发明涉及一种制备2,5-二取代的3-烷基 - 噻吩的方法，更具体地涉及一种制备它们的方法，其包括2-取代的3-烷基噻吩的5位的酰化反应。 该方法不需要难以处理并且不需要无水条件或惰性气氛的试剂。 得到的产物是高纯度的。

    Process for the preparation of (S)-N-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxyamide
    36.
    发明授权
    Process for the preparation of (S)-N-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxyamide 失效
    制备（S）-N-叔丁基-1,2,3,4-四氢异喹啉-3-甲酰胺的方法

    公开(公告)号：US06340760B1

    公开(公告)日：2002-01-22

    申请号：US09478690

    申请日：2000-01-06

    申请人： Pietro Bellani ,  Marco Frigerio

    发明人： Pietro Bellani ,  Marco Frigerio

    IPC分类号： C07D491048

    CPC分类号： C07D217/26

    摘要： A description is given here of a novel process for the synthesis of N-carboxyanhydride of formula VI by reacting (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid with triphosgene in dioxane; a description is also given of a process for the synthesis of (S)-N-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxyamide by treating the N-carboxyanhydride VI so obtained with tert-butylamine.

    摘要翻译： 这里给出了通过使（3S）-1,2,3,4-四氢异喹啉-3-羧酸与二恶烷中的三光气反应合成式VI的N-羧酸酐的新方法。 还描述了通过用叔丁胺处理所得的N-羧酸酐VI来合成（S）-N-叔丁基-1,2,3,4-四氢异喹啉-3-甲酰胺的方法。

    Takeup drum for wire drawing machine
    37.
    发明授权
    Takeup drum for wire drawing machine 失效
    拔丝滚筒拉丝机

    公开(公告)号：US5678443A

    公开(公告)日：1997-10-21

    申请号：US666701

    申请日：1996-06-18

    申请人： Marco Frigerio ,  Luigi Arnoldi

    发明人： Marco Frigerio ,  Luigi Arnoldi

    IPC分类号： B21C1/14 ,  B21C9/00

    CPC分类号： B21C1/14

    摘要： A takeup drum, particularly for wire drawing machines, having a fluid cooling unit, the drum comprising: a cylindrical body, which is rotatable about a central axis and is supported, through bearings, by the fixed frame of the machine; a chamber that is formed in the body; and a drum cooling unit that is arranged in the chamber. The cooling unit comprises: at least one circular sector that is located proximate to the internal lateral surface of the body and is connected to the fixed frame that supports the cylindrical drum body; and at least one nozzle for introducing the cooling fluid, located proximate to the outer surface of the sector, so as to form a jacket of cooling fluid that flows over the internal lateral surface of the body.

    摘要翻译： 一种卷取滚筒，特别是用于拉丝机，具有流体冷却单元，该滚筒包括：圆筒体，其可绕中心轴线旋转并且通过轴承由该机器的固定框架支撑; 在体内形成的腔室; 以及设置在所述室中的滚筒冷却单元。 所述冷却单元包括：至少一个圆形扇形体，其位于所述主体的内部侧表面附近并且连接到支撑所述圆柱形鼓体的所述固定框架; 以及用于引入冷却流体的至少一个喷嘴，所述喷嘴位于所述扇区的外表面附近，以便形成在所述主体的内侧表面上流动的冷却流体套。