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    PHAGE DISPLAYED CELL BINDING PEPTIDES
    31.
    发明申请
    PHAGE DISPLAYED CELL BINDING PEPTIDES 有权
    PHAGE显示细胞结合肽

    公开(公告)号：US20100137225A1

    公开(公告)日：2010-06-03

    申请号：US12701397

    申请日：2010-02-05

    Applicant: Richard E. Herman ,  Ekaterina G. Makienko ,  Douglas L. Badders ,  Mark Fuller

    Inventor： Richard E. Herman ,  Ekaterina G. Makienko ,  Douglas L. Badders ,  Mark Fuller

    IPC: A61K38/08 ,  C07K1/107 ,  A61P43/00

    CPC classification number: C07K14/001 ,  A61K47/62 ,  C07K2319/035 ,  C07K2319/33 ,  C12N15/1037

    Abstract: This disclosure provides the construction, expression, and selection of the mutated genes that encode novel Trp cage polypeptides with desirable binding properties, as well as the novel Trp cage polypeptides themselves. The substances or targets bound by these novel Trp cage polypeptides may be but need not be proteins or polypeptides. Targets may include other biological or synthetic macromolecules as well as other organic and inorganic substances. Further, targets may also include a single or multiple cell or tissue types. The present invention achieves genetic variants of Trp cage-encoding nucleic acids through controlled random mutagenesis of the nucleic acids yielding a mixture of Trp cage polypeptides that are capable of binding targets.

    Abstract translation: 本公开提供编码具有所需结合特性的新型Trp笼多肽的突变基因的构建，表达和选择，以及新型Trp笼多肽本身。 由这些新型Trp笼多肽结合的物质或靶标可能不一定是蛋白质或多肽。 目标可以包括其他生物或合成大分子以及其它有机和无机物质。 此外，靶也可以包括单个或多个细胞或组织类型。 本发明通过控制随机诱变获得Trp笼编码核酸的遗传变体，产生能够结合靶标的Trp笼多肽的混合物。

    Door core drilling apparatus
    32.
    发明申请
    Door core drilling apparatus 审中-公开
    门式钻孔装置

    公开(公告)号：US20060263154A1

    公开(公告)日：2006-11-23

    申请号：US11407876

    申请日：2006-04-19

    Applicant: Mark Fuller

    Inventor： Mark Fuller

    IPC: B23B39/00

    CPC classification number: B23B49/026 ,  B23B41/02 ,  B23B47/287 ,  B23B2247/06 ,  E05B17/06 ,  Y10T408/563

    Abstract: A method and apparatus for providing a bore across a width of a door to make an interconnection on opposite ends of the door, comprising a head assembly, a hinge mortise fixture assembly, and a drill motor guide assembly. Also, a method and apparatus for providing a bore across a width of a door to make an interconnection on opposite ends of the door, comprising applying a head assembly, a hinge mortise fixture assembly, and a drill motor guide assembly to a door, and drilling a bore into the door.

    Abstract translation: 一种用于在门的宽度上提供孔以在门的相对端上形成互连的方法和装置，包括头部组件，铰链榫眼夹具组件和钻子电动机引导组件。 另外，一种用于在门的宽度上提供孔的方法和装置，以在门的相对端部上形成互连，包括将头部组件，铰链榫眼固定装置和钻子电动机引导组件应用于门，以及 在门上钻一个孔。

    Water display pendant water dropper
    33.
    发明授权
    Water display pendant water dropper 失效
    水显示吊坠水滴

    公开(公告)号：US5603454A

    公开(公告)日：1997-02-18

    申请号：US285621

    申请日：1994-08-02

    Applicant: William Knapp ,  Mark Fuller

    Inventor： William Knapp ,  Mark Fuller

    IPC: B05B1/30 ,  B05B17/08 ,  F16K7/10 ,  F16K31/12

    CPC classification number: F16K7/10 ,  B05B1/30 ,  B05B17/08

    Abstract: A balloon valve that can control the flow of a display fluid through the supply pipe of a water display. The supply pipe is typically suspended from a structure and releases a slug of water into a pool. The pipe is located at a distance from the pool so that the water slug breaks up into a rain shower. The balloon valve includes an inflatable hose located within the supply pipe and coupled to a source of pressurized working fluid. The flow of working fluid into the balloon valve is controlled by a control valve. When the control valve is in a first state, working fluid flows into the balloon valve to expand the hose. The hose is expanded to completely fill a portion of the pipe and prevent the display fluid from flowing through the pipe. When the control valve is in a second state, the balloon valve is deflated so that the display fluid can again flow through the supply pipe and out of the display. The balloon valve is rapidly deflated and inflated to create a slug of water that falls out of the pipe and burst into a rain shower.

    Abstract translation: 一种球囊阀，其可以通过水显示器的供给管来控制显示液的流动。 供应管通常悬挂在结构上，并将一小块水放入池中。 管道距离游泳池有一段距离，这样水球就会分解成淋雨。 气囊阀包括位于供给管内并连接到加压工作流体源的充气软管。 工作流体进入球阀的流量由控制阀控制。 当控制阀处于第一状态时，工作流体流入球囊阀以膨胀软管。 软管膨胀以完全填充管道的一部分，并防止显示液体流过管道。 当控制阀处于第二状态时，气囊阀被放气，使得显示液体可以再次流过供给管并离开显示器。 气球阀迅速放气并充气，以产生从管道中流出并流入雨淋的水。

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