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42 条记录 (耗时 0.026 秒)

    MODIFIED PROTEINS AND PEPTIDES
    32.
    发明申请
    MODIFIED PROTEINS AND PEPTIDES 审中-公开
    改性蛋白和肽

    公开(公告)号：US20140227259A1

    公开(公告)日：2014-08-14

    申请号：US14239196

    申请日：2012-08-13

    申请人： Claire Ashman ,  Mary Birchler ,  Rudolf M.T. De Wildt ,  Claire Holland ,  Alan Peter Lewis ,  Peter Morley ,  Thomas Sandal ,  Michael Steward

    发明人： Claire Ashman ,  Mary Birchler ,  Rudolf M.T. De Wildt ,  Claire Holland ,  Alan Peter Lewis ,  Peter Morley ,  Thomas Sandal ,  Michael Steward

    IPC分类号： C07K16/42

    摘要： The present disclosure relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise C-terminal additions, extensions or tags and/or certain amino acid substitutions. Such modified molecules (e.g., fusions and conjugates) comprise proteins, peptides, antigen binding molecules, antibodies or antibody fragments such as single variable domains. The disclosure further relates to uses and formulations of compositions comprising such modified C-terminally extended and/or amino acid substituted molecules and also to methods of production and expression of these.

    摘要翻译： 本公开涉及具有降低与先前存在的抗体结合的能力的修饰的蛋白质和肽。 这种修饰的蛋白质/肽分子可以包含C-末端添加，延伸或标签和/或某些氨基酸取代。 这样的修饰分子（例如，融合物和缀合物）包含蛋白质，肽，抗原结合分子，抗体或抗体片段，例如单可变结构域。 本公开还涉及包含这种修饰的C-末端延伸和/或氨基酸取代的分子的组合物的用途和制剂，以及这些的生产和表达方法。

    Selectively deployable driving lights
    34.
    发明授权
    Selectively deployable driving lights 失效
    选择性部署的驾驶灯

    公开(公告)号：US06923564B2

    公开(公告)日：2005-08-02

    申请号：US10303131

    申请日：2002-11-25

    申请人： James Michael Steward

    发明人： James Michael Steward

    IPC分类号： B60Q1/05 ,  F21V7/04

    CPC分类号： B60Q1/05

    摘要： An improved system for selectively deploying an auxiliary lighting system in which the vehicle onboard power system is utilized to permit the operator of the vehicle to deploy lamps to an in use position and to stow the same in a protected environment.

    摘要翻译： 一种用于选择性地部署辅助照明系统的改进系统，其中车载车载电力系统被利用以允许车辆的操作者将灯部署到使用位置并将其放置在受保护的环境中。

    Cat immunisation vectors
    35.
    发明申请
    Cat immunisation vectors 审中-公开
    猫免疫载体

    公开(公告)号：US20050154191A1

    公开(公告)日：2005-07-14

    申请号：US10505546

    申请日：2003-02-21

    申请人： Michael Steward

    发明人： Michael Steward

    IPC分类号： C07K14/47 ,  C12N15/12 ,  C07K14/705 ,  C07H21/04

    CPC分类号： C07K14/472 ,  A61K2039/53 ,  A61K2039/6031 ,  C07K2319/00

    摘要： Cat C3d polypeptide, fragments thereof, and nucleic acid sequences encoding the polypeptide and fragments are described. Genetic constructs encoding such polypeptides can be used to enhance the immunogenicity of antigens in cats. Variant nucleic acid sequences encoding cat C3d polypeptides, when used to express tandem arrays of the polypeptide show enhanced stability, leading to high level expression in eukaryotic and prokaryotic cell expression systems. When incorporated into a DNA immunization vector or a recombinant live organism vaccine, the variant sequences have reduced risk of undergoing homologous recombination with genomic DNA compared to wild-type sequences, thus reducing the risk of potentially damaging integration events.

    摘要翻译： 描述了Cat C 3 d多肽，其片段和编码多肽和片段的核酸序列。 编码此类多肽的遗传构建体可用于增强猫中抗原的免疫原性。 当用于表达多肽的串联阵列时，编码猫C 3 d多肽的变体核酸序列表现出增强的稳定性，导致真核和原核细胞表达系统中的高水平表达。 当掺入DNA免疫载体或重组活体生物疫苗时，与野生型序列相比，变体序列具有与基因组DNA进行同源重组的风险降低，从而降低潜在的破坏整合事件的风险。

    Podport and Associated Podways for Unmanned Arial Vehicles
    37.
    发明申请
    Podport and Associated Podways for Unmanned Arial Vehicles 有权

    公开(公告)号：US20220189328A1

    公开(公告)日：2022-06-16

    申请号：US17683677

    申请日：2022-03-01

    申请人： Michael Steward Evans

    发明人： Michael Steward Evans

    IPC分类号： G08G9/00 ,  G08G5/00 ,  G08G1/097 ,  B60L53/00 ,  B61L27/10

    摘要： A transportation system has transport vehicles with electric motors, pods, being enclosed compartments that accommodate cargo, podports, being exchange stations, charging stations, and a computerized transport control system. An authorized person communicates a request to the computerized transport control system to transport a specific cargo from a first location in the geographic area to a second location in the geographic area, the computerized transport control system defines a journey from the first location to the second location, along a route comprising sequential hops through a series of podports and charging stations. The computerized transport control system manages movement of transport vehicles, exchanges at podports, and charging at charging stations along the defined route, and terminates the journey at the second location where the cargo disembarks.

    Intelligent pod management and transport
    39.
    发明授权
    Intelligent pod management and transport 有权

    公开(公告)号：US10443262B2

    公开(公告)日：2019-10-15

    申请号：US16028084

    申请日：2018-07-05

    申请人： Michael Steward Evans

    发明人： Michael Steward Evans

    IPC分类号： E04H14/00 ,  B64F1/31 ,  B60P3/00 ,  B60L53/14 ,  B60L53/30 ,  B61B1/02 ,  B62D31/00 ,  B62D31/02 ,  B62D47/00 ,  B61B3/02 ,  B61B13/00 ,  B60M1/30 ,  H02J7/00

    摘要： An exchange station has openings for drones, a passenger check-in/check-out bay for processing passengers, a drone connect/release bay, having apparatus adapted to manage passenger pods mounted on smart chassis, and a computerized control system in wireless communication with control circuitry in the drones and smart chassis, guiding smart chassis with mounted passenger pods and drones, to make the exchange of pods from the smart chassis to drones. A passenger entering the passenger check-in bay is loaded into a pod mounted on a smart chassis, the pod with passenger is transported to the drone-connect/release bay, and the pod is there joined to a bare drone and disconnected from the smart chassis, the drone leaving with the passenger pod to a destination, and the smart chassis traveling away from the drone connect-release bay.

    Drone transport system
    40.
    发明授权
    Drone transport system 有权

    公开(公告)号：US10207805B2

    公开(公告)日：2019-02-19

    申请号：US15456311

    申请日：2017-03-10

    申请人： Michael Steward Evans

    发明人： Michael Steward Evans

    IPC分类号： B64D9/00 ,  B64C39/02 ,  B64D11/06 ,  G06Q10/02

    摘要： A drone transport system has a carrier pod adapted for carrying a passenger or parcels with the passenger or parcels enclosed, the carrier pod having a first attachment interface at an uppermost extremity, the attachment interface having one or first physical attachment elements, and a flight-enabled drone having a downward-facing second attachment interface having one or more second physical attachment elements compatible with the first physical attachment elements of the carrier pod. The flight-enabled drone is controllable to approach the carrier pod from above, to align and engage the second physical attachment elements with the first physical attachment elements, to lift and carry the pod from one place to another, and to land and disengage the first and second physical attachment elements, leaving the carrier pod at a new place.