公开(公告)号：US06664093B2

公开(公告)日：2003-12-16

申请号：US10273992

申请日：2002-10-21

Applicant: Ming-Hui Wei ,  Chunhua Yan ,  Valentina Di Francesco ,  Ellen M. Beasley

Inventor： Ming-Hui Wei ,  Chunhua Yan ,  Valentina Di Francesco ,  Ellen M. Beasley

IPC: C12N964

CPC classification number: C12N9/6489

Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.

Abstract translation: 本发明提供由人基因组内的基因编码的肽的氨基酸序列，本发明的酶肽。 本发明特别提供分离的肽和核酸分子，鉴定酶肽的直系同源物和旁系同源物的方法，以及鉴定酶肽调节剂的方法。

公开(公告)号：US06649385B2

公开(公告)日：2003-11-18

申请号：US09820004

申请日：2001-03-29

Applicant: Ming-Hui Wei ,  Chunhua Yan ,  Valentina Di Francesco ,  Ellen M. Beasley

Inventor： Ming-Hui Wei ,  Chunhua Yan ,  Valentina Di Francesco ,  Ellen M. Beasley

IPC: C12N900

CPC classification number: C07K16/40 ,  A61K38/00 ,  C12N9/1085 ,  C12Q1/527 ,  C12Y205/01021

Abstract: The present invention provides amino acid sequences of human squalene synthase proteins and nucleic acid sequences encoding these squalene synthase proteins. The present invention provides isolated squalene synthase proteins and encoding nucleic acid molecules, vectors and host cells containing these nucleic acid molecules, and processes for producing the squalene synthase proteins.

Abstract translation: 本发明提供人类角鲨烯合酶蛋白质的氨基酸序列和编码这些角鲨烯合酶蛋白质的核酸序列。 本发明提供了分离的角鲨烯合酶蛋白和编码含有这些核酸分子的核酸分子，载体和宿主细胞，以及产生角鲨烯合酶蛋白的方法。

公开(公告)号：US06613554B2

公开(公告)日：2003-09-02

申请号：US09956993

申请日：2001-09-21

Applicant: Ming-Hui Wei ,  Chunhua Yan ,  Valentina DiFrancesco ,  Ellen M. Beasley

Inventor： Ming-Hui Wei ,  Chunhua Yan ,  Valentina DiFrancesco ,  Ellen M. Beasley

IPC: C12N902

CPC classification number: C12N9/0006 ,  C12Q1/6876

Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.

公开(公告)号：US06482624B2

公开(公告)日：2002-11-19

申请号：US09858664

申请日：2001-05-17

Applicant: Ming-Hui Wei ,  Karen A. Ketchum ,  Valentina Di Francesco ,  Ellen M. Beasley

Inventor： Ming-Hui Wei ,  Karen A. Ketchum ,  Valentina Di Francesco ,  Ellen M. Beasley

IPC: C12N912

CPC classification number: C12N9/1205

Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.

公开(公告)号：US06461846B2

公开(公告)日：2002-10-08

申请号：US09734030

申请日：2000-12-12

Applicant: Chunhua Yan ,  Ming-Hui Wei ,  Karen Ketchum ,  Gennady Merkulov ,  Ellen M Beasley

Inventor： Chunhua Yan ,  Ming-Hui Wei ,  Karen Ketchum ,  Gennady Merkulov ,  Ellen M Beasley

IPC: C12N912

CPC classification number: C12N9/1205 ,  A01K2217/05 ,  A61K38/00

Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.

公开(公告)号：US06441156B1

公开(公告)日：2002-08-27

申请号：US09470443

申请日：1999-12-22

Applicant: Michael Isaac Lerman ,  Farida Latif ,  Ming-Hui Wei ,  Fuh-Mei Duh ,  John Dorrance Minna ,  Yoshitaka Sekido ,  Boning Gao

Inventor： Michael Isaac Lerman ,  Farida Latif ,  Ming-Hui Wei ,  Fuh-Mei Duh ,  John Dorrance Minna ,  Yoshitaka Sekido ,  Boning Gao

IPC: C07H2102

CPC classification number: C07K14/705 ,  A61K38/00

Abstract: The present invention relates to calcium channel compositions and methods of making and using same. In particular, the invention relates to calcium channel alpha2delta (&agr;2&dgr;) subunits and nucleic acid sequences encoding them. These compositions are useful in methods for identifying compounds that modulate the activity of calcium channels and for identifying compounds as therapeutic for disease.

Abstract translation: 本发明涉及钙通道组合物及其制备和使用方法。 特别地，本发明涉及钙通道α2δ（α2delta）亚基和编码它们的核酸序列。 这些组合物可用于鉴定调节钙通道活性并鉴定化合物作为疾病治疗的化合物的方法。

公开(公告)号：US06436684B1

公开(公告)日：2002-08-20

申请号：US09609816

申请日：2000-07-03

Applicant: Trevor Woodage ,  Ming-Hui Wei ,  Chinnappa Kodira ,  Valentina Di Francesco ,  Ellen M. Beasley

Inventor： Trevor Woodage ,  Ming-Hui Wei ,  Chinnappa Kodira ,  Valentina Di Francesco ,  Ellen M. Beasley

IPC: C12N910

CPC classification number: C12N9/13 ,  A61K38/00

Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the proteins of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the proteins of the present invention, and methods of identifying modulators of the proteins of the present invention.

Abstract translation: 本发明提供由人类基因组内的基因编码的肽的氨基酸序列，本发明的蛋白质。 本发明具体提供分离的肽和核酸分子，鉴定本发明蛋白质的直向同源物和旁系同源物的方法，以及鉴定本发明蛋白质调节剂的方法。

公开(公告)号：US07138499B2

公开(公告)日：2006-11-21

申请号：US11108875

申请日：2005-04-19

Applicant: Trevor Woodage ,  Ming-Hui Wei ,  Chinnappa Kodira ,  Valentina Di Francesco ,  Ellen M Beasley

Inventor： Trevor Woodage ,  Ming-Hui Wei ,  Chinnappa Kodira ,  Valentina Di Francesco ,  Ellen M Beasley

IPC: C07K16/40

CPC classification number: C12N9/13 ,  A61K38/00

Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the proteins of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the proteins of the present invention, and methods of identifying modulators of the proteins of the present invention.

公开(公告)号：US07052893B2

公开(公告)日：2006-05-30

申请号：US10224413

申请日：2002-08-21

Applicant: Jane Ye ,  Ming-Hui Wei ,  Valentina Di Francesco ,  Ellen M Beasley

Inventor： Jane Ye ,  Ming-Hui Wei ,  Valentina Di Francesco ,  Ellen M Beasley

IPC: C12N9/16 ,  A61K38/00

CPC classification number: C12N9/16 ,  A01K2217/05

Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.

Abstract translation: 本发明提供由人基因组内的基因编码的肽的氨基酸序列，本发明的酶肽。 本发明特别提供分离的肽和核酸分子，鉴定酶肽的直系同源物和旁系同源物的方法，以及鉴定酶肽调节剂的方法。

公开(公告)号：US06967094B2

公开(公告)日：2005-11-22

申请号：US10199330

申请日：2002-07-22

Applicant: Trevor Woodage ,  Ming-Hui Wei ,  Chinnappa Kodira ,  Valentina Di Francesco ,  Ellen M. Beasley

Inventor： Trevor Woodage ,  Ming-Hui Wei ,  Chinnappa Kodira ,  Valentina Di Francesco ,  Ellen M. Beasley

IPC: A01K67/027 ,  A61K38/00 ,  A61K45/00 ,  A61P3/00 ,  A61P5/06 ,  A61P21/02 ,  A61P25/16 ,  A61P35/00 ,  C07K16/40 ,  C12M1/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12Q1/02 ,  C12Q1/48 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N37/00

CPC classification number: C12N9/13 ,  A61K38/00

Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the proteins of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the proteins of the present invention, and methods of identifying modulators of the proteins of the present invention.