公开(公告)号：US09487507B2

公开(公告)日：2016-11-08

申请号：US14125370

申请日：2012-06-15

Applicant: Carl Brooks ,  Mui Cheung ,  Hilary Schenck Eidam ,  Krista B. Goodman ,  Marlys Hammond ,  Mark A. Hilfiker ,  Jaclyn R. Patterson ,  Patrick Stoy ,  Guosen Ye

Inventor： Carl Brooks ,  Mui Cheung ,  Hilary Schenck Eidam ,  Krista B. Goodman ,  Marlys Hammond ,  Mark A. Hilfiker ,  Jaclyn R. Patterson ,  Patrick Stoy ,  Guosen Ye

IPC: A01N43/76 ,  A61K31/42 ,  C07D263/52 ,  C07D498/00 ,  C07D413/14 ,  C07D413/06 ,  C07D413/08

CPC classification number: C07D413/14 ,  C07D263/52 ,  C07D413/06 ,  C07D413/08

Abstract: The present invention relates to spirocarbamate analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

公开(公告)号：US08927585B2

公开(公告)日：2015-01-06

申请号：US14125367

申请日：2012-06-15

Applicant: Carl Brooks ,  Mui Cheung ,  Krista B. Goodman ,  Marlys Hammond

Inventor： Carl Brooks ,  Mui Cheung ,  Krista B. Goodman ,  Marlys Hammond

IPC: C07D413/06 ,  C07D413/14

CPC classification number: C07D413/14 ,  C07D413/06 ,  C07D413/08

Abstract: The present invention relates to spirocarbamate analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

Abstract translation: 本发明涉及螺氨酸甲酯类似物，含有它们的药物组合物及其作为TRPV4拮抗剂的用途。

公开(公告)号：US08859536B2

公开(公告)日：2014-10-14

申请号：US14118976

申请日：2012-05-18

Applicant: Donghui Qin ,  Mui Cheung ,  Hemant Joshi ,  Raghuram Tangirala ,  Sridhar Reddy Bethi

Inventor： Donghui Qin ,  Mui Cheung ,  Hemant Joshi ,  Raghuram Tangirala ,  Sridhar Reddy Bethi

IPC: C07D498/04 ,  A61K31/519 ,  C07D519/00

CPC classification number: C07D519/00 ,  C07D498/04

Abstract: This invention relates to novel compounds which are inhibitors of acyl coenzymeA: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of diseases related to DGAT-1 dysfunction or where modulation of DGAT-1 activity may have therapeutic benefit including but not limited to obesity, obesity related disorders, hypertriglyceridemia, hyperlipoproteinemia, chylomicronemia, dyslipidemia, non-alcoholic steatohepatitis, diabetes, insulin resistance, metabolic syndrome, hepatitis C virus infection and acne or other skin disorders.

Abstract translation: 本发明涉及作为酰基辅酶A：二酰基甘油酰基转移酶1（DGAT-1）的抑制剂的新化合物，含有它们的药物组合物，其制备方法及其在治疗中用于预防或治疗与DGAT有关的疾病 -1功能障碍或DGAT-1活性的调节可能具有治疗益处，包括但不限于肥胖症，肥胖相关疾病，高甘油三酯血症，高脂蛋白血症，乳糜微粒血症，血脂异常，非酒精性脂肪性肝炎，糖尿病，胰岛素抵抗，代谢综合征，丙型肝炎病毒 感染和痤疮或其他皮肤疾病。

公开(公告)号：US20140135369A1

公开(公告)日：2014-05-15

申请号：US14125367

申请日：2012-06-15

Applicant: Carl Brooks ,  Mui Cheung ,  Krista B. Goodman ,  Marlys Hammond

Inventor： Carl Brooks ,  Mui Cheung ,  Krista B. Goodman ,  Marlys Hammond

IPC: C07D413/14 ,  C07D413/06

CPC classification number: C07D413/14 ,  C07D413/06 ,  C07D413/08

Abstract: The present invention relates to spirocarbamate analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

Abstract translation: 本发明涉及螺氨酸甲酯类似物，含有它们的药物组合物及其作为TRPV4拮抗剂的用途。

公开(公告)号：US20140121206A1

公开(公告)日：2014-05-01

申请号：US14125378

申请日：2012-06-15

Applicant: Carl Brooks ,  Mui Cheung ,  Hilary Schenck Eidam ,  Krista B. Goodman ,  Marlys Hammond ,  Mark A. Hilfiker ,  Tram H. Hoang ,  Jaclyn R. Patterson ,  Patrick Stoy ,  Guosen Ye

Inventor： Carl Brooks ,  Mui Cheung ,  Hilary Schenck Eidam ,  Krista B. Goodman ,  Marlys Hammond ,  Mark A. Hilfiker ,  Tram H. Hoang ,  Jaclyn R. Patterson ,  Patrick Stoy ,  Guosen Ye

IPC: C07D413/14 ,  C07D495/04 ,  C07D417/14

CPC classification number: C07D413/14 ,  C07D417/14 ,  C07D419/14 ,  C07D495/04 ,  C07F9/65583

Abstract: The present invention relates to spirocarbamate compounds of Formula (I) in which R1, (R2)Y, R3, R4, X and A have the meanings given in the specification. The invention further provides pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and relates to their use of these compounds as TRPV4 antagonists in treating or preventing conditions associated with TRPV4 imbalance.

Abstract translation: 本发明涉及其中R1，（R2）Y，R3，R4，X和A具有本说明书中给出的含义的式（I）的螺氨酸甲酯化合物。 本发明还提供含有化合物或其药学上可接受的盐的药物组合物，并且涉及它们在治疗或预防与TRPV4不平衡相关的病症中作为TRPV4拮抗剂的用途。

公开(公告)号：US08450484B2

公开(公告)日：2013-05-28

申请号：US13054834

申请日：2009-07-24

Applicant: Michael Jonathan Bury ,  Mui Cheung ,  Hilary Schenck Eidam ,  Ryan Michael Fox ,  Krista Goodman ,  Eric Steven Manas

Inventor： Michael Jonathan Bury ,  Mui Cheung ,  Hilary Schenck Eidam ,  Ryan Michael Fox ,  Krista Goodman ,  Eric Steven Manas

IPC: C07D401/14 ,  C07D403/14

CPC classification number: A61K31/16 ,  A61K31/405 ,  C07D487/08

Abstract: The present invention relates to diazabicyclo[2.2.1]hept-2-yl analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

Abstract translation: 本发明涉及二氮杂双环[2.2.1]庚-2-基类似物，含有它们的药物组合物及其作为TRPV4拮抗剂的用途。

公开(公告)号：US20130012499A1

公开(公告)日：2013-01-10

申请号：US13635952

申请日：2011-03-23

Applicant: Carl A. Brooks ,  Mui Cheung ,  S. Eidam Hilary ,  Ryan M. Fox ,  Mark A. Hilfiker ,  Eric S. Manas

Inventor： Carl A. Brooks ,  Mui Cheung ,  S. Eidam Hilary ,  Ryan M. Fox ,  Mark A. Hilfiker ,  Eric S. Manas

IPC: C07D401/14 ,  C07D413/14 ,  A61K31/5377 ,  C07D401/06 ,  A61P19/02 ,  A61P9/04 ,  A61P13/10 ,  A61P29/00 ,  A61P9/00 ,  A61P25/00 ,  A61K31/4709 ,  A61K31/55

CPC classification number: C07D401/06 ,  C07D401/14

Abstract: The present invention relates to quinoline analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

Abstract translation: 本发明涉及喹啉类似物，含有它们的药物组合物及其作为TRPV4拮抗剂的用途。

公开(公告)号：US20120277258A1

公开(公告)日：2012-11-01

申请号：US13545029

申请日：2012-07-10

Applicant: Amogh Boloor ,  Mui Cheung ,  Philip Anthony Harris ,  Kevin Hinkle ,  Christopher P. Laudeman ,  Jeffrey Alan Stafford ,  James Marvin Veal

Inventor： Amogh Boloor ,  Mui Cheung ,  Philip Anthony Harris ,  Kevin Hinkle ,  Christopher P. Laudeman ,  Jeffrey Alan Stafford ,  James Marvin Veal

IPC: A61K31/506 ,  A61P35/00

CPC classification number: C07D239/30 ,  C07D231/56 ,  C07D235/08 ,  C07D403/12 ,  C07D413/14

Abstract: Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

Abstract translation: 本文描述了可用作VEGFR2抑制剂的嘧啶衍生物。 所述的发明还包括制备此类嘧啶衍生物的方法以及使用该嘧啶衍生物的方法来治疗过度增殖性疾病。

公开(公告)号：US20110130400A1

公开(公告)日：2011-06-02

申请号：US13054834

申请日：2009-07-24

Applicant: Michael Jonathan Bury ,  Mui Cheung ,  Hilary Schenck Eidam ,  Ryan Michael Fox ,  Krista Goodman ,  Eric Steven Manas

Inventor： Michael Jonathan Bury ,  Mui Cheung ,  Hilary Schenck Eidam ,  Ryan Michael Fox ,  Krista Goodman ,  Eric Steven Manas

IPC: A61K31/5377 ,  C07D487/08 ,  A61K31/407 ,  A61P9/04 ,  A61P13/10 ,  A61P19/02 ,  A61K31/416 ,  A61K31/437 ,  A61K31/428 ,  A61K31/4439 ,  C07D471/04 ,  A61K31/422

CPC classification number: A61K31/16 ,  A61K31/405 ,  C07D487/08

Abstract: The present invention relates to diazabicyclo[2.2.1]hept-2-yl analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

Abstract translation: 本发明涉及二氮杂双环[2.2.1]庚-2-基类似物，含有它们的药物组合物及其作为TRPV4拮抗剂的用途。

公开(公告)号：US20090326029A1

公开(公告)日：2009-12-31

申请号：US12303119

申请日：2007-05-31

Applicant: Kevin Wayne Kuntz ,  Holly Kathleen Emerson ,  Mui Cheung ,  Jennifer Gabriel Badiang

Inventor： Kevin Wayne Kuntz ,  Holly Kathleen Emerson ,  Mui Cheung ,  Jennifer Gabriel Badiang

IPC: A61K31/4184 ,  C07D235/04 ,  A61P35/00

CPC classification number: C07D409/04

Abstract: The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

Abstract translation: 本发明提供苯并咪唑噻吩化合物，其含有它们的药物组合物，其制备方法及其作为药剂的用途。