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公开(公告)号:US20140113916A1
公开(公告)日:2014-04-24
申请号:US14125370
申请日:2012-06-15
申请人: Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
发明人: Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
IPC分类号: C07D413/14 , C07D413/06
CPC分类号: C07D413/14 , C07D263/52 , C07D413/06 , C07D413/08
摘要: The present invention relates to spirocarbamate analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
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公开(公告)号:US09187464B2
公开(公告)日:2015-11-17
申请号:US14125378
申请日:2012-06-15
申请人: Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Tram H. Hoang , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
发明人: Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Tram H. Hoang , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
IPC分类号: C07D263/02 , A61K31/423 , C07D413/14 , C07D417/14 , C07D495/04 , C07F9/6558 , C07D419/14
CPC分类号: C07D413/14 , C07D417/14 , C07D419/14 , C07D495/04 , C07F9/65583
摘要: The present invention relates to spirocarbamate compounds of Formula (I) in which R1, (R2)Y, R3, R4, X and A have the meanings given in the specification. The invention further provides pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and relates to their use of these compounds as TRPV4 antagonists in treating or preventing conditions associated with TRPV4 imbalance.
摘要翻译: 本发明涉及其中R1,(R2)Y,R3,R4,X和A具有本说明书中给出的含义的式(I)的螺氨酸甲酯化合物。 本发明还提供含有化合物或其药学上可接受的盐的药物组合物,并且涉及它们在治疗或预防与TRPV4不平衡相关的病症中作为TRPV4拮抗剂的用途。
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公开(公告)号:US09487507B2
公开(公告)日:2016-11-08
申请号:US14125370
申请日:2012-06-15
申请人: Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
发明人: Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
IPC分类号: A01N43/76 , A61K31/42 , C07D263/52 , C07D498/00 , C07D413/14 , C07D413/06 , C07D413/08
CPC分类号: C07D413/14 , C07D263/52 , C07D413/06 , C07D413/08
摘要: The present invention relates to spirocarbamate analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
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公开(公告)号:US08927585B2
公开(公告)日:2015-01-06
申请号:US14125367
申请日:2012-06-15
申请人: Carl Brooks , Mui Cheung , Krista B. Goodman , Marlys Hammond
发明人: Carl Brooks , Mui Cheung , Krista B. Goodman , Marlys Hammond
IPC分类号: C07D413/06 , C07D413/14
CPC分类号: C07D413/14 , C07D413/06 , C07D413/08
摘要: The present invention relates to spirocarbamate analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
摘要翻译: 本发明涉及螺氨酸甲酯类似物,含有它们的药物组合物及其作为TRPV4拮抗剂的用途。
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公开(公告)号:US20140135369A1
公开(公告)日:2014-05-15
申请号:US14125367
申请日:2012-06-15
申请人: Carl Brooks , Mui Cheung , Krista B. Goodman , Marlys Hammond
发明人: Carl Brooks , Mui Cheung , Krista B. Goodman , Marlys Hammond
IPC分类号: C07D413/14 , C07D413/06
CPC分类号: C07D413/14 , C07D413/06 , C07D413/08
摘要: The present invention relates to spirocarbamate analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
摘要翻译: 本发明涉及螺氨酸甲酯类似物,含有它们的药物组合物及其作为TRPV4拮抗剂的用途。
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公开(公告)号:US20140121206A1
公开(公告)日:2014-05-01
申请号:US14125378
申请日:2012-06-15
申请人: Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Tram H. Hoang , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
发明人: Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Tram H. Hoang , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
IPC分类号: C07D413/14 , C07D495/04 , C07D417/14
CPC分类号: C07D413/14 , C07D417/14 , C07D419/14 , C07D495/04 , C07F9/65583
摘要: The present invention relates to spirocarbamate compounds of Formula (I) in which R1, (R2)Y, R3, R4, X and A have the meanings given in the specification. The invention further provides pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and relates to their use of these compounds as TRPV4 antagonists in treating or preventing conditions associated with TRPV4 imbalance.
摘要翻译: 本发明涉及其中R1,(R2)Y,R3,R4,X和A具有本说明书中给出的含义的式(I)的螺氨酸甲酯化合物。 本发明还提供含有化合物或其药学上可接受的盐的药物组合物,并且涉及它们在治疗或预防与TRPV4不平衡相关的病症中作为TRPV4拮抗剂的用途。
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公开(公告)号:US08114885B2
公开(公告)日:2012-02-14
申请号:US11830608
申请日:2007-07-30
申请人: Amogh Boloor , Mui Cheung , Philip Anthony Harris , Kevin Hinkle , Jeffery Alan Stafford , James Marvin Veal
发明人: Amogh Boloor , Mui Cheung , Philip Anthony Harris , Kevin Hinkle , Jeffery Alan Stafford , James Marvin Veal
IPC分类号: C07D239/48 , A61K31/506 , A61P35/00
CPC分类号: C07D239/30 , C07D231/56 , C07D235/08 , C07D403/12 , C07D413/14
摘要: Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译: 本文描述了可用作VEGFR2抑制剂的嘧啶衍生物。 所述的发明还包括制备此类嘧啶衍生物的方法以及使用该嘧啶衍生物的方法来治疗过度增殖性疾病。
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公开(公告)号:US07858626B2
公开(公告)日:2010-12-28
申请号:US11830024
申请日:2007-07-30
申请人: Amogh Boloor , Mui Cheung , Ronda Gayle Davis-Ward , Philip Anthony Harris , Kevin Hinkle , Christopher P. Lauderman , Robert Anthony Mook, Jr. , Jeffery Alan Stafford , James Marvin Veal
发明人: Amogh Boloor , Mui Cheung , Ronda Gayle Davis-Ward , Philip Anthony Harris , Kevin Hinkle , Christopher P. Lauderman , Robert Anthony Mook, Jr. , Jeffery Alan Stafford , James Marvin Veal
IPC分类号: C07D403/04 , A61K31/53 , A61P35/00
CPC分类号: C07D239/30 , C07D231/56 , C07D235/08 , C07D403/12 , C07D413/14
摘要: Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译: 本文描述了可用作VEGFR2抑制剂的嘧啶衍生物。 所述的发明还包括制备此类嘧啶衍生物的方法以及使用该嘧啶衍生物的方法来治疗过度增殖性疾病。
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公开(公告)号:US20100105712A1
公开(公告)日:2010-04-29
申请号:US12609398
申请日:2009-10-30
申请人: Amogh Boloor , Mui Cheung , Philip Anthony Harris , Kevin Hinkle , Jeffery Alan Stafford , James Marvin Veal
发明人: Amogh Boloor , Mui Cheung , Philip Anthony Harris , Kevin Hinkle , Jeffery Alan Stafford , James Marvin Veal
IPC分类号: A61K31/506 , A61P7/00 , A61P27/10 , C07D403/12
CPC分类号: C07D239/30 , C07D231/56 , C07D235/08 , C07D403/12 , C07D413/14
摘要: Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译: 本文描述了可用作VEGFR2抑制剂的嘧啶衍生物。 所述的发明还包括制备此类嘧啶衍生物的方法以及使用该嘧啶衍生物的方法来治疗过度增殖性疾病。
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公开(公告)号:US20060217382A1
公开(公告)日:2006-09-28
申请号:US10550434
申请日:2004-03-29
申请人: Mui Cheung , Nigel King , Kevin Kuntz , Robert Mook , Mark Pobanz , James Salovich , Brian Wilson
发明人: Mui Cheung , Nigel King , Kevin Kuntz , Robert Mook , Mark Pobanz , James Salovich , Brian Wilson
IPC分类号: A61K31/53 , C07D487/04
CPC分类号: C07D487/04
摘要: The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译: 本发明提供式(I)化合物:其中所有变量如本文所定义,含有该化合物的药物组合物,其制备方法及其作为药剂的用途。
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