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公开(公告)号：US20220316000A1
公开(公告)日：2022-10-06
申请号：US17642166
申请日：2020-09-11
Inventor： Hiroyuki EBINUMA , Hiroaki INOUE , Toru UCHIYAMA
IPC: C12Q1/6851 , C12Q1/686 , C12Q1/6876
Abstract: An object of the invention is to provide an optical detection method and a quantification method of a product obtained by amplifying a target nucleic acid contained in a paper piece of a blood spot in a filter paper obtained by blotting blood on a filter paper and then drying the blood using nucleic acid amplification reaction by real-time PCR and to further provide a kit used for the methods. The invention provides a method and a kit which can optically detect and quantify a target nucleic acid from a dried blood spot in a filter paper by real-time PCR without any complicated pretreatment, by adjusting the size of the punched piece of the dried blood spot in a filter paper or the whole blood amount contained in the punched piece, the amount of the PCR reaction reagent, or performing the PCR reaction in a PCR reaction tube closed with a cap.
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公开(公告)号：US20220285023A1
公开(公告)日：2022-09-08
申请号：US17635042
申请日：2020-08-13
Inventor： Takeshi URAMOTO , Tetsuaki KON , Tomoyoshi SHIROSHITA , Akira MATSUI , Hideki NAKAJIMA , Hiroyuki ABE
Abstract: There is provided a biliary atresia diagnosis support management system including a server, the server including a transmission/reception unit receiving an image of stool from a living body and a determination unit determining whether biliary atresia is contracted or not from the image, wherein the server further includes: a management unit including a usage fee saving unit saving received usage fees and a donation sending unit for sending a donation from the saved usage fees; and a doctor's determination request processing unit requesting a determination by a doctor if the determination unit determines that there is a suspected positive result; and if it is diagnosed that the living body needs treatment for biliary atresia as a result of a thorough examination, the server pays a donation for the treatment from the usage fees saved in the usage fee saving unit via the donation sending unit. According to such a system, not only a determination about biliary atresia is made by software, but also a determination and a thorough examination by a doctor, and treatment after that are supported.
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公开(公告)号：US20220265698A1
公开(公告)日：2022-08-25
申请号：US17631704
申请日：2020-09-10
Inventor： Ko RII , Masayuki FUJINO , Yukiko MORIYA
IPC: A61K31/716 , C07K16/28 , A61P35/00
Abstract: Provided is a composition capable of enhancing the effect of an antibody drug such as an immune checkpoint inhibitor, etc. A β-glucan is used as an active ingredient of a composition for enhancing the effect of an antibody drug. This composition is used suitably for antibody drugs that have an effect of suppressing growth of cancer via immune checkpoint inhibition; e.g., antibody drugs including a monoclonal antibody to PD-L1.
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Patent Agency Ranking
公开(公告)号：US11185561B2
公开(公告)日：2021-11-30
申请号：US15881302
申请日：2018-01-26
Inventor： Yukihiro Ohya , Shigenori Kabashima , Osamu Natsume , Hirohisa Saito
Abstract: The present invention provides an egg allergy prevention method to be carried out with respect to a human infant, including: a first administration period (first administration step) in which to administer, to an infant, heated egg white protein in an amount of 10 mg to 20 mg per day; and a second administration period (second administration step) which is a period after the first administration period and in which to administer, to the infant, the heated egg white protein in an amount of 65 mg to 90 mg per day.
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公开(公告)号：US20200270572A1
公开(公告)日：2020-08-27
申请号：US16808170
申请日：2020-03-03
Inventor： Noriyuki Azuma , Taku Tanaka , Tadashi Yokoi
Abstract: An object of the present invention is to provide a method of inducing pluripotent stem cells to differentiate into clinically applicable retinal ganglion cells.The present invention provides a method for inducing pluripotent stem cells to differentiate into retinal ganglion cells that can be used for clinical application. Such method is a method for producing retinal ganglion cells with elongated axons comprising the following steps: (a) a step of inducing pluripotent stem cells to differentiate into retinal progenitor cells via floating culture; (b) a step of inducing the retinal progenitor cells obtained in step (a) to differentiate into retinal ganglion cells via floating culture; and (c) a step of allowing axons to elongate via adhesion culture of the retinal ganglion cells obtained in step (b).
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公开(公告)号：US09937138B2
公开(公告)日：2018-04-10
申请号：US15064884
申请日：2016-03-09
Inventor： Ko Rii , Kiwamu Takahashi , Naomi Haga , Fuminori Abe , Tohru Tanaka , Motowo Nakajima , Hidenori Ito
IPC: A61K31/195 , A61K31/197 , A61K33/26 , A61K31/22 , A61K31/295 , A61K45/06 , A01N1/02 , A61K35/17 , A61K35/12
CPC classification number: A61K31/197 , A01N1/0226 , A61K31/22 , A61K31/295 , A61K33/26 , A61K35/17 , A61K45/06 , A61K2035/122 , A61K2035/124 , A61K2300/00
Abstract: The present invention provides an agent for promoting graft survival which can suppress rejection without use of existing immunosuppressants, an organ preservation solution capable of maintaining the freshness of an organ excised from a donor, and the like. An agent for promoting graft survival or an organ preservation solution is prepared, which comprises 5-aminolevulinic acid (ALA) or a derivative thereof, or a salt of ALA or the derivative and an iron compound as active ingredients. Preferable examples of the ALAs can include ALA and various esters such as methyl ester, ethyl ester, propyl ester, butyl ester, and pentyl ester of ALA, and their hydrochlorides, phosphates, and sulfates. Preferable examples of the iron compound can include sodium ferrous citrate.
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公开(公告)号：US20160184250A1
公开(公告)日：2016-06-30
申请号：US15064892
申请日：2016-03-09
Inventor： Ko RII , Kiwamu TAKAHASHI , Naomi HAGA , Fuminori ABE , Tohru TANAKA , Motowo NAKAJIMA , Hidenori ITO
IPC: A61K31/197 , A61K33/26 , A01N1/02
CPC classification number: A61K31/197 , A01N1/0226 , A61K31/22 , A61K31/295 , A61K33/26 , A61K35/17 , A61K45/06 , A61K2035/122 , A61K2035/124 , A61K2300/00
Abstract: The present invention provides an agent for promoting graft survival which can suppress rejection without use of existing immunosuppressants, an organ preservation solution capable of maintaining the freshness of an organ excised from a donor, and the like. An agent for promoting graft survival or an organ preservation solution is prepared, which comprises 5-aminolevulinic acid (ALA) or a derivative thereof, or a salt of ALA or the derivative and an iron compound as active ingredients. Preferable examples of the ALAs can include ALA and various esters such as methyl ester, ethyl ester, propyl ester, butyl ester, and pentyl ester of ALA, and their hydrochlorides, phosphates, and sulfates. Preferable examples of the iron compound can include sodium ferrous citrate.
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公开(公告)号：US20030148312A1
公开(公告)日：2003-08-07
申请号：US10205298
申请日：2002-07-24
Inventor： Nei Yoshida , Naoko Nagata , Tadahiro Oshida , Ryoichi Hashida , Yuji Sugita , Hirohisa Saito
IPC: C12Q001/68 , G01N033/53 , G01N033/567 , C07H021/04
CPC classification number: G01N33/5091 , A01K2217/05 , A61K38/00 , A61K48/00 , C07H21/04 , C07K14/47 , C07K14/705 , C07K16/18 , G01N33/5008 , G01N33/502 , G01N33/5023 , G01N33/505 , G01N33/5094 , G01N33/6893 , G01N2333/43556 , G01N2800/122 , G01N2800/24
Abstract: An objective of the present invention is to provide a method for testing for an allergic disease and a method of screening for a therapeutic agent for allergic diseases. MAL was identified as a gene the expression level of which is significantly increased in T cells contained in the peripheral blood monocyte (PBMC) upon stimulation thereof with a mite allergen in vitro. The present inventors found that this gene can be used in testing for allergic diseases and in screening for agents and compounds useful in the treatment of allergic diseases.
Abstract translation: 本发明的目的是提供一种过敏性疾病的检测方法和筛选过敏性疾病的治疗剂的方法。 MAL被鉴定为在体外用螨变应原刺激后，外周血单核细胞（PBMC）中含有的T细胞的表达水平显着升高的基因。 本发明人发现，该基因可用于过敏性疾病的检测和筛选用于治疗过敏性疾病的药剂和化合物。
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