公开(公告)号：US20090171766A1

公开(公告)日：2009-07-02

申请号：US12163978

申请日：2008-06-27

Applicant: Jeremy SCHIFF ,  Justin Fiedler ,  Dominic Antonelli ,  Heston Liebowitz ,  Neil Warren ,  Jonathan Burgstone ,  Sharam Shirazi

Inventor： Jeremy SCHIFF ,  Justin Fiedler ,  Dominic Antonelli ,  Heston Liebowitz ,  Neil Warren ,  Jonathan Burgstone ,  Sharam Shirazi

IPC: G06Q30/00

CPC classification number: G06Q30/02 ,  G06Q30/0244 ,  G06Q30/0273

Abstract: Systems and methods for providing advertisement optimization services are disclosed. In one aspect, embodiments of the present disclosure include a method, which may be implemented on a system, of analyzing a first set of images hosted by the web-publisher for display on the website. One embodiment can include, analyzing metadata associated with a set of advertisements available to the web-publisher for placement on the website, and identifying an advertisement suitable for placement on a webpage of the website for a fee.

Abstract translation: 公开了提供广告优化服务的系统和方法。 在一个方面，本公开的实施例包括可以在系统上实现的方法，该方法分析由web发布者托管的第一组图像以在网站上显示。 一个实施例可以包括：分析与web发布者可用于在网站上放置的一组广告相关联的元数据，以及识别适合于在网站的网页上放置费用的广告。

公开(公告)号：US06906213B1

公开(公告)日：2005-06-14

申请号：US10876492

申请日：2004-06-25

Applicant: Neil Warren Boaz

Inventor： Neil Warren Boaz

IPC: B01J31/18 ,  B01J31/22 ,  C07C51/36 ,  C07C231/18 ,  C07C269/06 ,  C07F9/6571 ,  C07F17/00 ,  C07F17/02 ,  B01J31/00

CPC classification number: C07F17/00 ,  B01J31/2295 ,  B01J31/2495 ,  B01J2231/323 ,  B01J2231/44 ,  B01J2231/52 ,  B01J2231/645 ,  B01J2531/822 ,  B01J2531/842 ,  C07C51/36 ,  C07C231/18 ,  C07C269/06 ,  C07F9/657154 ,  C07F17/02 ,  C07C55/02

Abstract: Disclosed is a process for the preparation of phosphine-aminophosphines that are useful in the formation of catalysts useful in carrying out a wide variety of reactions such as asymmetric hydrogenations, asymmetric reductions, asymmetric hydroborations, asymmetric olefin isomerizations, asymmetric hydrosilations, asymmetric allylations, asymmetric conjugate additions, and asymmetric organometallic additions. The process comprises the steps of (1) contacting a compound of formula 2 R2P—L—NHR3  2 with phosphorus trihalide PX3 in the presence of an inert, organic solvent and an acid acceptor to produce intermediate compound having formula 3 (2) contacting intermediate compound 3 with a reactant having the formula R1—M1, R2—M1 or a mixture thereof.

Abstract translation: 公开了一种制备膦 - 氨基膦的方法，其可用于形成可用于进行各种各样的反应的催化剂，例如不对称氢化，不对称还原，不对称氢化，不对称烯烃异构化，不对称氢化硅，不对称烯丙基化，不对称烯丙基化 共轭添加物和不对称有机金属添加剂。 该方法包括以下步骤：（1）使式2的化合物<？in-line-formula description =“In-Line Formulas”end =“lead”→> R 2 PL-NHR < 在惰性有机物的存在下，使用三卤代磷酸酯PX 3将“3”在线式描述=“In-line Formula”end =“tail”？> 溶剂和酸受体以产生具有式3（2）的中间体化合物，使中间体化合物3与具有式R 1，M 2，R 2， 或其混合物。

公开(公告)号：US06710206B2

公开(公告)日：2004-03-23

申请号：US10414885

申请日：2003-04-16

Applicant: John Clark Hubbs ,  Theresa Sims Barnette ,  Neil Warren Boaz

Inventor： John Clark Hubbs ,  Theresa Sims Barnette ,  Neil Warren Boaz

IPC: C07C6104

CPC classification number: C08G63/005 ,  C07C1/2078 ,  C07C1/213 ,  C07C13/04 ,  C07C17/02 ,  C07C51/09 ,  C07C51/363 ,  C07C51/367 ,  C07C51/377 ,  C07C51/412 ,  C07C67/03 ,  C07C67/313 ,  C07C69/708 ,  C07C2601/02 ,  C07D305/12 ,  C08G63/06 ,  C07C22/00 ,  C07C59/11 ,  C07C65/21 ,  C07C57/26 ,  C07C69/675 ,  C07C69/716

Abstract: Poly(3-cyclopropyl-3-hydroxypropionates) (I) which are useful for the preparation of vinylcyclopropane and cyclopropylacetylene are disclosed. Methods for the preparation of a variety of intermediates obtained from (I) such as 3-cyclopropyl-3-hydroxypropionic acid and esters and salts thereof, 3-cyclopropylacrylic acids and vinylcyclopropane also are disclosed.

Abstract translation: 公开了可用于制备乙烯基环丙烷和环丙基乙炔的聚（3-环丙基-3-羟基丙酸酯）（I）。 还公开了制备从（I）得到的各种中间体如3-环丙基-3-羟基丙酸及其酯和盐，3-环丙基丙烯酸和乙烯基环丙烷的方法。

公开(公告)号：US06610878B1

公开(公告)日：2003-08-26

申请号：US09546817

申请日：2000-04-11

Applicant: John Clark Hubbs ,  Theresa Sims Barnette ,  Neil Warren Boaz

Inventor： John Clark Hubbs ,  Theresa Sims Barnette ,  Neil Warren Boaz

IPC: C07C974

CPC classification number: C08G63/005 ,  C07C1/2078 ,  C07C1/213 ,  C07C13/04 ,  C07C17/02 ,  C07C51/09 ,  C07C51/363 ,  C07C51/367 ,  C07C51/377 ,  C07C51/412 ,  C07C67/03 ,  C07C67/313 ,  C07C69/708 ,  C07C2601/02 ,  C07D305/12 ,  C08G63/06 ,  C07C22/00 ,  C07C59/11 ,  C07C65/21 ,  C07C57/26 ,  C07C69/675 ,  C07C69/716

Abstract: Poly(3-cyclopropyl-3-hydroxypropionates) (I) which are useful for the preparation of vinylcyclopropane and cyclopropylacetylene are disclosed. Methods for the preparation of a variety of intermediates obtained from (I) such as 3-cyclopropyl-3-hydroxypropionic acid and esters and salts thereof, 3-cyclopropylacrylic acid, and vinylcyclopropane also are disclosed.

Abstract translation: 公开了可用于制备乙烯基环丙烷和环丙基乙炔的聚（3-环丙基-3-羟基丙酸酯）（I）。 还公开了制备从（I）得到的各种中间体如3-环丙基-3-羟基丙酸及其酯和盐，3-环丙基丙烯酸和乙烯基环丙烷的方法。

公开(公告)号：US06552217B2

公开(公告)日：2003-04-22

申请号：US09897872

申请日：2001-07-02

Applicant: John Clark Hubbs ,  David Carl Attride ,  Neil Warren Boaz ,  James Charles Ciula ,  John Thorton Maddox ,  Thomas Nabih ,  William Dell Nottingham ,  David Chris Spencer

Inventor： John Clark Hubbs ,  David Carl Attride ,  Neil Warren Boaz ,  James Charles Ciula ,  John Thorton Maddox ,  Thomas Nabih ,  William Dell Nottingham ,  David Chris Spencer

IPC: C07C6974

CPC classification number: C07C209/56 ,  C07C67/00 ,  C07C67/307 ,  C07C67/317 ,  C07C2601/02 ,  C07C69/74 ,  C07C69/63 ,  C07C211/35

Abstract: Disclosed is a 4-step process for the preparation of alkyl esters of 1-methylcyclopropanecarboxylic acid which comprises the steps of (1) converting &ggr;-butyrolactone to &agr;-methyl-&ggr;-butyrolactone; (2) converting the &agr;-methyl-&ggr;-butyrolactone from step (1) to an alkyl 4-halo-2-methylbutyrate; (3) producing a xylene solution of the alkyl 4-halo-2-methylbutyrate; and (4) contacting the xylene solution of an alkyl 4-halo-2-methylbutyrate from step (3) with an alkali metal alkoxide under conditions of temperature and pressure which causes vaporization of (i) an alkanol as it is formed and (ii) an alkyl 1-methylcyclopropanecarboxylate as it is formed from the alkyl 4-halo-2-methylbutyrate. Also disclosed are processes whereby the alkyl 1-methylcyclopropanecarboxylate, prepared as described above, is converted to 1-methylcyclopropylamine.

公开(公告)号：US5886214A

公开(公告)日：1999-03-23

申请号：US839477

申请日：1997-04-14

Applicant: Neil Warren Boaz

Inventor： Neil Warren Boaz

IPC: C07B57/00 ,  C07C33/03 ,  C07C67/283 ,  C07C69/14 ,  C07C69/157 ,  C07C7/02

CPC classification number: C07C67/283

Abstract: The catalytic asymmetric hydrogenation of enol esters with a vinyllic or acetylenic substituent proceeds with extremely high enantioselectivity using a Rhodium-chiral bisphosphine catalyst. This is at variance with the hydrogenation of enol esters bearing a saturated substituent, which are hydrogenated with only marginal enantioselectivity under the same conditions.

Abstract translation: 烯醇酯与乙烯基或炔属取代基的催化不对称氢化使用铑手性双膦催化剂进行极高的对映选择性。 这与具有饱和取代基的烯醇酯的氢化不同，在相同条件下氢化仅具有边际对映选择性。

公开(公告)号：US09308366B2

公开(公告)日：2016-04-12

申请号：US13291728

申请日：2011-11-08

Applicant: Neil Warren ,  Robin Crossley ,  Steven Brown ,  Andrew Cheer

Inventor： Neil Warren ,  Robin Crossley ,  Steven Brown ,  Andrew Cheer

IPC: B03C3/38 ,  A61N1/20 ,  A61B18/00 ,  B03C3/41 ,  A61B17/32 ,  A61B18/02 ,  A61B18/14 ,  A61B18/20

CPC classification number: A61N1/20 ,  A61B17/320068 ,  A61B18/00 ,  A61B18/02 ,  A61B18/1445 ,  A61B18/20 ,  A61B2018/00083 ,  A61B2018/00601 ,  A61B2018/1497 ,  A61B2218/008 ,  B03C3/383 ,  B03C3/41 ,  B03C2201/10 ,  B03C2201/26

Abstract: Disclosed is apparatus 100 for the reduction or removal of smoke particles suspended in a local atmosphere A and resulting from a surgical procedure, the apparatus including or comprising two electrodes 140 and 150 each in electrical communication with or being electrically connectable to opposite poles of a source of high voltage dc electricity. A first of the electrodes 140 may be electrically connectable to a patient P. and a second 150 may be positionable within or adjacent a patient such that the two electrodes, when in communication with opposite poles of said high voltage, ionize said particles in use, for attracting said particles toward the patient or toward the second of the electrodes.

Abstract translation: 公开了用于减少或去除悬浮在局部气氛A中并由外科手术产生的烟雾颗粒的装置100，该装置包括或包括两个电极140和150，两个电极140和150各自与源极的相反极电连通或可电连接 的高压直流电。 电极140中的第一个可以电连接到患者P.并且第二个150可以位于患者体内或邻近患者的位置，使得两个电极在与所述高电压的相反极连通时在使用中离子化所述粒子， 用于将所述颗粒吸引到患者或朝向第二电极。

公开(公告)号：US20130177951A1

公开(公告)日：2013-07-11

申请号：US13345028

申请日：2012-01-06

Applicant: Christopher Harlan Burk ,  Neil Warren Boaz ,  Stephanie Kay Clendennen

Inventor： Christopher Harlan Burk ,  Neil Warren Boaz ,  Stephanie Kay Clendennen

IPC: C12P13/00

CPC classification number: C07C213/06 ,  C11D1/62 ,  C12P13/001 ,  C07C219/06

Abstract: A process for producing surface-active quaternary ammonium esters is provided. These esters are advantageously prepared in high yield and purity by a chemo-enzymatic process. These compounds have excellent surfactant properties.

Abstract translation: 提供了一种生产表面活性季铵酯的方法。 这些酯通过化学酶法有利地以高产率和纯度制备。 这些化合物具有优异的表面活性剂性能。

公开(公告)号：US20120277324A1

公开(公告)日：2012-11-01

申请号：US13096221

申请日：2011-04-28

Applicant: Christopher Harlan Burk ,  Stephanie Kay Clendennen ,  Neil Warren Boaz

Inventor： Christopher Harlan Burk ,  Stephanie Kay Clendennen ,  Neil Warren Boaz

IPC: A61K47/18 ,  C07D203/10 ,  C12P13/04 ,  C10M129/72 ,  A01N25/30 ,  C11D1/66 ,  C09K3/00 ,  C07C227/14 ,  A61K8/44

CPC classification number: C11D1/90 ,  C07C229/12

Abstract: A variety of betaine esters, including dial kylaminoalkyl cocoate betaines. These betaines were advantageously prepared in high yield and purity by a three-step chemoenzymatic process. These betaine esters have excellent surfactant properties.

Abstract translation: 各种甜菜碱酯，包括拨号基氨基烷基椰油酸甜菜碱。 这些甜菜碱有利地通过三步化学酶法以高产率和纯度制备。 这些甜菜碱酯具有优异的表面活性剂特性。

公开(公告)号：US20120059056A1

公开(公告)日：2012-03-08

申请号：US12975562

申请日：2010-12-22

Applicant: Neil Warren Boaz

Inventor： Neil Warren Boaz

IPC: A61K8/37 ,  A61Q19/00 ,  C07C69/96

CPC classification number: A61K8/37 ,  A61K2800/522 ,  A61Q19/02 ,  A61Q19/08 ,  C07C68/02 ,  C07C69/96

Abstract: Carbonates of anti-aging ingredients, in particular anti-oxidants and skin illuminating phenol ingredients, have been prepared as derivatives of these ingredients with enhanced physical properties. It has been demonstrated that these carbonates will hydrolyze under enzymatic catalysis to release the parent ingredient. In contrast, esters of the phenolic groups in many cases do not hydrolyze under the same conditions.

Abstract translation: 已经制备了抗衰老成分的碳酸盐，特别是抗氧化剂和皮肤照射酚成分，作为具有增强物理性质的这些成分的衍生物。 已经证明这些碳酸酯将在酶催化下水解以释放母体成分。 相反，在许多情况下酚基的酯在相同的条件下不会水解。