公开(公告)号：US20240352123A1

公开(公告)日：2024-10-24

申请号：US18715007

申请日：2022-12-02

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  UNIVERSITY OF MARYLAND BALTIMORE, OFFICE OF TECHNOLOGY TRANSFER

Inventor： Tim C. Luetkens ,  Erica Vander Mause ,  Djordje Atanackovic

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  C07K14/705 ,  C07K14/725 ,  C07K14/73

CPC classification number: C07K16/2803 ,  A61K39/3955 ,  A61K39/4611 ,  A61K39/4631 ,  A61K39/464411 ,  A61K45/06 ,  A61P35/00 ,  C07K14/70503 ,  C07K14/7051 ,  C07K14/70514 ,  C07K14/70521 ,  C07K14/70578 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/30 ,  C07K2319/42

Abstract: Disclosed are chimeric antigen receptor (CAR) polypeptides comprising a CD229 antigen binding domain, a transmembrane domain, and an intracellular signaling domain, wherein the CD229 binding domain is a variant CD229 antigen binding domain. Disclosed are chimeric antigen receptor (CAR) polypeptides comprising a CD229 antigen binding domain, a transmembrane domain, and an intracellular signaling domain, wherein the CD229 antigen binding domain comprises the sequence of SEQ ID NO:134, SEQ ID NO:53, or SEQ ID NO:84. Disclosed are methods of using the CAR polypeptides or antibodies comprising the same CD229 antigen binding domain as the CAR polypeptides.

公开(公告)号：US20220367561A1

公开(公告)日：2022-11-17

申请号：US17745753

申请日：2022-05-16

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Office of Technology Transfer

Inventor： Xianhe LIU ,  Yi SUN ,  Yakshita MALHOTRA ,  Ayush PANDEY ,  Ping WANG ,  Yuanpeng WU ,  Kai SUN ,  Zetian MI

IPC: H01L27/15

Abstract: In various embodiments, the present disclosure includes a nitrogen-polar (N-polar) nanowire that includes an indium gallium nitride (InGaN) quantum well formed by selective area growth. It is noted that the N-polar nanowire is operable for emitting light.

公开(公告)号：US11426415B2

公开(公告)日：2022-08-30

申请号：US16491826

申请日：2018-03-06

Applicant: Washington University ,  The United States of America, As Represented by the Secretary, Department of Health and Human Services, Office of Technology Transfer, National Institutes of Health

Inventor： Fumihiko Urano ,  Jana Mahadevan ,  Amy Clark ,  Ajit Jadhav ,  David Maloney ,  Brandon Harvey ,  Shyh-ming Yang ,  Mark Henderson

IPC: A61K31/554 ,  A61K9/00 ,  A61K31/155 ,  A61K31/4178 ,  A61K31/4985 ,  A61K45/06 ,  C07K14/605

Abstract: The present invention generally relates to compositions and methods for treating or preventing an endoplasmic reticulum stress disorder in subjects, including compositions and methods for treating or preventing Wolfram syndrome. The present invention also relates to methods for treating symptoms of neurodegenerative diseases.

公开(公告)号：US11384131B2

公开(公告)日：2022-07-12

申请号：US15930057

申请日：2020-05-12

Applicant: The Board of Trustees of the Leland Stanford Junior University ,  United States Department of Health and Human Services, Office of Technology Transfer, National Institutes of Heath

Inventor： Christopher K. Garcia ,  Suman Mitra ,  Warren J. Leonard ,  Aaron M. Ring

IPC: A61K38/00 ,  C07K14/55

Abstract: Novel human interleukin-2 (IL-2) muteins or variants thereof are provided. In particular, provided are IL-2 muteins that have an increased binding capacity for IL-2Rβ receptor and a decreased binding capacity for IL-2Rγc receptor, as compared to wild-type IL-2. Such IL-2 muteins are useful, for example, as IL-2 partial agonist and antagonists in applications where reduction or inhibition of one or more IL-2 and/or IL-15 functions is useful (e.g., in the treatment of graft versus host disease (GVHD) and adult T cell leukemia). Also provided are nucleic acids encoding such IL-2 muteins, methods of making such IL-2 muteins, pharmaceutical compositions that include such IL-2 muteins and methods of treatment using such pharmaceutical compositions.

公开(公告)号：US20210060229A1

公开(公告)日：2021-03-04

申请号：US17013187

申请日：2020-09-04

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN OFFICE OF TECHNOLOGY TRANSFER

Inventor： Sunitha Nagrath ,  Tae Hyun Kim ,  Daniel F. Hayes

IPC: A61M1/36 ,  A61K31/727

Abstract: An apparatus for capturing circulating tumor cells (CTCs) from blood. The apparatus includes a wearable device that receives fluid from vasculature of a subject through an input channel. A pump is coupled to the input channel the pump configured to receive blood at a first flow rate and to convert the flow of the blood to a second flow rate. The device further includes a replaceable candidate cell capture module having a microfluidic capture stage with herringbone channel structures configured to capture the candidate cells by antibodies. The device is further configured to provide the blood back to the vasculature of the subject.

公开(公告)号：US20200146610A1

公开(公告)日：2020-05-14

申请号：US16450895

申请日：2019-06-24

Applicant: Galiana Technology Inc. ,  National Institutes of Health, Office of Technology Transfer

Inventor： Bruce T Hope ,  Mark A Wells ,  Gregory D Sutton

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/07

Abstract: An intracellular monitoring device (IMD) that fits completely inside a living cell, and causes no significant impairment, to a cell's normal biological processes. The IMD monitors a cell for its level of a biological substance (e.g., calcium ion concentration) of interest. If the biological substance reaches or exceeds a threshold, the IMD transmits an electromagnetic signal, received by an antenna outside the cell. Each IMD has its electromagnetic signal encoded with a unique frequency. Detection of the frequency components, in the signals received by an antenna, permits identification of the source IMD's. A high calcium ion concentration is indicative of a strongly-activated cerebral cortex neuron. Brain tissue is relatively transparent to near infrared, making it a good frequency band, for the electromagnetic signals from neuron-monitoring IMD's. The near infrared of each IMD can be produced by quantum dots, powered by bioelectric catalysis triggered by high calcium ion concentration.

公开(公告)号：US10393831B2

公开(公告)日：2019-08-27

申请号：US15309336

申请日：2015-05-07

Applicant: Joseph A. Murphy-Boesch ,  Stephen Dodd ,  Chunqi Qian ,  Alan Koretsky ,  OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH

Inventor： Joseph A. Murphy-Boesch ,  Stephen Dodd ,  Chunqi Qian ,  Alan Koretsky

IPC: G01R33/36 ,  G01R33/561

Abstract: A novel MRI-compatible amplifier design uses positive feedback from a low-noise Field-Effect Transistor to amplify the signal current within a resonant NMR coil. The amplified signal current in this low-power circuit produces RF flux can be coupled out to receiving loops positioned externally without significant loss in sensitivity. In other aspects, the amplifier may be remotely powered by external resonant loops, a small non-magnetic battery, or optical power, such that the NMR coil can be positioned during highly invasive procedures such as for surgical resection of tumors in deep-lying tissues to develop high-resolution images.

公开(公告)号：US20170224322A1

公开(公告)日：2017-08-10

申请号：US15437183

申请日：2017-02-20

Applicant: Emory University, Office of Technology Transfer

Inventor： John D. Puskas ,  Kelly Kloster Hon ,  Erick Eladio Rio ,  Brian Wong-Shui ,  Mark Joseph Moneypenny

IPC: A61B17/02

CPC classification number: A61B17/0206 ,  A61B1/32

Abstract: Devices and methods for sternal retraction that reduces bleeding from the cut edges of a sternum and reduces fracturing of the sternum during retraction. The devices and methods involve the use of sternal retractor blades having a certain geometry and inserts placed inside the sternal retractor blades during retraction of the sternotomy incision. The blades and inserts act to tamponade the blood flow from the cut sternal edge and reduce fracturing of the sternum during retraction.

公开(公告)号：US20160073946A1

公开(公告)日：2016-03-17

申请号：US14834334

申请日：2015-08-24

Applicant: Galiana Technology Inc. ,  National Institutes of Health, Office of Technology Transfer

Inventor： Bruce T Hope ,  Mark A Wells ,  Gregory D. Sutton

IPC: A61B5/00 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/07

CPC classification number: A61B5/4064 ,  A61B5/0031 ,  A61B5/076 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/6868 ,  A61B2560/0204 ,  A61B2562/028

Abstract: An intracellular monitoring device (IMD) that fits completely inside a living cell, and causes no significant impairment, to a cell's normal biological processes. The IMD monitors a cell for its level of a biological substance (e.g., calcium ion concentration) of interest. If the biological substance reaches or exceeds a threshold, the IMD transmits an electromagnetic signal, received by an antenna outside the cell. Each IMD has its electromagnetic signal encoded with a unique frequency. Detection of the frequency components, in the signals received by an antenna, permits identification of the source IMD's. A high calcium ion concentration is indicative of a strongly-activated cerebral cortex neuron. Brain tissue is relatively transparent to near infrared, making it a good frequency band, for the electromagnetic signals from neuron-monitoring IMD's. The near infrared of each IMD can be produced by quantum dots, powered by bioelectric catalysis triggered by high calcium ion concentration.

Abstract translation: 细胞内监测装置（IMD）完全适合活细胞，不会对细胞的正常生物过程造成重大损伤。 IMD监测细胞的感兴趣的生物物质水平（例如钙离子浓度）。 如果生物物质达到或超过阈值，则IMD将由电天线外的天线接收的电磁信号传输。 每个IMD的电磁信号都以独特的频率进行编码。 在天线接收到的信号中检测频率分量可以识别源IMD。 高钙离子浓度表示强烈激活的大脑皮层神经元。 脑组织对近红外线相对透明，使其成为良好的频带，用于来自神经元监测IMD的电磁信号。 每个IMD的近红外线可以通过量子点产生，由高钙离子浓度触发的生物电催化作用。

公开(公告)号：US20140010802A1

公开(公告)日：2014-01-09

申请号：US13969986

申请日：2013-08-19

Applicant: University of Hawaii, Office of Technology Transfer and Economic Development ,  Institute for Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center ("Fox Chase C

Inventor： Joseph R. Testa ,  Michele Carbone ,  Mitchell Cheung ,  Jianming Pei

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/156

Abstract: Systems, methods, and computer readable media for diagnosing or characterizing a genetic predisposition to develop cancer, including cancers of the BAP1 cancer syndrome, are provided. Nucleic acids comprising a germline nucleic acid sequence encoding the BRCA1 associated protein 1 (BAP1) are sequenced or probed to determine if the nucleic acid sequence includes alterations that predispose a subject to develop cancer.

Abstract translation: 提供用于诊断或表征发展癌症的遗传易感性的系统，方法和计算机可读介质，包括BAP1癌症综合征的癌症。 包含编码BRCA1相关蛋白1（BAP1）的种系核酸序列的核酸被测序或探测，以确定核酸序列是否包括倾向于使受试者发展为癌症的改变。