公开(公告)号：US20230382920A1

公开(公告)日：2023-11-30

申请号：US18027648

申请日：2021-09-23

Applicant: The Trustees of Princeton University

Inventor： Hahn Kim ,  Joshua D. Rabinowitz

IPC: C07D491/052 ,  A61K45/06

CPC classification number: C07D491/052 ,  A61K45/06

Abstract: Provided herein is a compound of the following structural formula: or a pharmaceutically acceptable salt thereof, wherein values for the variables are as described herein. Also provided herein are compositions comprising a compound of structural formula (I), or a pharmaceutically acceptable salt thereof, and methods of treating a disease, disorder or condition associated with serine hydroxymethyl transferase (SHMT) activity, e.g., cancer, an autoimmune disorder, fibrosis and/or a fibrotic disease, in a subject in need thereof with a compound of structural formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11815450B2

公开(公告)日：2023-11-14

申请号：US17689579

申请日：2022-03-08

Applicant: The Trustees of Princeton University

Inventor： Chu C. Teng ,  Gerard Wysocki

IPC: G01N21/31

CPC classification number: G01N21/31 ,  G01N2201/0231 ,  G01N2201/0612 ,  G01N2201/12

Abstract: Disclosed are a system and method for active stabilization of parasitic fringes in optical spectrometers, wherein the spectrometer obtains the transmission spectrum, and a signal processor extracts the etalon drift from the spectral signatures of parasitic fringes. The disclosed approach improves spectrometer accuracy, minimizes drift, and increases time between calibrations.

公开(公告)号：US20230356169A1

公开(公告)日：2023-11-09

申请号：US18223343

申请日：2023-07-18

Applicant: TheTrustees of Princeton University

Inventor： Robert K. PRUD'HOMME ,  Robert F. Pagels ,  Chester E. Markwalter

IPC: B01J13/02 ,  C08J3/21 ,  C08J3/215 ,  C08J3/22 ,  B01J13/22 ,  C08G81/02 ,  B01J13/14

CPC classification number: B01J13/025 ,  C08J3/212 ,  C08J3/215 ,  C08J3/226 ,  B01J13/22 ,  C08G81/025 ,  C08G81/027 ,  B01J13/14 ,  B82Y40/00

Abstract: A method for controlling the encapsulation efficiency and burst release of water soluble molecules from nanoparticle and microparticle formulations produced by the inverted Flash NanoPrecipitation (iFNP) process and subsequent processing steps is presented. The processing steps and materials used can be adjusted to tune the encapsulation efficiency and burst release of the encapsulated water-soluble material. The encapsulation efficiency of the soluble agent in the particles and the burst release of the soluble agent from the particles can be controlled by: (1) the copolymers used in the assembly or coating process, (2) the degree of crosslinking of the nanoparticle core, (3) the incorporation of small molecule or polymeric additives, and/or (4) the processing and release conditions employed.

公开(公告)号：US11807563B2

公开(公告)日：2023-11-07

申请号：US17280501

申请日：2019-09-27

Applicant: The Trustees of Princeton University

Inventor： Peter R. Jaffe

IPC: C02F3/34 ,  B09C1/10 ,  C02F11/02 ,  C02F101/36

CPC classification number: C02F3/342 ,  B09C1/10 ,  C02F11/02 ,  C02F2101/36

Abstract: Microbial reactors are provided for ammonium oxidation. Briefly, a reactor comprises a medium including an ammonium component and a Feammox bacterium and/or enzyme(s) thereof capable of oxidizing ammonium with electron transfer to an anode in contact with the medium. As described further herein, use of the anode as an electron acceptor can mitigate or overcome the disadvantages associated Fe(III) acceptor. In some embodiments, for example, ammonium oxidation in the reactor can proceed in the absence of Fe(III) and/or other metal compounds operable to function as an electron acceptor in the medium. Moreover, the medium may further comprise one more contaminants in addition to the ammonium component.

公开(公告)号：US11803974B2

公开(公告)日：2023-10-31

申请号：US17282818

申请日：2019-10-04

Applicant: The Trustees of Princeton University

Inventor： Joshua W. Shaevitz ,  Mala Murthy ,  Talmo D. Pereira ,  Diego E. Aldarondo

IPC: G06T7/246 ,  G06F3/04845 ,  G06N3/04 ,  G06N3/08 ,  G06V40/10 ,  G06V20/40 ,  G06F18/23213 ,  G06V10/764 ,  G06V10/82 ,  G06V10/50 ,  G06V40/20

CPC classification number: G06T7/246 ,  G06F3/04845 ,  G06F18/23213 ,  G06N3/04 ,  G06N3/08 ,  G06T7/251 ,  G06V10/50 ,  G06V10/764 ,  G06V10/82 ,  G06V20/46 ,  G06V40/10 ,  G06V40/20 ,  G06T2207/10016 ,  G06T2207/20101

Abstract: Disclosed are a system and method for quantifying changes in animal posture from video recordings of multiple interacting animals. Also disclosed are a system and method for training a posture identification algorithm efficiently with minimal human effort and evaluating the posture of millions of animal images. The disclosed process employs video recordings of behaving animals to produce a full set of geometrical coordinates for each body part over time. Inter alia, the disclosed system should be useful for organizations interested in doing large small-molecule screens to find drugs that affect the behavior of animals, and for those investigating new behavioral diagnostics for human patients. The disclosed system allows one to record video of animals and then automatically calculate the position of each body part over time. The output of this calculation can be used for simple analysis of the amount of movement for specific body parts, or part of a more complex scheme for measuring behaviors.

公开(公告)号：US20230330142A1

公开(公告)日：2023-10-19

申请号：US18017849

申请日：2021-08-12

Applicant: The Regents of the University of California ,  THE TRUSTEES OF PRINCETON UNIVERSITY ,  THE SIMONS FOUNDATION, INC.

Inventor： Ruth DANNENFELSER ,  Gregory ALLEN ,  Olga G. TROYANSKAYA ,  Wendell A. LIM

IPC: A61K35/17 ,  C07K14/725 ,  A61P35/00

CPC classification number: A61K35/17 ,  C07K14/7051 ,  A61P35/00

Abstract: The present disclosure provides immune cells genetically modified to produce two antigen-triggered polypeptides, each recognizing a different cell surface antigen, wherein the two different cell surface antigens employed are selected from those pairs described herein. The present disclosure further provides systems comprising two antigen-triggered polypeptides (or nucleic acids encoding same), each recognizing a different cell surface antigen, wherein the two different cell surface antigens employed are selected from those pairs described herein. Also provided are method of killing a target cancer cell, using the described genetically modified immune cells and/or systems. The present disclosure also provides polyspecific-immune inducing polypeptides including first and second antigen binding domains specific for first and second antigens, respectively, present on the surface of a target cancer cell.

公开(公告)号：US20230289473A1

公开(公告)日：2023-09-14

申请号：US18009765

申请日：2021-06-17

Applicant: The Trustees of Princeton University

Inventor： Sanjeev ARORA ,  Kai LI ,  Yangsibo HUANG ,  Zhao SONG ,  Danqi CHEN

IPC: G06F21/62 ,  G06F21/60 ,  G06N3/098

CPC classification number: G06F21/6254 ,  G06F21/602 ,  G06N3/098

Abstract: According to various embodiments, a method for encrypting image data for a neural network are disclosed. The method includes mixing the image data with other datapoints to form mixed data; and applying a pixel-wise random mask to the mixed data to form encrypted data. According to various embodiments, a method for encrypting text data for a neural network for natural language processing is disclosed. The method includes encoding each text datapoint via a pretrained text encoder to form encoded datapoints; mixing the encoded datapoints with other encoded datapoints to form mixed data; applying a random mask to the mixed data to form encrypted data; and incorporating the encrypted data into training a classifier of the neural network and fine-tuning the text encoder.

公开(公告)号：US20230284629A1

公开(公告)日：2023-09-14

申请号：US18247028

申请日：2021-09-28

Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY ,  ORTHOBOND CORPORATION

Inventor： Jeffrey Schwartz ,  Carlos E. Caicedo-Carvajal ,  Gregorg E. Lutz ,  Siyang Yang

IPC: A01N59/20 ,  A01N25/34 ,  A01N59/16 ,  A01P1/00

CPC classification number: A01N59/20 ,  A01N25/34 ,  A01N59/16 ,  A01P1/00

Abstract: Disclosed are methods of forming an antimicrobial and/or antiviral metal coating on a substrate comprising surface groups that bond to a metal alkoxide to form a 3-dimensional metal oxide/alkoxide adhesion layer. The methods include A) soaking or spraying a substrate comprising a 3-dimensional metal oxide/alkoxide layer with a solution of a transition metal salt, and reduction of the transition metal salt to form a continuous network of transition metal within the 3-D layer, or B) soaking or spraying a substrate comprising a 3-dimensional metal oxide/alkoxide layer with a solution of a post-transition metal salt, sintering at high temperature to form a continuous post-transition metal network within the 3-D layer, and electrolyzing to replace post-transition metal with a transition metal.

公开(公告)号：US20230273282A1

公开(公告)日：2023-08-31

申请号：US17920202

申请日：2021-04-21

Applicant: The Trustees of Princeton University

Inventor： Alexei GOUN ,  Herschel RABITZ

IPC: G01R33/44 ,  G01R33/34 ,  G01R33/36

CPC classification number: G01R33/441 ,  G01R33/34015 ,  G01R33/3607

Abstract: Systems and methods are described, and one method includes illuminating a target-of-interest (TI) with an RF energy configured to effect, over a time duration extending from a first time to a second time, an increase in a temperature of the TI. At a first detection time within the time duration, a first temperature NQR signal spectrum of the TI is detected, and a corresponding first temperature NQR spectrum data set is generates. At a second detection time, subsequent to the first detection time, a second temperature NQR signal spectrum of the TI is detected and corresponding second temperature NQR spectrum data set is output. Based at least in part on the first temperature NQR spectral dataset and the second temperature NQR spectral dataset, the TI is classified between including the SI and not including the SI.

公开(公告)号：US20230255997A1

公开(公告)日：2023-08-17

申请号：US18003753

申请日：2021-07-15

Applicant: The Trustees of Princeton University

Inventor： Joshua D. Rabinowitz ,  Lifeng Yang

IPC: A61K31/7068 ,  A61K31/337 ,  A61K31/519 ,  A61K33/243 ,  A61P1/18 ,  A61P35/04 ,  A61P1/00 ,  A61P35/00 ,  A61K45/06 ,  A23L33/00

CPC classification number: A61K31/7068 ,  A61K31/337 ,  A61K31/519 ,  A61K33/243 ,  A61P1/18 ,  A61P35/04 ,  A61P1/00 ,  A61P35/00 ,  A61K45/06 ,  A23L33/30

Abstract: Disclosed herein are methods for treating cancer, particularly gastrointestinal cancers, such as pancreatic cancer and colon cancer, with chemotherapeutic agent(s) in subjects on a ketogenic diet or a ketone supplement or both.