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83 条记录 (耗时 0.081 秒)

    Oxime and hydroxylamine substituted thiazolo[4,5-c] ring compounds and methods
    31.
    发明授权
    Oxime and hydroxylamine substituted thiazolo[4,5-c] ring compounds and methods 失效
    肟和羟胺取代的噻唑并[4,5-c]环化合物和方法

    公开(公告)号：US08378102B2

    公开(公告)日：2013-02-19

    申请号：US11884060

    申请日：2006-02-08

    申请人： Gregory D. Lundquist, Jr. ,  Tushar A. Kshirsagar ,  Philip D. Heppner

    发明人： Gregory D. Lundquist, Jr. ,  Tushar A. Kshirsagar ,  Philip D. Heppner

    IPC分类号： C07D513/14 ,  A61K31/4365

    CPC分类号： C07D513/04

    摘要： Thiazolo[4,5-c]ring compounds, (e.g. thiazolopyridine, thiazoloquinoline, 6,7,8,9-tetrahydrothiazoloquinoline, thiazolonaphthyridine, and 6,7,8,9-tetrahydrothiazolonaphthyridine compounds) having an oxime or hydroxylamine substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

    摘要翻译： 噻唑并[4,5-c]环化合物（例如噻唑并吡啶，噻唑并喹啉，6,7,8,9-四氢噻唑并喹啉，噻唑烷萘啶和6,7,8,9-四氢噻唑并萘啶化合物）在2位具有肟或羟胺取代基 公开了含有化合物的药物组合物，中间体和制备方法以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

    Hydroxy and alkoxy substituted 1H-imidazoquinolines and methods
    32.
    发明授权
    Hydroxy and alkoxy substituted 1H-imidazoquinolines and methods 有权
    羟基和烷氧基取代的1H-咪唑并喹啉及其方法

    公开(公告)号：US08377957B2

    公开(公告)日：2013-02-19

    申请号：US13306366

    申请日：2011-11-29

    申请人： Tushar A. Kshirsagar ,  Philip D. Heppner ,  Scott E. Langer

    发明人： Tushar A. Kshirsagar ,  Philip D. Heppner ,  Scott E. Langer

    IPC分类号： C07D471/04 ,  A61K31/541 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/4745

    CPC分类号： C07D471/04

    摘要： 1H-Imidazo[4,5-c]quinolin-4-amines with a hydroxy, alkoxy, hydroxyalkoxy, or alkoxyalkoxy substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

    摘要翻译： 在2-位具有羟基，烷氧基，羟基烷氧基或烷氧基烷氧基取代基的1H-咪唑并[4,5-c]喹啉-4-胺，含有这些化合物的药物组合物，制备化合物的方法，中间体和使用方法 的这些化合物作为免疫调节剂，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病的疾病。

    Substituted fused [1,2]imidazo[4,5-C] ring compounds and methods
    36.
    发明授权
    Substituted fused [1,2]imidazo[4,5-C] ring compounds and methods 失效
    取代的稠合[1,2]咪唑并[4,5-C]环化合物和方法

    公开(公告)号：US08093390B2

    公开(公告)日：2012-01-10

    申请号：US11884186

    申请日：2006-02-10

    申请人： Michael J. Rice ,  Bryon A. Merrill ,  Philip D. Heppner

    发明人： Michael J. Rice ,  Bryon A. Merrill ,  Philip D. Heppner

    IPC分类号： C07D513/00 ,  A61K31/44

    CPC分类号： C07D498/14 ,  C07D519/00

    摘要： Fused [1,2]imidazo[4,5-c] ring compounds, e.g., fused [1,2]imidazo[4,5-c]quinolines and [1,2]imidazo[4,5-c]naphthyridines, with a substituent, e.g., a substituted alkoxy substituent, at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

    摘要翻译： 熔融[1,2]咪唑并[4,5-c]环化合物，例如稠合[1,2]咪唑并[4,5-c]喹啉和[1,2]咪唑并[4,5-c]萘啶， 在6,7,8或9位具有取代基的取代烷氧基取代基，含有化合物，中间体，制备方法和这些化合物作为免疫调节剂的用途的药物组合物，用于诱导细胞因子生物合成 公开了动物和治疗包括病毒和肿瘤疾病在内的疾病。