公开(公告)号：US20100166676A1

公开(公告)日：2010-07-01

申请号：US12700188

申请日：2010-02-04

Applicant: Allan R. Shepard ,  Jon E. Chatterton ,  Abbot F. Clark ,  Martin B. Wax

Inventor： Allan R. Shepard ,  Jon E. Chatterton ,  Abbot F. Clark ,  Martin B. Wax

IPC: A61K9/12 ,  A61K31/7088 ,  A61K31/7125

CPC classification number: C12N15/1138 ,  A61K31/7088 ,  A61K31/713 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2320/30

Abstract: RNA interference is provided for inhibition of tumor necrosis factor α (TNFα) by silencing TNFα cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFα converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNFα targets, in particular, is useful for treating patients having a TNFα-related condition or at risk of developing a TNFα-related condition such as the ocular conditions dry eye, allergic conjunctivitis, or ocular inflammation, or such as dermatitis, rhinitis, or asthma, for example.

Abstract translation: 通过沉默TNFα细胞表面受体TNF受体-1（TNFR1）mRNA表达或沉默TNFα转化酶（TACE / ADAM17）mRNA表达，提供RNA干扰抑制肿瘤坏死因子α（TNFα）。 特别是沉默这样的TNFα靶标可用于治疗患有TNFα相关病症或具有发展TNFα相关病症如眼病干眼症，过敏性结膜炎或眼部炎症或诸如皮炎，鼻炎的患者的患者 ，或哮喘。

公开(公告)号：US20100165727A1

公开(公告)日：2010-07-01

申请号：US12650682

申请日：2009-12-31

Applicant: Daniel R. Shepard

Inventor： Daniel R. Shepard

IPC: G11C11/00 ,  G11C7/00

CPC classification number: G11C13/0069 ,  G11C13/0004 ,  G11C13/0007 ,  G11C13/0038 ,  G11C13/0061 ,  G11C13/0097 ,  G11C2013/0092 ,  G11C2213/31

Abstract: An information storage array includes a programmable material at one or more storage locations and pulse generation circuitry for generating at least two pulses—in particular, a write pulse that writes a value into the programmable material an erase pulse that erases a value from the programmable material. In general, the erase pulse is greater in duration than the write pulse. Either the write pulse or the erase pulse is selected based at least in part on a state of a data bit to be stored in the programmable material.

Abstract translation: 信息存储阵列包括在一个或多个存储位置处的可编程材料和脉冲产生电路，用于产生至少两个脉冲，特别是写入脉冲，该写脉冲将值写入可编程材料中，擦除脉冲从可编程材料中擦除值 。 通常，擦除脉冲的持续时间大于写入脉冲。 至少部分地基于要存储在可编程材料中的数据位的状态来选择写入脉冲或擦除脉冲。

公开(公告)号：US20100158897A1

公开(公告)日：2010-06-24

申请号：US12716137

申请日：2010-03-02

Applicant: Debra L. Fleenor ,  Allan R. Shepard

Inventor： Debra L. Fleenor ,  Allan R. Shepard

IPC: A61K31/4709 ,  A61K39/395 ,  A61P27/02 ,  A61P27/06

CPC classification number: A61K31/122 ,  A61K31/19 ,  A61K31/41 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention concerns in one embodiment a method for treating glaucoma or elevated IOP in a patient comprising administering to the patient an effective amount of a composition comprising an agent that modulates PAI-1 activity. In a preferred embodiment, the agent that modulates PAI-1 expression and/or activity is cilostazol or an analog or metabolite of cilostazol.

Abstract translation: 本发明在一个实施方案中涉及用于治疗患者青光眼或升高的IOP的方法，包括向患者施用有效量的包含调节PAI-1活性的药剂的组合物。 在优选的实施方案中，调节PAI-1表达和/或活性的药物是西洛他唑或西洛他唑的类似物或代谢物。

公开(公告)号：US07622454B2

公开(公告)日：2009-11-24

申请号：US11313200

申请日：2005-12-19

Applicant: Allan R. Shepard ,  Iok-Hou Pang

Inventor： Allan R. Shepard ,  Iok-Hou Pang

IPC: A61K48/00 ,  C07H21/02 ,  C07H21/04

CPC classification number: C12N15/1136 ,  A61K31/713 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/32

Abstract: RNA interference is provided for inhibition of connective tissue growth factor mRNA expression in ocular disorders involving CTGF expression. Ocular disorders involving aberrant CTGF expression include glaucoma, macular degeneration, diabetic retinopathy, choroidal neovascularization, proliferative vitreoretinopathy and wound healing. Such disorders are treated by administering interfering RNAs of the present invention.

Abstract translation: 提供RNA干扰用于抑制涉及CTGF表达的眼部疾病中的结缔组织生长因子mRNA表达。 涉及异常CTGF表达的眼部疾病包括青光眼，黄斑变性，糖尿病性视网膜病变，脉络膜新生血管形成，增生性玻璃体视网膜病变和伤口愈合。 通过施用本发明的干扰RNA来治疗这些病症。

公开(公告)号：US20090225621A1

公开(公告)日：2009-09-10

申请号：US12398659

申请日：2009-03-05

Applicant: Daniel R. Shepard

Inventor： Daniel R. Shepard

IPC: G11C8/10 ,  H01S4/00 ,  G11C8/00

CPC classification number: G11C8/10 ,  Y10T29/49002

Abstract: A memory device includes a memory array comprising a plurality of generally parallel rows and a plurality of generally parallel columns intersecting the plurality of rows; a first address decoder circuit disposed on a first side of the memory array; and a second address decoder circuit disposed on a second side of the memory array different from the first side. At least two consecutive rows are connected to the first address decoder circuit and at least two other consecutive rows are connected to the second address decoder circuit.

Abstract translation: 存储器装置包括存储器阵列，该存储器阵列包括多个大致平行的行和与多个行交叉的多个大致平行的列; 第一地址解码器电路，设置在存储器阵列的第一侧上; 以及设置在与第一侧不同的存储器阵列的第二侧上的第二地址解码器电路。 至少两个连续的行连接到第一地址解码器电路，并且至少两个其他连续的行连接到第二地址解码器电路。

公开(公告)号：US20090117098A1

公开(公告)日：2009-05-07

申请号：US12262841

申请日：2008-10-31

Applicant: Allan R. SHEPARD ,  Abbot F. Clark ,  Peter G. Klimko ,  Martin B. Wax

Inventor： Allan R. SHEPARD ,  Abbot F. Clark ,  Peter G. Klimko ,  Martin B. Wax

IPC: A61K39/395 ,  A61P27/06

CPC classification number: A61K45/06 ,  A61K31/00

Abstract: The invention concerns in one embodiment a method of treating glaucoma or elevated intraocular pressure comprising administering a pharmaceutically effective amount of a composition comprising a Complement C1q inhibitor. In another embodiment, the invention concerns a composition for the treatment of elevated intraocular pressure and glaucoma, the composition comprising a pharmaceutically effective amount of a Complement C1q inhibitor.

Abstract translation: 本发明在一个实施方案中涉及治疗青光眼或升高的眼内压的方法，包括施用药学有效量的包含补体C1q抑制剂的组合物。 在另一个实施方案中，本发明涉及用于治疗眼内压升高和青光眼的组合物，该组合物包含药学上有效量的补体C1q抑制剂。

公开(公告)号：US20090109726A1

公开(公告)日：2009-04-30

申请号：US11926778

申请日：2007-10-29

Applicant: Daniel R. Shepard

Inventor： Daniel R. Shepard

IPC: G11C17/06 ,  G11C11/36 ,  G11C8/00

CPC classification number: G11C8/10 ,  G11C13/02

Abstract: A high-speed, low-power memory device comprises an array of non-linear conductors wherein the storage, address decoding, and output detection are all accomplished with diodes or other non-linear conductors. In various embodiments, the row and column resistors are switchable between a high resistance when connected to a row or column that is non-selected, and a low resistance when connected to the selected row and column.

Abstract translation: 高速，低功率存储器件包括非线性导体阵列，其中存储，地址解码和输出检测全部由二极管或其它非线性导体完成。 在各种实施例中，行和列电阻器可以在连接到未选择的行或列之间的高电阻之间切换，并且当连接到所选择的行和列时可以是低电阻。

公开(公告)号：US20090097415A1

公开(公告)日：2009-04-16

申请号：US12250410

申请日：2008-10-13

Applicant: John R. Shepard ,  Joe Nelson

Inventor： John R. Shepard ,  Joe Nelson

IPC: H04L12/28 ,  H04W4/00

CPC classification number: H04W40/24 ,  G05B2219/21079 ,  G05B2219/25061 ,  G05B2219/25101 ,  G05B2219/31121 ,  G05B2219/31123 ,  G05B2219/31151 ,  G05B2219/33192 ,  H04W8/20 ,  H04W76/14 ,  Y02P90/10 ,  Y02P90/18 ,  Y02P90/86

Abstract: A wireless communication system for use in a process environment uses mesh and possibly a combination of mesh and point-to-point communications to produce a wireless communication network that can be easily set up, configured, changed and monitored, thereby making a wireless communication network that is less expensive, and more robust and reliable. The wireless communication system allows virtual communication paths to be established and used within the process control system in a manner that is independent of the manner in which the wireless signals are sent between different wireless transmitting and receiving devices within the process plant, to thereby operate in a manner that is independent of the specific messages or virtual communication paths within the process plant. Still further, communication analysis tools are provided to enable a user or operator to view the operation of the wireless communication network to thereby analyze the ongoing operation of the wireless communications within the wireless communication network.

Abstract translation: 在过程环境中使用的无线通信系统使用网格以及可能的网格和点对点通信的组合来产生可以容易地建立，配置，改变和监视的无线通信网络，从而形成无线通信网络 这是更便宜，更强大和可靠。 无线通信系统允许在过程控制系统内建立和使用虚拟通信路径，其方式是独立于无线信号在过程工厂内的不同无线发送和接收设备之间发送的方式，从而在 一种独立于过程工厂内的特定消息或虚拟通信路径的方式。 还提供了通信分析工具，以使用户或操作者能够查看无线通信网络的操作，从而分析无线通信网络内的无线通信的正在进行的操作。

公开(公告)号：US20090087413A1

公开(公告)日：2009-04-02

申请号：US12243100

申请日：2008-10-01

Applicant: Allan R. Shepard

Inventor： Allan R. Shepard

IPC: A61K48/00 ,  A61K35/76 ,  A61P27/02 ,  A61K31/7105

CPC classification number: C12N15/86 ,  C12N2750/14143

Abstract: The invention provides methods for delivering interfering RNA molecules to an eye of a patient to treat ocular disorders. In particular, the methods of the invention comprise the use of a self-complementary adeno-associated (scAAV) viral vector that can deliver an interfering RNA molecule to an eye of a patient to inhibit expression of a gene that is associated with an ocular disorder.

Abstract translation: 本发明提供了将干扰RNA分子递送到患者眼睛以治疗眼部疾病的方法。 特别地，本发明的方法包括使用能够将干扰RNA分子递送至患者眼睛的自补体腺相关（scAAV）病毒载体，以抑制与眼部疾病相关的基因的表达 。

公开(公告)号：US07436797B2

公开(公告)日：2008-10-14

申请号：US11156215

申请日：2005-06-17

Applicant: John R. Shepard ,  Joe Nelson

Inventor： John R. Shepard ,  Joe Nelson

IPC: H04L12/28

CPC classification number: H04W84/18 ,  G05B2219/21079 ,  G05B2219/25061 ,  G05B2219/25101 ,  G05B2219/31121 ,  G05B2219/31123 ,  G05B2219/31151 ,  G05B2219/33192 ,  H04L45/42 ,  H04L67/12 ,  H04L67/36 ,  H04L69/08 ,  H04W8/20 ,  H04W40/24

Abstract: A wireless communication system for use in a process environment uses mesh and possibly a combination of mesh and point-to-point communications to produce a wireless communication network that can be easily set up, configured, changed and monitored, thereby making a wireless communication network that is less expensive, and more robust and reliable. The wireless communication system allows virtual communication paths to be established and used within the process control system in a manner that is independent of the manner in which the wireless signals are sent between different wireless transmitting and receiving devices within the process plant, to thereby operate in a manner that is independent of the specific messages or virtual communication paths within the process plant. Still further, communication analysis tools are provided to enable a user or operator to view the operation of the wireless communication network to thereby analyze the ongoing operation of the wireless communications within the wireless communication network.

Abstract translation: 在过程环境中使用的无线通信系统使用网格以及可能的网格和点对点通信的组合来产生可以容易地建立，配置，改变和监视的无线通信网络，从而形成无线通信网络 这是更便宜，更强大和可靠。 无线通信系统允许在过程控制系统内建立和使用虚拟通信路径，其方式是独立于无线信号在过程工厂内的不同无线发送和接收设备之间发送的方式，从而在 一种独立于过程工厂内的特定消息或虚拟通信路径的方式。 还提供了通信分析工具，以使用户或操作者能够查看无线通信网络的操作，从而分析无线通信网络内的无线通信的正在进行的操作。