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公开(公告)号：US20220356955A1
公开(公告)日：2022-11-10
申请号：US17869031
申请日：2022-07-20
Applicant: Repligen Corporation
Inventor： Michael C. Gagne , Dean C. Richards , Steven V. Cates
Abstract: Fluid management systems for handling pressurized fluid connect various subsystems or subunits without the need to use reinforced tubing. The system utilizes one or more segments of unreinforced conduit that are encapsulated at various points along a length of the segment with one or more rigid encapsulating members. The unreinforced conduit may be made a disposable element while the rigid encapsulating members may be re-used. In one aspect, the encapsulating member may include a two-part valve body that surrounds and encapsulates a portion of the unreinforced conduit. In another aspect, the encapsulating member may include a two-part jacket that surrounds and encapsulates a portion of the unreinforced conduit. The two-part valve bodies and two-part jackets may be joined at various points within the system as part of the overall flow system.
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公开(公告)号：US20220356954A1
公开(公告)日：2022-11-10
申请号：US17869009
申请日：2022-07-20
Applicant: Repligen Corporation
Inventor： Michael C. Gagne , Steven V. Cates
Abstract: An encapsulated valve system includes a first housing portion having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface. The valve system further includes a second housing portion having a second facing surface, the second facing surface comprising a plurality of branch pathways formed as a recess within the second facing surface. A disposable conduit is configured to be interposed between the first and second housing portions and disposed within the recess of the first facing surface and the recess of the second facing surface. The disposable conduit is thus sandwiched between the first and second facing surfaces. A plurality of pinch valve actuators are mounted on one or both of the first housing portion and the second housing portion, the plurality of pinch valve actuators configured to pinch the disposable conduit at selective branch pathways.
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公开(公告)号：US20220325708A1
公开(公告)日：2022-10-13
申请号：US17731295
申请日：2022-04-28
Applicant: Repligen Corporation
Inventor： Shashi Kiran Kudugunti , WengLong Roy Lin , John Bonham-Carter , James R. Rusche
IPC: F04B43/06 , C07K1/34 , B01D63/02 , C12M1/00 , F04B53/16 , B01D61/14 , B01D65/08 , C12M1/26 , C12N5/00
Abstract: Methods and systems of harvesting a cell product from a cell culture by culturing cells in a fluid medium until the cells have produced a cell product at a harvest concentration are disclosed. The cells are cultured in a cell culture system including a bioreactor connected to an ATF device. The methods include draining fluid medium from the bioreactor through the outlet and the ATF device until the bioreactor volume reaches a predetermined volume, and the ATF column yields at an ATF outlet a liquid containing cell product and passes fluid medium with a concentration of cell product that is lower than the harvest concentration back into the bioreactor, extracting the liquid containing cell product from the ATF outlet, refilling the bioreactor with sterile phosphate buffered saline or fluid medium without any cell product, and repeating steps until a desired amount of cell product has been removed.
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公开(公告)号：US20220323910A1
公开(公告)日：2022-10-13
申请号：US17719850
申请日：2022-04-13
Applicant: Repligen Corporation
Inventor： Michael Bransby , Philip Yuen , Rene Daniel Jean-Marie Gantier , David Bianchi , Jonathan Kuhlmann
Abstract: The present disclosure relates to hollow fiber tangential flow filter units, including hollow fiber tangential flow depth filter units, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.
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公开(公告)号：US20220282204A1
公开(公告)日：2022-09-08
申请号：US17752345
申请日：2022-05-24
Applicant: Repligen Corporation
Inventor： Rudolf Pavlik
IPC: C12M1/36 , F04B49/20 , C12M1/34 , F04B23/04 , C12M1/00 , F04B43/073 , F04B43/00 , F04B49/06 , B01D61/22 , B01D61/58 , B01D63/02 , B01D61/20
Abstract: A control unit includes a first connector configured to connect a proportional pressure regulator to a positive pressure supply and a second connector configured to connect the proportional pressure regulator to a negative pressure supply. The control unit further includes at least one sensor configured to detect an amount of air flow (volume per unit of time), positive or negative, within an air flow line connected to an output of the proportional pressure regulator, and a third connector configured to connect the air flow line to an air side of a diaphragm. Additionally, the control unit includes a controller programmed to control at least an opening and closing function of the proportional pressure regulator to attain a desired amount of air flow (volume per unit of time), positive or negative, within the air flow line.
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Patent Agency Ranking
公开(公告)号：US20220196162A1
公开(公告)日：2022-06-23
申请号：US17690169
申请日：2022-03-09
Applicant: Repligen Corporation
Inventor： Michael C. Gagne , Steven V. Cates
Abstract: An encapsulated valve system includes a first housing portion having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface. The valve system further includes a second housing portion having a second facing surface, the second facing surface comprising a plurality of branch pathways formed as a recess within the second facing surface. A disposable conduit is configured to be interposed between the first and second housing portions and disposed within the recess of the first facing surface and the recess of the second facing surface. The disposable conduit is thus sandwiched between the first and second facing surfaces. A plurality of pinch valve actuators are mounted on one or both of the first housing portion and the second housing portion, the plurality of pinch valve actuators configured to pinch the disposable conduit at selective branch pathways.
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公开(公告)号：US20220193582A1
公开(公告)日：2022-06-23
申请号：US17601653
申请日：2020-05-21
Applicant: REPLIGEN CORPORATION
Inventor： Rudolf Pavlik
Abstract: The present disclosure relates generally to alternating tangential flow (ATF) perfusion pumping methods, including novel methods for generating positive and negative pressure at the point of use, and more particularly, to apparatuses, systems and methods for use of the same.
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公开(公告)号：US20220088538A1
公开(公告)日：2022-03-24
申请号：US17417618
申请日：2020-01-10
Applicant: Repligen Corporation
Inventor： Rudolf Pavlik
Abstract: The present disclosure provides apparatuses and methods that integrate sensors into bioprocessing systems and, advantageously, do not require significant re-engineering of these systems. The disclosure describes an assembly for alternating tangential flow filtration. The assembly also includes a sensor inserted into the first hemisphere of the pump housing via the port. In various embodiments, the port comprises a tri-clover connector, and the sensor is optionally inserted into the port through a plug sized to substantially occlude the port and to place the sensor in contact with a fluid in the pump housing.
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公开(公告)号：US11274954B2
公开(公告)日：2022-03-15
申请号：US16718084
申请日：2019-12-17
Applicant: Repligen Corporation
Inventor： Michael C. Gagne , Dean C. Richards , Steven V. Cates
Abstract: A method of using a fluid monitoring assembly for measuring the flow rate of a fluid through a flexible conduit comprising a wall that defines a lumen through which the fluid passes. The assembly includes a housing having first and second portions each defining respective recessed interior portions that define a cavity that is configured to encapsulate and retain the flow sensor and the flexible tubing contained therein. The flow sensor may be removably secured around the outside of the flexible conduit and include one or more transducer/receiver pairs.
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公开(公告)号：US20220026160A1
公开(公告)日：2022-01-27
申请号：US17374050
申请日：2021-07-13
Applicant: Repligen Corporation
Inventor： Mark A. Perreault
Abstract: A dual path heat exchanger integrated as a single unit able to process fluid stream through a continuous, single-use high temperature short time process. The heat exchanger contains both a heating section and a cooling section in the same unit. In one embodiment, the heating and cooling sections (which may be formed separately for other uses) are formed as a plate and frame structure with a thermally conductive thin film or foil forming the physical barrier between the process stream flow path and the thermal medium (heating or cooling) flow path. The film/foil renders the heat exchanger suitable for single-use and/or to be disposable. A manifold, which also may be formed as a single unit, may be used to transfer fluid flow between the sections of the heat exchanger, and/or to transfer fluid into and out of the system formed by the heat exchanger and manifold.
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