Abstract:
The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.
Abstract:
A method for performing entropy coding comprising the steps of (A) receiving an input stream and side information and (B) replacing the input stream with an index to a list of a number of valid input streams that satisfy all constraints associated with each specific type of the side information, where the list of the number of valid input streams that satisfy all constraints associated with each specific type of side information is based on an amount of redundancy in a system.
Abstract:
A process assembles and/or reassembles a software application. In an embodiment, assemblies are loaded from an architecture description markup language (ADML) document. Class objects and type objects are activated based on the ADML document. Components and connectors are created based on the ADML document. The components are serialized, and an architecture is assembled based on connections described in the ADML document. A main active component designated in the ADML document is then activated.
Abstract:
A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo in comparison to naturally occurring or recombinant native human erythropoietin. In one embodiment of the invention, the protein has a half-life in vivo at least three fold higher than native human erythropoietin. The fusion protein also exhibits enhanced erythropoietic bioactivity in comparison to native human erythropoietin. In one embodiment, the fusion protein comprises the complete peptide sequence of a human erythropoietin (EPO) molecule and the peptide sequence of an Fc fragment of human immunoglobulin IgG1. The Fc fragment in the fusion protein includes the hinge region, CH2 and CH3 domains of human immunoglobulin IgG1. The EPO molecule may be linked directly to the Fc fragment to avoid extraneous peptide linkers and lessen the risk of an immunogenic response when administered in vivo. In one embodiment the hinge region is a human Fc fragment variant having a non-cysteine residue at amino acid 6. The invention also relates to nucleic acid and amino acid sequences encoding the fusion protein and transfected cell lines and methods for producing the fusion protein. The invention further includes pharmaceutical compositions comprising the fusion protein and methods of using the fusion protein and/or the pharmaceutical compositions, for example to stimulate erythropoiesis in subjects in need of therapy.
Abstract:
A unitary resonator assembly for use in dielectric resonator filters and multiplexers. The unitary resonator assembly comprises a plurality of resonators joined by bridges, where the resonators and bridges are all constructed from a single piece of a dielectric material. The unitary resonator assemblies may be used in conjunction with unitary mounting structures that support a unitary resonator assembly in a filter or multiplexer. Also disclosed are 2-pole, 4-pole, and triplet filters implementing a unitary resonator assembly in conjunction with a unitary mounting structure, and a diplexer implementing a unitary resonator assembly in conjunction with a unitary mounting structure.
Abstract:
Mixed mode inferencing is provided by creating an extension to a RETE network to handle both forward and backward chaining efficiently. The extended RETE network is traversed from a root node through intermediate nodes to the rules of the network. The intermediate nodes contain objects that have values assigned by rules, and the intermediate nodes are linked to those rules appropriately. When using the network in a backward chaining context, rules linked to the intermediate node of interest are checked to see if they are active and the rule is solvable. If not, the related rules are checked. Because the system takes advantage of the previously formed RETE network, these checks can be done at the rule nodes without the need to retest each condition.
Abstract:
One aspect of the present invention is directed to triblock peptides comprising a lipid moiety, a peptide block and a zwittenon-like block. Another aspect of the invention is directed to pharmaceutical compositions comprising the triblock peptides of the present in invention arranged in micelles in a pharmaceutically acceptable carrier. In certain embodiments, the pharmaceutical compositions of the present invention are vaccine compositions, which may further comprise an adjuvant. Another aspect of the invention is directed to methods of using the triblock peptides and compositions of the invention to treat a disease or condition.
Abstract:
A lighting system includes a solid state lighting device capable of generating mixed light and a controller. The solid state lighting device includes light sources for producing mixed light and a sensor configured to detect light from one of the light sources. The controller controls two or more of the light sources based on output from the sensor. The controller can communicate with the sensor to provide closed-loop control.
Abstract:
Systems and methods are disclosed herein for annotating video tracks obtained from video data streams. Video tracks are treated as positive if they contain at least one region of interest containing a particular person, and negative if the video track does not contain a region of interest containing the particular person. Visual similarity models are trained using the positive bags.
Abstract:
A MEMS microphone, includes a base with a back cavity and a capacitor system fixed to the base. The capacitor system includes a back plate above the base and a diaphragm opposite to the back plate for forming an insulated gap. The back plate includes a body part and multiple spaced fixation parts extending from the body part, and the diaphragm includes a vibrating part and a connecting part extending from the vibrating part. An orthographic projection of the body part of the back plate along a vibration direction of the diaphragm is completely located on the diaphragm; and at least a part of an orthographic projection of the fixation parts along the vibration direction is located on the diaphragm.