公开(公告)号：US20090060847A1

公开(公告)日：2009-03-05

申请号：US12203193

申请日：2008-09-03

Applicant: Sueleyman Erguen ,  Jens Fehre ,  Ralf Nanke ,  Bernhard Singer ,  Derya Tilki

Inventor： Sueleyman Erguen ,  Jens Fehre ,  Ralf Nanke ,  Bernhard Singer ,  Derya Tilki

IPC: A61B8/08

CPC classification number: A61K49/223 ,  A61K49/225

Abstract: A contrast agent for ultrasound examination of the prostate has contrast-intensifying particles on an exterior of which at least one binding molecule is present that specifically binds to CEACAM-1. In a method for ultrasound examination of the prostate, such a contrast agent is administered to the patient and a sonography of the prostate is subsequently implemented.

Abstract translation: 用于前列腺超声检查的造影剂具有在其外部具有特异性结合CEACAM-1的至少一个结合分子的造影剂增强颗粒。 在用于前列腺超声检查的方法中，将这样的造影剂施用于患者，随后实施前列腺超声检查。

公开(公告)号：US20070016115A1

公开(公告)日：2007-01-18

申请号：US11479347

申请日：2006-06-30

Applicant: Gerhard Buchholtz ,  Jens Fehre ,  Bernd Granz ,  Martin Hoheisel ,  Werner Kruft ,  Markus Lanski ,  Matthias Mahler ,  Christian Meinert ,  Thomas Mertelmeier ,  Ralf Nanke ,  Manfred Rattner

Inventor： Gerhard Buchholtz ,  Jens Fehre ,  Bernd Granz ,  Martin Hoheisel ,  Werner Kruft ,  Markus Lanski ,  Matthias Mahler ,  Christian Meinert ,  Thomas Mertelmeier ,  Ralf Nanke ,  Manfred Rattner

IPC: A61H1/00

CPC classification number: A61B17/2251 ,  A61B5/021 ,  A61B17/22004 ,  A61B2017/00022 ,  A61B2017/00044 ,  A61B2017/00119 ,  A61B2017/00194

Abstract: In a shockwave system with a shockwave source for treatment of a patient with shockwaves, a control and evaluation unit for evaluating an input signal supplied directly thereto that is correlated with a blood pressure value of the patient determined during the treatment, and controls the shockwave source dependent on the input signal.

Abstract translation: 在具有用于治疗患有冲击波的患者的冲击波源的冲击波系统中，用于评估与其直接供应的输入信号相关联的控制和评估单元，其与在治疗期间确定的患者的血压值相关联，并且控制冲击波源 取决于输入信号。

公开(公告)号：US20070016113A1

公开(公告)日：2007-01-18

申请号：US11478824

申请日：2006-06-30

Applicant: Gerhard Buchholtz ,  Jens Fehre ,  Bernd Granz ,  Martin Hoheisel ,  Werner Kruft ,  Markus Lanski ,  Matthias Mahler ,  Christian Meinert ,  Thomas Mertelmeier ,  Ralf Nanke ,  Manfred Rattner

Inventor： Gerhard Buchholtz ,  Jens Fehre ,  Bernd Granz ,  Martin Hoheisel ,  Werner Kruft ,  Markus Lanski ,  Matthias Mahler ,  Christian Meinert ,  Thomas Mertelmeier ,  Ralf Nanke ,  Manfred Rattner

IPC: A61H1/00

CPC classification number: A61B17/2258 ,  A61B2017/00194 ,  A61B2017/00199 ,  A61B2090/378

Abstract: In a method to determine an operating parameter of a shockwave source for the generation of a shockwave to disintegrate a calculus in a patient by a shockwave lithotripsy, a characteristic of the patient and/or of the calculus is determined before and/or during the shockwave lithotripsy and the operating parameter is automatically determined dependent on the characteristic. A device for determining an operating parameter of a shockwave source for the destruction of a calculus in a patient has an acquisition and control unit for determination and/or input of a characteristic of the patient and/or of the calculus, and for automatic determination of the operating parameter dependent on the characteristic.

Abstract translation: 在确定用于产生冲击波的冲击波源的操作参数以便通过冲击波碎石碎裂来分解患者的结石的方法中，在冲击波之前和/或期间确定患者和/或微积分的特征 碎石术和操作参数根据特性自动确定。 用于确定用于破坏患者结石的冲击波源的操作参数的装置具有用于确定和/或输入患者特征和/或微积分的获取和控制单元，并且用于自动确定 操作参数取决于特性。

公开(公告)号：US10674979B2

公开(公告)日：2020-06-09

申请号：US15764558

申请日：2016-08-09

Applicant: Jens Fehre ,  Alexander Gemmel ,  Andreas Limmer ,  Ralf Nanke

Inventor： Jens Fehre ,  Alexander Gemmel ,  Andreas Limmer ,  Ralf Nanke

IPC: A61B6/00

Abstract: The invention relates to a mobile C-arm system (C1), at least comprising at least three wheels, at least two wheels each having an electric motor, wherein the electric motor has a stator (S) and a rotor (R), the stator (S) being connected to a wheel suspension (T) of the wheel and the rotor (R) being surrounded peripherally by a running wheel (L).

公开(公告)号：US08981317B2

公开(公告)日：2015-03-17

申请号：US13320610

申请日：2010-05-12

Applicant: Juergen Schreiber ,  Joerg Opitz ,  Carola Gerich ,  Jens Fehre ,  Georg Salomon ,  Ralf Nanke

Inventor： Juergen Schreiber ,  Joerg Opitz ,  Carola Gerich ,  Jens Fehre ,  Georg Salomon ,  Ralf Nanke

IPC: G01N21/64 ,  A61B5/00

CPC classification number: G01N21/6486 ,  A61B5/0059 ,  G01N21/6408

Abstract: The invention relates to a method and to an apparatus for recognizing tumorous living cell tissue. It furthermore relates to a method and to an apparatus for recognizing tumorous cell tissue at collected living cell tissue samples. In the method, electromagnetic radiation is emitted with local definition onto cell tissue by a radiation source and, after deactivation of the radiation source, the decay behavior of the inherent fluorescence intensity of the cell tissue excited by the electromagnetic radiation is detected at the cell tissue in a time resolved and spectrally resolved manner at known sampling rate(s) for at least one wavelength using a detector. The difference autocorrelation function C(t) of the intensity decay behavior is determined using the determined measured intensity values, the fractal dimension DF for the respective irradiated cell tissue is calculated from this and the value of the fractal dimension DF is used for a classification with respect to a presence of a tumor in the respective irradiated cell tissue.

Abstract translation: 本发明涉及用于识别肿瘤活细胞组织的方法和装置。 此外，本发明还涉及用于在收集的活细胞组织样品处识别肿瘤细胞组织的方法和装置。 在该方法中，电磁辐射通过辐射源以局部定义发射到细胞组织上，并且在放射源失活之后，在细胞组织处检测由电磁辐射激发的细胞组织的固有荧光强度的衰变行为 以使用检测器的至少一个波长的已知采样速率以时间分辨和频谱分辨的方式。 使用确定的测量强度值确定强度衰减行为的差分自相关函数C（t），并从其计算相应的照射细胞组织的分形维数DF，并且使用分形维数DF的值进行分类， 相对于各自照射的细胞组织中肿瘤的存在。

公开(公告)号：US20110230752A1

公开(公告)日：2011-09-22

申请号：US12671643

申请日：2008-07-31

Applicant: Jens Fehre ,  Ralf Nanke ,  Martin Stetter

Inventor： Jens Fehre ,  Ralf Nanke ,  Martin Stetter

IPC: A61B5/05

CPC classification number: G01R33/1269 ,  A61B5/06 ,  A61B5/4381 ,  A61K49/00 ,  A61K49/0004

Abstract: In a screening test method, and a device for implementing the screening test method, a diagnostic substance is provided that contains at least one biomarker connected with at least one ferromagnetic particle, the biomarker binding specifically to a target molecule that is formed by specific pathological prostrate tissue. The diagnostic substance is administered to the blood stream of a patient. A magnetometer is used to detect enrichment of the ferromagnetic particle in the prostrate, as an indicator of a level of the specific pathological prostrate tissue.

Abstract translation: 在筛选试验方法以及实施筛选试验方法的装置中，提供了含有至少一种与至少一个铁磁性粒子连接的生物标志物的诊断物质，特异性结合由特异性病理性前列腺素形成的靶分子的生物标志物 组织。 将诊断物质施用于患者的血液流。 磁力计用于检测前列腺中铁磁颗粒的富集，作为特定病理性pro层组织水平的指标。

公开(公告)号：US20100189659A1

公开(公告)日：2010-07-29

申请号：US12665904

申请日：2008-06-17

Applicant: Jens Fehre ,  Ralf Nanke ,  Martin Stetter

Inventor： Jens Fehre ,  Ralf Nanke ,  Martin Stetter

IPC: A61K49/16 ,  A61P13/08

CPC classification number: G01N33/57434 ,  A61K47/66 ,  A61K47/6853 ,  A61K49/0058 ,  B82Y5/00 ,  G01N2333/70546 ,  G01N2333/70564 ,  G01N2800/342

Abstract: A diagnostic substance for use in a method for diagnosing prostate diseases contains multiple different coupling molecules that respectively bind to signal molecules (target molecules) of a molecular surface structure of a pathological tissue that is associated with a prostate disease. A first of the coupling molecules specifically binds to signal molecules of cancer tissue, and a second of the coupling molecules specifically binds to signal molecules formed in inflamed tissue. First and second markers are respectively associated with the first and second coupling molecules, the first and second markers being detectable, and differentiated from each other, with a detection device.

Abstract translation: 用于诊断前列腺疾病的方法的诊断物质包含分别结合与前列腺疾病相关的病理组织的分子表面结构的信号分子（靶分子）的多种不同的偶联分子。 耦合分子中的第一个特异性结合癌组织的信号分子，并且第二个偶联分子特异性结合发炎组织中形成的信号分子。 第一和第二标记分别与第一和第二耦合分子相关联，第一和第二标记可用检测装置检测并彼此区分。

公开(公告)号：US20100022912A1

公开(公告)日：2010-01-28

申请号：US12508723

申请日：2009-07-24

Applicant: Jens Fehre ,  Ralf Nanke ,  Martin Stetter

Inventor： Jens Fehre ,  Ralf Nanke ,  Martin Stetter

IPC: A61B10/00 ,  A61B5/00 ,  G06Q50/00

CPC classification number: A61B8/12 ,  B01L3/5027 ,  G06Q50/24 ,  G16H50/20 ,  G16H50/30

Abstract: In a method to determine at least one parameter pertaining to a prostate of a patient, an integrated diagnostic support system implements the following steps. A first risk value for prostate illness is determined using a screening method. In the event that this first characteristic risk value exceeds a first limit value, at least one second characteristic risk value for prostate illness and its location are determined using a method supplying a medical image of the patient. An integrated report system outputs at least one of the characteristic risk values and/or the location. A corresponding device has a mini-laboratory analysis unit for the screening test, an intelligent decision support system for the first characteristic risk value, a first interface with an imaging system, an evaluation system for the medical image for the second characteristic risk value, and a report system with a user interface.

Abstract translation: 在确定与患者的前列腺有关的至少一个参数的方法中，集成诊断支持系统实现以下步骤。 使用筛选方法确定前列腺疾病的第一个风险值。 在第一特征风险值超过第一极限值的情况下，使用提供患者的医学图像的方法确定前列腺疾病及其位置的至少一个第二特征风险值。 综合报告系统输出至少一个特征风险值和/或位置。 相应的设备具有用于筛选测试的微型实验室分析单元，用于第一特征风险值的智能决策支持系统，具有成像系统的第一界面，用于第二特征风险值的医学图像评估系统，以及 具有用户界面的报表系统。

公开(公告)号：US20090060845A1

公开(公告)日：2009-03-05

申请号：US12203268

申请日：2008-09-03

Applicant: Jens Fehre ,  Ralf Nanke ,  Martin Stetter

Inventor： Jens Fehre ,  Ralf Nanke ,  Martin Stetter

IPC: A61K49/06 ,  A61K49/04

CPC classification number: C12Q1/6883

Abstract: A diagnosis substance for application in a method for diagnosis of pathological tissue, contains at least one virus population with virus particles specifically binding to target molecules typical of a specific pathological tissue, with a label that is detectable with the use of a detection device being bound to the virus particles. In a method for production of such a diagnosis substance, the principle of directed biological evolution is applied.

Abstract translation: 用于诊断病理组织的方法的诊断物质包含至少一个具有特异性结合特定病理组织的靶分子的病毒颗粒的病毒群体，其中可使用结合检测装置可检测的标记物 对病毒颗粒。 在生产这种诊断物质的方法中，应用定向生物进化的原理。

公开(公告)号：US20090060842A1

公开(公告)日：2009-03-05

申请号：US12203262

申请日：2008-09-03

Applicant: Jens Fehre ,  Ralf Nanke ,  Martin Stetter

Inventor： Jens Fehre ,  Ralf Nanke ,  Martin Stetter

IPC: A61K49/06 ,  A61P35/00

CPC classification number: A61B5/055 ,  A61B5/4381

Abstract: In a method for diagnosis and treatment of a patient with regard to prostatitis, a differential diagnosis of prostatitis versus prostate cancer and/or BPH is conducted on a patient using a cost-effective diagnosis method. Given diagnosed prostatitis, a cost-effective decision test is implemented on the patient to determine whether the patient exhibits complaints locally in the region of the prostate or in the rest of the body. A molecular inflammation marker is administered to the patient, wherein a cost-effective imaging method is implemented in the region of the prostate of the patient given local complaints or a cost-intensive imaging method is implemented on the entire patient given complaints in the rest of the body. An inflammation-inhibiting treatment is implemented in the body region of the patient that is detected as inflamed via the respective imaging method.

Abstract translation: 在用于前列腺炎患者的诊断和治疗的方法中，使用成本有效的诊断方法对患者进行前列腺炎与前列腺癌和/或BPH的鉴别诊断。 鉴于诊断前列腺炎，对患者进行成本效益的决定测试，以确定患者是否在前列腺区域或身体其他部位出现局部投诉。 向患者施用分子炎症标记物，其中在给予局部投诉的患者的前列腺区域中实施成本有效的成像方法，或者在整个患者中实施成本密集的成像方法，其中指出其余部分的投诉 身体。 在通过各自的成像方法被检测为发炎的患者的身体区域中实施炎症抑制治疗。