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公开(公告)号：US20160138095A1
公开(公告)日：2016-05-19
申请号：US14898112
申请日：2014-06-11
Applicant: Stichting VU-VUMC
CPC classification number: C12Q1/6837 , G01N29/0681 , G02B21/32
Abstract: A molecular manipulation system for investigating molecules, having a sample holder constructed to hold a sample comprising a plurality of molecules attached on one side to a surface in the sample holder and on another side attached to a microbead of a plurality of microbeads. The system having; an acoustic wave generator to generate an acoustic wave exerting a force on the microbeads in the sample; and a detector device to detect a response of the plurality of microbeads in the sample on the force exerted by the acoustic wave to investigate the molecules attached to the microbeads.
Abstract translation: 一种用于调查分子的分子操纵系统，具有样品架，其被构造成将包含附着在一侧的多个分子的样品保持在样品保持器中的表面上，另一侧附着在多个微珠的微珠上。 系统有 声波发生器，用于产生在样品中的微珠上施加力的声波; 以及检测器装置，用于检测样品中的多个微珠对由声波施加的力的响应，以研究附着于微珠的分子。
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公开(公告)号：US11963663B2
公开(公告)日：2024-04-23
申请号：US17042488
申请日：2019-03-28
Applicant: Stichting VU
Inventor： Fabio Feroldi , Johannes Fitzgerald De Boer
CPC classification number: A61B1/00167 , A61B1/0017 , A61B5/0062 , A61B5/0084 , G02B6/2821
Abstract: A fibre endoscope system (100) comprises a catheter (10) with a probe head (10a) for entering into a body cavity (C) adjacent or near a sample region (S). A source fiber (11) has a first fiber ending (11a) and a signal fiber (12) has a second fiber ending (12a) both remote from the probe head (10a) but separate. A sampling fiber (13) has a third fiber ending (13a) disposed at the probe head (10a). A fiber coupler (15) is configured to optically couple at least the source fiber (11) to the sampling fiber (13), and the sampling fiber (13) to the signal fiber (12). A sampling fiber length (L13) of the sampling fiber (13) between a fiber coupler (15) and the third fiber ending (13a) is shorter than a source fiber length (L11) of the source fiber (11) between the fiber coupler (15) and the first fiber ending (11a).
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33.发明公开公开(公告)号：US20230366801A1
公开(公告)日：2023-11-16
申请号：US18030034
申请日：2021-10-05
Applicant: Stichting VU , LUMICKS CA HOLDING B.V.
Inventor： Andreas Sebastian Biebricher , Vadim Bogatyr , Gijs Jan Lodewijk Wuite , Erwin Johannes Gerard Peterman , Iddo Heller , Rogier Martijn Reijmers
CPC classification number: G01N15/1404 , G01N15/1434 , G06T7/60 , G06T7/20 , G06T7/70 , G06V20/698 , G01N2015/149 , G01N2015/1493 , G01N2015/1075
Abstract: A method comprises receiving images representing manipulating cellular bodies that includes exerting force pulses to the bodies on a wall surface; analyzing the images to determine the size of the bodies and tracking locations during and after each of force pulses, the tracking locations defining first trajectories of the bodies moving away from the wall surface and trajectories of the bodies moving towards the wall surface; determining densities of the bodies using the second trajectories and a sedimentation model of the bodies moving towards the wall surface and determining body velocities based on the first trajectories and a velocity model of the bodies moving away from the wall surface; and, determining a contrast factor for each body based on the sizes and the densities, the force applied to the bodies and the body velocities and determining a compressibility for each of the bodies based on the determined contrast factors.
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公开(公告)号：US11788081B2
公开(公告)日：2023-10-17
申请号：US17048284
申请日：2019-04-18
Applicant: Stichting VU
Inventor： Tom Norbert Grossmann , Marta Pelay Gimeno , Sven Hennig , Saskia Antonie Neubacher
IPC: C12N9/96 , C12N9/52 , C12N15/113
CPC classification number: C12N9/52 , C12N15/113 , C12Y304/2207
Abstract: The present invention relates to methods and cross-linkers for the macrocyclization of proteins. The invention is useful for increasing the stability of a protein.
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公开(公告)号：US20230324298A1
公开(公告)日：2023-10-12
申请号：US18023172
申请日：2021-08-19
Applicant: STICHTING VU
Inventor： Alfred Holzwarth , Jacopo URBANI , Lukas JASMONTAS
IPC: G01N21/64
CPC classification number: G01N21/6408 , G01N2021/635
Abstract: There is provided a spectroscopy apparatus for measuring fluorescence signals from a photosynthetic object. The spectroscopy apparatus comprises:
one or more light excitation sources (26,28) operable to carry out time-varying excitation of the fluorescence from the photosynthetic object; and
one or more fluorescence-sensitive detection channels (36,38,44,46) configured to simultaneously record the fluorescence as a function of time with a microsecond to millisecond time resolution and as a function of wavelength with a wavelength resolution of 10 nm or better, responsive to the excitation of the fluorescence from the photosynthetic object by the or each light excitation source (26,28).-
Patent Agency Ranking
公开(公告)号：US20230054792A1
公开(公告)日：2023-02-23
申请号：US17744502
申请日：2022-05-13
Applicant: Liverpool School of Tropical Medicine , Stichting VU
Inventor： Nicholas Casewell , Laura-Oana Albulescu , Jeroen Kool
IPC: A61K31/405 , A61K31/16 , A61K31/10 , A61P39/02
Abstract: The disclosure herein are materials and methods for the treatment of snake bite. Aspects of the disclosure includes pharmaceutical compositions, and kits, both of which may be of use in the treatment of snake bite.
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公开(公告)号：US20220324947A1
公开(公告)日：2022-10-13
申请号：US17632023
申请日：2020-08-05
Applicant: Stichting VU , Cambridge Enterprise Limited
Inventor： Martine Joyce Smit , Timo Werner Marcella De Groof , Raimond Heukers , John Sinclair , Elizabeth Elder
Abstract: The invention relates to the use of a single heavy chain variable domain antibody against human cytomegalovirus protein US28, which antibody binds to the extracellular region including, for example, the N-terminal extracellular region and/or the extracellular loops of US28, for isolation of cells that are infected with cytomegalovirus and/or for ex vivo reactivation of cytomegalovirus in latently infected cells. The invention further relates to the anti-US28 antibody for use in a method of reactivating cytomegalovirus in infected cells, or in a method of eliminating infected cells. The invention further relates to a tissue, organ, or cells such as bone marrow stem cells, from which cells that were infected with CMV have been removed with the use of the anti-US28 antibody.
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公开(公告)号：US20220151900A1
公开(公告)日：2022-05-19
申请号：US17592162
申请日：2022-02-03
Applicant: STICHTING VU
Inventor： Floris Jacob BIKKER , Engelmundus Cornelis Ignatius VEERMAN , Marianne VALENTIJN-BENZ , Willem VAN 'T HOF
IPC: A61K8/55 , A61K8/41 , A61Q11/02 , A61K8/68 , A61Q11/00 , A23L33/10 , A61C13/08 , A61K8/24 , A61K8/42
Abstract: The invention relates to the use of sphingosine-based compounds, in particular phytosphingosine compounds, in the protection of hydroxyapatite containing materials such as teeth and bone. Such compounds are especially useful in the treatment and prevention of dental caries, dental erosion, dentine hypersensitivity and tartar (dental calculus) formation. Methods and devices are also provided for preventing biofilm formation using sphingosine-based compounds. Compositions comprising sphingosine-based compounds are also provided.
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公开(公告)号：US11273113B2
公开(公告)日：2022-03-15
申请号：US14397016
申请日：2013-04-26
Applicant: Stichting VU
Inventor： Floris Jacob Bikker , Engelmundus Cornelis Ignatius Veerman , Marianne Valentijn-Benz , Willem Van 'T Hof
IPC: A61K8/55 , A61K8/41 , A61Q11/02 , A61K8/68 , A61Q11/00 , A23L33/10 , A61C13/08 , A61K8/24 , A61K8/42
Abstract: The invention relates to the use of sphingosine based compounds, in particular phytosphingosine compounds, in the protection of hydroxyapatite containing materials such as teeth and bone. Such compounds are especially useful in the treatment and prevention of dental caries, dental erosion, dentine hypersensitivity and tartar (dental calculus) formation. Methods and devices are also provided for preventing biofilm formation using sphingosine based compounds. Compositions comprising sphingosine based compounds are also provided.
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公开(公告)号：US20210022590A1
公开(公告)日：2021-01-28
申请号：US17042488
申请日：2019-03-28
Applicant: Stichting VU
Inventor： Fabio FEROLDI , Johannes Fitzgerald DE BOER
Abstract: A fibre endoscope system (100) comprises a catheter (10) with a probe head (10a) for entering into a body cavity (C) adjacent or near a sample region (S). A source fiber (11) has a first fiber ending (11a) and a signal fiber (12) has a second fiber ending (12a) both remote from the probe head (10a) but separate. A sampling fiber (13) has a third fiber ending (13a) disposed at the probe head (10a). A fiber coupler (15) is configured to optically couple at least the source fiber (11) to the sampling fiber (13), and the sampling fiber (13) to the signal fiber (12). A sampling fiber length (L13) of the sampling fiber (13) between a fiber coupler (15) and the third fiber ending (13a) is shorter than a source fiber length (L11) of the source fiber (11) between the fiber coupler (15) and the first fiber ending (11a).
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