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公开(公告)号：US20220036252A1
公开(公告)日：2022-02-03
申请号：US17277514
申请日：2019-09-20
发明人： Leroy CRONIN
摘要： The invention provides a chemical computer having a matrix, an input device and an analytical device. The matrix is a plurality of interconnected reaction spaces holding a reaction mixture; the input device is provided to independently address each of a plurality of reaction spaces within the matrix; and the analytical device has a sensor to analyse a reaction characteristic of a reaction mixture in one or more reaction spaces. Also provides are methods for using the chemical computer, and the use of the chemical computer as a logic gate.
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公开(公告)号：US20210107877A1
公开(公告)日：2021-04-15
申请号：US17251712
申请日：2019-06-21
申请人： The University Court of the University of Glasgow , The University Court of the University of Edinburgh
IPC分类号： C07D215/48 , A61K51/04
摘要： The invention provides a compound of formula (I), and salts, solvates and radiolabelled forms thereof, together with complexes of the compound of formula (I) with TSPO, and methods for forming such complexes, and methods for detecting the compound of formula (I), such as in complex with TSPO.
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公开(公告)号：US20210063136A1
公开(公告)日：2021-03-04
申请号：US17008070
申请日：2020-08-31
申请人： INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE , The University Court of the University of Glasgow
发明人： MEHEDI ISLAM , PIOTR ROZTOCKI , MICHAEL KUES , CHRISTIAN REIMER , BENNET FISCHER , STEFANIA SCIARA , ROBIN HELSTEN , YANBING ZHANG , YOANN JESTIN , ROBERTO MORANDOTTI
IPC分类号： G01B9/02
摘要： A system and a method for phase extraction of a multi-path interferometer, the method comprising generating a reference signal of a coherence length longer than an arm length difference of the multi-path interferometer; splitting the reference signal into a frequency shifted reference signal and an unshifted reference signal; recombining the frequency shifted reference signal and the unshifted reference signal into a polarization- and frequency-multiplexed reference signal, and feeding the polarization- and frequency-multiplexed reference signal to the multi-path interferometer; detecting frequency shifted and unshifted output signals of the multi-path interferometer; and determining the interferometer phase from the detected signal.
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公开(公告)号：US20200335181A1
公开(公告)日：2020-10-22
申请号：US16960707
申请日：2019-01-09
发明人： Leroy CRONIN
摘要： The invention provides a method for digitising a method of synthesis. The method includes the steps of identifying a method of synthesis for a target product; (ii) establishing a process sequence for that method, which process sequence is a collection of chemical and/or physical steps within the method of synthesis; and subsequently (iii) translating the process sequence to a digital model of the method of synthesis, which digital model comprises a digital description of the chemical and/or physical steps within the method of synthesis.
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35.发明授权公开(公告)号：US10768175B2
公开(公告)日：2020-09-08
申请号：US15630524
申请日：2017-06-22
IPC分类号： G01N21/00 , G01N33/543 , G01N21/552 , G02B5/30 , G02B1/00 , G01N21/27 , G02B5/00
摘要： A plasmonic device is disclosed, the plasmonic device having a base substrate and an electrically conductive film formed on the base substrate. The base substrate has a reference upper surface and an arrangement of chiral nanostructures formed in relief from the reference upper surface. Each chiral nanostructure has a nanostructure upper surface which is disposed at a distance of at least 30 nm from the reference upper surface in a thickness direction. The electrically conductive film is formed on the nanostructure upper surface of each chiral nanostructure and on at least part of the reference upper surface of the base substrate. Also disclosed is a method of analysis of a biological material using the plasmonic device, by depositing the biological material onto the plasmonic device and irradiating the plasmonic device and the biological material with electromagnetic radiation. The arrangement of chiral nanostructures and electrically conductive film generates a superchiral electromagnetic field, the effect of the presence of the biological material on the superchiral electromagnetic field then being detected.
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公开(公告)号：US20180251719A1
公开(公告)日：2018-09-06
申请号：US15759388
申请日：2016-08-19
发明人： Matthew DALBY , Habib NIKUKAR , Gabriel PEMBERTON , Adam CURTIS , Stuart REID , Peter CHILDS
摘要： A mechanical bioreactor for transferring vibrations to cell cultures for the purpose of stimulating various biological processes across a relatively large (relative to the amplitude of the vibrations) sample receiving surface. This bioreactor allows multiple samples to receive identical stimulation, which may enable the process to be significantly scaled up. The invention may be particularly applicable to nanoscale vibration amplitudes, where it is non-trivial to design a device that performs this function, because many materials exhibit natural deformation on a scale that would mask or inhibit transfer of nanoscale vibration energy.
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公开(公告)号：US09981005B2
公开(公告)日：2018-05-29
申请号：US15025273
申请日：2014-09-29
发明人： George Baillie
CPC分类号： A61K38/08 , G01N33/566 , G01N33/6896 , G01N2333/47 , G01N2500/02 , G01N2800/28 , G01N2800/2814 , G01N2800/30 , G01N2800/52
摘要： The invention relates to the finding that turnover of DISC1 (Disrupted in schizophrenia 1) is mediated by the F-box-containing protein FBXW7 (F-box/WD repeat-containing protein 7). The sequence within DISC1 that binds to FBXW7 and targets DISC1 for turnover by the ubiquitin-proteasome system is identified. The invention provides antagonists that inhibit this interaction and methods of using these antagonists to decrease DISC1 turnover, for example in treatment of neuropsychiatric disorders, as well as methods of identifying new antagonists.
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公开(公告)号：US20170276697A1
公开(公告)日：2017-09-28
申请号：US15506675
申请日：2015-08-26
发明人： Paul Campsie , Giles Dominic Hammond , Richard Paul Middlemiss , Douglas John Paul , Antonio Samarelli
摘要： An acceleration measuring device is disclosed, for use as a gravimeter or gradiometer for example. The device has a support and a proof mass, connected to each other by at flexures allowing displacement of the proof mass relative to the support. The support defines a space for displacement of the proof mass. The device is configured so that the modulus of the gradient of the force-displacement curve of the proof mass decreases with increasing displacement, for at least part of the force-displacement curve. This is the so-called anti-spring effect. The resonant frequency of oscillation of the proof mass is determined at least in part by the orientation of the device relative to the direction of the force due to gravity. The proof mass is capable of oscillating with a resonant frequency of 10 Hz or less. The proof mass has a mass of less than 1 gram.
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公开(公告)号：US20170198347A1
公开(公告)日：2017-07-13
申请号：US15405181
申请日：2017-01-12
CPC分类号： C12Q1/6881 , C12Q1/6886 , C12Q2600/158 , G16B20/00 , G16B25/00
摘要： This invention relates to methods and systems for measuring T cell diversity. It is particularly related to methods of identifying T cell receptor (TCR) pairs and their relative frequencies and finds particular use in antigen-specific T cell populations and other T cell populations with limited polyclonality. An exemplary embodiment of the invention provides a method estimating the clonal composition of a T cell population, the method including the steps of: obtaining a plurality of samples from said population, each sample containing a plurality of T cells; sequencing the CDR3α and CDR3β regions of each of those samples; calculating, for every α and β chain found in common in at least one of the samples, an association score which reflects the likelihood of pairing between each of those chains; repeatedly, for a randomly selected subset of said samples, determining, from the calculated association scores, the most likely αβ pairs in each of said selected samples and selecting those pairs as candidate αβ pairs; comparing the number of instances that each of said candidate αβ pairs appears in all of said repeats to a threshold and selecting those pairs whose instances exceed said threshold as true αβ pairs; estimating, from the frequency of co-existence of α and β chains in each of said samples and the sample size of said sample, the frequency of each of said true αβ pairs; and discriminating, amongst said αβ pairs, between possible dual T cell receptors or two clones which share a common β chain.
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公开(公告)号：US20160325248A1
公开(公告)日：2016-11-10
申请号：US15167712
申请日：2016-05-27
发明人： Rab Wilson , Jonathan M. Cooper , Julien Reboud
CPC分类号： B01F13/0071 , B01F11/0266 , B01F2215/0073 , B01J19/0093 , B01J2219/00783 , B01J2219/00824 , B01J2219/00828 , B01J2219/00837 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00905 , B01J2219/00932 , B01J2219/00952 , B01L3/502792 , B01L2200/10 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/089 , B01L2400/0436 , B01L2400/0439 , B01L2400/0496 , C12N13/00 , G01N33/48 , Y10T436/25125
摘要： A fluidics apparatus is disclosed for manipulation of at least one fluid sample, typically in the form of a droplet. The apparatus has a substrate surface with a sample manipulation zone for location of the fluid sample. A transducer arrangement such as an interdigitated electrode structure on a piezoelectric body provides surface acoustic waves at the substrate surface for manipulation of the fluid sample. The substrate surface has an arrangement of surface acoustic wave scattering elements forming a phononic crystal structure for affecting the transmission, distribution and/or behaviour of surface acoustic waves at the substrate surface. Also disclosed is a method for lysing a cell. In this method, the cell is comprised in a fluid sample contacting a substrate surface, the method comprising providing surface acoustic waves at the substrate surface, such that the cell lyses.
摘要翻译： 公开了用于操纵至少一种流体样品的流体装置，通常为液滴的形式。 该设备具有一个具有用于定位流体样品的样品操作区的基底表面。 诸如压电体之间的交错电极结构的换能器装置在衬底表面上提供表面声波，用于操纵流体样品。 衬底表面具有形成声子晶体结构的表面声波散射元件的布置，用于影响衬底表面处的表面声波的透射，分布和/或行为。 还公开了一种裂解细胞的方法。 在该方法中，电池被包含在与衬底表面接触的流体样品中，该方法包括在衬底表面提供表面声波，使得细胞裂解。
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