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31.发明申请公开(公告)号：US20200232996A1
公开(公告)日：2020-07-23
申请号：US16652804
申请日：2018-09-26
发明人： Byron Winslow Caughey , Bradley Richard Groveman , Christina Doriana Groveman , Lynne DePuma Raymond , Andrew Gregory Hughson
IPC分类号： G01N33/68 , G01N33/543
摘要： Methods are disclosed for determining whether a subject has a synucleinopathy. Methods are also disclosed for detecting misfolded alpha synuclein (αSyn) in a biological sample or fraction thereof. These methods include the use of an αSyn seeding assay.
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32.发明申请公开(公告)号：US20200063216A1
公开(公告)日：2020-02-27
申请号：US16609994
申请日：2018-04-27
发明人： Amanda E. Calvert
IPC分类号： C12Q1/6888 , C12Q1/70 , C12Q1/6844
摘要： A highly sensitive and specific reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay to detect ZIKV nucleic acid in biological samples is described. The disclosed assay is capable of detecting as few as one RNA copy per μl and can be performed in a clinical or field setting with minimal equipment and technological expertise. Oligonucleotide primers and kits for detecting ZIKV nucleic acid are also described.
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公开(公告)号：US10548987B2
公开(公告)日：2020-02-04
申请号：US15747620
申请日：2016-07-29
申请人： The U.S.A., as represented by the Secretary, Department of Health and Human Services , The Children's Hospital of Philadelphia
摘要： The identification and characterization of two fully human CD56-specific monoclonal antibodies targeting spatially separated epitopes proximal and distal to the plasma membrane is described. Also described are antibody-drug conjugates (ADCs) of the identified antibodies and their use for targeting CD56-expressing tumor cells.
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公开(公告)号：US10543263B2
公开(公告)日：2020-01-28
申请号：US16161542
申请日：2018-10-16
申请人： LentigenTechnology, Inc. , The U.S.A., as represented by the Secretary, Department of Health and Human Services
IPC分类号： C12N15/63 , C12N15/13 , C07K14/47 , A61K39/395 , A61K39/00 , C07K16/28 , C07K14/705 , C07K14/725 , A61P35/00
摘要： Chimeric antigen receptors (CARs) containing CD22 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the CARs are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making CAR T cells are also disclosed.
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公开(公告)号：US10538588B2
公开(公告)日：2020-01-21
申请号：US15981142
申请日：2018-05-16
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , The U.S.A. as Represented by the Secretary, Department Of Health and Human Services
IPC分类号： C07K16/28 , C07K14/725 , C07K16/30 , C07K14/705 , C07K14/47 , A61K39/00 , A61K38/00 , A61K35/00
摘要： The presently disclosed subject matter provides for methods and compositions for enhancing the immune response toward cancers and pathogens. It relates to chimeric antigen receptors (CARs) that specifically target human mesothelin, and immunoresponsive cells comprising such CARs. The presently disclosed mesothelin-targeted CARs have enhanced immune-activating properties, including anti-tumor activity.
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公开(公告)号：US20190352408A1
公开(公告)日：2019-11-21
申请号：US16471485
申请日：2017-12-21
IPC分类号： C07K16/28 , C07K14/705 , C07K14/725 , A61K47/68 , C07K16/46 , A61K47/69 , A61P35/00 , A61P35/04 , A61P35/02 , G01N33/577
摘要： Human monoclonal antibodies that specifically bind Fms-like tyrosine kinase 3 (FLT3) are described. Chimeric antigen receptors (CARs) and other antibody conjugates that include the FLT3-specific monoclonal antibodies are also described. Methods for the diagnosis and treatment of FLT3-associated cancer, such as acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML), are further described.
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公开(公告)号：US20190315875A1
公开(公告)日：2019-10-17
申请号：US16459396
申请日：2019-07-01
申请人： The U.S.A., as represented by the Secretary, Department of Health and Human Services , University of Maryland, College Park
发明人： Scott Durum , Julie Hixon , Wen Qing Li , Scott Walsh , Lila Kashi
IPC分类号： C07K16/28 , A61K45/06 , G01N33/574 , A61K39/395
摘要： Antibodies and antigen binding fragments that specifically bind to IL-7Rα are disclosed. Nucleic acids encoding the antibodies and antigen binding fragments, and vectors including the nucleic acid molecules are also provided. Methods for detecting a ca cancer or a cell that expresses IL-7Rα using the antibodies and antigen binding fragments are disclosed, as is the use of the antibodies and antigen binding fragments to prevent and/or treat a subject with a cancer that expresses IL-7Rα, such as acute lymphoblastic leukemia.
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公开(公告)号：US20190177298A1
公开(公告)日：2019-06-13
申请号：US16132973
申请日：2018-09-17
申请人： Mycovia Pharmaceuticals, Inc , The U.S.A., as represented by the Secretary, Department of Health and Human Services
发明人： William J. Hoekstra , Christopher M. Yates , Mark Behnke , Asaf Alimardanov , Scott A. David , Douglas Franklin Fry
IPC分类号： C07D401/06 , C07D213/56 , C07D405/06 , C07D213/38 , C07D213/50
摘要： The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
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公开(公告)号：US20180244757A1
公开(公告)日：2018-08-30
申请号：US15761789
申请日：2016-01-12
发明人： Amanda E. Calvert , Aaron C. Brault
IPC分类号： C07K16/10 , G01N33/569
CPC分类号： C07K16/10 , A61K39/12 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/76 , C07K2319/00 , C12N2760/12211 , G01N33/56983 , G01N2333/175 , G01N2469/20
摘要： Monoclonal antibodies that specifically bind the nucleocapsid protein of Heartland virus (HRTV) are described. The monoclonal antibodies can be used, for example, in immunoassays to detect HRTV-specific antibodies in a biological sample or to detect HRTV in a cell or tissue sample. The monoclonal antibodies can also be used to diagnose or treat an HRTV infection.
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公开(公告)号：US20180064828A1
公开(公告)日：2018-03-08
申请号：US15798969
申请日：2017-10-31
发明人： John A. Chiorini , Hongen Yin
IPC分类号： A61K49/00 , A61K38/17 , G01N33/68 , C07K16/22 , C12N15/113 , C12N15/115 , C12Q1/68 , G01N33/74 , A61K31/519
CPC分类号： A61K49/0004 , A61K31/519 , A61K38/177 , A61K38/179 , C07K16/22 , C07K2317/622 , C07K2317/76 , C12N15/1136 , C12N15/115 , C12N2320/30 , C12Q1/6883 , G01N33/6872 , G01N33/6893 , G01N33/74 , G01N2333/4704 , G01N2333/51 , G01N2800/101
摘要： The finding that patients with Sjögren's syndrome exhibit a statistically significant increase in expression of BMP6 in the salivary gland relative to healthy control subjects is described. Also described is the finding that overexpression of BMP6 in the salivary glands of mice results in an increase in electrical potential across the salivary gland. Thus, methods of diagnosing a subject as having Sjögren's syndrome, or at risk for developing Sjögren's syndrome, by measuring the level of BMP6 expression in a salivary gland of a subject, measuring electrical potential in a salivary gland of a subject, or both, are disclosed. Also described are methods of treating a subject with Sjögren's syndrome by administering an agent that inhibits expression of BMP6 expression or activity. Further disclosed is the use of XIST and MECP2 as diagnostic and therapeutic targets for male Sjögren's syndrome patients.
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