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37 条记录 (耗时 0.018 秒)

    S-NITROSO GROUP-CONTAINING ALBUMIN, METHOD FOR PRODUCTION, AND ANTICANCER AGENT
    31.
    发明申请
    S-NITROSO GROUP-CONTAINING ALBUMIN, METHOD FOR PRODUCTION, AND ANTICANCER AGENT 有权
    含硝基组合的铝，生产方法和反应剂

    公开(公告)号：US20090099337A1

    公开(公告)日：2009-04-16

    申请号：US12201825

    申请日：2008-08-29

    申请人： Masaki Otagiri ,  Keisuke Nakajo ,  Naohisa Katayama ,  Toshiya Kai

    发明人： Masaki Otagiri ,  Keisuke Nakajo ,  Naohisa Katayama ,  Toshiya Kai

    IPC分类号： C07K14/76

    CPC分类号： C07K14/76

    摘要： The present invention provides an S-nitroso group-containing albumin, comprising an S-nitroso group introduced to at least one lysine in the amino acid sequence for albumin. The S-nitro group has been introduced into a lysine in the S-nitroso group-containing albumin of the invention to allow more S-nitroso groups to be included in the albumin, thus ensuring more potent inhibition of cancer cells in NO groups.

    摘要翻译： 本发明提供含有S-亚硝基的白蛋白，其包含引入白蛋白氨基酸序列中的至少一个赖氨酸的S-亚硝基。 已将S-硝基引入本发明的含S-亚硝基基团的白蛋白中的赖氨酸中，以允许更多的S-亚硝基被包括在白蛋白中，从而确保NO组中对癌细胞的更有效的抑制。

    BASIS PARTICLES, METHOD FOR MANUFACTURING THE SAME, AND ORALLY-DISINTEGRATING TABLET
    32.
    发明申请
    BASIS PARTICLES, METHOD FOR MANUFACTURING THE SAME, AND ORALLY-DISINTEGRATING TABLET 审中-公开
    基础颗粒，其制造方法和异位消毒片

    公开(公告)号：US20080311195A1

    公开(公告)日：2008-12-18

    申请号：US12099688

    申请日：2008-04-08

    申请人： Shiho SAKURAGI ,  Naomi Ohmichi ,  Yohei Hoashi ,  Naohisa Katayama ,  Toshiya Kai

    发明人： Shiho SAKURAGI ,  Naomi Ohmichi ,  Yohei Hoashi ,  Naohisa Katayama ,  Toshiya Kai

    IPC分类号： A61K9/20 ,  A61K9/14

    CPC分类号： A61K9/0056 ,  A61K9/2081

    摘要： A basis particle comprises a basic or acidic basis particle coated by a water-insoluble coating film, wherein the water-insoluble coating film contains a substance that is acidic with respect to the basic basis or basic with respect to the acidic basis. According to the basis particles (i.e., a main ingredient or an active drug)of the present invention, it is possible to temporarily adjust pH occurring in the immediate proximity of the basis particles by using a coating film, elution of the basis particles is suppressed and superior elution is exhibited without dependence on bodily pH. It is also possible to mask tastes such as the bitterness of the basis and it is possible to ingest drugs without sensing any bitterness.

    摘要翻译： 基础颗粒包含由水不溶性涂膜包衣的碱性或酸性基质颗粒，其中所述水不溶性涂膜含有相对于碱性基础为酸性的物质或相对于酸性基质为碱性的物质。 根据本发明的基础颗粒（即主要成分或活性药物），可以通过使用涂膜临时调节在基础颗粒附近发生的pH，抑制基础颗粒的洗脱 并且在不依赖于身体pH的情况下表现出优异的洗脱。 也可以掩盖基础的苦味，并且可以摄取药物而不感觉到任何苦味。

    Recombinant protein containing serum albumin multimer
    36.
    发明申请
    Recombinant protein containing serum albumin multimer 审中-公开
    含重组蛋白的血清白蛋白多聚体

    公开(公告)号：US20050203020A1

    公开(公告)日：2005-09-15

    申请号：US11068502

    申请日：2005-03-01

    申请人： Masaki Otagiri ,  Yoshinori Kida ,  Naohisa Katayama ,  Toshiya Kai

    发明人： Masaki Otagiri ,  Yoshinori Kida ,  Naohisa Katayama ,  Toshiya Kai

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/38 ,  A61K47/42 ,  C07K14/765 ,  C12P21/02 ,  C07H21/04

    CPC分类号： C07K14/765 ,  A61K38/00

    摘要： A recombinant protein is provided containing a serum albumin multimer wherein at least two genes encoding serum albumin are combined with each other by gene recombinant technology and incorporated into a host cell for the effective production of the protein. The gene encoding a human serum albumin multimer and the recombinant vector are also provided. The protein is used as a safe drug administration carrier that is capable of extending the half life of a drug in the blood without the risk of contamination of viruses and so on, as compared with a conventional drug administration carrier.

    摘要翻译： 提供了含有血清白蛋白多聚体的重组蛋白质，其中至少两个编码血清白蛋白的基因通过基因重组技术彼此组合并且并入宿主细胞中以有效产生蛋白质。 还提供编码人血清白蛋白多聚体和重组载体的基因。 与常规药物给药载体相比，该蛋白质被用作能够延长血液中药物半衰期的安全药物给药载体，而没有病毒等的污染风险。

    Plastic vessel containing an albumin preparation
    37.
    发明授权
    Plastic vessel containing an albumin preparation 有权
    含有白蛋白制剂的塑料容器

    公开(公告)号：US06326010B1

    公开(公告)日：2001-12-04

    申请号：US09695215

    申请日：2000-10-25

    申请人： Minoru Sano ,  Yoshihisa Hama ,  Toshiya Kai ,  Masakazu Mameta

    发明人： Minoru Sano ,  Yoshihisa Hama ,  Toshiya Kai ,  Masakazu Mameta

    IPC分类号： A61J105

    摘要： To provide a plastic vessel containing an albumin preparation which completely restrains formation of thermally denatured albumin, a plastic molded member in a cylindrical shape is extruded in a molten state into opened dies, one end of which is closed in the dies, and a vessel is molded by blowing a compressed gas into the molded member in the dies or by bringing inner portions of the dies into a vacuum state. While the vessel is still disposed in the dies, an albumin preparation is introduced from an opening portion into an inner portion of the vessel and, therefore, the albumin preparation can be filled into the vessel in a sterilized state without being brought into contact with the atmosphere. Then, an opening portion of the vessel filled with the albumin preparation is hermetically sealed at an internal temperature of the opening portion of about 40 to 70° C. Thus formation of thermally denatured albumin can be completely restrained.

    摘要翻译： 为了提供一种含有完全抑制热变性白蛋白形成的白蛋白制剂的塑料容器，将具有圆筒形状的塑料成型体以熔融状态挤出成开模，其一端在模具中封闭，容器为 通过将压缩气体吹入模具中的模制构件中或通过使模具的内部部分成为真空状态来模制。 当容器仍然设置在模具中时，白蛋白制剂从开口部分引入容器的内部，因此白蛋白制剂可以在灭菌状态下填充到容器中而不与其接触 大气层。 然后，填充有白蛋白制剂的容器的开口部分在约40-70℃的开口部分的内部温度下气密密封。因此可以完全抑制热变性白蛋白的形成。