公开(公告)号：US20090099071A1

公开(公告)日：2009-04-16

申请号：US11873393

申请日：2007-10-16

申请人： Keisuke NAKAJOU ,  Naohisa KATAYAMA ,  Toshiya KAI ,  Masaki OTAGIRI

发明人： Keisuke NAKAJOU ,  Naohisa KATAYAMA ,  Toshiya KAI ,  Masaki OTAGIRI

IPC分类号： A61K38/00 ,  C07K14/00 ,  C12N15/11 ,  C12N15/00 ,  A61P1/16 ,  C12N5/06 ,  C12N1/00 ,  C12P21/04

CPC分类号： C07K14/765 ,  A61K38/00 ,  C07K14/76 ,  C12P21/005

摘要： Glycosylated albumin as a drug carrier for a DDS targeting the liver (particularly kupffer's cell) can be provided by mutating a DNA encoding albumin to encode a mutant albumin containing a partial amino acid sequence permitting glycosylation modification by eukaryotic cell, preferably a consensus sequence of N-linked sugar chain, introducing an expression vector containing the mutant DNA into a host eukaryotic cell, preferably a host cell permitting addition of a high-mannose type sugar chain, culturing the obtained transformant, and recovering a glycosylated albumin protein from the obtained culture.

摘要翻译： 作为靶向肝脏（特别是枯否氏细胞）的DDS的药物载体的糖基化白蛋白可以通过使编码白蛋白的DNA突变来编码含有允许真核细胞进行糖基化修饰的部分氨基酸序列的突变白蛋白，优选N 连接的糖链，将含有突变型DNA的表达载体导入宿主真核细胞，优选宿主细胞，允许加入高甘露糖型糖链，培养获得的转化体，并从获得的培养物中回收糖基化白蛋白。

公开(公告)号：US20080254120A1

公开(公告)日：2008-10-16

申请号：US12099668

申请日：2008-04-08

申请人： Shiho Sakuragi ,  Jun-ichi Yokoe ,  Naohisa Katayama ,  Toshiya Kai

发明人： Shiho Sakuragi ,  Jun-ichi Yokoe ,  Naohisa Katayama ,  Toshiya Kai

IPC分类号： A61K9/26

CPC分类号： A61K9/0056 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2095

摘要： An orally-disintegrating tablet comprises a principal agent, a sugar alcohol powder and a sugar alcohol granule, wherein the orally-disintegrating tablet has a hardness of 30 N or greater. According to the present invention, a smooth swallowing orally-disintegrating tablet, for which both the mechanical strength and the disintegration properties in the buccal cavity are favorable with using a normal tableting machine and without using special devices and the feeling on the tongue and taste are favorable, is provided.

摘要翻译： 口腔崩解片包含主剂，糖醇粉和糖醇颗粒，其中口腔崩解片的硬度为30N以上。 根据本发明，使用普通压片机，颊腔的机械强度和崩解性能均匀且不使用特殊的装置和舌头和口感的口感崩解片是平滑吞咽口腔崩解片， 有利的。

公开(公告)号：US20080166769A1

公开(公告)日：2008-07-10

申请号：US11921329

申请日：2006-06-01

申请人： Tadayuki Uno ,  Yohei Hoashi ,  Naohisa Katayama ,  Toshiya Kai

发明人： Tadayuki Uno ,  Yohei Hoashi ,  Naohisa Katayama ,  Toshiya Kai

IPC分类号： C12N15/63 ,  C12N1/21

CPC分类号： C12N15/70 ,  C07K14/805 ,  C12N15/69 ,  C12P21/02

摘要： Provided is a high-copy-number, high-expression vector capable of producing a protein having satisfactory functions and activity of the same level as that of a natural form of the protein, in a large quantity and in a simple manner. Also provided is a vector including: (A) a target gene or a cloning site of the target gene, (B) a sequence element necessary for the high copying of the target gene, (C) a sequence element necessary for the expression of the target gene and a methionine aminopeptidase gene; a method of producing the vector; a transformant having the vector introduced therein; and a process for producing a protein using the transformant.

摘要翻译： 提供了能够以大量和简单的方式产生具有与天然形式的蛋白质相同水平的令人满意的功能和活性的蛋白质的高拷贝数高表达载体。 还提供了载体，其包括：（A）靶基因的靶基因或克隆位点，（B）靶基因的高拷贝所必需的序列元件，（C）表达所需靶序列所需的序列元件 靶基因和甲硫氨酸氨基肽酶基因; 生成载体的方法; 其中引入载体的转化体; 以及使用该转化体生产蛋白质的方法。

公开(公告)号：US07351800B2

公开(公告)日：2008-04-01

申请号：US10505783

申请日：2003-02-28

申请人： Masaki Otagiri ,  Toshiya Kai ,  Makoto Sato

发明人： Masaki Otagiri ,  Toshiya Kai ,  Makoto Sato

IPC分类号： C07K1/00

CPC分类号： A61K38/38 ,  A61K9/0019 ,  A61K47/12 ,  A61K47/183

摘要： This invention provides albumin preparations with safety and without any risk of side effects, which are free from viruses or contaminating proteins and can be stably stored over a long time while showing neither changes in appearance nor decrease in content.There are provided a stabilized albumin preparation produced by uniformly mixing a medium-chain fatty acid or a salt thereof and a sulfur-containing amino acid or a derivative thereof with an aqueous albumin solution (e.g., a buffer such as phosphate buffer which can be administered as pharmaceutical preparations, injection water, or a physiological saline) and dissolving them therein, and then processing the mixture solution into a formulation suitable for parenteral administration such as an intravenous fluid preparation or an injectable solution, and a stabilization method for an albumin preparation.

摘要翻译： 本发明提供具有安全性且没有任何副作用的白蛋白制剂，其不含病毒或污染蛋白质，并且可长期稳定地储存，同时既不显示外观变化，也不显示内容物的减少。 提供了通过将中链脂肪酸或其盐和含硫氨基酸或其衍生物与白蛋白水溶液（例如，可以施用的磷酸盐缓冲液的缓冲液）均匀混合而制备的稳定的白蛋白制剂 作为药物制剂，注射用水或生理盐水）并将其溶解在其中，然后将该混合溶液加工成适用于肠胃外给药的制剂如静脉内液体制剂或注射溶液，以及白蛋白制备的稳定化方法。

公开(公告)号：US20060249456A1

公开(公告)日：2006-11-09

申请号：US11403188

申请日：2006-04-13

申请人： Ippei Fukutomi ,  Toshiya Kai ,  Naohisa Katayama ,  Takeshi Nizuka ,  Yoshinori Kida

发明人： Ippei Fukutomi ,  Toshiya Kai ,  Naohisa Katayama ,  Takeshi Nizuka ,  Yoshinori Kida

IPC分类号： C07K14/80 ,  C02F1/44

CPC分类号： B01D61/20 ,  A61K9/0026 ,  A61K38/42 ,  B01D19/0005 ,  B01D19/0031 ,  B01D61/36

摘要： A method of removing carbon monoxide from an oxygen carrier including setting a carbon monoxide bonded oxygen carrier solution across a separation membrane from an oxygen-dissolved solution; and exposing the setting part to the light and a method of removing carbon monoxide from an oxygen carrier including setting a carbon monoxide oxygen carrier solution across a hollow fiber separation membrane from an oxygen-dissolved solution; and exposing the setting part to light.

公开(公告)号：US20060166861A1

公开(公告)日：2006-07-27

申请号：US11337473

申请日：2006-01-24

申请人： Yoshinori Kida ,  Ippei Fukutomi ,  Naohisa Katayama ,  Toshiya Kai

发明人： Yoshinori Kida ,  Ippei Fukutomi ,  Naohisa Katayama ,  Toshiya Kai

IPC分类号： A61K38/41 ,  C07D487/22 ,  C07K14/765

CPC分类号： B82Y5/00 ,  A61K47/643 ,  A61K47/6949

摘要： A novel inclusion compound obtained by including in albumin a tetraphenylporphyrin metal complex represented by the following chemical formula (1) and having 2-position side chains: where R1 is a cyclohexyl group or the like; R2 represents a substituent; M represents a transition metal atom or metal ion belonging to Groups 6 to 10 of the periodic table; X− represents a halogen ion; and the number of X− is obtained by subtracting 2 from a valence of the metal ion.

摘要翻译： 通过在白蛋白中含有由下列化学式（1）表示的具有2-位侧链的四苯基卟啉金属络合物，其中R1是环己基等，得到的新型包合物; R2表示取代基; M表示属于周期表第6至10族的过渡金属原子或金属离子; X - 表示卤素离子; 并且通过从金属离子的化合价中减去2来获得X 的数量。

公开(公告)号：US20050256303A1

公开(公告)日：2005-11-17

申请号：US11044265

申请日：2005-01-28

申请人： Masaki Otagiri ,  Yoshinori Kida ,  Naoshisa Katayama ,  Toshiya Kai

发明人： Masaki Otagiri ,  Yoshinori Kida ,  Naoshisa Katayama ,  Toshiya Kai

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61P39/06 ,  C07K14/765 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/02

CPC分类号： C07K14/765

摘要： A protein produced by gene recombinant technology, including at least one domain selected from domains I, II, and III of serum albumin but having a different structure from that of native albumin; and a method of producing the protein. The protein has an enhanced functional activity or activities selected from among various functional activities or serum albumin including antibacterial activity, antioxidative effect, inflammation inhibitory effect, in vivo substance transporting action, and enzymatic activity.

摘要翻译： 由基因重组技术产生的蛋白质，其包括至少一个选自血清白蛋白结构域I，II和III的结构域，但与天然白蛋白结构不同的结构域; 和蛋白质的制造方法。 蛋白质具有增强的功能活性或选自各种功能活性或血清白蛋白的活性，包括抗菌活性，抗氧化作用，炎症抑制作用，体内物质运输作用和酶活性。

公开(公告)号：US06197936B1

公开(公告)日：2001-03-06

申请号：US09400000

申请日：1999-10-20

申请人： Minoru Sano ,  Yoshihisa Hama ,  Toshiya Kai ,  Masakazu Mameta

发明人： Minoru Sano ,  Yoshihisa Hama ,  Toshiya Kai ,  Masakazu Mameta

IPC分类号： A61J105

CPC分类号： A61J1/05 ,  A61J1/14 ,  A61M2207/00 ,  B29C49/04 ,  B65B3/022

摘要： To provide a plastic vessel containing an albumin preparation which completely restrains formation of thermally denatured albumin, a plastic molded member in a cylindrical shape is extruded in a molten state into opened dies, one end of which is closed in the dies, and a vessel is molded by blowing a compressed gas into the molded member in the dies or by bringing inner portions of the dies into a vacuum state. While the vessel is still disposed in the dies, an albumin preparation is introduced from an opening portion into an inner portion of the vessel and, therefore, the albumin preparation can be filled into the vessel in a sterilized state without being brought into contact with the atmosphere. Then, an opening portion of the vessel filled with the albumin preparation is hermetically sealed at an internal temperature of the opening portion of about 40° to 70° C. Thus formation of thermally denatured albumin can be completely restrained. A METHOD FOR PRODUCING A PLASTIC VESSEL CONTAINING AN ALBUMIN PREPARATION

摘要翻译： 为了提供一种含有完全抑制热变性白蛋白形成的白蛋白制剂的塑料容器，将具有圆筒形状的塑料成型体以熔融状态挤出成开模，其一端在模具中封闭，容器为 通过将压缩气体吹入模具中的模制构件中或通过使模具的内部部分成为真空状态来模制。 当容器仍然设置在模具中时，白蛋白制剂从开口部分引入容器的内部，因此白蛋白制剂可以在灭菌状态下填充到容器中而不与其接触 大气层。 然后，将填充有白蛋白制剂的容器的开口部分在约40℃至70℃的开口部分的内部温度下气密密封。因此可以完全抑制热变性白蛋白的形成。 一种生产含有铝制品的塑料容器的方法

公开(公告)号：US20120294947A1

公开(公告)日：2012-11-22

申请号：US13519193

申请日：2010-12-28

申请人： Kennichiro Kuninobu ,  Yohei Hoashi ,  Naohisa Katayama ,  Toshiya Kai

发明人： Kennichiro Kuninobu ,  Yohei Hoashi ,  Naohisa Katayama ,  Toshiya Kai

IPC分类号： A61K9/14 ,  A61K31/437 ,  A61J3/10 ,  A61K31/4422 ,  A61P25/28 ,  A61K31/445 ,  A61K31/519

CPC分类号： A61K31/445 ,  A61K9/2077 ,  A61K9/2846 ,  A61K31/437 ,  A61K31/4422 ,  A61K31/519

摘要： Provided is an oral preparation that contains a medicinal component having an unpleasant taste and that has better qualities, for example, generation of an analogue can be reduced, better than oral preparations that are produced by conventional techniques and that contain a medicinal component having an unpleasant taste. This objective is achieved by adding a coating agent on the medicinal component and a disintegrator that has a carboxymethyl group.

摘要翻译： 本发明提供含有具有令人不快的味道并且具有更好质量的药物成分的口服制剂，例如可以减少类似物的产生，优于常规技术制备的含有不愉快的药物成分的口服制剂 味道。 该目的通过在药物成分上添加涂布剂和具有羧甲基的崩解剂来实现。

公开(公告)号：US07893212B2

公开(公告)日：2011-02-22

申请号：US12201825

申请日：2008-08-29

申请人： Masaki Otagiri ,  Keisuke Nakajo ,  Naohisa Katayama ,  Toshiya Kai

发明人： Masaki Otagiri ,  Keisuke Nakajo ,  Naohisa Katayama ,  Toshiya Kai

IPC分类号： C07K16/00

CPC分类号： C07K14/76

摘要： The present invention provides an S-nitroso group-containing albumin, comprising an S-nitroso group introduced to at least one lysine in the amino acid sequence for albumin. The S-nitro group has been introduced into a lysine in the S-nitroso group-containing albumin of the invention to allow more S-nitroso groups to be included in the albumin, thus ensuring more potent inhibition of cancer cells in NO groups.

摘要翻译： 本发明提供含有S-亚硝基的白蛋白，其包含引入白蛋白氨基酸序列中的至少一个赖氨酸的S-亚硝基。 已将S-硝基引入本发明的含S-亚硝基基团的白蛋白中的赖氨酸中，以允许更多的S-亚硝基被包括在白蛋白中，从而确保NO组中对癌细胞的更有效的抑制。