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公开(公告)号：US20170080149A1
公开(公告)日：2017-03-23
申请号：US15369125
申请日：2016-12-05
发明人： Sean M. O'Connor , Robert Decker , Gautam N. Shetty , Mark A. DeStefano , Ian B. Hanson , Paul F. Bente, IV
摘要： An insertion mechanism for a drug pump includes an insertion mechanism housing; a manifold guide; an insertion biasing members initially held in an energized state; a retraction biasing member and a hub connected to a proximal end of a needle, wherein the retraction biasing member is held initially in an energized state between the hub and the manifold guide; and a manifold having a septum and a cannula, wherein the annular space between the septum and the cannula defines a manifold header. The needle and cannula are inserted into the body of a user by the insertion biasing member(s), after which only the needle is retracted. Retraction of the needle may open a fluid pathway from the manifold header to the body through the cannula. A drug delivery pump includes an activation mechanism, a drive mechanism, a fluid pathway connection, and the insertion mechanism. Assembly and operation methods are provided.
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公开(公告)号：US09592343B2
公开(公告)日：2017-03-14
申请号：US14333451
申请日：2014-07-16
发明人： Gautam N. Shetty , Lou Castagna
CPC分类号： A61M5/2448 , A61M5/31525 , A61M5/31533 , A61M5/31535 , A61M5/31578 , A61M5/31591 , A61M5/31596 , A61M5/322 , A61M5/3234 , A61M2005/2451 , A61M2005/3128
摘要： Mixing syringes including a valve mechanism are configured and configurable to enable one or more substances to be prefilled into the syringe. The valve mechanism may be an aspect of a distal seal assembly. Actuation of the valve mechanism permits opening of a fluid passage for the mixing of one or more substances, and the resulting mixed substance can be delivered by the syringe, for example, for administration of a pharmaceutical to a subject. The repetitive mixing of substances contained in a distal and proximal chamber is also provided, where the plunger rod is configured to releasably engage a locking mechanism to actuate the valve, and can axially displace the distal seal assembly while the fluid passage is open.
摘要翻译： 包括阀机构的混合注射器被配置和配置以使一种或多种物质能够预填充到注射器中。 阀机构可以是远端密封组件的一个方面。 阀机构的致动允许打开用于混合一种或多种物质的流体通道，并且所得到的混合物质可以通过注射器输送，例如用于向受试者施用药物。 还提供了包含在远端和近侧腔室中的物质的重复混合，其中柱塞杆构造成可释放地接合锁定机构以致动阀门，并且可以在流体通道打开时轴向移动远端密封组件。
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公开(公告)号：US09539393B2
公开(公告)日：2017-01-10
申请号：US14296194
申请日：2014-06-04
CPC分类号： A61M5/2066 , A61M5/284 , A61M5/31596 , A61M5/3234 , A61M2005/31598 , A61M2005/3231 , A61M2005/3236
摘要： An automatic mixing device, an actuating device having integrated plunger and configured to be removably mounted to the automatic mixing device, and a retractable syringe having the automatic mixing device are provided. The actuating device has an initially compressed spring and a trigger member that is rotatable to initiate spring decompression to drive depression of a mixing plunger seal of the automatic mixing device. Another seal located in an outer chamber of the mixing device is capable of axial movement upon depression of the mixing plunger, from a first position in sealing engagement with one or more apertures in an inner barrel to a second position intermediate the apertures and vents in an outer barrel. This allows depression of the mixing plunger to force a first substance from the outer chamber through the apertures to mix with a second substance in an inner chamber of the inner barrel. The mixed substance in the inner barrel is then delivered by the syringe with subsequent needle retraction.
摘要翻译： 一种自动混合装置，具有集成柱塞并构造成可移除地安装到自动混合装置的致动装置，以及具有自动混合装置的可缩回注射器。 致动装置具有初始压缩的弹簧和可旋转以启动弹簧减压以驱动自动混合装置的混合柱塞密封件的按压的触发构件。 位于混合装置的外部腔室中的另一个密封件能够在从与第一位置密封接合的第一位置处按压混合柱塞时轴向运动，该第一位置与内筒中的一个或多个孔密封接合到孔和通风口中的第二位置 外桶。 这允许压低混合柱塞以迫使第一物质从外室通过孔与第二物质混合在内筒的内腔中。 然后将内筒中的混合物质通过注射器递送，随后针回缩。
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公开(公告)号：USD768288S1
公开(公告)日：2016-10-04
申请号：US29523037
申请日：2015-04-06
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公开(公告)号：US20150320935A1
公开(公告)日：2015-11-12
申请号：US14648376
申请日：2013-11-18
CPC分类号： A61M5/284 , A61J1/2093 , A61M5/19 , A61M5/3148 , A61M5/3221 , A61M5/3234 , A61M2005/3117 , A61M2005/31598 , A61M2005/3231 , A61M2005/3238 , A61M2202/0007 , A61M2207/00 , B01F11/0054 , B01F11/0082 , B01F13/0023 , B01F15/00279 , B01F15/0224
摘要： A combination plunger, a mixing device and a mixing syringe including the same are provided. The mixing syringe includes concentric outer and inner barrels that form an outer chamber, the inner barrel having an inner chamber. The combination plunger includes a mixing plunger and a delivery plunger and a biasing means. The mixing plunger is slidably located in the outer chamber and translated by coordinated depression of the delivery plunger to transfer a first substance from the outer chamber to mix with a second substance in the inner chamber. After the mixing stage is complete, the delivery plunger is disengaged from the mixing plunger and permitted, such as by rotation, to be further depressed in the axial direction to deliver fluid contents of the mixing syringe to a recipient. The mixing syringe needle is then retracted as result of engagement by the delivery plunger and activation of the biasing means.
摘要翻译： 提供组合柱塞，混合装置和包括其的混合注射器。 混合注射器包括形成外室的同心外筒和内筒，内筒具有内腔。 组合柱塞包括混合柱塞和输送柱塞以及偏置装置。 混合柱塞可滑动地定位在外室中，并且通过协调的输送柱塞的凹陷平移，以将第一物质从外室转移以与内室中的第二物质混合。 在混合阶段完成之后，输送柱塞从混合柱塞脱离并允许，例如通过旋转，以进一步在轴向上被压下，以将混合注射器的流体内容物输送到接收器。 然后由输送柱塞的接合和偏置装置的启动使混合注射器针头缩回。
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公开(公告)号：US20150209505A1
公开(公告)日：2015-07-30
申请号：US14423529
申请日：2013-08-29
发明人： Ian B Hanson , Paul F Bente , Kevin Bokelman , John C Love
IPC分类号： A61M5/145
CPC分类号： A61M5/1454 , A61M5/1452 , A61M5/14546 , A61M5/14566 , A61M5/16804 , A61M2005/14208 , A61M2202/0007 , A61M2205/3334
摘要： A controlled delivery drive mechanism includes a drive housing, a piston, and a biasing member initially retained in an energized state and is configured to bear upon an interface surface of the piston. The piston is configured to translate a plunger seal and a barrel. A tether is connected between the piston and the winch drum to restrain the free expansion of the biasing member and the free axial translation of the piston upon which the biasing member bears upon. The drive mechanism may further include a gear assembly having a motor configured to drive the gear assembly to release the tether from the winch drum. The metering of the tether by the motor controls the rate or profile of drug delivery to a user. A drug delivery pump includes such a controlled delivery drive mechanism. A control system may be utilized to control the desired drug delivery rate/profile.
摘要翻译： 控制传递驱动机构包括驱动壳体，活塞和初始保持在通电状态的偏置构件，并且构造成承载在活塞的界面表面上。 活塞构造成平移柱塞密封件和筒体。 连杆系连接在活塞和绞盘鼓之间，以限制偏置构件的自由膨胀和偏置构件所承载的活塞的自由轴向平移。 驱动机构还可以包括具有马达的齿轮组件，该马达构造成驱动齿轮组件以从绞盘鼓释放系绳。 电动机对系绳的计量控制药物递送给用户的速率或分布。 药物输送泵包括这种受控输送驱动机构。 可以使用控制系统来控制所需的药物递送速率/分布。
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37.发明申请公开(公告)号：US20150174326A1
公开(公告)日：2015-06-25
申请号：US14572161
申请日：2014-12-16
发明人： Kevin Bokelman , George M. Wohlhieter , Thomas F. McGee , Arthur G. Marlin , Stefanie A. Hurowitz , David R. Jansen , Ellen Ni Chathail
CPC分类号： A61M5/2033 , A61M5/20 , A61M5/24 , A61M5/31513 , A61M5/31515 , A61M5/31581 , A61M2205/502
摘要： An automatic injector includes a housing having a guide, a drive control mechanism, a transmission assembly, a motor, and an energy source. The housing may further include a cartridge cover. A drive control mechanism includes a drive screw, a cartridge carrier, a plunger carrier, and one or more control transfer instruments, such as a puck or cylinder. The drive screw interfaces and connects with the plunger carrier. The automatic injector is configured to accept a variety of syringes as cartridges for drug delivery. The cartridges may be ejected from the injector and safely disposed after use, making the injector a reusable automatic injector. The reusable automatic injector may further include one or more sensors, such as a cartridge sensor and a patient sensor. The novel incorporation of the drive control mechanisms into the automatic injectors of the present invention enables a single motor and transmission assembly to drive the function of multiple components, which may include the steps of: preparation and alignment of a cartridge for injection, removal of a safety cap or needle shield, needle injection, drug dose delivery, and syringe and/or needle retraction. Methods of manufacture and methods of use are also disclosed.
摘要翻译： 自动注射器包括具有引导件的壳体，驱动控制机构，变速器组件，马达和能量源。 壳体还可以包括盒盖。 驱动控制机构包括驱动螺杆，筒式载体，柱塞架，以及一个或多个控制转移装置，例如圆盘或圆筒。 驱动螺丝接口并与柱塞支架连接。 自动注射器被配置为接受各种注射器作为用于药物递送的药筒。 墨盒可以从喷射器喷射并在使用后安全地放置，使喷射器成为可重复使用的自动喷射器。 可重复使用的自动注射器还可以包括一个或多个传感器，例如筒传感器和患者传感器。 驱动控制机构在本发明的自动喷射器中的新颖结合使得单个电动机和变速器组件能够驱动多个部件的功能，其可以包括以下步骤：准备和对准用于注射的药筒， 安全帽或针罩，针注射，药物剂量递送，注射器和/或针回缩。 还公开了制造方法和使用方法。
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38.发明申请INTEGRATED PIERCEABLE SEAL FLUID PATHWAY CONNECTION AND DRUG CONTAINERS FOR DRUG DELIVERY PUMPS 有权集成式密封流体路径连接和药物输送泵的药物容器公开(公告)号：US20150057613A1
公开(公告)日：2015-02-26
申请号：US14466403
申请日：2014-08-22
CPC分类号： A61M5/14224 , A61M5/14244 , A61M5/14248 , A61M5/14566 , A61M39/10 , A61M39/18 , A61M2039/1072
摘要： A sterile fluid pathway connector includes a piercing member, a connector hub, and a pierceable seal; wherein at least a portion of the pierceable seal is configured to move from a first position in which the piercing member is retained within a sterile cavity between the pierceable seal and the connector hub, to a second position in which the pierceable seal has been penetrated by the piercing member. A filter may be utilized to enclose the sterile cavity from the outside environment. Such fluid pathway connections may be integrated into a fluid container having a barrel and a plunger seal. The components of the fluid pathway connector may further be capable of transmitting a signal to the user upon completion of fluid delivery, for example, upon contact between the plunger seal and the pierceable seal. A fluid delivery pump includes such integrated fluid pathway connectors and fluid containers.
摘要翻译： 无菌流体通道连接器包括刺穿构件，连接器毂和可刺穿密封件; 其中所述可刺穿密封件的至少一部分被构造成从所述刺穿构件保持在所述可刺破密封件和所述连接器毂之间的无菌腔中的第一位置移动到所述可刺破密封件已经被穿透的第二位置 穿孔构件。 可以使用过滤器来从外界环境封闭无菌腔。 这种流体通道连接可以集成到具有桶和柱塞密封件的流体容器中。 流体通路连接器的部件还可以在流体输送完成时例如在柱塞密封件和可刺破密封件接触之后向使用者传递信号。 流体输送泵包括这种集成流体通道连接器和流体容器。
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公开(公告)号：US20150045744A1
公开(公告)日：2015-02-12
申请号：US14453354
申请日：2014-08-06
发明人： Jyoti Gupta , Brandon J. McKee
IPC分类号： A61M5/34
CPC分类号： A61M5/347 , A61M5/3134 , A61M5/322 , A61M5/345 , A61M5/5086 , A61M2005/3104 , A61M2005/3106 , A61M2005/3231 , A61M2205/0216
摘要： A connector mountable to a syringe barrel has a proximal barrel-engaging portion, a distal luer fitment portion, and a fluid aperture therethrough. The barrel-engaging portion of the connector includes an axial ledge configured to abut the axial distal edge of a glass syringe barrel. The connector facilitates mounting a luer assembly to the barrel. The luer assembly may be a tip cap, a luer needle assembly, or a luer needle-less assembly, having a complementary luer fitment for connection to the luer fitment portion of the connector. The connector and syringe may further include an immobile, compressible needle seal. The needle seal is adjacent to or engageable with the barrel-engaging portion of the connector.
摘要翻译： 可连接到注射器筒的连接器具有近端针筒接合部分，远端鲁尔配件部分和穿过其中的流体孔。 连接器的筒体接合部分包括构造成邻接玻璃注射器筒的轴向远端边缘的轴向凸缘。 连接器便于将路厄组件安装到筒体上。 鲁尔组件可以是尖端盖，鲁尔针组件或无路无针组件，其具有用于连接到连接器的鲁尔配件部分的互补鲁尔配件。 连接器和注射器还可以包括不可移动的可压缩的针密封件。 针状密封件与连接器的筒形接合部分相邻或接合。
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公开(公告)号：US20150045731A1
公开(公告)日：2015-02-12
申请号：US14454172
申请日：2014-08-07
CPC分类号： A61M5/5086 , A61M5/3134 , A61M5/3221 , A61M5/3232 , A61M5/3234 , A61M5/345 , A61M5/347 , A61M2005/3104 , A61M2005/3106 , A61M2005/323 , A61M2005/3231 , A61M2005/3241
摘要： A connector mountable to a syringe barrel has a proximal barrel-engaging portion, a distal luer fitment portion, and a fluid aperture therethrough. The barrel-engaging portion of the connector includes an axial ledge configured to abut the axial distal edge of a glass syringe barrel. The connector facilitates mounting a luer assembly to the barrel. The luer assembly may be a tip cap having a complementary luer fitment for connection to the luer fitment portion of the connector. The luer assembly may be a luer needle assembly having a complementary luer fitment for connection to the luer fitment portion of the connector. The connector and syringe may further include an immobile, compressible needle seal. The needle seal is adjacent to or engageable with the barrel-engaging portion of the connector. The syringe may be configured with a plunger capable of engaging a retractable needle.
摘要翻译： 可连接到注射器筒的连接器具有近端针筒接合部分，远端鲁尔配件部分和穿过其中的流体孔。 连接器的筒体接合部分包括构造成邻接玻璃注射器筒的轴向远端边缘的轴向凸缘。 连接器便于将路厄组件安装到筒体上。 鲁尔组件可以是具有用于连接到连接器的鲁尔配件部分的互补鲁尔配件的尖端盖。 鲁尔组件可以是具有用于连接到连接器的鲁尔配件部分的互补鲁棒配件的路厄针组件。 连接器和注射器还可以包括不可移动的可压缩的针密封件。 针状密封件与连接器的筒形接合部分相邻或接合。 注射器可以配置有能够接合可缩回针的柱塞。
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